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Viral diseases

Section edited by Julian Tang

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of viral diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV, HIV-associated infections and sexually transmitted diseases are considered in separate sections.

Page 1 of 19

  1. Cytomegalovirus (CMV) infection is one of the most common opportunistic infections following organ transplantation, despite administration of CMV prophylaxis. CMV-specific T-cell immunity (TCI) has been associ...

    Authors: Ralph Rogers, Kapil Saharia, Aditya Chandrokar, Zoe F. Weiss, Kendra Vieira, Sophia Koo and Dimitrios Farmakiotis

    Citation: BMC Infectious Diseases 2020 20:58

    Content type: Research article

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  2. This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children.

    Authors: Moussa Lingani, Tomoyuki Akita, Serge Ouoba, Shintaro Nagashima, Palwende Romuald Boua, Kazuaki Takahashi, Basile Kam, Aya Sugiyama, Théodore Nikiema, Chikako Yamamoto, Athanase Somé, Karim Derra, Ko Ko, Hermann Sorgho, Zekiba Tarnagda, Halidou Tinto…

    Citation: BMC Infectious Diseases 2020 20:46

    Content type: Research article

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  3. Impact of climate change on tick-borne encephalitis (TBE) prevalence in the tick-host enzootic cycle in a given region depends on how the region-specific climate change patterns influence tick population devel...

    Authors: Kyeongah Nah, Ákos Bede-Fazekas, Attila János Trájer and Jianhong Wu

    Citation: BMC Infectious Diseases 2020 20:34

    Content type: Research Article

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  4. Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pat...

    Authors: Maria Stavrou, Jing Ming Yeo, Alexander David Slater, Oliver Koch, Sarosh Irani and Peter Foley

    Citation: BMC Infectious Diseases 2020 20:21

    Content type: Case report

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  5. Despite the benefits of Antiretroviral Therapy (ART), there is a growing concern of treatment failure. This study aimed to assess viral non suppression rate and factors associated with HIV viral non suppressio...

    Authors: Abraham Aregay Desta, Tewolde Wubayehu Woldearegay, Nesredin Futwi, Gebrecherkos Teame Gebrehiwot, Goyitom Gebremedhn Gebru, Asfawosen Aregay Berhe and Hagos Godefay

    Citation: BMC Infectious Diseases 2020 20:4

    Content type: Research article

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  6. Outbreaks of infectious gastroenteritis are common in care homes for the elderly. Norovirus can cause these outbreaks, but diagnosis is frequently based solely on clinical characteristics. Our objective in thi...

    Authors: Thomas Inns, Deb Wilson, Petra Manley, John P. Harris, Sarah J. O’Brien and Roberto Vivancos

    Citation: BMC Infectious Diseases 2019 20:2

    Content type: Research article

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  7. Varicella-zoster virus (VZV) causes herpes zoster. Pneumocystis jirovecii (PJ) also causes pneumonia in immunocompromised hosts. Although both cause opportunistic infections, it is rare to have a co-infection in ...

    Authors: Hirotada Muramatsu, Akira Kuriyama, Yoshiaki Anzai and Tetsunori Ikegami

    Citation: BMC Infectious Diseases 2019 19:1092

    Content type: Case report

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  8. The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were s...

    Authors: Vivian I. Avelino-Silva, Philippe Mayaud, Adriana Tami, Maria C. Miranda, Kerstin D. Rosenberger, Neal Alexander, Luis Nacul, Aluisio Segurado, Moritz Pohl, Sarah Bethencourt, Luis A. Villar, Isabelle F. T. Viana, Renata Rabello, Carmen Soria, Silvia P. Salgado, Eduardo Gotuzzo…

    Citation: BMC Infectious Diseases 2019 19:1081

    Content type: Study protocol

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  9. Current studies regarding glucocorticosteroid treatment of influenza have only estimated risk of critical illness or death which can be easily confounded by timing of treatment administration. We used severe a...

