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Viral diseases

Section edited by Jodie McVernon and Julian Tang

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of viral diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV, HIV-associated infections and sexually transmitted diseases are considered in separate sections.

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  1. Content type: Research article

    To describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection.

    Authors: Marion Dollat, Benjamin Chaigne, Grégoire Cormier, Nathalie Costedoat-Chalumeau, François Lifermann, Alban Deroux, Emilie Berthoux, Emmanuelle Dernis, Thomas Sené, Gilles Blaison, Olivier Lambotte, Benjamin Terrier, Jérémie Sellam, Luc De Saint-Martin, Laurent Chiche, Nicolas Dupin…

    Citation: BMC Infectious Diseases 2018 18:302

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  2. Content type: Research article

    Most infections are spread through social networks (detrimental effect). However, social networks may also lower infection acquisition (beneficial effect). This study aimed to examine associations between soci...

    Authors: Stephanie Brinkhues, Miranda T. Schram, Christian J. P. A. Hoebe, Mirjam E. E. Kretzschmar, Annemarie Koster, Pieter C. Dagnelie, Simone J. S. Sep, Sander M. J. van Kuijk, Paul H. M. Savelkoul and Nicole H. T. M. Dukers-Muijrers

    Citation: BMC Infectious Diseases 2018 18:300

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  3. Content type: Research article

    The first autochthonous Zika virus (ZIKV) outbreak in Singapore was detected in August 2016. We report an analysis of the correlation of clinical illness with viremia and laboratory parameters in this Asian co...

    Authors: Deborah H. L. Ng, Hanley J. Ho, Angela Chow, Joshua Wong, Win Mar Kyaw, Adriana Tan, Po Ying Chia, Chiaw Yee Choy, Glorijoy Tan, Tsin Wen Yeo and Yee Sin Leo

    Citation: BMC Infectious Diseases 2018 18:301

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  4. Content type: Research article

    Acute respiratory infections (ARIs) remains a disease of public health importance in Nigeria. Though, previous studies have identified factors associated with childhood ARI symptoms, the progress made in reduc...

    Authors: Joshua Odunayo Akinyemi and Oyewale Mayowa Morakinyo

    Citation: BMC Infectious Diseases 2018 18:296

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  5. Content type: Research article

    Cytomegalovirus (CMV) infection is common in immunocompetent patients in intensive care units (ICUs). However, whether CMV infection or CMV reactivation contributes to mortality of immunocompetent patients rem...

    Authors: Xi Li, Yongbo Huang, Zhiheng Xu, Rong Zhang, Xiaoqing Liu, Yimin Li and Pu Mao

    Citation: BMC Infectious Diseases 2018 18:289

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  6. Content type: Research article

    Dengue and West Nile viruses are highly cross-reactive and have numerous parallels in geography, potential vector host (Aedes family of mosquitoes), and initial symptoms of infection. While the vast majority (> 8...

    Authors: Megan E. Cahill, Samantha Conley, Andrew T. DeWan and Ruth R. Montgomery

    Citation: BMC Infectious Diseases 2018 18:282

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  7. Content type: Research article

    In the past two decades, Rift Valley Fever (RVF) outbreaks have been reported twice in Tanzania, with the most recent outbreak occurring in 2006/07. Given the ecology and climatic factors that support mosquito...

    Authors: Abade Ahmed, Jabir Makame, Fyumagwa Robert, Keyyu Julius and Matee Mecky

    Citation: BMC Infectious Diseases 2018 18:276

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  8. Content type: Case report

    Due to the increasing number of DCD transplantations since 2015, the transmission of rabies through solid organ transplantation has become a notable problem in China and has attracted the attention of the public.

    Authors: Jian Zhang, Jun Lin, Ye Tian, Linlin Ma, Wen Sun, Lei Zhang, Yichen Zhu, Wei Qiu and Lujia Zhang

    Citation: BMC Infectious Diseases 2018 18:273

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  9. Content type: Research article

    Zika virus (ZIKV) had spread rapidly in the past few years in southern hemisphere where dengue virus (DENV) had caused epidemic problems for over half a century. The high degree of cross-reactivity of Envelope...

    Authors: Xiujie Gao, Yingfen Wen, Jian Wang, Wenxin Hong, Chunlin Li, Lingzhai Zhao, Chibiao Yin, Xia Jin, Fuchun Zhang and Lei Yu

    Citation: BMC Infectious Diseases 2018 18:275

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  10. Content type: Research article

    Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data ...

