Figure 2From: Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation Hepatotoxicity. Box plot of liver parameters the day before posaconazole therapy began (Before), their maximums during therapy (Maximum), and values at the end of oral antimycotic monoprophylaxis with posaconazole (End). A: Plasma alanine aminotransferase (ALT) (normal value, ≤ 39 U/L). B: Plasma aspartate aminotransferase (AST) (normal value, ≤ 59 U/L for pediatric patients < 12 years of age). C: Total plasma bilirubin (normal value, ≤ 1.1 mg/dL). D: Direct plasma bilirubin (normal value, ≤ 0.3 mg/dL). Statistical analysis by the Wilcoxon matched-pairs signed-ranks test showed a significant increase (***P < 0.001) in ALT and AST beyond their upper normal limits during treatment post-transplant respective to baseline measurements taken the day before the start of posaconazole prophylaxis (Before).Back to article page