Figure 1

Plasma antibody titres against Pf AMA1 alleles and allele mixtures. Anti-PfAMA1 antibody titres in plasma of malaria-exposed children were measured by an indirect ELISA using four PfAMA1 alleles (from the FVO, HB3, 3D7 and CAMP parasite strains) and three different allele mixtures (DiCo mix or DM, a mixture of the four natural alleles, designated as Four, and a mixture of all seven alleles, designated as Seven) separately as capture antigens. Titres are presented for children aged 3 - 5 years (lower panel), 6 - 10 years (middle panel) and 11 - 15 years (upper panel). Each symbol represents plasma antibody titres of a study participant. Boxplots show the upper and lower quartiles as well as the median of each distribution. The vertical axis (antibody titre) is expressed in kilo arbitrary units (kAU), with one arbitrary unit being equivalent to the reciprocal plasma dilution that gives an OD of 1.0 over background.