    Authors: Saverio Caini, Peter Spreeuwenberg, Gabriela F. Kusznierz, Juan Manuel Rudi, Rhonda Owen, Kate Pennington, Sonam Wangchuk, Sonam Gyeltshen, Walquiria Aparecida Ferreira de Almeida, Cláudio Maierovitch Pessanha Henriques, Richard Njouom, Marie-Astrid Vernet, Rodrigo A. Fasce, Winston Andrade, Hongjie Yu, Luzhao Feng…

    Citation: BMC Infectious Diseases 2018 18:269

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  11. Content type: Research article

    Dengue fever is the most common arboviral infection in humans, with viral transmissions occurring in more than 100 countries in tropical regions. A global strategy for dengue prevention and control was establi...

    Authors: Wei-Ting Lai, Chien-Hsiun Chen, Hsin Hung, Ray-Bing Chen, Sanjay Shete and Chih-Chieh Wu

    Citation: BMC Infectious Diseases 2018 18:256

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  12. Content type: Research article

    Background: Emerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are crit...

    Authors: Sara Y. Del Valle, Benjamin H. McMahon, Jason Asher, Richard Hatchett, Joceline C. Lega, Heidi E. Brown, Mark E. Leany, Yannis Pantazis, David J. Roberts, Sean Moore, A Townsend Peterson, Luis E. Escobar, Huijie Qiao, Nicholas W. Hengartner and Harshini Mukundan

    Citation: BMC Infectious Diseases 2018 18:245

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  13. Content type: Research article

    Norovirus is a leading cause of viral gastroenteritis worldwide with a peak of disease seen in children. The epidemiological analysis regarding the virus strains in Africa is limited. The first report of norov...

    Authors: Kgomotso Makhaola, Sikhulile Moyo, Kwana Lechiile, David M. Goldfarb and Lemme P. Kebaabetswe

    Citation: BMC Infectious Diseases 2018 18:246

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  14. Content type: Research article

    Varicella zoster virus (VZV) reactivation is a common infectious disease in neurology and VZV the second most frequent virus detected in encephalitis. This study investigated characteristics of clinical and la...

    Authors: Thomas Skripuletz, Kaweh Pars, Alina Schulte, Philipp Schwenkenbecher, Özlem Yildiz, Tina Ganzenmueller, Maike Kuhn, Annette Spreer, Ulrich Wurster, Refik Pul, Martin Stangel, Kurt-Wolfram Sühs and Corinna Trebst

    Citation: BMC Infectious Diseases 2018 18:238

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  15. Content type: Research article

    Increasing incidence of dengue cases in Malaysia over the last few years has been paralleled by increased deaths. Mortality prediction models will therefore be useful in clinical management. The aim of this st...

    Authors: Saiful Safuan Md-Sani, Julina Md-Noor, Winn-Hui Han, Syang-Pyang Gan, Nor-Salina Rani, Hui-Loo Tan, Kanimoli Rathakrishnan, Mohd Azizuddin A-Shariffuddin and Marzilawati Abd-Rahman

    Citation: BMC Infectious Diseases 2018 18:232

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  16. Content type: Research article

    The symptoms of many infectious diseases influence their host to withdraw from social activity limiting their potential to spread. Successful transmission therefore requires the onset of infectiousness to coin...

    Authors: Ewan Colman, Kristen Spies and Shweta Bansal

    Citation: BMC Infectious Diseases 2018 18:219

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  17. Content type: Case report

    Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include prematur...

    Authors: Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian and Zhengde Xie

    Citation: BMC Infectious Diseases 2018 18:217

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  18. Content type: Research article

    Human papillomavirus (HPV) DNA testing is an important method in cervical cancer screening. However, the studies on prevalence and genotype distribution of HPV among women in northeastern Guangdong Province of...

    Authors: Pingsen Zhao, Sudong Liu, Zhixiong Zhong, Jingyuan Hou, Lifang Lin, Ruiqiang Weng, Luxian Su, Nanxiang Lei, Tao Hou and Haikun Yang

    Citation: BMC Infectious Diseases 2018 18:204

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  19. Content type: Research article

    Information on the incubation period and period of infectiousness or shedding of infectious pathogens is critical for management and control of communicable diseases in schools and other childcare settings.