    Authors: Xuesen Xing, Shixiong Hu, Meihua Chen, Faxian Zhan, Huihui Liu, Zhang Chen, Hengjiao Zhang, Ge Zeng, Qiaohua Xu, Hong Zhang, Man Liu, Honghui Liu, Lidong Gao and Lijie Zhang

    Citation: BMC Infectious Diseases 2019 19:1080

    Content type: Research article

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  10. Approximately 50% of cases of penile carcinoma (PeCa), a rare neoplasm worldwide, are associated with human papillomavirus (HPV). However, the detection of HPV-DNA is not sufficient to consider it the etiologi...

    Authors: Cecilia Martínez-Bailón, Alejandra Mantilla-Morales, Galo Méndez-Matías, Isabel Alvarado-Cabrero, Rogelio Maldonado-Rodríguez, Joel Quintero-Becerra, Rafael Arias-Flores and Patricia Piña-Sánchez

    Citation: BMC Infectious Diseases 2019 19:1068

    Content type: Research article

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  11. West Nile virus (WNV) is a mosquito-borne flavivirus, first detected in the Western Hemisphere in 1999 and spread across North America over the next decade. Though endemic in the most populous areas of North A...

    Authors: Emily Shing, John Wang, Mark P. Nelder, Camilla Parpia, Jonathan B. Gubbay, Mark Loeb, Erik Kristjanson, Alex Marchand-Austin, Stephen Moore, Curtis Russell, Doug Sider and Beate Sander

    Citation: BMC Infectious Diseases 2019 19:1059

    Content type: Research article

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  12. Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and a leading cause of long-term neurological and sensory sequelae, the most common being sensorineural hearing loss (SNHL). ...

    Authors: G. Clement Dobbins, Amit Patki, Dongquan Chen, Hemant K. Tiwari, Curtis Hendrickson, William J. Britt, Karen Fowler, Jake Y. Chen, Suresh B. Boppana and Shannon A. Ross

    Citation: BMC Infectious Diseases 2019 19:1046

    Content type: Research article

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  13. Hand, foot, and mouth disease (HFMD) raises an urgent public health issue in the Asia-Pacific region, especially in China. The associations between weather factors and HFMD have been widely studied but with in...

    Authors: Zhicheng Du, Shao Lin, Tia Marks, Wangjian Zhang, Te Deng, Shicheng Yu and Yuantao Hao

    Citation: BMC Infectious Diseases 2019 19:1029

    Content type: Research article

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  14. Currently, norovirus (NoV) is associated with one-fifth of all acute gastroenteritis (AGE) cases worldwide. The NoV GII.17_2014 variant has been associated with gastroenteritis outbreaks in several Asian count...

    Authors: Larissa Cristina Prado das Neves Costa, Dielle Monteiro Teixeira, Ana Caroline Rodrigues Portela, Ian Carlos Gomes de Lima, Renato da Silva Bandeira, Edivaldo Costa Sousa Júnior, Jones Anderson Monteiro Siqueira, Hugo Reis Resque, Luciana Damascena da Silva and Yvone Benchimol Gabbay

    Citation: BMC Infectious Diseases 2019 19:1021

    Content type: Research article

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  15. Influenza is the most frequent cause of acute upper respiratory tract infections during winter season. Although rare, neurological manifestations are known to occur during influenza infection and approximative...

    Authors: Maria Vincenza Mastrolia, Chiara Rubino, Massimo Resti, Sandra Trapani and Luisa Galli

    Citation: BMC Infectious Diseases 2019 19:1012

    Content type: Research article

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  16. Aseptic meningitis epidemics may pose various health care challenges.

