From: Characterization of a pneumococcal meningitis mouse model
Parameter | Value | Weighted score | Maximum score |
---|---|---|---|
Weight loss from baseline | 5% | 0 | Â |
 | 10% | 1 |  |
 | 15% | 2 |  |
 | 20% | 3 |  |
 | 25% | 4 | 4 |
Activity | normal | 0 | Â |
 | increased/decreased | 1 |  |
 | mildely deminished | 1 |  |
 | deminished | 2 |  |
 | severely deminished | 3 |  |
 | coma | 4 | 4 |
Time to return to upright | normal | 0 | Â |
position | upright < 5 sec | 2 | Â |
 | upright < 30 sec | 4 |  |
 | no turn upright | 6 | 6 |
Coat | normal | 0 | Â |
 | deminished grooming | 1 |  |
 | soiled | 1 |  |
 | piloerection | 1 | 3 |
Posture | normal | 0 | Â |
 | sligh hunched back | 1 |  |
 | sev hunched back | 2 | 2 |
Eyes | normal | 0 | Â |
 | protruding | 1 |  |
 | sunken eyes | 1 |  |
 | closed eyelids | 1 |  |
 | discharge | 1 | 4 |
Respiration rate (per min) | > 150 | 0 | Â |
 | < 150 | 1 |  |
 | < 100 | 2 |  |
 | < 75 | 3 |  |
 | < 50 | 4 | 4 |
Breathing | irregular | 2 | Â |
 | laboured | 2 | 4 |
Neurologic exam | normal | 0 | Â |
 | ataxia | 2 |  |
 | limb paresis/paralysis | 2 |  |
 | epileptic seizure | 2 |  |
 | status epilepticus | 6 | 10 |
Total | Â | Â | 41 |