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Table 1 Data Used

From: Dose-response model of murine typhus (Rickettsia typhi): time post inoculation and host age dependency analysis

Pathogen/strain

Study/Reference

Mode of inoculation

Test animal/Response

Organism/Reponses end point

Dose

Number of Test Animals

Positive Responses

Negative Responses

R. typhi

(Wilmington)

[10]

s.c.

BALB/c mice

(sero-conversion on day 9)

0.01(PFU)

10

0

10

    

0.1

10

0

10

    

1

10

0

10

    

10

10

0

10

    

100

10

0

10

    

1000

10

0

10

    

10000

10

10

0

R. typhi

(Wilmington)

[10]

s.c.

BALB/c mice

(sero-conversion on day 12)

0.01(PFU)

10

0

10

    

0.1

10

0

10

    

1

10

0

10

    

10

10

0

10

    

100

10

7

3

    

1000

10

8

2

    

10000

10

10

0

R. typhi

(Wilmington)

[10]

s.c.

BALB/c mice

(sero-conversion on day 15)

0.01(PFU)

10

0

10

    

0.1

10

0

10

    

1

10

1

9

    

10

10

5

5

    

100

10

9

1

    

1000

10

9

1

    

10000

10

10

0

R. typhi

(Wilmington)

[10]

s.c.

BALB/c mice

(sero-conversion on day 21)

0.01(PFU)

10

0

10

    

0.1

10

0

10

    

1

10

5

5

    

10

10

8

2

    

100

10

9

1

    

1000

10

10

0

    

10000

10

10

0

R. typhi

(Wilmington)

[10]

s.c.

BALB/c mice

(sero-conversion on day 28)

0.01(PFU)

10

0

10

    

0.1

10

3

7

    

1

10

8

2

    

10

10

9

1

    

100

10

10

0

    

1000

10

10

0

    

10000

10

10

0

R. typhi

(Ethiopian)

[8]

i.d.

Adult rat

(sero-conversion)

0.0435(PFU)

5

0

5

    

0.435

5

1

4

    

4.35

5

5

0

    

43.5

5

5

0

    

435

5

5

0

    

4350

5

5

0

    

43500

5

5

0

R. typhi

(Ethiopian)

[8]

i.d.

Newborn rat

(sero-conversion)

0.0435(PFU)

8

0

8

    

0.435

8

2

6

    

4.35

8

8

0

    

43.5

8

8

0

    

435

8

8

0

    

4350

8

8

0

R. typhi

(Ethiopian)

[9]

Oral

Young rat

3 day old

(sero-conversion)

10(PFU)

3

1

2

    

100

6

4

2

    

1000

3

3

0

    

10000

3

2

1

    

100000

5

5

0

R. typhi

(Ethiopian)

[9]

Oral

Young rat

7 day old

(sero-conversion)

10(PFU)

3

1

2

    

100

3

2

1

    

1000

2

2

0

    

10000

3

2

1

    

100000

3

3

0

R. typhi

(Ethiopian)

[9]

Oral

Young rat

30 day old

(sero-conversion)

10(PFU)

3

0

3

    

100

6

1

5

    

1000

3

2

1

    

10000

3

2

1

    

100000

3

2

1