    Authors: Ida Czumbel, Chantal Quinten, Pierluigi Lopalco and Jan C. Semenza

    Citation: BMC Infectious Diseases 2018 18:199

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  20. Content type: Case report

    Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is defined as a severe, progressive lymphoproliferative disorder associated with active EBV infection persisting longer than 6 months and developing in p...

    Authors: Jacek Roliński, Ewelina Grywalska, Aleksandra Pyzik, Michał Dzik, Violetta Opoka-Winiarska, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Piotr Grabarczyk and Elżbieta Starosławska

    Citation: BMC Infectious Diseases 2018 18:190

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  21. Content type: Research article

    Zika virus (ZIKV) infection is a pandemic and a public health emergency. It is transmitted by mosquitoes, primarily the Aedes genus. In light of no treatment currently, it is crucial to develop effective vector c...

    Authors: Lung-Chang Chien, Ro-Ting Lin, Yunqi Liao, Francisco S. Sy and Adriana Pérez

    Citation: BMC Infectious Diseases 2018 18:180

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  22. Content type: Research article

    Several studies have applied ecological factors such as meteorological variables to develop models and accurately predict the temporal pattern of dengue incidence or occurrence. With the vast amount of studies...

    Authors: Thaddeus M. Carvajal, Katherine M. Viacrusis, Lara Fides T. Hernandez, Howell T. Ho, Divina M. Amalin and Kozo Watanabe

    Citation: BMC Infectious Diseases 2018 18:183

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  23. Content type: Case report

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease. Haemophysalis longicornis ticks have been considered the vector of severe fever with thrombocytopenia syndrome virus (SFTSV). ...

    Authors: Uh. Jin Kim, Dong-Min Kim, Seong Eun Kim, Seung Ji Kang, Hee-Chang Jang, Kyung-Hwa Park and Sook In Jung

    Citation: BMC Infectious Diseases 2018 18:181

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  24. Content type: Research article

    Despite universal prophylaxis, late cytomegalovirus (CMV) infection occurs in a high proportion of kidney transplant recipients. We evaluated whether a specific viral T-cell response allows for the better iden...

    Authors: Dominika Deborska-Materkowska, Agnieszka Perkowska-Ptasinska, Anna Sadowska, Jolanta Gozdowska, Michał Ciszek, Marta Serwanska-Swietek, Piotr Domagala, Dorota Miszewska-Szyszkowska, Elzbieta Sitarek, Agnieszka Jozwik, Artur Kwiatkowski and Magdalena Durlik

    Citation: BMC Infectious Diseases 2018 18:179

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  25. Content type: Research article

    To support poliomyelitis eradication in Pakistan, environmental surveillance (ES) of wastewater has been expanded alongside surveillance for acute flaccid paralysis (AFP). ES is a relatively new method of surv...

    Authors: Kathleen M. O’Reilly, Robert Verity, Elias Durry, Humayun Asghar, Salmaan Sharif, Sohail Z. Zaidi, M. Zubair M. Wadood, Ousmane M. Diop, Hiro Okayasu, Rana M. Safdar and Nicholas C. Grassly

    Citation: BMC Infectious Diseases 2018 18:176

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  26. Content type: Research article

    A method for rapid detection of dengue virus using the reverse-transcription recombinase polymerase amplification (RT-RPA) was recently developed, evaluated and made ready for deployment. However, reliance sol...

    Authors: Kim-Kee Tan, Noor Syahida Azizan, Che Norainon Yaacob, Nurul Asma Anati Che Mat Seri, Nur Izyan Samsudin, Boon-Teong Teoh, Sing-Sin Sam and Sazaly AbuBakar

    Citation: BMC Infectious Diseases 2018 18:169

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  27. Content type: Research article

    Hand-foot-mouth disease (HFMD) is a common infectious disease in China and occurs mostly in infants and children. Beijing is a densely populated megacity, in which HFMD has been increasing in the last decade. ...

    Authors: Lin Tian, Fengchao Liang, Meimei Xu, Lei Jia, Xiaochuan Pan and Archie C. A. Clements

    Citation: BMC Infectious Diseases 2018 18:158

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  28. Content type: Research article

    Globally, Norovirus (NoV) is considered the most common cause of diarrheal episodes across all age groups. Despite its wide genetic diversity, the GII.4 strain is the most predominant and has been associated w...

    Authors: Juliana Merces Hernandez, Luciana Damascena Silva, Edivaldo Costa Sousa Junior, Renato Silva Bandeira, Elmer Abraão Martins Rodrigues, Maria Silvia Souza Lucena, Samya Thalita Picanço Costa and Yvone Benchimol Gabbay

    Citation: BMC Infectious Diseases 2018 18:147

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  29. Content type: Research article

    Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Unders...

