| Incidence ofmedical death | Estimated excess mortality per 1000 person-years (95% CI) | P-value | Number needed to treat per year (95% CI) to avert 1 death |
---|---|---|---|---|
HIV-1 uninfected | 3.6 | Reference | - | Reference |
HIV-1 infected | 13.7 | 10.2 (6.9, 13.5) | <.001 | Â |
CD4 cell count | Â | Â | Â | Â |
  ≥500 | 4.8 | 1.2 (−1.8, 4.2) | .44 | 851 |
  350-499 | 13.1 | 8.9 (3.8, 14.0) | <.001 | 113 |
  250-349 | 19.9 | 15.2 (8.1, 22.2) | <.001 | 66 |
  <250 | 42.7 | 29.3 (13.9, 44.7) | <.001 | 34 |
HIV-1 RNA | Â | Â | Â | Â |
  HIV-1 <10 K | 7.7 | 2.0 (−1.1, 5.0) | .21 | 509 |
  10 K-50 K | 3.7 | −0.6 (−3.4, 2.3) | .69 | NA |
  50 K-100 K | 13.9 | 6.7 (−0.6, 14.0) | .071 | 149 |
  >100 K | 46.9 | 43.0†(29.6, 56.4) | <.001 | 23 |