Table 1 Univariate analysis of the risk factors for defaulting from TB treatment among HIV subjects in the State of Pernambuco, 2007-2009
VARIABLES | Default | Treatment success | OR | 95% CI | P-value | ||
|---|---|---|---|---|---|---|---|
n | % | n | % | ||||
BIOLOGICAL | |||||||
Sex | |||||||
Female | 15 | 17.6 | 57 | 30.3 | 1.00 | - | - |
Male | 70 | 82.3 | 131 | 69.7 | 2.03 | 1.07 - 3.84 | 0.030 |
Age group | |||||||
18 to 29 years | 33 | 38.8 | 35 | 18.6 | 1.00 | - | - |
30 to 49 years | 48 | 56.5 | 131 | 69.7 | 0.38 | 0.21 - 0.69 | 0.001 |
50 years or more | 4 | 4.7 | 22 | 11.7 | 0.19 | 0.06 - 0.61 | 0.006 |
Race | |||||||
White | 15 | 17.6 | 42 | 22.3 | 1.00 | - | - |
Non-white | 70 | 82.3 | 146 | 77.7 | 1.34 | 0.69 - 2.58 | 0.378 |
SOCIOECONOMIC | |||||||
City of Residence | |||||||
Recife | 39 | 45.9 | 78 | 41.5 | 1.00 | - | - |
Metropolitan Region | 35 | 41.2 | 78 | 41.5 | 0.89 | 0.51 - 1.56 | 0.702 |
Inland | 11 | 12.9 | 32 | 17.0 | 0.68 | 0.31 - 1.50 | 0.350 |
Marital status | |||||||
Married | 12 | 14.1 | 54 | 28.7 | 1.00 | - | |
Single/Separated/Widowed | 73 | 85.9 | 134 | 71.3 | 2.45 | 1.23 - 4.87 | 0.011 |
Shared residence | |||||||
Family/Partner | 17 | 20.0 | 33 | 17.6 | 1.00 | ||
Alone | 68 | 80.0 | 155 | 82.4 | 1.74 | 0.61 - 2.25 | 0.629 |
Education level | |||||||
Complete or incomplete primary education | 69 | 81.2 | 128 | 69.1 | 1.00 | - | - |
Complete or incomplete secondary or university education | 16 | 21.0 | 60 | 31.9 | 0.49 | 0.26 - 0.92 | 0.027 |
Employment | |||||||
Yes | 17 | 20.0 | 34 | 18.1 | 1.00 | - | - |
No | 68 | 80.0 | 154 | 81.9 | 0.88 | 0.46 - 1.68 | 0.707 |
Income* | |||||||
< 1 minimum wage | 65 | 22.6 | 117 | 37.4 | 1.00 | - | - |
≥ 1 minimum wage | 19 | 77.4 | 70 | 62.6 | 0.48 | 0.27 - 0.88 | 0.017 |
HABITS | |||||||
Alcohol consumption | |||||||
None or light drinker | 69 | 81.2 | 177 | 94.1 | 1.00 | - | - |
Moderate or Heavy drinker | 16 | 18.8 | 11 | 5.8 | 3.73 | 1.64 - 8.44 | 0.002 |
Smoking status | |||||||
Never smoked | 22 | 25.9 | 81 | 43.1 | 1.00 | - | - |
Former smokers | 14 | 16.5 | 45 | 23.9 | 1.14 | 0.53 - 2.45 | 0.727 |
Current smokers | 49 | 57.6 | 62 | 33.0 | 2.90 | 1.59 - 5.31 | 0.001 |
Illicit drug use | |||||||
No | 63 | 74.1 | 129 | 68.6 | 1.00 | ||
Yes | 22 | 25.9 | 59 | 31.4 | 0.76 | 0.42 - 1.35 | 0.358 |
HIV VARIABLES | |||||||
Opportunistic Disease | |||||||
No | 13 | 15.3 | 32 | 17.0 | 1.00 | - | - |
Yes | 72 | 84.7 | 156 | 83.0 | 1.13 | 0.56 - 2.29 | 0.722 |
AIDS | |||||||
No | 3 | 3.5 | 6 | 3.2 | 1.00 | - | |
Yes | 82 | 96.5 | 182 | 97.0 | 0.90 | 0.21 - 3.69 | 0.885 |
CD4 T-cell count* (cell/mm 3 ) | |||||||
200 or more | 33 | 42.3 | 114 | 62.3 | 1.00 | - | - |
Less than 200 | 45 | 57.7 | 69 | 37.7 | 2.25 | 1.31 - 3.86 | 0.003 |
Beginning of HAART | |||||||
Did not start HAART | 33 | 38.8 | 23 | 12.23 | 1.00 | - | - |
Before treatment for TB | 42 | 49.4 | 96 | 51.1 | 0.30 | 0.16 - 0.58 | 0.000 |
Up to second month of TB treatment | 8 | 9.4 | 41 | 21.8 | 0.13 | 0.05 - 0.34 | 0.000 |
After the second month of TB treatment | 2 | 2.3 | 28 | 14.9 | 0.05 | 0.01 - 0.23 | 0.000 |
TB VARIABLES | |||||||
Setting of beginning of TB treatment | |||||||
Outpatient clinic | 33 | 38.8 | 88 | 46.8 | 1.00 | - | - |
Hospital | 52 | 61.2 | 100 | 53.2 | 1.38 | 0.82 - 2.33 | 0.220 |
TB clinical site | |||||||
Pulmonary | 57 | 32.4 | 119 | 67.6 | 1.00 | - | - |
Extra-pulmonary | 19 | 22.3 | 47 | 25.0 | 0.84 | 0.45 - 1.56 | 0.591 |
Disseminated | 9 | 10.6 | 22 | 11.7 | 0.85 | 0.63 - 1.97 | 0.369 |
Type of regimen for TB treatment | |||||||
Regimen 1 | 62 | 75.9 | 134 | 71.3 | 1.00 | - | - |
Regimen 1R | 19 | 22.3 | 41 | 21.8 | 1.00 | 0.53 - 1.86 | 0.996 |
Other regimens | 4 | 4.7 | 13 | 6.9 | 0.66 | 0.20 - 2.12 | 0.491 |
Adverse effects | |||||||
No | 76 | 89.4 | 171 | 91.0 | 1.00 | - | - |
Yes | 9 | 10.6 | 17 | 9.0 | 1.19 | 0.50 - 2.79 | 0.687 |
Previous Treatment | |||||||
No | 39 | 45.9 | 84 | 44.7 | 1.00 | - | - |
Yes | 46 | 30.7 | 104 | 69.3 | 0.95 | 0.56 - 1.59 | 0.853 |