Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil

Table 1 Anti-HCV antibodies (s/co) during first 12 months of follow-up in 65 patients with acute HCV infection, stratified according to viral clearing status, Rio de Janeiro, Brazil, 2001-2009.^a

Anti-HCV Antibodies (s/co)	SVC^b(n = 34)			Non-SVC (n = 31)	p-value SVC vs. Non-SVC	p-value before SVC vs. after SVC
	Total	Before SVC	After SVC
At Baseline/First Visit	78.7 (60.7-93.8)	n.a.^c	n.a.	93.9 (67.8-111.9)	0.26	n.a.
Median during follow-up	66.2 (47.8-79.5)	71.0 (55.8-80.0)	55.1 (17.9-71.8)	105.5 (75.4-123.6)	<0.0001	0.04
Serial during follow-up^d	62.7 (35.2-85.0)	79.4 (66.3-103.0)	56.0 (25.4-79.3)	98.4 (70.4-127.4)	<0.0001	<0.0001

^a Data given as median (interquartile range).
^b Spontaneous Viral Clearance (SVC) was defined as a series of at least 3 negative HCV RNA results within 12 months after the estimated point of infection.
^c n.a. denotes not applicable.
^d All anti-HCV antibody measures per patient during the first 12 months from the estimated date of infection were considered and weighted equally.
P-value for group comparison calculated from linear-mixed effects regression.

ISSN: 1471-2334