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Vaccines

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune responses against the parasite, as well as a valuable tool for vaccine development. We have pre...

    Authors: Xiu-Zhen Li, Xiao-Hu Wang, Li-Jun Xia, Ya-Biao Weng, Jorge A Hernandez, Li-Qing Tu, Lu-Tao Li, Shou-Jun Li and Zi-Guo Yuan

    Citation: BMC Infectious Diseases 2015 15:114

    Content type: Research article

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  2. H1N1 influenza viruses mutate rapidly, rendering vaccines developed in any given year relatively ineffective in subsequent years. Thus it is necessary to generate new vaccines every year, but this is time-cons...

    Authors: Owen Proudfoot, Sandra Esparon, Choon-Kit Tang, Karen Laurie, Ian Barr and Geoffrey Pietersz

    Citation: BMC Infectious Diseases 2015 15:101

    Content type: Research article

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  3. Although rotavirus vaccines have been licensed in Spain for over 8 years, they are not funded by its public health systems. The analysis of their effectiveness in the Valencia Region could better inform decisi...

    Authors: Silvia Pérez-Vilar, Javier Díez-Domingo, Mónica López-Lacort, Sergio Martínez-Úbeda and Miguel A Martinez-Beneito

    Citation: BMC Infectious Diseases 2015 15:92

    Content type: Research article

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  4. Healthcare workers (HCWs) are at particular risk of acquiring pertussis and transmitting the infection to high-risk susceptible patients and colleagues. In this paper, the return on investment (ROI) of prevent...

    Authors: Luqman Tariq, Marie-Josée J Mangen, Anke Hövels, Gerard Frijstein and Hero de Boer

    Citation: BMC Infectious Diseases 2015 15:75

    Content type: Research article

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  6. The success of 7-valent pneumococcal conjugate vaccination (PCV-7) introduced to the US childhood immunization schedule in 2000 was partially offset by increases in invasive pneumococcal disease (IPD) and pneu...

    Authors: Qiuzhi Chang, Abbie E Stevenson, Nicholas J Croucher, Grace M Lee, Stephen I Pelton, Marc Lipsitch, Jonathan A Finkelstein and William P Hanage

    Citation: BMC Infectious Diseases 2015 15:68

    Content type: Research article

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  7. Most poliovirus infections occur with no symptoms and this leads to the possibility of silent circulation, which complicates the confirmation of global goals to permanently end poliovirus transmission. Previou...

    Authors: Dominika A Kalkowska, Radboud J Duintjer Tebbens, Mark A Pallansch, Stephen L Cochi, Steven G F Wassilak and Kimberly M Thompson

    Citation: BMC Infectious Diseases 2015 15:66

    Content type: Research article

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  8. Long-term complications and a case mortality rate of 7.5% make meningitis caused by Streptococcus pneumoniae a serious clinical threat. In 2006, a general pneumococcal conjugate vaccination (PCV) recommendation w...

    Authors: Matthias Imöhl, Jens Möller, Ralf René Reinert, Stephanie Perniciaro, Mark van der Linden and Orhan Aktas

    Citation: BMC Infectious Diseases 2015 15:61

    Content type: Research article

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  9. Recent studies worldwide have reported increasing numbers of adults diagnosed with Bordetella pertussis despite receiving childhood vaccinations. This study describes a pertussis outbreak at a university medical ...

    Authors: Megumi Hara, Mami Fukuoka, Katsuya Tashiro, Iwata Ozaki, Satoko Ohfuji, Kenji Okada, Takashi Nakano, Wakaba Fukushima and Yoshio Hirota

    Citation: BMC Infectious Diseases 2015 15:45

    Content type: Research article

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  10. China is approaching measles elimination, but indigenous measles still circulates. County L in China has reported measles-containing vaccine (MCV) coverage rates >95% since 2000. Despite high reported coverage...

    Authors: Chao Ma, Fangjun Li, Xiang Zheng, Hong Zhang, Mengjuan Duan, Yanhua Yang, Lixin Hao, Qiru Su, Lance Rodewald, Bosong Guo, Shanliang Xiao, Huaqing Wang, Li Li, Junhua Li, Huiming Luo and Lidong Gao

    Citation: BMC Infectious Diseases 2015 15:23

    Content type: Research article

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  11. Although mouse brain-derived, inactivated Japanese encephalitis vaccines (JE-MBs) have been successfully used for a long time, potential rare neurological complications have prompted the development of a Vero ...

