Figure 2
Effects of SCH-58261 treatment on ATL 370-treated C. difficile toxin A-challenged loops. Increasing doses of adenosine A2A receptor blocker, SCH 58261 (given IV), reversed the effects of ATL 370 (1.5 ng IV) on secretion (A) and epithelial injury (B) in a dose-dependent manner in rabbit ileal loops. 3.5 ng of SCH 58261 is equimolar to 1.5 ng of ATL370. Panel 2A: a- P < 0.0001 (one-way ANOVA), and b(PBS vs. Toxin A)- P < 0.001, c(Toxin A vs ATL + SCH)- P < 0.01 (Bonferroni's). Panel 2B: a- P < 0.0001 (one-way ANOVA), b(PBS vs. Toxin A)- P < 0.001 (Bonferroni's). Results were data pooled from 4 to 28 loops from 1 to 6 rabbits per group from 5 separate experiments.