    Authors: Jonas Graf, Christian J. Hartmann, Helmar C. Lehmann, Carolin Otto, Ortwin Adams, Michael Karenfort, Christian Schneider, Klemens Ruprecht, Hans Martin Bosse, Sabine Diedrich, Sindy Böttcher, Alfons Schnitzler, Hans-Peter Hartung, Orhan Aktas and Philipp Albrecht

    Citation: BMC Infectious Diseases 2019 19:1010

    Content type: Research article

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  17. Epstein-Barr virus (EBV) is an important human pathogen which causes lifelong infection of > 90% people globally and is linked to infectious mononucleosis (arising from infection in the later teenage years) an...

    Authors: Joanne R. Winter, Graham S. Taylor, Olivia G. Thomas, Charlotte Jackson, Joanna E. A. Lewis and Helen R. Stagg

    Citation: BMC Infectious Diseases 2019 19:1007

    Content type: Research article

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  18. Chikungunya virus (CHIKV) is a widespread mosquito-borne virus representing a serious challenge to public health. The largest outbreak in the Middle-East was recorded in 2016–2017 in Pakistan. Sistan and Baluc...

    Authors: Mohammad Hassan Pouriayevali, Farshid Rezaei, Tahmineh Jalali, Vahid Baniasadi, Mehdi Fazlalipour, Ehsan Mostafavi, Sahar Khakifirouz, Tahereh Mohammadi, Zahra Fereydooni, Mahsa Tavakoli, Sanam Azad-Manjiri, Motahareh Hosseini, Mahsa Ghalejoogh, Mohammad Mehdi Gouya, Anna-Bella Failloux and Mostafa Salehi-Vaziri

    Citation: BMC Infectious Diseases 2019 19:1004

    Content type: Research article

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  19. Dengue is the most prevalent mosquito-borne disease in the world, with China affected seriously in recent years. 65.8% of dengue cases identified in mainland China since 2005 were reported from the city of Gua...

    Authors: Zhoubin Zhang, Qinlong Jing, Zongqiu Chen, Tiegang Li, Liyun Jiang, Yilan Li, Lei Luo, John Marshall and Zhicong Yang

    Citation: BMC Infectious Diseases 2019 19:1002

    Content type: Research article

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  20. Dengue fever is prevalent in the world; in recent years, several outbreaks occurred in West Africa. It affects pregnant women. We aimed to assess the consequences of dengue fever on pregnant women and their fe...

    Authors: Kongnimissom Apoline Sondo, Adama Ouattara, Eric Arnaud Diendéré, Ismaèl Diallo, Jacques Zoungrana, Guelilou Zémané, Léa Da, Arouna Gnamou, Bertrand Meda, Armel Poda, Hyacinthe Zamané, Ali Ouédraogo, Macaire Ouédraogo and Blandine Thieba/Bonané

    Citation: BMC Infectious Diseases 2019 19:997

    Content type: Research article

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  21. In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak.

    Authors: Dan Li, Yang Wu, Xuesen Xing, Jigui Huang, Anlu Mao, Tian Liu, Ping Rao, Wei Qin, Lijie Zhang, Luzhao Feng, Shangren Gao and Xuhua Guan

    Citation: BMC Infectious Diseases 2019 19:995

    Content type: Research article

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  22. Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A stra...

    Authors: Simona Puzelli, Angela Di Martino, Marzia Facchini, Concetta Fabiani, Laura Calzoletti, Giuseppina Di Mario, Annapina Palmieri, Paola Affanni, Barbara Camilloni, Maria Chironna, Pierlanfranco D’Agaro, Simone Giannecchini, Elena Pariani, Caterina Serra, Caterina Rizzo, Antonino Bella…

    Citation: BMC Infectious Diseases 2019 19:990

    Content type: Research article

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  23. Zika virus (ZIKV) infection gained public health concern after the 2015 outbreak in Brazil, when microcephaly rates increased in babies born from infected mothers. It was demonstrated that ZIKV causes a congen...

