Definitive antibiotic therapy | |||||
---|---|---|---|---|---|
Median (interquartile range) or percentage | Benzylpenicillin | Cefuroxime | Aminopenicillins | Broadspectrum antibiotics | |
n = 26 | n = 50 | n = 12 | n = 16 | ||
Combination therapy with gentamicin or ciprofloxacin | 34.6% (9/26) | 22.0% (11/50) | 25.0% (3/12) | 43.8% (7/16) | |
Gender (female) | 46.2% (12/26) | 40.0% (20/50) | 58.3% (7/12) | 37.5% (6/16) | |
Age | 73 (58–84) (n = 26) | 69 (52–76) (n = 50) | 62 (26–82) (n = 12) | 68 (56–79) (n = 16) | |
Charlson index | |||||
Low (0) | 57.7% (15/26) | 36.0% (18/50) | 58.3% (7/12) | 25.0% (4/16) | |
Medium (1–2) | 30.8% (8/26) | 48.0% (24/50) | 25.0% (3/12) | 56.2% (9/16) | |
High (>2) | 11.5% (3/26) | 16.0% (8/50) | 16.7% (2/12) | 18.8% (3/16) | |
Smoking | 45.8% (11/24) | 49.0% (24/49) | 45.5% (5/11) | 43.8% (7/16) | |
Alcohol abuse | 26.1% (6/23) | 21.7% (10/46) | 9.1% (1/11) | 25.0% (4/16) | |
Immunosuppression | 3.8% (1/26) d f | 30.0% (15/50) | 16.7% (2/12) | 31.2% (5/16) | |
Haemophilus species | |||||
Non-typeable | 69.2% (18/26) | 76.0% (38/50) | 75.0% (9/12) | 62.5% (10/16) | |
Typeable | 15.4% (4/26) | 14.0% (7/50) | 16.7% (2/12) | 25.0% (4/16) | |
Other types | 15.4% (4/26) | 14.0% (7/50) | 8.3% (1/12) | 12.5% (2/16) | |
Polymicrobial bacteremia | 19.2% (5/26) d | 4.0% (2/50) | 0% (0/12) | 6.2% (1/16) | |
Acquisition of bacteremia | |||||
Community-acquired | 65.4% (17/26) | 56.0% (28/50) g | 91.7% (11/12) i | 31.2% (5/16) | |
Healthcare-related | 23.1% (6/26) | 34.0% (17/50) | 8.3% (1/12) | 43.8% (7/16) | |
Hospital-acquired | 11.5% (3/26) | 10.0% (5/50) | 0% (0/12) | 25.0% (4/16) | |
Focus of infection | |||||
Lung | 38.5% (10/26) | 52.0% (26/50) | 58.3% (7/12) | 43.8% (7/16) | |
Upper respiratory tract | 3.8% (1/26) | 6.0% (3/50) | 16.7% (2/12) | 0.0% (0/16) | |
Meningitis | 0% (0/26) f | 0% (0/50) h | 0% (0/12) | 25.0% (4/16) | |
Endocarditis | 3.8% (1/26) | 2.0% (1/50) | 0% (0/12) | 6.2% (1/16) | |
Hepato-billiary | 11.5% (3/26) | 8.0% (4/50) | 0% (0/12) | 6.2% (1/16) | |
Miscellaneous | 11.5% (3/26) | 12.0% (6/50) | 16.7% (2/12) | 0.0% (0/16) | |
Unknown | 30.8% (8/26) | 20.0% (10/50) | 8.3% (1/12) | 18.8% (3/16) | |
Hospital specialty | |||||
Medical department | 69.2% (18/26) | 70.0% (35/50) | 41.7% (5/12) | 75.0% (12/16) | |
Surgical department | 26.9% (7/26) | 16.0% (8/50) | 8.3% (1/12) | 12.5% (2/16) | |
Intensive care unit | 0.0% (0/26) | 4.0% (2/50) | 16.7% (2/12) | 12.5% (2/16) | |
Other departments b | 3.8% (1/26) | 10.0% (5/50) | 33.3% (4/12) | 0.0% (0/16) | |
Altered mental state | 26.9% (7/26) | 24.0% (12/50) | 25.0% (3/12) | 53.3% (8/15) | |
Temp. <38 °C | 30.8% (8/26) | 26.0% (13/50) | 9.1% (1/11) | 14.3% (2/14) | |
Mean blood pressure (mmHg) | 90 (82–102) (n = 25) | 91 (84–100) (n = 48) | 92 (71–109) (n = 10) | 94 (73–103) (n = 15) | |
Heart rate | 100 (79–108) (n = 25) | 95 (80–108) (n = 47) | 105 (89–136) (n = 10) | 94 (84–106) (n =15) | |
B-hgb (mmol/L) | 6.8 (6.4-8.3) (n = 23) | 7.3 (6.3-8.3) (n = 43) | 7.9 (6.9-8.7) (n = 9) | 7.7 (6.0-9.0) (n = 14) | |
B-WBC (109 cells/L) | 13.3 (10.5-16.6) (n = 23) | 15.5 (9.7-20.5) (n = 49) | 10.6 (7.5-17.7) (n = 10) | 8.2 (2.1-18.8) (n = 15) | |
P-creatinine (μmol/L) | 79 (58–137) (n =19) | 90 (62–133) (n = 43) | 69 (56–99) (n = 9) | 105 (71–240) (n = 14) | |
Abnormal liver parameters c | 72.2% (13/18) | 54.1% (20/37) | 40.0% (2/5) | 40.0% (4/10) | |
P-CRP (mg/L) | 145 (45–214) (n = 24) d | 184 (105–262) (n = 48) | 186 (55–241) (n = 10) | 173 (119–271) (n = 14) | |
Transfer to ICU | 11.5% (3/26) | 12.2% (6/49) h | 25.0% (3/12) | 37.5% (6/16) | |
Septic shock | 11.5% (3/26) | 0% (0/48) h | 8.3% (1/12) | 26.7% (4/15) | |
Mechanical ventilation | 7.7% (2/26) f | 8.2% (4/49) h | 8.3% (1/12) | 37.5% (6/16) | |
Hemodialysis | 3.8% (1/26) | 2.1% (1/48) h | 0% (0/12) | 18.8% (3/16) | |
Death | 38.5% (10/26) d e | 12.0% (6/50) h | 0% (0/12) i | 37.5% (6/16) |