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Vaccines

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. The World Health Organization reported in 2007 that inclusion of PCV7 in national immunization programs should be seen as a priority, also encouraging countries to conduct appropriate surveillances for monitor...

    Authors: Juan Picazo, Joaquin Dueñas, Antonio Ramirez, Andres-Ricardo Perez, Emma Padilla, Susana Herrero, Carmen Gallegos, Esther Culebras, Cesar Balseiro and Cristina Mendez

    Citation: BMC Infectious Diseases 2013 13:503

    Content type: Research article

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  2. Toxoplasma gondii is a widespread intracellular parasite, which infects most vertebrate animal hosts and causes zoonotic infection in humans. Vaccine strategy remains a promising method for the prevention and co...

    Authors: Min Meng, Aihua Zhou, Gang Lu, Lin Wang, Guanghui Zhao, Yali Han, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu and Shenyi He

    Citation: BMC Infectious Diseases 2013 13:494

    Content type: Research article

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  3. A high prevalence of bacterial nasopharyngeal co-infections has been reported in children, however, such data is limited in adults. We examined the interaction of Haemophilus influenzae, Staphylococcus aureus and...

    Authors: Tinevimbo Shiri, Marta C Nunes, Peter V Adrian, Nadia Van Niekerk, Keith P Klugman and Shabir A Madhi

    Citation: BMC Infectious Diseases 2013 13:483

    Content type: Research article

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  4. We investigated the immune response to serogroup 6 with the opsonophagocytic killing assay (OPKA) in children aged 12–23 months of age after immunization with the 7-valent pneumococcal conjugate vaccine (PCV7)...

    Authors: Hyunju Lee, Jung Hwa Cha, Moon H Nahm, Robert L Burton and Kyung-Hyo Kim

    Citation: BMC Infectious Diseases 2013 13:474

    Content type: Research article

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  5. Despite almost 30 years of effective chemotherapy with MDT, the global new case detection rate of leprosy has remained quite constant over the past years. New tools and methodologies are necessary to interrupt...

    Authors: Renate A Richardus, Khorshed Alam, David Pahan, Sabiena G Feenstra, Annemieke Geluk and Jan H Richardus

    Citation: BMC Infectious Diseases 2013 13:456

    Content type: Study protocol

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  6. In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance Sy...

    Authors: Silvia Jiménez-Jorge, Salvador de Mateo, Concha Delgado-Sanz, Francisco Pozo, Inmaculada Casas, Manuel Garcia-Cenoz, Jesús Castilla, Esteban Pérez, Virtudes Gallardo, Carolina Rodriguez, Tomás Vega, Carmen Quiñones, Eva Martínez, Juana María Vanrell, Jaume Giménez, Daniel Castrillejo…

    Citation: BMC Infectious Diseases 2013 13:441

    Content type: Research article

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  7. Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity betwe...

    Authors: Odile Launay, Xavier Duval, Serge Fitoussi, Wolfgang Jilg, Angkool Kerdpanich, May Montellano, Tino F Schwarz, Veerachai Watanveerade, Jürgen J Wenzel, Gerard Zalcman, Vinod Bambure, Ping Li, Adrian Caplanusi, Anuradha Madan, Paul Gillard and David W Vaughn

    Citation: BMC Infectious Diseases 2013 13:435

    Content type: Research article

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  8. Interruption of measles transmission was achieved in Catalonia (Spain) in 2000. Six years later, a measles outbreak occurred between August 2006 and June 2007 with 381 cases, 11 of whom were health care worker...

    Authors: Luis Urbiztondo, Eva Borràs, Josep Costa, Sonia Broner, Magda Campins, José María Bayas, María Esteve and Angela Domínguez

    Citation: BMC Infectious Diseases 2013 13:391

    Content type: Research article

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  9. The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, was first introduced in mass vaccination campaigns of the 1-29-year-olds in Burkina Faso in 2010. The aim of this study was to g...