    Authors: Carolina V. Messias, Julia P. Lemos, Daniela P. Cunha, Zilton Vasconcelos, Lidiane M. S. Raphael, Myrna C. Bonaldo, Bruno Cister-Alves, Dumith Chequer Bou-Habib, Vinicius Cotta-de-Almeida, Wilson Savino and Daniella A. Mendes-da-Cruz

    Citation: BMC Infectious Diseases 2019 19:986

    Content type: Research article

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  24. Vaccine escape mutants (VEMs) are one of the causes of breakthrough infections in the mother-to-child transmission of hepatitis B virus (HBV). We hypothesized that VEMs existing as minor populations in the mat...

    Authors: Haruki Komatsu, Ayano Inui, Yasuto Suzuki, Masaya Sugiyama and Tomoo Fujisawa

    Citation: BMC Infectious Diseases 2019 19:985

    Content type: Case report

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  25. The ninth outbreak of Ebola Virus Disease (EVD) in the Democratic Republic of the Congo occurred in Équateur Province from 8 May-24 July 2018. A system of health facility (HF)-based active case finding (ACF) w...

    Authors: Amber Kunkel, Mory Keita, Boubacar Diallo, Olivier le Polain de Waroux, Lorenzo Subissi, Bocar Wague, Roger Molala, Pierre Lonfandjo, Sébastien Bokoo Bokete, William Perea and Mamoudou Harouna Djingarey

    Citation: BMC Infectious Diseases 2019 19:981

    Content type: Research article

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  26. Rabies is estimated to cause 59,000 deaths and economic losses of US$8.6 billion every year. Despite several years of rabies surveillance and awareness programmes, increased availability of post-exposure proph...

    Authors: Carlos Sánchez-Soriano, Andrew D. Gibson, Luke Gamble, Jordana L. Burdon Bailey, Samantha Green, Mark Green, Barend M. deC. Bronsvoort, Ian G. Handel, Richard J. Mellanby and Stella Mazeri

    Citation: BMC Infectious Diseases 2019 19:977

    Content type: Research article

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  27. Adjustment of immunosuppression is the main therapy for BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) after kidney transplantation (KT). Studies of BKPyV-specific T cell immune response are scarce. ...

    Authors: Jackrapong Bruminhent, Supranart Srisala, Chompunut Klinmalai, Subencha Pinsai, Siriorn P. Watcharananan, Surasak Kantachuvesiri, Suradej Hongeng and Nopporn Apiwattanakul

    Citation: BMC Infectious Diseases 2019 19:974

    Content type: Research article

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  28. Acute febrile illness (AFI) is characterized by malaise, myalgia and a raised temperature that is a nonspecific manifestation of infectious diseases in the tropics. The lack of appropriate diagnostics for the ...

    Authors: Divyalakshmi Bhaskaran, Sarabjit Singh Chadha, Sanjay Sarin, Rajashree Sen, Sonia Arafah and Sabine Dittrich

    Citation: BMC Infectious Diseases 2019 19:970

    Content type: Research article

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  29. Seasonal influenza causes a considerable burden to healthcare services every year. To better measure the impact of severe influenza cases in Romania, we analyzed active surveillance data collected during the 2...

    Authors: Anca Drăgănescu, Oana Săndulescu, Dragoș Florea, Ovidiu Vlaicu, Anca Streinu-Cercel, Dan Oțelea, Monica Luminița Luminos, Victoria Aramă, Sorin Abrudan, Adrian Streinu-Cercel and Daniela Pițigoi

    Citation: BMC Infectious Diseases 2019 19:967

    Content type: Research article

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  30. The aim of this study was to evaluate the correlation between clinical and imaging findings with a worse clinical outcome in patients with a confirmed diagnosis of H1N1 influenza A virus.

    Authors: Karla Schoen, Natally Horvat, Nicolau F. C. Guerreiro, Isac de Castro and Karina S. de Giassi

    Citation: BMC Infectious Diseases 2019 19:964

    Content type: Research article

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  31. Colombia was the second most affected country during the American Zika virus (ZIKV) epidemic, with over 109,000 reported cases. Despite the scale of the outbreak, limited genomic sequence data were available f...

