Herpes zoster in Germany: Quantifying the burden of disease

BMC Infectious Diseases

Table 5 Annual deaths, PHN₃ ^a incidence and QALY^b loss due to Herpes Zoster (HZ) in Germany^c, 2007/2008

	Deaths			PHN incidence based on different szenarios^d				QALY loss due to HZ
				Min		Max
age group (years)	Deaths	mortality rate^e	CI (95%)	Incidence^f	CI (95%)	Incidence^f	CI (95%)	Min^g	Max^g
50 - 54	1	0.02	0.00 - 0.10	0.05	0.04 - 0.06	0.50	0.48 - 0.52	362	942
55 - 59	0	0.00	NA	0.22	0.21 - 0.23	0.76	0.74 - 0.78	403	1,047
60 - 64	1	0.02	0.00 - 0.13	0.26	0.24 - 0.28	0.98	0.95 - 1.01	378	2,531
65 - 69	3	0.06	0.01 - 0.17	0.35	0.34 - 0.37	1.39	1.36 - 1.42	558	3,740
70 - 74	5	0.11	0.04 - 0.27	0.37	0.36 - 0.39	1.70	1.66 - 1.74	495	5,442
75 - 79	9	0.30	0.14 - 0.57	0.78	0.75 - 0.81	2.19	2.14 - 2.24	366	4,030
80 - 84	12	0.54	0.28 - 0.94	0.96	0.92 - 1.01	2.63	2.56 - 2.70	278	5,562
85 - 89	15	1.20	0.67 - 1.98	0.97	0.92- 1.03	2.39	2.31 - 2.48	157	3,137
90+	20	3.86	2.36 - 5.96	1.02	0.93 - 1.11	2.51	2.37 - 2.65	68	1,366
total	66	0.21	0.16 - 0.26	0.43	0.43 - 0.44	1.33	1.32 - 1.34	3,065	24,094

CI = confidence interval; NA = not applicable
^apostherpetic neuralgia lasting over three months after HZ diagnosis.
^bquality-adjusted life year.
^cextrapolation on living population in Germany based on study sample
^ddata based on Schiffner-Rohe et al. 2010 [28], Gauthier et al. 2009 [25], Opstelten et al. 2002 [27].
^edeaths per 100,000 person-years.
^fcases per 1,000 person-years.
^gdata based on van Hoek et al. 2009 [29], Brisson et al. 2008 [24], Edmunds et al. 2001 [31].

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