    Authors: Paul A Kristiansen, Absatou Ky Ba, Idrissa Sanou, Abdoul-Salam Ouédraogo, Rasmata Ouédraogo, Lassana Sangaré, Fabien Diomandé, Denis Kandolo, Jennifer Dolan Thomas, Thomas A Clark, Marc LaForce and Dominique A Caugant

    Citation: BMC Infectious Diseases 2013 13:363

    Content type: Research article

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  10. Countries of the Americas have been working towards rubella elimination since 2003 and endemic rubella virus transmission appears to have been interrupted since 2009. To contribute towards monitoring of rubell...

    Authors: Gillian H Lim, Tara Harris, Shalini Desai, Natasha S Crowcroft, Tony Mazzulli, Tina Kozlowski and Shelley L Deeks

    Citation: BMC Infectious Diseases 2013 13:362

    Content type: Research article

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  11. Community-acquired pneumonia (CAP) is a serious cause of morbidity among children in developed countries. The real impact of 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal pneumonia is difficul...

    Authors: Hélène Chappuy, Kristina Keitel, Mario Gehri, René Tabin, Lynda Robitaille, Frederic Raymond, Jacques Corbeil, Veronica Maspoli, Naim Bouazza, Gabriel Alcoba, Laurence Lacroix, Sergio Manzano, Annick Galetto-Lacour and Alain Gervaix

    Citation: BMC Infectious Diseases 2013 13:357

    Content type: Research article

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  12. Improved influenza vaccines are needed to reduce influenza-associated complications in older adults. The aim of this study was to identify the optimal formulation of adjuvanted seasonal influenza vaccine for u...

    Authors: Hans C Rümke, Jan Hendrik Richardus, Lars Rombo, Karlis Pauksens, Georg Plaßmann, Christelle Durand, Jeanne-Marie Devaster, Walthère Dewé and Lidia Oostvogels

    Citation: BMC Infectious Diseases 2013 13:348

    Content type: Research article

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  13. Two antigenically distinct influenza B lineages have co-circulated since the 1980s, yet inactivated trivalent influenza vaccines (TIVs) include strains of influenza A/H1N1, A/H3N2, and only one influenza B fro...

    Authors: Dorothee Kieninger, Eric Sheldon, Wen-Yuan Lin, Chong-Jen Yu, Jose M Bayas, Julian J Gabor, Meral Esen, Jose Luis Fernandez Roure, Silvia Narejos Perez, Carmen Alvarez Sanchez, Yang Feng, Carine Claeys, Mathieu Peeters, Bruce L Innis and Varsha Jain

    Citation: BMC Infectious Diseases 2013 13:343

    Content type: Research article

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  14. Streptococcus pneumoniae remains a major cause of childhood morbidity and mortality worldwide. Nasopharyngeal colonization plays an important role in the development and transmission of pneumococcal diseases, an...

    Authors: Felipe Piedade Gonçalves Neves, Tatiana Castro Abreu Pinto, Mariane Alves Corrêa, Roberta dos Anjos Barreto, Laís de Souza Gouveia Moreira, Havana Gomes Rodrigues, Claudete Araújo Cardoso, Rosana Rocha Barros and Lúcia Martins Teixeira

    Citation: BMC Infectious Diseases 2013 13:318

    Content type: Research article

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  16. In 2004, routine varicella vaccination was recommended in Germany for children 11-14 months of age with one dose, and since 2009, with a second dose at 15-23 months of age. The effects on varicella epidemiolog...

    Authors: Andrea Streng, Veit Grote, David Carr, Christine Hagemann and Johannes G Liese

    Citation: BMC Infectious Diseases 2013 13:303

    Content type: Research article

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  17. Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform investment and adop...

    Authors: Julia K Nunes, Vicky Cárdenas, Christian Loucq, Nicolas Maire, Thomas Smith, Craig Shaffer, Kårstein Måseide and Alan Brooks

    Citation: BMC Infectious Diseases 2013 13:295

    Content type: Research article

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  18. Influenza transmitted by health care workers (HCWs) is a potential threat to frail patients in acute health care settings. Therefore, immunizing HCWs against influenza should receive high priority. Despite rec...

