Prognostic factor | Moderate/high quality studies with multivariate analysis | Moderate/high quality studies with univariate analysis | Low quality studies with multivariate analysis | Low quality studies with univariate analysis | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Hearing loss | Mortality | Neurological sequelae | Poor outcome | Hearing loss | Mortality | Neurological sequelae | Poor outcome | All outcomes | All outcomes |
History of symptoms >48 h | 1x | Â | Â | 1x | Â | Â | Â | Â | 1x | Â |
Coma/impaired consciousness | Â | 2x | 2x | 2x | 1x | 4x | 1x | 3x | 1x | 6x |
Seizures | Â | 1x | 2x | 2x | Â | 2x | 1x | 2x | 2x | 4x |
Shock/hypotension | Â | Â | Â | Â | Â | 3x | 1x | 2x | Â | 3x |
Peripheral circulatory failure | Â | 1x | Â | 1x | Â | 1x | Â | Â | Â | 1x |
Severe respiratory distress | Â | 1x | Â | Â | Â | 1x | Â | Â | Â | 1x |
Prolonged fever (>7 days) | Â | Â | 1x | Â | Â | Â | 1x | 1x | Â | Â |
Seizures >12 h after admission | Â | Â | Â | Â | Â | 1x | Â | 2x | 1x | Â |
Low peripheral WBC count | Â | Â | Â | 2x | 1x | 3x | 1x | 2x | 2x | 3x |
Low CSF WBC count | Â | Â | 1x | 1x | Â | 1x | 1x | 1x | 2x | 3x |
Low CSF glucose level | 2x | Â | Â | 1x | Â | 1x | 1x | 1x | 2x | 6x |
High CSF protein level | Â | 1x | Â | 1x | 1x | 2x | Â | 1x | Â | 4x |
S. pneumonia as causative pathogen | 2x | Â | 2x | 1x | Â | Â | Â | Â | Â | Â |
Young age | Â | Â | Â | Â | Â | 1x | 1x | 2x | 1x | 1x |
<1 years | Â | Â | Â | Â | Â | 1x | Â | 1x | 1x | 1x |
<2 years | Â | Â | Â | Â | Â | Â | 1x | 1x | Â | Â |
Male gender | 1x | Â | 1x | 1x | Â | Â | Â | Â | 2x | Â |
Fever >40°C |  |  | 1x |  |  | 1x |  |  |  |  |
Absence of petechiae | 1x | Â | 1x | Â | Â | Â | Â | Â | 1x | Â |