Table 3 Antibiotic treatment patterns by infection type
| Â | Overall | Diabetic foot infection | Surgical site infection | Deep soft tissue abscess | Cellulitis |
|---|---|---|---|---|---|
(N=1,033) | (N=278) | (N=330) | (N=147) | (N=278) | |
Initial intravenous antibiotics: N (%) * | |||||
 Glycopeptidesa | 630 (61.0) | 167 (60.1) | 186 (56.4) | 109 (74.1) | 169 (60.4) |
 Penicillinsb | 386 (37.4) | 141 (50.7) | 101 (30.6) | 53 (36.1) | 91 (32.7) |
 Beta-lactamase -inhibitorsc | 380 (36.8) | 140 (50.4) | 98 (29.7) | 53 (36.1) | 89 (32.0) |
 Beta-lactamase -resistantd | 7 (0.7) | 1 (0.4) | 3 (0.9) | 0 (0.0) | 3 (1.1) |
 Non-beta-lactamase inhibitorse | 7 (0.7) | 2 (0.7) | 1 (0.3) | 0 (0.0) | 4 (1.4) |
 Cephalosporinsf | 188 (18.2) | 41 (14.8) | 64 (19.4) | 15 (10.2) | 68 (24.5) |
 First-generation | 90 (8.7) | 13 (4.7) | 37 (11.2) | 3 (2.0) | 37 (13.3) |
 Third-generation | 69 (6.7) | 18 (6.5) | 15 (4.5) | 11 (7.5) | 25 (9.0) |
 Fourth-generation | 27 (2.6) | 9 (3.2) | 13 (3.9) | 0 (0.0) | 5 (1.8) |
 Lincosamidesj | 147 (14.2) | 31 (11.2) | 38 (11.5) | 25 (17.0) | 53 (19.1) |
 Fluoroquinolonesk | 90 (8.7) | 28 (10.1) | 35 (10.6) | 11 (7.5) | 16 (5.8) |
 Daptomycin | 28 (2.7) | 5 (1.8) | 13 (3.9) | 4 (2.7) | 6 (2.2) |
 Nitroimidazole derivativesm | 27 (2.6) | 7 (2.5) | 14 (4.2) | 1 (0.7) | 5 (1.8) |
 Other Antibiotics n | 26 (2.5) | 8 (2.9) | 8 (2.4) | 4 (2.7) | 6 (2.2) |
Treatment duration of the most common initial intravenous antibiotics: mean (median, minimum-maximum) | |||||
 First-generation cephalosporins | 2.5 (1.7, 0–27) | 1.5 (1.7, 0–3) | 3.2 (1.7, 0–27) | 1.6 (1.5, 0–3) | 2.2 (1.5, 0–12) |
 Glycopeptides | 3.2 (2.6, 0–24) | 3.7 (2.7, 0–24) | 3.1 (2.6, 0–16) | 2.8 (2.6, 0–11) | 3.0 (2.7, 0–14) |
 Lincosamides | 2.2 (1.6, 0–10) | 1.9 (1.2, 0–8) | 2.5 (1.5, 0–10) | 2.3 (2.3, 0–7) | 2.1 (1.7, 0–9) |
 Penicillins (beta-lactamase-inhibitors) | 3.4 (2.6, 0–36) | 3.8 (2.8, 0–24) | 3.9 (2.9, 0–36) | 2.4 (2.1, 0–7) | 2.8 (2.4, 0–13) |
Reason for administration of initial intravenous antibiotics: N (%)* | |||||
 Empiric treatment prior to culture test results | 917 (88.8) | 243 (87.4) | 292 (88.5) | 137 (93.2) | 245 (88.1) |
 Not responding to previous antibiotic treatment | 42 (4.1) | 6 (2.2) | 13 (3.9) | 6 (4.1) | 17 (6.1) |
 Other | 64 (6.2) | 13 (4.7) | 24 (7.3) | 6 (4.1) | 21 (7.6) |
Reason for discontinuation of initial antibiotics: N (%)* | 886 | 232 | 271 | 136 | 247 |
 Switched to another route/formulation^ | 475 (53.6) | 108 (46.6) | 147 (54.2) | 82 (60.3) | 138 (55.9) |
 Infection improved, resolved, or cured^ | 386 (43.6) | 105 (45.3) | 99 (36.5) | 62 (45.6) | 120 (48.6) |
 Culture results indicate this antibiotic agent not needed | 155 (17.5) | 43 (18.5) | 56 (20.7) | 32 (23.5) | 24 (9.7) |
 Pathogen not susceptible to this antibiotic agent^ | 36 (4.1) | 8 (3.4) | 19 (7.0) | 3 (2.2) | 6 (2.4) |