    Authors: Ki Wook Yun, Hoan Jong Lee, Jin Han Kang, Byung Wook Eun, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim and Sung-Ho Cha

    Citation: BMC Infectious Diseases 2015 15:7

    Content type: Research article

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  12. Toxoplasmosis caused by the intracellular parasite Toxoplasma gondii (T. gondii) is a global epidemic parasitic disease. DNA vaccines play an important role in preventing the spread of toxoplasmosis. SAG family g...

    Authors: Gang Lu, Aihua Zhou, Min Meng, Lin Wang, Yali Han, Jingjing Guo, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu and Shenyi He

    Citation: BMC Infectious Diseases 2014 14:3862

    Content type: Research article

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  13. The natural (i.e. unvaccinated population) attack rate of an infectious disease is an important parameter required for understanding disease transmission. As such, it is an input parameter in infectious diseas...

    Authors: Kavisha Jayasundara, Charlene Soobiah, Edward Thommes, Andrea C Tricco and Ayman Chit

    Citation: BMC Infectious Diseases 2014 14:670

    Content type: Research article

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  14. The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, is currently being introduced throughout the African meningitis belt. In repeated multicentre cross-sectional studies in Burkina...

    Authors: Paul A Kristiansen, Absatou Ky Ba, Abdoul-Salam Ouédraogo, Idrissa Sanou, Rasmata Ouédraogo, Lassana Sangaré, Fabien Diomandé, Denis Kandolo, Inger Marie Saga, Lara Misegades, Thomas A Clark, Marie-Pierre Préziosi and Dominique A Caugant

    Citation: BMC Infectious Diseases 2014 14:663

    Content type: Research article

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  15. There is an urgent need for improved vaccines to protect against tuberculosis. The currently available vaccine Bacille Calmette-Guerin (BCG) has varying immunogenicity and efficacy across different populations...

    Authors: Rachel Tanner, Kristina Kakalacheva, Ellen Miller, Ansar A Pathan, Rod Chalk, Clare R Sander, Tom Scriba, Michelle Tameris, Tony Hawkridge, Hassan Mahomed, Greg Hussey, Willem Hanekom, Anna Checkley, Helen McShane and Helen A Fletcher

    Citation: BMC Infectious Diseases 2014 14:660

    Content type: Research article

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  17. Tétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history...

    Authors: Dieynaba S N'Diaye, Michaël Schwarzinger, Dorothée Obach, Julien Poissy, Sophie Matheron, Enrique Casalino and Yazdan Yazdanpanah

    Citation: BMC Infectious Diseases 2014 14:603

    Content type: Research article

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  18. World Health Organization (WHO) has recommended individuals with increased risk of contracting influenza A H5N1 infection to be immunized against the virus during the inter-pandemic period. Safety and immunoge...

    Authors: Sung-Hsi Wei, Ming-Tsan Liu, Yao-Chou Tsai, Chung-Hsin Liao, Chih-Ming Chen, Wei-Yao Wang, Yi-Lung Huang, Feng-Yee Chang and Pesus Chou

    Citation: BMC Infectious Diseases 2014 14:587

    Content type: Research article

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  19. In Italy, free-of-charge HPV vaccination is offered to 11-year-old girls since 2007. The National Immunization Plan established the target coverage at a minimum of 70%; it should increase to 95% within 3-year ...

    Authors: Cristina Giambi, Fortunato D'Ancona, Martina Del Manso, Barbara De Mei, Ilaria Giovannelli, Chiara Cattaneo, Valentina Possenti and Silvia Declich

    Citation: BMC Infectious Diseases 2014 14:545

    Content type: Research article

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  20. The immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines were evaluate...

    Authors: Fong Seng Lim, Mia Tuang Koh, Kah Kee Tan, Poh Chong Chan, Chia Yin Chong, Yeo Wee Shung Yehudi, Yee Leong Teoh, Fakrudeen Shafi, Marjan Hezareh, Kristien Swinnen and Dorota Borys

    Citation: BMC Infectious Diseases 2014 14:530

    Content type: Research article

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  21. Toxoplasma gondii can infect all warm-blooded animals including humans. Infection with T. gondii is probably the leading cause of posterior uveitis in humans and the most comment route of transmission is raw and...

