Primary care clinical provider knowledge and experiences in the diagnosis and treatment of tick-borne illness: a qualitative assessment from a Lyme disease endemic community

Background Primary care and frontline healthcare providers are often the first point of contact for patients experiencing tick-borne disease (TBD) but face challenges when recognizing and diagnosing these diseases. The specific aim of this study was to gain a qualitative understanding of frontline and primary care providers’ knowledge and practices for identifying TBDs in patients. Methods From fall 2018 to spring 2019, three focus groups were conducted with primary care providers practicing in a small-town community endemic to Lyme disease (LD) and with emerging incidence of additional TBDs. A follow up online survey was distributed to urgent and emergency care providers in the small-town community and an academic medical center within the referral network of the local clinical community in spring and summer 2019. Qualitative analysis of focus group data was performed following a grounded theory approach and survey responses were analyzed through the calculation of descriptive statistics. Results Fourteen clinicians from three primary care practices participated in focus groups, and 24 urgent and emergency care clinicians completed the survey questionnaire. Four overarching themes emerged from focus group data which were corroborated by survey data. Themes highlighted a moderate level of awareness on diagnosis and treatment of LD among participants and limited knowledge of diagnosis and treatment for two other regionally relevant TBDs, anaplasmosis and babesiosis. Providers described challenges and frustrations in counseling patients with strong preconceptions of LD diagnosis and treatment in the context of chronic infection. Providers desired additional point-of-care resources to facilitate patient education and correct misinformation on the diagnosis and treatment of TBDs. Conclusions Through this small study, it appears that clinicians in the small-town and academic medical center settings are experiencing uncertainties related to TBD recognition, diagnosis, and patient communication. These findings can inform the development of point-of-care resources to aid in patient-provider communication regarding TBDs and inform the development of continuing medical education programs for frontline and primary care providers. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-021-06622-6.

Disease Control and Prevention (CDC) have identified eight species of hard tick responsible for transmitting multiple bacterial, viral, and protozoan pathogens detrimental to human health in the United States [1,2]. In the period of 2004-2016, TBDs accounted for over 75% of vector-borne disease reports in the United States, the majority of which being Lyme disease. During this same period, additional TBDs, including spotted fevers, babesiosis, and anaplasmosis, have become increasingly prevalent [1].
Primary care and urgent care clinicians are often the first point of contact for patients suffering from TBDs [3,4]. However, lack of dedicated clinical training on TBDs can result in uncertainties and challenges when treating patients, as the symptoms of various TBDs can be overlapping, nonspecific, and are often unrecognized [5,6]. Clinicians are responsible for recognizing, diagnosing, and educating patients on infectious diseases, including tick-borne disease. Incorrect diagnosis or delays in treatments may lead to disease complications and increased healthcare costs [3,5,6]. Medical education and residency training programs often provide little instruction regarding TBDs in most specialties and disciplines. The 2020 Health and Human Services Tickborne Disease Working Group Report called for an increase in education on TBDs for the clinical audience [6]. However, limited research has been conducted on optimal continuing medical education (CME) content, methods, and resources for practicing clinicians regarding TBD diagnosis, treatment, and patient communication [7]. The Northeast Regional Center for Excellence in Vector-Borne Diseases (NEVBD) fosters research and education on diseases spread by mosquitoes and ticks in the Northeastern United States. NEVBD collaborated with a local health department, community hospital system, and the Cornell Master of Public Health program, to directly engage with primary care and urgent care clinicians on TBD education in an area endemic to Lyme and other TBDs. The purpose of this effort was to gain a qualitative understanding of the knowledge and experiences of frontline providers in diagnosing and treating TBDs to inform the development of training and resources for this community. Current evidence on provider knowledge and practice regarding the diagnosis and treatment of TBDs has been gained through survey research, and medical chart and billing reviews [7][8][9][10]. While these efforts have provided valuable insight into gaps in physician training and practice, they do not provide nuanced details of the thoughts, challenges, and needs of providers as they recognize and treat these diseases during clinical patient encounters. Our work addresses this gap in understanding through a small-scale qualitative-quantitative mixed methods study using focus groups and online surveys.

