Syndrome & treatment | Vancomycin MIC < 2 N = 97 Number of patients (%) | Vancomycin MIC = 2 N = 26 Number of patients (%) | p-value a |
---|---|---|---|
Syndrome | Â | Â | Â |
Primary bacteremia | 18 (18.6) | 5 (19.2) | 0.938 |
Pneumonia | 32 (33.0) | 9 (34.6) | 0.876 |
Catheter related infection | 40 (41.2) | 12 (46.2) | 0.652 |
Prosthesis | 6(6.2) | 0 (0) | 0.341 |
Infective endocarditis | 6 (6.2) | 0 (0) | 0.341 |
Treatment | Â | Â | Â |
Empirical glycopeptide use within 48 hours | 71 (73.2) | 19 (73.1) | 1.000 |
Vancomycin trough level (mg/L) | 14.9 ± 7.6 (n = 47) | 13.5 ± 4.9 (n = 12) | 0.176 |
Vancomycin trough level > 10 mg/L in first week | 34 (72.3) | 9 (75.0) | 1.000 |
With a DNR orderb | 26 (26.8) | 11 (42.3) | 0.151 |
Outcome | Â | Â | Â |
2 week death | 14 (14.4) | 8 (30.8) | 0.081 |
30 days death | 27 (27.8) | 13 (50.0) | 0.057 |