    Authors: Jia Chen, Zhong-Yuan Li, Si-Yang Huang, Eskild Petersen, Hui-Qun Song, Dong-Hui Zhou and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2014 14:487

    Content type: Research article

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  22. Pneumonia is an important cause of illness and death, particularly in elderly adults. This retrospective study was conducted to estimate the trend of hospitalization for pneumonia in the Veneto from the record...

    Authors: Vincenzo Baldo, Silvia Cocchio, Tatjana Baldovin, Alessandra Buja, Patrizia Furlan, Chiara Bertoncello, Francesca Russo and Mario Saia

    Citation: BMC Infectious Diseases 2014 14:485

    Content type: Research article

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  23. The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat...

    Authors: Robert B Couch, José M Bayas, Covadonga Caso, Innocent Nnadi Mbawuike, Concepción Núñez López, Carine Claeys, Mohamed El Idrissi, Caroline Hervé, Béatrice Laupèze, Lidia Oostvogels and Philippe Moris

    Citation: BMC Infectious Diseases 2014 14:425

    Content type: Research article

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  25. The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwi...

    Authors: Ana Carolina Campi-Azevedo, Paula de Almeida Estevam, Jordana Grazziela Coelho-dos-Reis, Vanessa Peruhype-Magalhães, Gabriela Villela-Rezende, Patrícia Flávia Quaresma, Maria de Lourdes Sousa Maia, Roberto Henrique Guedes Farias, Luiz Antonio Bastos Camacho, Marcos da Silva Freire, Ricardo Galler, Anna Maya Yoshida Yamamura, Luiz Fernando Carvalho Almeida, Sheila Maria Barbosa Lima, Rita Maria Ribeiro Nogueira, Gloria Regina Silva Sá…

    Citation: BMC Infectious Diseases 2014 14:391

    Content type: Research article

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  26. Influenza vaccines contain Influenza A and B antigens and are adjusted annually to match the characteristics of circulating viruses. In Germany, Influenza B viruses belonged to the B/Yamagata lineage, but sinc...

    Authors: Martin Eichner, Markus Schwehm, Johannes Hain, Helmut Uphoff, Bernd Salzberger, Markus Knuf and Ruprecht Schmidt-Ott

    Citation: BMC Infectious Diseases 2014 14:365

    Content type: Research article

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  27. Rotavirus gastroenteritis (RGE) is the leading cause of diarrhea in young children in Oman, incurring substantial healthcare and economic burden. We propose to formally assess the potential cost effectiveness ...

    Authors: Salah Thabit Al Awaidy, Berhanu G Gebremeskel, Idris Al Obeidani, Said Al Baqlani, Wisam Haddadin and Megan A O’Brien

    Citation: BMC Infectious Diseases 2014 14:334

    Content type: Research article

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  28. Previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic H1N1 influenza strain. Qualitative a...

    Authors: Isabelle Magalhaes, Mikael Eriksson, Charlotte Linde, Rashid Muhammad, Lalit Rane, Aditya Ambati, Rebecca Axelsson-Robertson, Bahareh Khalaj, Nancy Alvarez-Corrales, Giulia Lapini, Emanuele Montomoli, Annika Linde, Nancy L Pedersen and Markus Maeurer

    Citation: BMC Infectious Diseases 2014 14:319

    Content type: Research article

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  29. Tuberculosis (TB) remains a global health problem, with vaccination likely to be a necessary part of a successful control strategy. Results of the first Phase 2b efficacy trial of a candidate vaccine, MVA85A, ...

    Authors: Magali Matsumiya, Stephanie A Harris, Iman Satti, Lisa Stockdale, Rachel Tanner, Matthew K O’Shea, Michelle Tameris, Hassan Mahomed, Mark Hatherill, Thomas J Scriba, Willem A Hanekom, Helen McShane and Helen A Fletcher

    Citation: BMC Infectious Diseases 2014 14:314

    Content type: Research article

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  30. Over the past decade, there has been sustained interest and efforts to develop a S. aureus vaccine. There is a need to better evaluate the potential public health impact of S. aureus vaccination, particularly giv...