    Authors: Josien Riphagen-Dalhuisen, Gerard Frijstein, Nannet van der Geest-Blankert, Marita Danhof-Pont, Herbert de Jager, Nita Bos, Ed Smeets, Marjan de Vries, Pieter Gallee and Eelko Hak

    Citation: BMC Infectious Diseases 2013 13:235

    Content type: Research article

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  19. High rates of bacterial coinfection in autopsy data from the 2009 H1N1 influenza (“flu”) pandemic suggest synergies between flu and pneumococcal disease (PD) during pandemic conditions, and highlight the impor...

    Authors: Lisa J McGarry, Kristen E Gilmore, Jaime L Rubin, Keith P Klugman, David R Strutton and Milton C Weinstein

    Citation: BMC Infectious Diseases 2013 13:229

    Content type: Research article

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  20. Two phylogenetic lineages of influenza B virus coexist and circulate in the human population (B/Yamagata and B/Victoria) but only one B-strain is included in each seasonal vaccine. Mismatch regularly occurs be...

    Authors: Jiří Beran, Mathieu Peeters, Walthère Dewé, Jolana Raupachová, Lenka Hobzová and Jeanne-Marie Devaster

    Citation: BMC Infectious Diseases 2013 13:224

    Content type: Research article

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  21. Liver cancer is the second most-frequent cause of cancer death in Korea. Hepatitis B virus (HBV) infection is a major cause of liver cancer, and this disease is effectively prevented by HBV vaccination. This s...

    Authors: Boyoung Park, Kui Son Choi, Hoo-Yeon Lee, Min-Son Kwak, Jae Kwan Jun and Eun-Cheol Park

    Citation: BMC Infectious Diseases 2013 13:218

    Content type: Research article

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  22. Toxoplasma gondii, an obligate intracellular apicomplexan parasite, infects a wide range of warm-blooded animals including humans. T. gondii expresses five members of the C1 family of cysteine proteases, includi...

    Authors: Guanghui Zhao, Aihua Zhou, Gang Lv, Min Meng, Min Sun, Yang Bai, Yali Han, Lin Wang, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu and Shenyi He

    Citation: BMC Infectious Diseases 2013 13:207

    Content type: Research article

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  23. The 2009 pandemic influenza was milder than expected. Based on the apparent lack of pre-existing cross-protective antibodies to the A (H1N1)pdm09 strain, it was hypothesized that pre-existing CD4+ T cellular i...

    Authors: Venkata R Duvvuri, Bhargavi Duvvuri, Veronica Jamnik, Jonathan B Gubbay, Jianhong Wu and Gillian E Wu

    Citation: BMC Infectious Diseases 2013 13:204

    Content type: Research article

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  24. Resurgence of pertussis in the post-vaccination era has been reported in Western countries. A shift of cases from school-age children to adolescents, adults and children under 1 year of age has been described ...

    Authors: Elena Chiappini, Alessia Stival, Luisa Galli and Maurizio de Martino

    Citation: BMC Infectious Diseases 2013 13:151

    Content type: Debate

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  25. The best strategy to protect individuals against meningococcal disease is to immunize against multiple serogroups. Immunogenicity, antibody persistence, and safety of the EU-licensed meningococcal ACWY-tetanus...

    Authors: Charissa Borja-Tabora, Cecilia Montalban, Ziad A Memish, Marie Van der Wielen, Veronique Bianco, Dominique Boutriau and Jacqueline Miller

    Citation: BMC Infectious Diseases 2013 13:116

    Content type: Research article

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  26. The aim of the study was to evaluate the effects of universal mass vaccination (UMV) against rotavirus (RV) on the hospitalization rates, nosocomial RV infections and RV-gastroenteritis (GE)-associated seconda...

    Authors: Manuela Zlamy, Sabine Kofler, Dorothea Orth, Reinhard Würzner, Peter Heinz-Erian, Andrea Streng and Martina Prelog

    Citation: BMC Infectious Diseases 2013 13:112

    Content type: Research article

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  27. Despite huge efforts to promote widespread vaccination, measles remains an important cause of morbidity and mortality worldwide, especially in African children. In March 2011, an abnormally high number of case...

