Impact of Herpes simplex virus load and red blood cells in cerebrospinal fluid upon herpes simplex meningo-encephalitis outcome

Table 2 Univariate analysis of factors associated with HSE mortality and morbidity

Variables	Mortality (n=43)			Morbidity (n=39*)
	Alive (n=29)	Dead (n=14)	p	Low (n=17) GOS 1-3	High (n=22) GOS 4-5	P
Median HSV load (Log₁₀ copies/μL)	2.1	1.7	0.95	2.0	1.8	0.95
Age in years (median)	59	71	0.03	57	64	0.04
Knaus score (%)			0.07			0.004
Normal health status (A)	64.3	35.7		81,3	18.8
Moderate limitation in bedridden patients (B-D)	35.7	64.3		33.3	66.7
Lymphocytic CSF (%)	66.7	41.7	0.17	80.0	42.1	0.04
Median blood red cell counts in CSF (cells/μL)	4	49	0.17	0	49	0.05
Median time to lumbar puncture (days)	0	1	0.23	0	1	0.02
Median time to acyclovir initiation (days)	0	2	0.08	0	2	0.006

* Morbidity analysis was performed for 38 patients, since Glasgow outcome scale was not available for five patients.
GOS 1–3: Glasgow outcome scale, classes 1 to 3: good recovery to moderate disability.
GOS 4–5: Glasgow outcome scale, classes 4 and 5: severe disability and death.

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