Focus group data collection and analysis
The initial target study population included primary care and emergency and urgent (frontline) healthcare providers practicing in a small-town community endemic to Lyme disease with emerging incidence of additional TBDs. Invitation emails for focus group participation were sent to practice managers and medical directors for medical practices employing members of the study target population. Researchers coordinated with these key contacts within the practices to schedule in-person focus groups at a date and time convenient to the participating providers. Focus groups were scheduled in late fall 2018 and early spring 2019. Participants included both prescribing (physicians, nurse practitioners, physician assistants) and non-prescribing (licensed practical nurse, registered nurse) providers.
Academic project team members developed guided focus group questions covering current knowledge, perceived challenges, and needed resources on tick-borne illness, which were reviewed by physician and health department team members prior to finalization (Additional file 1). Focus groups were hosted at each participating practice's office location and time-appropriate meals were offered to participants. After receiving verbal informed consent from participants, a project team member trained in qualitative interviewing techniques (EM or SM) led a group discussion based on the guided questions. All focus groups were audio-recorded and transcribed verbatim for analysis. No names or other personally identifiable information were recorded in the transcripts, including the business names of the participating clinics.
Analysis of the focus group transcripts included open coding of the data with identification of emergent themes, following a predominantly grounded theory approach [11]. Focus group analyses were conducted using Atlas.ti (Scientific Software Development GmbH, Version 8). Four members of the project team (EM, SM, CB, ABC) independently coded one transcript, followed by a joint review and consolidation of the code list. Authors EM and SM then coded all transcripts. Discrepancies between the coding schemes were resolved, and the finalized themes and concepts were reviewed by the larger team.

Survey data collection and analysis
The project team was unsuccessful in efforts to engage frontline clinicians via focus groups during the project period. After discussing barriers with clinic practice managers, our team determined that we would be unable to engage frontline clinicians in focus groups due to variable schedules and constraints among that population. The project team pursued an alternate approach to engage this group through an online survey questionnaire. Two project team members (CB and ABC) developed a survey questionnaire using validated questions from the published literature [3,12,13] and focus group data to measure both baseline provider knowledge and the perceptions and experiences of frontline clinicians practicing in the study's geographic area. Project team physicians reviewed and beta tested the questionnaire prior to finalization. The questionnaire was open for responses from March to May 2019. Participants were invited via email invitation and informational flyers delivered to hospital and urgent care clinics in the small-town community. Despite several recruitment efforts, and a participation incentive in the form of gift cards to local restaurants, the number of responses to the survey in the targeted small-town community fell well short of the project's goal.
The project team contacted colleagues at an academic medical center within the referral network of the local clinical community for expanded distribution of the questionnaire to this hard-to-reach population. The survey questionnaire was moderately modified to adapt to the academic medical center clinical community by reducing rating scale complexity, informed by additional beta testing by an infectious disease physician at the academic medical center. This version of the questionnaire was distributed through the clinical network of the academic medical center via email and was open for responses from July 1 to August 31, 2019. Due to the limited sample size generated, analysis of survey responses consisted of calculation of descriptive statistics using Microsoft Excel (Microsoft Corporation, Version 2103).
Protocols and procedures for this study involving human subjects were deemed exempt for review under criterion three by the Institutional Review Board of Cornell University, Protocol Numbers: 1806008097 and 1903008648.

Respondent demographics
Three primary care practices scheduled focus groups with the study team. These practices represented internal medicine, family medicine, and pediatric medicine. Participants across the three focus groups included eight physicians (MD/DO), five nurse practitioners, and one licensed practical nurse (total of 14 clinicians). Six clinicians completed the survey questionnaire distributed within the small-town community, including three physicians, two physician assistants, and one nurse practitioner. Eighteen clinicians completed the survey questionnaire distributed to the academic medical center, including 14 physicians, two physician assistants, and two nurse practitioners. Table 1 provides a summary of additional demographic characteristics for survey respondents. Internal medicine -

Years in practice
Less than 1 -

Focus group findings
Four overarching themes emerged from analysis of the focus group transcripts: difficulty in diagnosis; challenges presented by patients and combating misinformation; resources and support to improve diagnosis and treatment; and continuing education and clinical proficiency. Table 2 provides an overview of these themes, explanatory subthemes, and exemplary quotations from the focus group data.