    Authors: Allison Black, Louise H. Moncla, Katherine Laiton-Donato, Barney Potter, Lissethe Pardo, Angelica Rico, Catalina Tovar, Diana P. Rojas, Ira M. Longini, M. Elizabeth Halloran, Dioselina Peláez-Carvajal, Juan D. Ramírez, Marcela Mercado-Reyes and Trevor Bedford

    Citation: BMC Infectious Diseases 2019 19:963

    Content type: Research Article

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  32. Human cytomegalovirus (HCMV) can cause poor outcomes in solid organ transplant (SOT) recipients; moreover, it is associated with cardiovascular diseases (CVD) in the general population. Accordingly, anti-HCMV ...

    Authors: Yeonju La, Da Eun Kwon, Seul Gi Yoo, Kyoung Hwa Lee, Sang Hoon Han and Yong Goo Song

    Citation: BMC Infectious Diseases 2019 19:948

    Content type: Research article

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  33. Despite the numerous intervention programmes, HIV still remains a public health concern with a high impact in Sub-Saharan Africa region. Oxidative stress has been documented in HIV subjects as viral infection ...

    Authors: Stephen Bassey Coco-Bassey, Enosakhare A. Asemota, Henshaw Uchechi Okoroiwu, Joyce E. Etura, Esienanwan Esien Efiong, Imeobong J. Inyang and Emmanuel K. Uko

    Citation: BMC Infectious Diseases 2019 19:944

    Content type: Research article

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  34. Hand, foot and mouth disease (HFMD) has emerged as a major public health issue in Vietnam since 2003. We aimed to investigate the household transmission of HFMD and its causative viruses from 150 households in...

    Authors: Cuong Quoc Hoang, Thao Thanh Thi Nguyen, Nguyen Xuan Ho, Hai Duc Nguyen, An Binh Nguyen, Tham Hong Thi Nguyen, Hung Cong Phan and Lan Trong Phan

    Citation: BMC Infectious Diseases 2019 19:933

    Content type: Research article

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  35. Myeloid-derived suppressor cells (MDSCs) play immunosuppressive roles in cancers and some infectious diseases; however, their role in dengue fever (DF) remains unknown. This study evaluated the clinical signif...

    Authors: Peng-Le Guo, Ling-Hua Li, Wen-Li Li, Jin-Cun Zhao, Feng-Yu Hu, Fu-Chun Zhang, Wei-Ping Cai and Xiao-Ping Tang

    Citation: BMC Infectious Diseases 2019 19:926

    Content type: Research article

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  36. This short reply contests two assumptions made by the authors of Mayrhuber et al’s. “With fever it’s the real flu I would say.” The first is that there is influenza can be reliably defined by a medical case de...

    Authors: Annemarie Jutel

    Citation: BMC Infectious Diseases 2019 19:921

    Content type: Correspondence

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  37. West Nile virus (WNV) circulates across Australia and was referred to historically as Kunjin virus (WNVKUN). WNVKUN has been considered more benign than other WNV strains circulating globally. In 2011, a more vir...

    Authors: Bixing Huang, Nic West, Jelena Vider, Ping Zhang, Rebecca E. Griffiths, Ernst Wolvetang, Peter Burtonclay and David Warrilow

    Citation: BMC Infectious Diseases 2019 19:912

    Content type: Research article

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  38. On September 4, 2018, a boarding school in the Shunyi District of Beijing, China reported an outbreak of acute gastroenteritis. At least 209 suspected students caused of diarrhea and vomiting. The case was inv...