    Authors: Yu-Wen Chien, Zi-Hu Liu, Fan-Chen Tseng, Tzu-Chuan Ho, How-Ran Guo, Nai-Ying Ko, Wen-Chien Ko and Guey Chuen Perng

    Citation: BMC Infectious Diseases 2018 18:156

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  30. Content type: Research article

    West Nile Virus (WNV) is a mosquito-borne pathogen that has become established in North America. Risk for human infection varies geographically in accordance with climate and population factors. Though often a...

    Authors: Shruti Mallya, Beate Sander, Marie-Hélène Roy-Gagnon, Monica Taljaard, Ann Jolly and Manisha A. Kulkarni

    Citation: BMC Infectious Diseases 2018 18:141

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  31. Content type: Case report

    We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far.

    Authors: Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, Wei Chen and Jie Hu

    Citation: BMC Infectious Diseases 2018 18:143

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  32. Content type: Research article

    Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China. However, little is known about the epidemiology and ty...

    Authors: Jie Li, Xiaoyan Lu, Baoming Jiang, Yiwei Du, Yang Yang, Haikun Qian, Baiwei Liu, Changying Lin, Lei Jia, Lijuan Chen and Quanyi Wang

    Citation: BMC Infectious Diseases 2018 18:135

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  33. Content type: Research article

    Respiratory illnesses have been identified as a significant factor leading to lost training time and morbidity among Singapore military recruits. A surveillance programme has been put in place to determine eti...

    Authors: Yuk-Fai Lau, Wee-Hong Victor Koh, Clement Kan, Poh-Choo Alethea Dua, Ai-Sim Elizabeth Lim, Chin-Wen Jasper Liaw, Qiu-Han Gao, Jeremiah Chng, Vernon J. Lee, Boon-Huan Tan and Jin-Phang Loh

    Citation: BMC Infectious Diseases 2018 18:123

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  34. Content type: Research article

    End stage renal disease (ESRD)/ end stage renal failure (ESRF) is on the rise globally and especially in Singapore. Varicella or chickenpox is not uncommon among adults especially ESRD/ESRF patients. It has be...

    Authors: Chong Yau Ong, Sher Guan Low, Farhad Fakhrudin Vasanwala, Stephanie, MC Fook-Chong, Manish Kaushik and Lian Leng Low

    Citation: BMC Infectious Diseases 2018 18:118

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  35. Content type: Research article

    Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, with less known about other immunocompromised patients.

    Authors: Olga Chatzis, Stephanie Darbre, Jérôme Pasquier, Pascal Meylan, Oriol Manuel, John David Aubert, Maja Beck-Popovic, Stavroula Masouridi-Levrat, Marc Ansari, Laurent Kaiser, Klara M. Posfay-Barbe and Sandra A. Asner

    Citation: BMC Infectious Diseases 2018 18:111

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  36. Content type: Research article

    Until now, there is non-specific treatment, and exploring early and novel biomarkers to determine the disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS) would be of importance for c...

    Authors: Jing Li, Hong Du, Xue-Fan Bai, Xiao-Yan Wang, Ying Zhang, Hong Jiang and Ping-Zhong Wang

    Citation: BMC Infectious Diseases 2018 18:100

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  37. Content type: Research article

    The Indonesian region of Aceh was the area most severely affected by the earthquake and tsunami of 26 December 2004. Department of Health data reveal an upward trend of dengue cases in Aceh since the events of...

    Authors: Harapan Harapan, Yogambigai Rajamoorthy, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Rovy Pratama…

    Citation: BMC Infectious Diseases 2018 18:96

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  38. Content type: Research article

    The World Health Organization recommends that countries conduct two phase evaluations of HIV rapid tests (RTs) in order to come up with the best algorithms. In this report, we present the first ever such evalu...

    Authors: Pontiano Kaleebu, Paul Kato Kitandwe, Tom Lutalo, Aminah Kigozi, Christine Watera, Mary Bridget Nanteza, Peter Hughes, Joshua Musinguzi, Alex Opio, Robert Downing and Edward Katongole Mbidde

    Citation: BMC Infectious Diseases 2018 18:93

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  39. Content type: Research article

    Cross-reacting antibodies enhanced dengue infection in humans and antibody dependent enhancement (ADE) have been proposed as early mechanisms underlying DHF/DSS. However, the duration of dengue IgG antibodies ...