    Authors: Vianney Tricou, Marilou Pagonendji, Casimir Manengu, Jeff Mutombo, Rock Ouambita Mabo and Ionela Gouandjika-Vasilache

    Citation: BMC Infectious Diseases 2013 13:103

    Content type: Research article

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  28. Pneumococcal infections are major causes of child mortality and morbidity worldwide and antibiotic resistance of Streptococcus pneumoniae is a major concern, especially in Asian countries. The present study was d...

    Authors: Tran Ngoc Huu, Nguyen Trong Toan, Ha Manh Tuan, Ho Lu Viet, Pham Le Thanh Binh, Ta-Wen Yu, Fakrudeen Shafi, Ahsan Habib and Dorota Borys

    Citation: BMC Infectious Diseases 2013 13:95

    Content type: Research article

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  29. A critical issue in planning pandemic influenza mitigation strategies is the delay between the arrival of the pandemic in a community and the availability of an effective vaccine. The likely scenario, born out...

    Authors: Joel K Kelso, Nilimesh Halder and George J Milne

    Citation: BMC Infectious Diseases 2013 13:81

    Content type: Research article

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  30. Infection with HPV 16 and 18, the major causative agents of cervical cancer, can be prevented through vaccination with a bivalent or quadrivalent vaccine. Both vaccines provide cross-protection against HPV-typ...

    Authors: Tjalke A Westra, Irina Stirbu-Wagner, Sara Dorsman, Eric D Tutuhatunewa, Edwin L de Vrij, Hans W Nijman, Toos Daemen, Jan C Wilschut and Maarten J Postma

    Citation: BMC Infectious Diseases 2013 13:75

    Content type: Research article

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  31. This study presents an analysis of 159 serotype 19A isolates from IPD in children before and after the general recommendation for childhood pneumococcal conjugate vaccination in Germany in July 2006. Vaccinati...

    Authors: Mark van der Linden, Ralf René Reinert, Winfried V Kern and Matthias Imöhl

    Citation: BMC Infectious Diseases 2013 13:70

    Content type: Research article

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  33. Indirect herd effect from vaccination of children offers potential for improving the effectiveness of influenza prevention in the remaining unvaccinated population. Static models used in cost-effectiveness ana...

    Authors: Ilse Van Vlaenderen, Laure-Anne Van Bellinghen, Genevieve Meier and Barbara Poulsen Nautrup

    Citation: BMC Infectious Diseases 2013 13:25

    Content type: Research article

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  34. The primary strategy to interrupt transmission of wild poliovirus in India is to improve supplemental immunization activities (SIAs) and routine immunization coverage in priority districts. The CORE Group, par...

    Authors: William M Weiss, Md Hafizur Rahman, Roma Solomon and Dora Ward

    Citation: BMC Infectious Diseases 2013 13:17

    Content type: Research article

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  35. Raw seafood consumption was identified as the major risk factor for hepatitis A during the large epidemic of 1996 and 1997 in Puglia (South Italy). In Puglia, vaccination for toddlers and preadolescents has be...

    Authors: Maria Chironna, Rosa Prato, Anna Sallustio, Domenico Martinelli, Silvio Tafuri, Michele Quarto and Cinzia Germinario

    Citation: BMC Infectious Diseases 2012 12:271

    Content type: Research article

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  36. Cervical cancer is the second most common cancer among women in Brazil. We examined the health and economic impacts of quadrivalent HPV vaccination in Brazil.

    Authors: Kosuke Kawai, Gabriela Tannus Branco de Araujo, Marcelo Fonseca, Matthew Pillsbury and Puneet K Singhal

    Citation: BMC Infectious Diseases 2012 12:250

    Content type: Research article

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  37. The burden of invasive pneumococcal disease in young children decreased dramatically following introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). The epidemiology of S. pneumoniae now reflects in...

    Authors: Catherine Weil-Olivier, Mark van der Linden, Iris de Schutter, Ron Dagan and Lorenzo Mantovani

    Citation: BMC Infectious Diseases 2012 12:207

    Content type: Debate

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  39. The first meningococcal serogroup C (MenC) conjugate vaccine was licensed in 1999 and introduced in the United Kingdom. Countries that have implemented the MenC vaccine since then in their national immunisatio...