    Authors: Dongwan Chen, Yongjin Li, Jinchang Lv, Xiufeng Liu, Peng Gao, Guoxin Zhen, Wenzeng Zhang, Dan Wu, Hongbo Jing, Ying Li, Yao Zhao, Xiaochen Ma, Huilai Ma and Lijie Zhang

    Citation: BMC Infectious Diseases 2019 19:910

    Content type: Research article

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  39. Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infection that has recently emerged. This infectious disease is due to the transfer of SFTS virus (SFTSV) from the infected blood of animals t...

    Authors: Osamu Imataki, Makiko Uemura and Hisashi Masugata

    Citation: BMC Infectious Diseases 2019 19:885

    Content type: Case report

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  40. We recently conducted a serosurvey of newly arrived workers in Taiwan from four Southeast Asian countries which revealed that 1% of the migrant workers had laboratory-confirmed recent Zika virus (ZIKV) infecti...

    Authors: Yu-Wen Chien, Tzu-Chuan Ho, Pei-Wen Huang, Nai-Ying Ko, Wen-Chien Ko and Guey Chuen Perng

    Citation: BMC Infectious Diseases 2019 19:884

    Content type: Research article

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  41. Bendamustine, used for the treatment of indolent B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia, is known to cause prolonged myelosuppression and lymphocytopenia and has been associated with the ...

    Authors: Andrea Cona, Daniele Tesoro, Margherita Chiamenti, Esther Merlini, Daris Ferrari, Antonio Marti, Carla Codecà, Giuseppe Ancona, Camilla Tincati, Antonella d’Arminio Monforte and Giulia Marchetti

    Citation: BMC Infectious Diseases 2019 19:881

    Content type: Case report

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  42. Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV pati...

    Authors: Abdulrahman Mohammed G. Habib, Mohamed Abd Elghafour Ali, Baha R. Zouaoui, Mustafa Ahmed H. Taha, Bassem Sahsah Mohammed and Nazmus Saquib

    Citation: BMC Infectious Diseases 2019 19:870

    Content type: Research article

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  43. Hand, foot and mouth disease (HFMD) remains a burdensome health issue in mainland China. Enterovirus71 (EV-A71) is the main pathogen of severe HFMD. Continuous hemofiltration improves fluid overload, restores ...

    Authors: Chunxia Wang, Yun Cui, Yan Zhu, Fei Wang, Qunfang Rong and Yucai Zhang

    Citation: BMC Infectious Diseases 2019 19:866

    Content type: Research article

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  44. Intravenous (IV) zanamivir could be a suitable alternative for the treatment of severe influenza A(H1N1)pdm09 infection in patients who are unable to take oral or inhaled medication, for example, those on mech...

    Authors: Carlo Torti, Maria Mazzitelli, Federico Longhini, Eugenio Garofalo, Andrea Bruni, Aida Giancotti, Giorgio Settimo Barreca, Angela Quirino, Maria Carla Liberto, Francesca Serapide, Giovanni Matera, Enrico Maria Trecarichi and Paolo Navalesi

    Citation: BMC Infectious Diseases 2019 19:858

    Content type: Case report

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  45. CD40, encoded by TNFRSF5, participates in the survival of B cells, process of antigen presentation and generation of CD8+ T cell memory. It also has an important effect on HCV antiviral immune response. This stud...

    Authors: Ting Tian, Peng Huang, Jingjing Wu, Chunhui Wang, Haozhi Fan, Yun Zhang, Rongbin Yu, Chao Wu, Xueshan Xia, Zuqiang Fu, Jun Li and Ming Yue

    Citation: BMC Infectious Diseases 2019 19:840

    Content type: Research article

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  46. Hand, foot and mouth disease (HFMD) is a rising public health problem and has attracted considerable attention worldwide. The purpose of this study was to develop an optimal model with meteorological factors t...

    Authors: Wendong Liu, Changjun Bao, Yuping Zhou, Hong Ji, Ying Wu, Yingying Shi, Wenqi Shen, Jing Bao, Juan Li, Jianli Hu and Xiang Huo

    Citation: BMC Infectious Diseases 2019 19:828

    Content type: Research article

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