    Authors: Cosmina Hogea, Thierry Van Effelterre and Adrian Cassidy

    Citation: BMC Infectious Diseases 2014 14:291

    Content type: Research article

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  31. Meningococcal C (MenC) conjugate vaccines have controlled invasive diseases associated with this serogroup in countries where they are included in National Immunization Programs and also in an extensive catch-...

    Authors: Lina Pérez-Breva, Rafael J Villanueva, Javier Villanueva-Oller, Luis Acedo, Francisco Santonja, José A Moraño, Raquel Abad, Julio A Vázquez and Javier Díez-Domingo

    Citation: BMC Infectious Diseases 2014 14:280

    Content type: Research article

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  33. Schistosomiasis is one of the most important neglected diseases found in developing countries and affects 249 million people worldwide. The development of an efficient vaccination strategy is essential for the...

    Authors: Milena Sobral Espíndola, Fabiani Gai Frantz, Luana Silva Soares, Ana Paula Masson, Cristiane Tefé-Silva, Claudia Silva Bitencourt, Sérgio Costa Oliveira, Vanderlei Rodrigues, Simone Gusmão Ramos, Célio Lopes Silva and Lúcia Helena Faccioli

    Citation: BMC Infectious Diseases 2014 14:263

    Content type: Research article

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  34. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes serious problems in immunocompromised or immunologically immature hosts. Vaccination is the preferred approach for prevention of HCMV infection...

    Authors: Huadong Wang, Yanfeng Yao, Chaoyang Huang, Xingxing Fu, Quanjiao Chen, Hongbo Zhang, Jianjun Chen, Fang Fang, Zhenyuan Xie and Ze Chen

    Citation: BMC Infectious Diseases 2014 14:195

    Content type: Research article

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  35. BCG immunogenicity in infants differs between populations and these differences have been attributed to various factors. In this study, the influence of geographical location, season of birth, timing of vaccin...

    Authors: Yun-Gyoung Hur, Patricia Gorak-Stolinska, Maeve K Lalor, Hazzie Mvula, Sian Floyd, John Raynes, Anne Ben-Smith, Joseph R Fitchett, Katie L Flanagan, Sarah Burl, Martin O Ota, Amelia C Crampin, Steven G Smith and Hazel M Dockrell

    Citation: BMC Infectious Diseases 2014 14:184

    Content type: Research article

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  37. During clinical development of the licensed Japanese encephalitis chimeric virus vaccine (JE-CV), the neutralization capacity of vaccine-induced antibodies was assessed against the vaccine virus and against we...

    Authors: Matthew Bonaparte, Bashir Dweik, Emmanuel Feroldi, Claude Meric, Alain Bouckenooghe, Stephen Hildreth, Branda Hu, Sutee Yoksan and Mark Boaz

    Citation: BMC Infectious Diseases 2014 14:156

    Content type: Research article

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  38. The pandemic potential of avian influenza A/H5N1 should not be overlooked, and the continued development of vaccines against these highly pathogenic viruses is a public health priority.

    Authors: Paul Gillard, Daniel Wai Sing Chu, Shinn-Jang Hwang, Pan-Chyr Yang, Prasert Thongcharoen, Fong Seng Lim, Mamadou Dramé, Karl Walravens and François Roman

    Citation: BMC Infectious Diseases 2014 14:142

    Content type: Research article

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  39. An inactivated quadrivalent influenza vaccine (QIV) was recently licenced in the US as a thimerosal-free formulation presented in a pre-filled syringe. A multidose presentation is preferred in some settings du...

    Authors: Varsha K Jain, Vijayalakshmi Chandrasekaran, Long Wang, Ping Li, Aixue Liu and Bruce L Innis

    Citation: BMC Infectious Diseases 2014 14:133

    Content type: Research article

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  40. In many GAVI-eligible countries, effectiveness of new vaccines will be evaluated by case-control methodology. To inform the design and assess selection bias of a future case-control study of rotavirus vaccine ...

    Authors: Sammy Khagayi, Jacqueline E Tate, Reuben Onkoba, Umesh Parashar, Frank Odhiambo, Deron Burton, Kayla Laserson and Daniel R Feikin

    Citation: BMC Infectious Diseases 2014 14:77

    Content type: Research article

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  41. Global efforts to eradicate wild polioviruses (WPVs) continue to face challenges due to uninterrupted endemic WPV transmission in three countries and importation-related outbreaks into previously polio-free co...

