From: Emergence of serogroup C meningococcal disease associated with a high mortality rate in Hefei, China
Feature | Serogroup C (n = 493) | Serogroup A (n = 177) | P | |
---|---|---|---|---|
onset | ||||
Presentation days (mean ± SD) | 1.8 ± 2.5 | 1.9 ± 2.4 | 0.810 | |
Fever | 481(97.6) | 169(95.5) | 0.162 | |
Nausea and/or vomiting | 141(28.5) | 55(31.2) | 0.535 | |
Headache | 165(33.4) | 52(29.1) | 0.319 | |
Petechia and/or purpura | 396(80.3) | 126(73.4) | 0.063 | |
Altered mental status | 136(27.6) | 49(27.7) | 0.980 | |
Disease classification | ||||
Meningitis | 114(23.1) | 92(52.0) | <0.001 | |
Meningococcemia | 379(76.9) | 85(48.0) | ||
With Shock | 91(18.5) | 13(7.3) | <0.001 | |
With pneumonia | 12(2.8) | 3(1.7) | 0.784 | |
With arthritis | 9 (1.8) | 4(2.3) | 0.967 | |
Complications | 161 | 23 | <0.001 | |
Shock | 91(18.5) | 13(7.3) | <0.001 | |
DIC | 60(12.2) | 7(4.0) | 0.002 | |
kidney failure | 10(2) | 3(1.7) | 0.783 | |
MOF | 4(0.8) | 1(0.6) | 1.0 | |
WBC count | ||||
>10 × 109/L | 302(61.3) | 99(56.1) | 0.019 | |
10~4 × 109/L | 117(23.7) | 35(19.8) | ||
<4 × 109/L | 74(15.0) | 43(24.3) | ||
Platelet count | ||||
>100 × 109/L | 361(73.2) | 162(91.5) | <0.001 | |
100~50 × 109/L | 87(17.6) | 11(6.2) | ||
100~50 × 109/L | 87(17.6) | 11(6.2) | ||
CSF data (mean ± SD) | ||||
Glucose level(mmol/L) | 2.07 ± 1.7 | 1.91 ± 1.8 | 0.717 | |
CSF glucose / blood glucose ratio | 0.24 ± 0.23 | 0.21 ± 0.29 | 0.438 | |
Total protein level(g/L) | 3.41 ± 2.9 | 3.17 ± 2.18 | 0.106 | |
Lactate level(mmol/L) | 10.4 ± 9.2 | 11.0 ± 8.9 | 0.113 | |
WBC count(109/L) | 5.3 ± 13.8 | 8.1 ± 13.6 | 0.895 | |
Sequelae | 46/484(9.5) | 6/171(3.5) | 0.013 | |
Scars | 19/484(3.9) | 2/171(1.2) | 0.132 | |
Amputations | 14/484(2.9) | 0 | 0.026 | |
sensorineural hearing loss | 5/484(1.0) | 3/171(1.8) | 0.739 | |
Others | 8/484(17) | 1/171(0.6) | 0.516 | |
Death | 55/484(11.4) | 9/171(5.3) | 0.021 |