Theme 1: Difficulty in diagnosis
Clinicians described multiple challenges in the diagnostic process for TBDs. Clinicians from each of the three participating practices felt that differential diagnoses for TBDs were complicated by the nonspecific symptoms associated with these diseases. Clinicians had a selfprofessed lack of awareness of TBDs outside of Lyme disease, noting that they were unfamiliar with the signs, symptoms, and appropriate serologic testing needed to diagnose non-Lyme TBDs, as well as the prevalence of these TBDs in their local communities. Focus group participants reported confidence in diagnosing Lyme disease and developing treatment plans when serologic test results and/or empiric assessment of the patient was conclusive, particularly when the erythema migrans (EM) lesion, or rash, was present. However, interpreting test results for Lyme disease was more difficult in scenarios where patients had nonspecific symptoms in the absence of the characteristic EM rash. At least one participant from each focus group described patients associating nonspecific symptoms, such as fatigue, with Lyme disease specifically and expressed uncertainty around interpreting serology results for Lyme disease. This juxtaposition of nonspecific symptoms and unclear diagnostic testing results proved challenging for clinicians making decisions on how to treat and diagnose their patients for Lyme disease. Another common challenge cited by focus group participants centered on interactions with clinicians from different specialties who had alternative and, at times, conflicting practice patterns for diagnosing and treating TBDs. Focus group participants from the pediatric practice consistently described challenges when patients visited their office following an emergency or urgent care visit related to their TBD due to differences in the diagnostic approaches taken between providers in these two medical specialties. For example, the pediatric providers stated that their first approach to the assessment of swollen joints with no history of trauma is to conduct noninvasive diagnostic testing for Lyme disease. Conversely, these providers felt that patients presenting to the urgent care setting with the same symptoms often received more invasive joint aspiration. Additionally, providers from this practice felt that urgent care and emergency medicine clinicians often prescribed treatments that did not follow established guidelines for tick bite prophylaxis.

Theme 2: Challenges presented by patients and misinformation
Focus group participants highlighted challenges in the patient-provider communication dynamic that stemmed from patient orientations toward Lyme disease diagnosis and treatment, competing care plans from outside providers, and the need to address misinformation on TBDs during clinical encounters. Clinicians described the process of redressing misinformation as difficult when patients were attached to specific beliefs and did not accept 'new' information discussed during the clinical encounter. In several instances, participants described patients referencing materials on Lyme disease that were counter to the guideline-based resources and evidence they personally rely upon in their medical practice. The patient-provider relationship was at times negatively affected during these interactions. Patient education was more difficult when patients had existing relationships with outside healthcare providers delivering contradictory information. Two focus group discussions centered around differences in care plans between participants' primary care offices and what they termed the 'Lyme literate' community. These participants noted a strong disagreement with the care delivered by these outside providers. In these scenarios of conflict, Clinicians have a self-professed lack of awareness of TBDs outside of Lyme disease "…I think probably the non-Lyme tick-borne illnesses, which aren't as readily prevalent, probably aren't thought of as much as they probably should be.  Current training program formats are not conducive to healthcare provider education "I don't think just inviting us to a random webinar -we get invited every two days to some drug or some whatever in emails, and I just keep deleting them. " [FG3] Local epidemiological data and information about tick vectors can directly inform diagnosis and treatment "I did this tick panel and she came in two weeks later, she had anaplasmosis. But, that was like, whoa. Where did that come from? But, knowing what's in the community is very useful. " [FG2] There is a consistent need for education on TBD basics, covering presentation, diagnosis, and treatment "I mean, most providers have some basic knowledge and don't have to go back to square one, but there's new information all the time. " [FG3] participants in the family medicine focus group identified infectious disease specialists as a resource of authority to whom they could refer patients. However, providers in the other two focus groups expressed a resigned view of the issue as something they could no longer effectively address within the clinical encounter without damaging the patient-provider dynamic. Discussion around the subject of chronic Lyme disease occurred within all three focus groups and coincided with sentiments of frustration. Clinicians described patients who self-diagnose or otherwise identify with the diagnosis of chronic Lyme disease as particularly challenging in both the disease diagnostic process as well as treatment. Clinical encounters with these patients were described as time consuming and difficult. Participants in all three focus groups described experiences where they provided clinical information contradictory to their patients' pre-existing ideas regarding the biology of Lyme disease infection, resulting in those patients challenging the proposed treatment plans. This commonly came in the form of patients rejecting results of serologic testing, wanting a different length of antibiotic course than that prescribed, or seeking an alternative treatment modality.

Theme 3: Resources and support to improve diagnosis and treatment of patients
Clinicians participating in the focus groups largely felt that existing resources to aid with patient education did not meet their needs. Clinicians felt their ability to disseminate information to patients was influenced by patient education level, and there was sentiment among participants that resources for the lay audience on Lyme and other TBDs are limited. Clinicians also described wanting point-of-care resources for patients, either through flyers, pamphlets, or a reference list of online resources. Ideally, this educational material would support clinicians' recommendations, help to minimize patient doubt, and support trust in the patient-provider relationship. Participants in two focus groups specifically described wanting resources that directly address misinformation and myths around chronic Lyme disease using evidence-based information.
When describing reference materials to inform their clinical practice, focus group participants emphasized that the resources need to be both available at the pointof-care and up to date. Participants in two focus groups described using UpToDate.com as their primary source for both obtaining information for their clinical practice and to give to patients. Participants in each focus group felt that access to infectious disease specialists for patient consults and recommendations was helpful for their practice and often referred patients to infectious disease specialists when diagnoses were unclear.

