Laboratory influenza | |||||||
---|---|---|---|---|---|---|---|
Clinical test | diagnosis | ||||||
Clinical test | result | Positive | Negative | SN (%) (95% CI) | SP (%) (95% CI) | PPV (%) (95% CI) | NPV (%) (95% CI) |
At least 1 criteriona | Positive | 157 | 363 | 100.0 (undefined) b | 0.8 (0.0–1.6) | 30.2 (26.3–34.1) | 100.0 (undefined) b |
Negative | 0 | 3 | |||||
At least 2 criteriaa | Positive | 149 | 292 | 94.9 (93.0–96.8) | 20.2 (16.8–23.7) | 33.8 (29.7–37.8) | 90.2 (87.7–92.8) |
Negative | 8 | 74 | |||||
At least 3 criteriaa | Positive | 91 | 73 | 58.0 (53.7–62.2) | 80.1 (76.6–83.5) | 55.5 (51.2–59.7) | 81.6 (78.3–84.9) |
Negative | 66 | 293 | |||||
All 4 criteriaa | Positive | 23 | 5 | 14.6 (11.6–17.7) | 98.6 (97.6–99.6) | 82.1 (78.9–85.4) | 72.9 (69.1–76.7) |
Negative | 134 | 361 | |||||
Exact 2 criteria c | |||||||
Acute onset and fever | Positive | 31 | 22 | 19.7 (16.3–23.2) | 94.0 (92.0–96.0) | 58.5 (54.3–62.7) | 73.2 (69.4–77.0) |
Negative | 126 | 344 | |||||
Acute onset and cough | Positive | 86 | 85 | 54.8 (50.5–59.0) | 76.8 (73.2–80.4) | 50.3 (46.0–54.6) | 79.8 (76.4–83.3) |
Negative | 71 | 281 | |||||
Acute onset and body aches | Positive | 64 | 68 | 40.8 (36.6–45.0) | 81.4 (78.1–84.8) | 48.5 (44.2–52.8) | 76.2 (72.6–79.9) |
Negative | 93 | 298 | |||||
Fever and cough | Positive | 51 | 29 | 32.5 (28.5–36.5) | 92.1 (89.8–94.4) | 63.8 (59.6–67.9) | 76.1 (72.4–79.7) |
Negative | 106 | 337 | |||||
Fever and body aches | Positive | 42 | 25 | 26.8 (23.0–30.5) | 93.2 (91.0–95.3) | 62.7 (58.5–66.8) | 74.8 (71.1–78.5) |
Negative | 115 | 341 | |||||
Cough and body aches | Positive | 126 | 224 | 80.3 (76.8–83.7) | 38.8 (34.6–43.0) | 36.0 (31.9–40.1) | 82.1 (78.8–85.4) |
Negative | 31 | 142 | |||||
Cough + any of other 3 criteria | Positive | 149 | 264 | 94.9 (93.0–96.8) | 27.9 (24.0–31.7) | 36.1 (32.0–40.2) | 92.7 (90.5–95.0) |
Negative | 8 | 102 | |||||
Exact 3 criteria c | |||||||
Acute onset, fever, cough | Positive | 31 | 14 | 19.7 (16.3–23.2) | 96.2 (94.5–97.8) | 68.9 (64.9–72.9) | 73.6 (69.9–77.4) |
Negative | 126 | 352 | |||||
Acute onset, cough, body aches | Positive | 64 | 47 | 40.8 (36.6–45.0) | 87.2 (84.3–90.0) | 57.7 (53.4–61.9) | 77.4 (73.8–81.0) |
Negative | 93 | 319 | |||||
Acute onset, fever, body aches | Positive | 23 | 9 | 14.6 (11.6–17.7) | 97.5 (96.2–98.9) | 71.9 (68.0–75.7) | 72.7 (68.9–76.5) |
Negative | 134 | 357 | |||||
Fever, cough, body aches | Positive | 42 | 18 | 26.8 (23.0–30.5) | 95.1 (93.2–96.9) | 70.0 (66.1–74.0) | 75.2 (71.5–78.9) |
Negative | 115 | 348 | |||||
CDC ILI case definition d | |||||||
Total study population | Positive | 83 | 82 | 37.7 (33.6–41.9) | 85.6 (82.6–88.6) | 50.3 (46.0–54.6) | 78.0 (74.5–81.6) |
Negative | 137 | 487 | |||||
Subjects ages 3–5 years | Positive | 3 | 15 | 25.0 (21.3–28.7) | 71.7 (67.8–75.6) | 16.7 (13.4–19.9) | 80.9 (77.5–84.2) |
Negative | 9 | 38 | |||||
Subjects ages 6–49 years | Positive | 63 | 52 | 40.1 (35.9–44.3) | 85.8 (82.8–88.8) | 54.8 (50.5–59.0) | 77.0 (73.4–80.6) |
Negative | 94 | 314 | |||||
Subjects ages 50–80 years | Positive | 17 | 15 | 33.3 (29.3–37.4) | 90.0 (87.4–92.6) | 53.1 (48.8–57.4) | 79.9 (76.4–83.3) |
Negative | 34 | 135 |