    Authors: Shuying Luo, Weihong Cui, Chan Li, Feng Ling, Tao Fu, Qiyong Liu, Jiangping Ren and Jimin Sun

    Citation: BMC Infectious Diseases 2018 18:92

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  40. Content type: Research article

    The Dengue Score is a model for predicting pleural effusion and/or ascites and uses the hematocrit (Hct), albumin concentration, platelet count and aspartate aminotransferase (AST) ratio as independent variabl...

    Authors: Suhendro Suwarto, Mohammad Jauharsyah Hidayat and Bing Widjaya

    Citation: BMC Infectious Diseases 2018 18:90

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  41. Content type: Research article

    Socio-economic, demographic factors and Knowledge Attitude Practices (KAPs) have been recognized as critical factors that influence the incidence and transmission of dengue epidemics. However, studies that cha...

    Authors: Lahiru Udayanga, Nayana Gunathilaka, M. C. M. Iqbal, Kusumawathie Pahalagedara, Upali S. Amarasinghe and Wimaladharma Abeyewickreme

    Citation: BMC Infectious Diseases 2018 18:88

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  42. Content type: Research article

    Measles is one of the leading causes of death among young children even though a safe and cost-effective vaccine is available. Timely analysis of measles surveillance data is crucial for epidemic control and c...

    Authors: Misganu Endriyas, Tarekegn Solomon, Bekele Belayhun and Emebet Mekonnen

    Citation: BMC Infectious Diseases 2018 18:77

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  43. Content type: Research article

    From October 2010 through February 2016, Arizona conducted surveillance for severe acute respiratory infections (SARI) among adults hospitalized in the Arizona-Mexico border region. There are few accurate mort...

    Authors: Steve R. Barnes, Zimy Wansaula, Kristen Herrick, Eyal Oren, Kacey Ernst, Sonja J. Olsen and Mariana G. Casal

    Citation: BMC Infectious Diseases 2018 18:78

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  44. Content type: Study protocol

    People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, ho...

    Authors: Matthew J. Akiyama, Linda Agyemang, Julia H. Arnsten, Moonseong Heo, Brianna L. Norton, Bruce R. Schackman, Benjamin P. Linas and Alain H. Litwin

    Citation: BMC Infectious Diseases 2018 18:74

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  45. Content type: Research article

    Acute respiratory infections (ARIs) are a great public health challenge globally. The prevalence of respiratory viruses in patients with ARIs attending at different hospital settings is fully undetermined.

    Authors: Jianxing Yu, Zhengde Xie, Tiegang Zhang, Yanqin Lu, Hongwei Fan, Donghong Yang, Thomas Bénet, Philippe Vanhems, Kunling Shen, Fang Huang, Jinxiang Han, Taisheng Li, Zhancheng Gao, Lili Ren and Jianwei Wang

    Citation: BMC Infectious Diseases 2018 18:72

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  46. Content type: Research article

    Severe fever with thrombocytopenia syndrome (SFTS) is a severe viral disease caused by SFTSV. It is important to estimate the rate of missed SFTS diagnosis and to further understand the actual incidence in hig...

    Authors: Xiaoxia Huang, Shiwen Wang, Xianjun Wang, Yong Lyu, Mei Jiang, Deying Chen, Kaichun Li, Jingyu Liu, Shaoyu Xie, Tao Lyu, Jie Sun, Pengpeng Xu, Minghua Cao, Mifang Liang and Dexin Li

    Citation: BMC Infectious Diseases 2018 18:66

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  47. Content type: Research article

    In Colombia, the dengue virus (DENV) has been endemic for decades, and with the recent entry of the chikungunya virus (CHIKV) (2014) and the Zika virus (ZIKV) (2015), health systems are overloaded because the ...

    Authors: Marlen Yelitza Carrillo-Hernández, Julian Ruiz-Saenz, Lucy Jaimes Villamizar, Sergio Yebrail Gómez-Rangel and Marlen Martínez-Gutierrez

    Citation: BMC Infectious Diseases 2018 18:61

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  48. Content type: Case report

    We report a fatal case of disseminated adenovirus infection in a non-transplant haematology adult patient with chronic lymphocytic leukaemia who had completed combination chemoimmunotherapy a few months before...

    Authors: Michael Joffe, Simon D. Wagner and Julian W. Tang

    Citation: BMC Infectious Diseases 2018 18:58

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