Theme 4: Continuing education and clinical proficiency
Participants in all three focus groups felt that the predominant web-based format for CME is not accessible or conducive to their education. Specific suggestions on effective training included interactive instruction and review of case studies. Specific content areas to include in CME programs included resources and information on treatment modalities for unique populations, including pediatrics and individuals with antibiotic allergies; local epidemiological data and information on tick vectors; and updates on TBD basics including presentation, diagnostics, and treatment. Clinicians felt resources that included case studies and images of EM rashes would improve their ability to diagnose TBDs. Data from the focus group transcripts also identified an issue regarding diagnostic testing for TBDs related specifically to appropriate test selection in the electronic medical record (EMR). Clinicians expressed a lack of knowledge on differentiating test options in the EMR and their appropriateness for Lyme disease diagnosis. Clinicians may not be familiar with the differences between available tests and, when given multiple options, make inappropriate selections. Clinicians felt additional training and guidance in this area would be beneficial.
"I ordered what I thought was sort of the standard Lyme titer. It came back negative and this kid continued to have a swollen knee...He went to the orthopedist. They couldn't figure it out. He's going up to the rheumatologist. And it's just because I ordered the wrong test...I think [I] ordered the PCR, which was like, you know, the quick and easy one. But actually that wasn't probably a good one to do." [FG3,Pediatrics] Survey findings Approximately half of survey respondents self-rated as moderately knowledgeable on the treatment of anaplasmosis, babesiosis, and Lyme disease (Table 3). While a sizeable proportion reported feeling not at all knowledgeable on anaplasmosis (45.8%), roughly the same proportion reported feeling extremely knowledgeable on the treatment of Lyme disease. When presented with a clinical scenario and list of treatment options, the majority of respondents selected the CDC-recommended treatment approach for each of the indicated TBDs. However, respondents appeared to have difficulty in identifying the appropriate treatment approach for patients with nonspecific symptoms and negative Lyme disease serology, with only 66.7% providing the correct answer (See Additional file 2 for full question item text).
Half of the respondents reported feeling neutral on their ability to address misinformation on TBDs and misinformation on Lyme disease specifically, while 37.5% and 41.7% felt confident in their ability to address misinformation on TBDs and Lyme disease, respectively. Most respondents (91.7%) reported that patients rarely or never refused to take the antibiotic treatment they prescribe to treat TBDs. Moreover, 37.5% of respondents reported that, about half of the time, patients request a longer course of antibiotic treatment, and 45.8% reported patients try to negotiate on the length of antibiotic treatment to treat TBDs.
Half the respondents reported using educational tools to help their patients better understand TBDs, but only 41.7% reported that current resources for patient education are sufficient and 83.3% reported wanting additional educational resources for their patients on TBDs. Respondents indicated they often use information on UpToDate.com, the CDC website, and the CDC tickborne disease handbook [2] to educate their patients on TBDs. In written responses on why these materials were their preferred resources, respondents indicated they were readily accessible, easy to understand, and accurate.
The majority of respondents (79.2%) reported they have access to the resources they need to update their personal knowledge on TBDs, and close to half of respondents (45.8%) reported regularly looking up peer-reviewed literature on the treatment and diagnosis of TBDs. All respondents reported sometimes or often using UpTo-Date.com to access information on TBDs. Other common resources respondents used (sometimes or often) included the CDC website (79.2%), medical journals (66.7%), and Infectious Disease Society of American (IDSA) guidelines (54.2%). Just over half of respondents (55.6%) reported never attending CME accredited seminars, and 88.9% reported never watching CME accredited webinars to learn about TBDs. Additional summaries on survey response distributions are available in Additional file 2.

