Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice

Table 1 Virus Titer Day 4 post-infection in mice inoculated with HSV-1 strain SC16 or HSV-2 strain SB5 and treated orally with Placebo, FCV or VCV

^aGeometric mean titer ± standard deviation of virus obtained from the ears of five mice and titrated independently. ^bA total of 10⁵ PFU was inoculated into each ear pinna. ^cTreatment in the drinking water from the time of virus inoculation. Mice drank approximately 1.5 ml per day. No differences in intake volume or spillage between treatment groups were evident. ^dPercent virus yield compared to placebo-treated mice.

ISSN: 1471-2334