R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes

BMC Infectious Diseases

Table 2 Details of HIV infected subjects from whom monocytes were isolated and cultured ex vivo

Subject No.^a	Sex (age)^c	CD4 Count (cells/μl)	CD8 Count (cells/μl)	Plasma Viral Load (copies/ml)	HCV^b	HBV^b	HIV Subtype
1	M(42)	332	1326	18800	P	P	CRF07-BC
2	F(38)	412	1373	92300	N	N	CRF01-AE
3	M(45)	368	463	71000	P	N	B
4	M(22)	484	1333	60100	N	N	B
5	M(40)	364	842	3200	N	N	CRF01-AE
6	M(46)	265	421	140000	N	N	CRF01-AE
7	M(33)	328	485	63000	N	N	CRF01-AE
8	F(45)	480	737	< 10	P	N	B'
9	F(45)	359	1064	3600	N	P	B'
10	M(32)	276	869	830000	P	P	B'

^a Monocytes from subjects no.2,3,4,5,7 were used to analyze R-848 influence on expression of TLR7/8; Monocytes from subjects no.1-10 were used to examine TLR7/8 signaling capacity; monocytes from subjects no.1-9 were used to examine HIV replication suppression mediated by TLR7/8. No subjects received HAART therapy
^b Minor or no biochemical signs of ongoing liver inflammation (alanine aminotransferase level < 70); P, Positive; N, Negative
^c M, male; F, female; age in years

ISSN: 1471-2334