    Authors: Patricia Kaaijk, Arie van der Ende, Guy Berbers, Germie PJM van den Dobbelsteen and Nynke Y Rots

    Citation: BMC Infectious Diseases 2012 12:35

    Content type: Debate

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  40. In acute-care hospitals, no evidence of a protective effect of healthcare worker (HCW) vaccination on hospital-acquired influenza (HAI) in patients has been documented. Our study objective was to ascertain the...

    Authors: Thomas Bénet, Corinne Régis, Nicolas Voirin, Olivier Robert, Bruno Lina, Silene Cronenberger, Brigitte Comte, Brigitte Coppéré and Philippe Vanhems

    Citation: BMC Infectious Diseases 2012 12:30

    Content type: Research article

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  42. Enterovirus 71 (EV71) has caused recurrent epidemics of hand, foot and mouth disease among children in Singapore. Between August 2008 and July 2010, we conducted a survey to estimate the seroprevalence of EV71...

    Authors: Li-Wei Ang, Meng-Chee Phoon, Yan Wu, Jeffery Cutter, Lyn James and Vincent T Chow

    Citation: BMC Infectious Diseases 2011 11:270

    Content type: Research article

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  43. Pneumococcal disease is the leading cause of vaccine-preventable death in children younger than 5 years of age worldwide. The World Health Organization recommends pneumococcal conjugate vaccine as a priority f...

    Authors: Syed Aljunid, Gulifeiya Abuduxike, Zafar Ahmed, Saperi Sulong, Amrizal Muhd Nur and Adrian Goh

    Citation: BMC Infectious Diseases 2011 11:248

    Content type: Research article

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  44. Vaccination is generally considered to be the best primary prevention measure against influenza virus infection. Many countries encourage specific target groups of people to undertake vaccination, often with f...

    Authors: Sophia Ng, Peng Wu, Hiroshi Nishiura, Dennis KM Ip, Esther ST Lee and Benjamin J Cowling

    Citation: BMC Infectious Diseases 2011 11:230

    Content type: Research article

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  45. In the Netherlands, epidemics of vaccine preventable diseases are largely confined to an orthodox protestant minority with religious objections to vaccination. The clustering of unvaccinated children in orthod...

    Authors: Wilhelmina LM Ruijs, Jeannine LA Hautvast, Reinier P Akkermans, Marlies EJL Hulscher and Koos van der Velden

    Citation: BMC Infectious Diseases 2011 11:227

    Content type: Research article

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  46. There was a low adherence to influenza A (H1N1) vaccination program among university students and health care workers during the pandemic influenza in many parts of the world. Vaccination of high risk individu...

    Authors: Padmanaban S Suresh, Venkatesh Thejaswini and Thangarasu Rajan

    Citation: BMC Infectious Diseases 2011 11:205

    Content type: Research article

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  47. During the 2009 influenza A/H1N1 pandemic, adjuvanted influenza vaccines were used for the first time on a large scale. Results on the effectiveness of the vaccines in preventing 2009 influenza A/H1N1-related ...

    Authors: Anneke Steens, Eleonora G Wijnans, Jeanne P Dieleman, Miriam CJM Sturkenboom, Marianne AB van der Sande and Wim van der Hoek

    Citation: BMC Infectious Diseases 2011 11:196

    Content type: Research article

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  48. Antigenic variation of influenza virus necessitates annual reformulation of seasonal influenza vaccines, which contain two type A strains (H1N1 and H3N2) and one type B strain. We used a test negative case con...

    Authors: James E Fielding, Kristina A Grant, Georgina Papadakis and Heath A Kelly

    Citation: BMC Infectious Diseases 2011 11:170

    Content type: Research article

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  49. After the implementation of 7-valent pneumococcal conjugate vaccine (PCV7), in several countries, serotype 19A is now the serotype most frequently involved in pneumococcal diseases and carriage. To determine f...

    Authors: Robert Cohen, Corinne Levy, Eric Bonnet, Franck Thollot, Michel Boucherat, Bernard Fritzell, Véronique Derkx, Edouard Bingen and Emmanuelle Varon

    Citation: BMC Infectious Diseases 2011 11:95

    Content type: Research article

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