    Authors: Radboud J Duintjer Tebbens, Dominika A Kalkowska, Steven GF Wassilak, Mark A Pallansch, Stephen L Cochi and Kimberly M Thompson

    Citation: BMC Infectious Diseases 2014 14:45

    Content type: Research article

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  42. Routine annual influenza vaccination is primarily recommended for all persons aged 60 and above and for people with underlying chronic conditions in Germany. Other countries have already adopted additional chi...

    Authors: Markus A Rose, Oliver Damm, Wolfgang Greiner, Markus Knuf, Peter Wutzler, Johannes G Liese, Hagen Krüger, Ulrich Wahn, Tom Schaberg, Markus Schwehm, Thomas F Kochmann and Martin Eichner

    Citation: BMC Infectious Diseases 2014 14:40

    Content type: Research article

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  43. Gambian infants were not routinely vaccinated against hepatitis B virus (HBV) before 1986. During 1986–90 the Gambia Hepatitis Intervention Study (GHIS) allocated 125,000 infants, by area, to vaccination or no...

    Authors: Thomas J Peto, Maimuma E Mendy, Yamundow Lowe, Emily L Webb, Hilton C Whittle and Andrew J Hall

    Citation: BMC Infectious Diseases 2014 14:7

    Content type: Research article

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  45. The epidemiology of bacterial meningitis in the African ‘meningitis belt’ changes periodically. In order to design an effective vaccination strategy, we have examined the epidemiological and microbiological pa...

    Authors: Jean-Marc Collard, Bassira Issaka, Maman Zaneidou, Stéphane Hugonnet, Pierre Nicolas, Muhamed-Kheir Taha, Brian Greenwood and Jean-François Jusot

    Citation: BMC Infectious Diseases 2013 13:576

    Content type: Research article

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  46. Human Papillomavirus (HPV) is the most common sexually transmitted infection. In Italy, HPV vaccination is now offered free of charge to 12-year-old females. However, some regional health authorities have exte...

    Authors: Donatella Panatto, Daniela Amicizia, Elisabetta Tanzi, Silvia Bianchi, Elena Rosanna Frati, Carla Maria Zotti, Piero Luigi Lai, Angela Bechini, Stefania Rossi and Roberto Gasparini

    Citation: BMC Infectious Diseases 2013 13:575

    Content type: Research article

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  47. Recommendations for diphtheria immunization are to apply an effective primary immunization in infancy and to maintain immunity throughout life. Immunity against diphtheria depends primarily on antibody to the ...

    Authors: Aleksandra A Zasada, Waldemar Rastawicki, Natalia Rokosz and Marek Jagielski

    Citation: BMC Infectious Diseases 2013 13:551

    Content type: Research article

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  48. The efficacy of the H1N1 influenza vaccine relies on the induction of both humoral and cellular responses. This study evaluated the humoral and cellular responses to a monovalent non-adjuvanted pandemic influe...

    Authors: Ma Teresa Herrera, Yolanda Gonzalez, Esmeralda Juárez, Fernando Hernández-Sánchez, Claudia Carranza, Carmen Sarabia, Silvia Guzman-Beltran, Ma Eugenia Manjarrez, Marcela Muñoz-Torrico, Lourdes Garcia-Garcia, Eduardo Sada and Martha Torres

    Citation: BMC Infectious Diseases 2013 13:544

    Content type: Research article

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  49. The introduction of universal pertussis immunization and the high coverage achieved in most developed countries have largely changed the epidemiology of the disease. Although vaccination rates are high in the ...

    Authors: Silvio Tafuri, Maria Serena Gallone, Domenico Martinelli, Rosa Prato, Maria Chironna and Cinzia Germinario

    Citation: BMC Infectious Diseases 2013 13:541

    Content type: Research article

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  50. Toxoplasma gondii can infect almost all warm-blood animals including human beings. The plant-like calcium-dependent protein kinases (CDPKs) harbored by T. gondii are involved in gliding motility, cell invasion, ...

    Authors: Nian-Zhang Zhang, Si-Yang Huang, Dong-Hui Zhou, Jia Chen, Ying Xu, Wei-Peng Tian, Jing Lu and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2013 13:512

    Content type: Research article

    Published on:

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