Biomarker (units) | ABC/3TC arm, % (IQR) | TDF/FTC arm, % (IQR) | P values |
---|---|---|---|
D-dimer (μg/l) |  |  |  |
   Week 4 | na | na | na |
   Week 12 | 9 (-10-44) | 8 (-17-29) | 0.770 |
   Week 48 | 1 (-24-40) | 22 (-9-47) | 0.301 |
hs-CRP (mg/l) | Â | Â | Â |
   Week 4 | 41 (-32-82) | -27 (-50-59) | 0.378 |
   Week 12 | 32 (-36-106) | -9 (-46-44) | 0.279 |
   Week 48 | 23 (-44-120) | -27 (-59- [-]2) | 0.110 |
IL-6 (pg/ml) | Â | Â | Â |
   Week 4 | 0 (-33-6) | 0 (-22-88) | 0.555 |
   Week 12 | 0 (-15-58) | 0 (-15-38) | 0.883 |
   Week 48 | 0 (-15-39) | 0 (-25-29) | 0.673 |
E-selectin (ng/ml) | Â | Â | Â |
   Week 4 | 14 (-1-31) | -7 (-28-3) | 0.004 |
   Week 12 | 19 (-2-56) | 6 (-11-20) | 0.152 |
   Week 48 | 19 (-1-36) | 6 (-11-21) | 0.162 |
sVCAM-1 (ng/ml) | Â | Â | Â |
   Week 4 | 8 (-10-15) | -11 (-24-4) | 0.041 |
   Week 12 | 17 (-11-59) | 6 (-19-17) | 0.198 |
   Week 48 | 2 (-12-16) | -3 (-15-12) | 0.739 |
sICAM-1 (ng/ml) | Â | Â | Â |
   Week 4 | -1 (-9-10) | -10 (-26-3) | 0.061 |
   Week 12 | 8 (-6-53) | 9 (-8-21) | 0.501 |
   Week 48 | 0 (-18-15) | -3 (-12-13) | 0.973 |
MPO (ng/ml) | Â | Â | Â |
   Week 4 | 77 (0-508) | 31 (-9-821) | 0.793 |
   Week 12 | 51 (4-264) | 67 (30-214) | 0.726 |
   Week 48 | 25 (-30-128) | 11 (-78-71) | 1.000 |
Total cholesterol (mmol/l) | Â | Â | Â |
   Week 12 | 4 (-2-13) | -3 (-11-0) | 0.020 |
   Week 48 | 11 (4-19) | -10 (-13-1) | 0.002 |
LDL (mmol/l) | Â | Â | Â |
   Week 12 | 0 (-9-6) | -4 (-13-15) | 0.640 |
   Week 48 | 4 (-5-14) | -12 (-18-17) | 0.117 |
HDL (mmol/l) | Â | Â | Â |
   Week 12 | 6 (-8-20) | 0 (-19-0) | 0.059 |
   Week 48 | 23 (10-30) | 0 (-9-9) | 0.002 |
Triglycerides (mmol/l) | Â | Â | Â |
   Week 12 | 27 (-14-50) | -8 (-21-18) | 0.065 |
   Week 48 | 20 (-14-90) | 0 (-25-12) | 0.121 |
Total cholesterol/HDL ratio | Â | Â | Â |
   Week 12 | 2 (-15-16) | 1 (-7-10) | 0.872 |
   Week 48 | -6 (-16-3) | -4 (-20-8) | 0.894 |