Characteristics | Total n = 305 | Group 1 (≤ 6 d) n = 166 | Group 2 (> 6 d) n = 139 | p value* |
---|---|---|---|---|
Time until diagnosis (days) | 6 (2-12) | 2 (1 - 4) | 12 (9 - 19) | - |
Demographic characteristics | 41.9 ± 17.4 | 40.3 ± 16.1 | 43.8 ± 18.7 | 0.079 |
Age, yr | ||||
Age > 60 years | 40 (13.1) | 17 (10.2) | 25 (18.0) | 0.051 |
Male sex | 108 (35.4) | 61 (37.7) | 47 (33.8) | 0.594 |
White race | 230 (75.4) | 123 (74.1) | 107 (77.0) | 0.560 |
Current smokers | 91 (35.4) | 56 (41.5) | 35 (28.7) | 0.032 |
Alcoholism | 89 (29.2) | 46 (27.9) | 43 (30.9) | 0.560 |
Injection drug use | 81 (26.6) | 50 (30.3) | 31 (22.3) | 0.116 |
Forms of TB | ||||
Isolated Pulmonary TB | 110 (36.1) | 77 (46.4) | 33 (23.7) | < 0.0001 |
Isolated Extra-pulmonary TB | 143 (46.9) | 53 (31.9) | 90 (64.7) | < 0.0001 |
Pulmonary + extra-pulmonary TB | 52 (17.0) | 36 (21.7) | 16 (11.5) | 0.019 |
Symptoms | ||||
Cough | 132 (43.3) | 89 (53.6) | 43 (30.9) | < 0.0001 |
Night sweats | 74 (24.3) | 54 (32.5) | 20 (14.4) | < 0.0001 |
Fever | 190 (62.3) | 111(66.9) | 79 (56.8) | 0.072 |
Laboratory results | ||||
Smear-negative sputum | 93 (56.7) | 45 (42.1) | 48 (84.2) | < 0.0001 |
Radiographic patterns | ||||
Cavitary disease | 33 (10.8) | 28 (16.9) | 5 (3.6) | < 0.0001 |
Pleural effusion | 58 (19.0) | 24 (14.5) | 34 (24.5) | 0.027 |
Miliary pattern | 37 (12.1) | 29 (17.5) | 8 (5.8) | 0.002 |
Consolidation | 52 (17.0) | 31 (18.7) | 21 (15.1) | 0.409 |
Normal | 42 (13.8) | 14 (8.4) | 28 (20.1) | 0.003 |
Previous default from TB treatment | 24 (7.9) | 20 (12.0) | 4 (2.9) | 0.003 |
Comorbidities | ||||
Presence of any comorbidity | 224 (73.4) | 130 (78.3) | 94 (67.6) | 0.035 |
HIV positive | 191 (71.0) | 117 (75.5) | 74 (64.9) | 0.059 |
Diabetes mellitus | 19 (6.2) | 3 (1.8) | 16 (11.5) | < 0.0001 |
Chronic renal failure | 8 (2.6) | 1 (0.6) | 7 (5.0) | 0.016 |
Mechanical ventilation | 48 (16.3) | 28 (17.4) | 20 (15.0) | 0.587 |
In-hospital mortality | 50 (16.4) | 29 (17.5) | 21 (15.1) | 0.579 |
Mortality after discharge | 47 (18.4) | 22 (16.1) | 25 (21.2) | 0.292 |