Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia

Table 1 Patient characteristics

Characteristics	Sepsis ¥ (n = 31)	Septic shock (n = 10)	P
Sex (male:female)	13:18	7:3	0.16 **
Age (median, range)	37 (16-55)	55 (24-62)	P < 0.01 *
Diagnosis
Acute leukemias	17	4
Other ^€	14	6
Disease status			0.12 **
Complete remission	13 (42%)	1 (10%)
Active disease	18 (58%)	9 (90%)
Treatment			0.48 **
Intensive CTx/autologous HSCT	17	6
Allogeneic HSCT	14	4
Neutrophils/μl - Fever (median, range)	60 (0 - 290)	50 (20 - 470)	0.40 *
Days of neutropenia (median, range)	12 (4 - 22)	14 (7 - 30)	0.36 *
Platelets × 10 ³ /μl - fever (median, range)	25 (6 - 169)	38 (12 - 90)	0.16 *
Days with fever (median, range)	4 (1 - 12)	5 (1 - 12)	0.65 *
SOFA score - fever onset (median, range)	3 (0 - 7)	4 (2 - 8 )	0.31 *
SOFA score - 48 hours (median, range)	4 (2 - 7)	7 (4 - 16)	P = 0.01 *
MASCC score (median, range)	21 (16 - 23)	18 (11 - 24)	P = 0.03 *
Agent isolation in bloodstream (yes:no) ^£	4:27	8:2	P < 0.001 **
Von Willebrand Factor U/ml - fever (median, range)	205.12(88.94 -341.95)	262.72 (208.19-430.09)	0.11 *

¥ Non-complicated sepsis; *Mann-Whitney test; **Fisher's exact test; €: Lymphoma (n = 8); Multiple Myeloma (n = 5); Myeloproliferative diseases (n = 5); Paroxysmal Nocturnal Hemoglobinuria (n = 2); HSCT: Hematopoietic stem cell transplantation; CTx: chemotherapy. £: Gram negative: n = 7; Gram positive: 7; Fungi: n = 2 (4 patients with mixed flora infections).

ISSN: 1471-2334