Discussion
From our small study in a Lyme disease endemic community, it appears that primary care and frontline healthcare providers experience uncertainty in the diagnosis and clinical management of TBDs. The first focus group theme we identified indicates that primary care clinicians lack confidence in their ability to diagnose and treat non-Lyme TBDs and to identify Lyme disease infection in ambiguous clinical scenarios. Participant statements reflected several points of frustration related to this uncertainty. Frustration in the decision-making process in the context of inconclusive Lyme disease serology centered not only on the clinicians' internal misgivings about their own knowledge, but also on how this uncertainty resulted in lengthy and difficult conversations with patients. The study data also indicate that the approach to Lyme disease diagnosis and treatment is variable across medical specialties. Inconsistency in practice patterns Table 3 Combined self-reported and measured knowledge on the clinical management of anaplasmosis, babesiosis, and Lyme disease for small-town and academic medical center clinicians a Correct response corresponds to selection of CDC recommended treatment for indicated TBD from multiple choice question item b Patient with a 3-month history of recurrent, asymmetric arthritis involving large, weight-bearing joints; no history of erythema migrans; unknown tick bite history; outdoor enthusiast and variable adherence to guideline-based care across healthcare providers negatively affected patient trust, further complicating patient education, counseling, and care plan development.
Another prevalent focus group theme focused on the contentious issue of chronic Lyme disease and conflicting guidance from alternative care providers. Participants frequently mentioned conversations with patients on this topic, consistently reporting the need to address misinformation on Lyme disease during the patient encounter. Participants often felt frustrated about this misinformation, knowing it came from sources they did not regard as authoritative or guideline-based, including word of mouth, social media, and alternative "Lyme literate" care providers. As stated by the National Institutes of Health, "chronic Lyme disease" is not a universally recognized disease due to confusion on diagnosis and the lack of a clear clinical definition [14]. Several clinicians described a shared experience of feeling helpless to correct misinformation when confronted with strongly held patient beliefs and anxieties regarding persistent Lyme disease infection, at the risk of alienating their patients. This introduced a reliance on consultation and referral to infectious disease physicians to assist in managing care for these patients.
While only 24 clinicians participated in our survey questionnaire, their responses reflect certain findings from the focus group data. Roughly one-third of respondents failed to identify the CDC-recommended treatment approach for patients with nonspecific symptoms and negative Lyme disease serology, reflecting a similar challenge identified through the focus group data. While survey respondents reported feeling confident in their ability to address misinformation on TBDs with their patients, close to half reported receiving push back from patients on the recommended treatment regimen. While our survey sample size is too small to draw broad conclusions or generalize to larger populations, these novel question items may be useful in future, larger surveys measuring clinician experiences regarding TBD diagnosis and treatment.
We identified opportunities to improve clinician knowledge regarding TBD diagnosis and management, including development of a comprehensive algorithm to standardize care across specialties, providing updated epidemiological data for regional TBDs, and a primer on how to order the appropriate Lyme serology in the EMR. While our study particularly struggled to reach emergency and urgent care specialists, making connections with practicing clinicians overall is challenging [15,16]. Our data indicate that training formats of CME-based webinars or seminars are not useful for reaching these populations. Unfortunately, many of the existing training formats on Lyme and other TBDs fall within these categories [17][18][19]. Results from both the focus groups and survey questionnaires indicate that providers gather information for themselves and for their patients through trusted point-of-care resources, specifically UpToDate.com. Future efforts to provide resources on TBDs for healthcare providers should take into consideration where and how this information will be accessed. In addition, resources developed with shared decision-making and clinical decision support incorporated have demonstrated positive effects on patient-provider communication in other areas of healthcare [6,[20][21][22][23]. Similar resource development targeting TBDs may prove beneficial for challenging scenarios described by clinicians in this study.

Limitations
One issue we encountered in focus group recruitment for this study was a hesitancy of practices to participate due to differing orientations of medical staff on the issue of chronic Lyme disease. In cases where practices included clinical staff with strong and discordant beliefs on diagnosis and treatment of chronic Lyme disease, these focus groups were perceived as harmful to office dynamics. Medical directors at two practices declined to organize focus groups at their practices due to this contentious issue. While we did not specifically ask focus group participants to identify their opinions on this issue, several of our participants openly stated they did not believe in the chronic Lyme disease diagnosis. Thus, our focus group findings do not include the experiences of alternative care providers or providers who follow International Lyme and Associated Diseases Society (ILADS) guidelines.
An additional issue encountered in this project was the low response rate from the emergency and urgent care clinical community, for both the focus group interviews and the online survey questionnaire. Our low response rates limit the generalizability of our findings beyond the small group of study participants. Frontline providers in the emergency and urgent care clinical community play an important role in diagnosing and treating TBDs, and additional efforts are needed to engage with this hard-to-reach community. Additionally, during the survey, clinician's knowledge was tested on CDC-recommended treatments for specific TBDs. Due to the survey being online, it is possible that the high-performance scores were due to respondents looking up the correct answers.