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Vaccines

Section edited by Susanna Esposito

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

Page 3 of 4

  1. Content type: Research article

    There is an urgent need for improved vaccines to protect against tuberculosis. The currently available vaccine Bacille Calmette-Guerin (BCG) has varying immunogenicity and efficacy across different populations...

    Authors: Rachel Tanner, Kristina Kakalacheva, Ellen Miller, Ansar A Pathan, Rod Chalk, Clare R Sander, Tom Scriba, Michelle Tameris, Tony Hawkridge, Hassan Mahomed, Greg Hussey, Willem Hanekom, Anna Checkley, Helen McShane and Helen A Fletcher

    Citation: BMC Infectious Diseases 2014 14:660

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  2. Content type: Research article

    Tétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history...

    Authors: Dieynaba S N'Diaye, Michaël Schwarzinger, Dorothée Obach, Julien Poissy, Sophie Matheron, Enrique Casalino and Yazdan Yazdanpanah

    Citation: BMC Infectious Diseases 2014 14:603

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  3. Content type: Research article

    World Health Organization (WHO) has recommended individuals with increased risk of contracting influenza A H5N1 infection to be immunized against the virus during the inter-pandemic period. Safety and immunoge...

    Authors: Sung-Hsi Wei, Ming-Tsan Liu, Yao-Chou Tsai, Chung-Hsin Liao, Chih-Ming Chen, Wei-Yao Wang, Yi-Lung Huang, Feng-Yee Chang and Pesus Chou

    Citation: BMC Infectious Diseases 2014 14:587

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  4. Content type: Research article

    In Italy, free-of-charge HPV vaccination is offered to 11-year-old girls since 2007. The National Immunization Plan established the target coverage at a minimum of 70%; it should increase to 95% within 3-year ...

    Authors: Cristina Giambi, Fortunato D'Ancona, Martina Del Manso, Barbara De Mei, Ilaria Giovannelli, Chiara Cattaneo, Valentina Possenti and Silvia Declich

    Citation: BMC Infectious Diseases 2014 14:545

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  5. Content type: Research article

    The immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines were evaluate...

    Authors: Fong Seng Lim, Mia Tuang Koh, Kah Kee Tan, Poh Chong Chan, Chia Yin Chong, Yeo Wee Shung Yehudi, Yee Leong Teoh, Fakrudeen Shafi, Marjan Hezareh, Kristien Swinnen and Dorota Borys

    Citation: BMC Infectious Diseases 2014 14:530

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  6. Content type: Research article

    Toxoplasma gondii can infect all warm-blooded animals including humans. Infection with T. gondii is probably the leading cause of posterior uveitis in humans and the most comment route of transmission is raw and...

    Authors: Jia Chen, Zhong-Yuan Li, Si-Yang Huang, Eskild Petersen, Hui-Qun Song, Dong-Hui Zhou and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2014 14:487

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  7. Content type: Research article

    Pneumonia is an important cause of illness and death, particularly in elderly adults. This retrospective study was conducted to estimate the trend of hospitalization for pneumonia in the Veneto from the record...

    Authors: Vincenzo Baldo, Silvia Cocchio, Tatjana Baldovin, Alessandra Buja, Patrizia Furlan, Chiara Bertoncello, Francesca Russo and Mario Saia

    Citation: BMC Infectious Diseases 2014 14:485

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  8. Content type: Research article

    The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat...

    Authors: Robert B Couch, José M Bayas, Covadonga Caso, Innocent Nnadi Mbawuike, Concepción Núñez López, Carine Claeys, Mohamed El Idrissi, Caroline Hervé, Béatrice Laupèze, Lidia Oostvogels and Philippe Moris

    Citation: BMC Infectious Diseases 2014 14:425

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  9. Content type: Research article

    The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwi...

    Authors: Ana Carolina Campi-Azevedo, Paula de Almeida Estevam, Jordana Grazziela Coelho-dos-Reis, Vanessa Peruhype-Magalhães, Gabriela Villela-Rezende, Patrícia Flávia Quaresma, Maria de Lourdes Sousa Maia, Roberto Henrique Guedes Farias, Luiz Antonio Bastos Camacho, Marcos da Silva Freire, Ricardo Galler, Anna Maya Yoshida Yamamura, Luiz Fernando Carvalho Almeida, Sheila Maria Barbosa Lima, Rita Maria Ribeiro Nogueira, Gloria Regina Silva Sá…

    Citation: BMC Infectious Diseases 2014 14:391

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  10. Content type: Research article

    Influenza vaccines contain Influenza A and B antigens and are adjusted annually to match the characteristics of circulating viruses. In Germany, Influenza B viruses belonged to the B/Yamagata lineage, but sinc...

    Authors: Martin Eichner, Markus Schwehm, Johannes Hain, Helmut Uphoff, Bernd Salzberger, Markus Knuf and Ruprecht Schmidt-Ott

    Citation: BMC Infectious Diseases 2014 14:365

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  11. Content type: Research article

    Rotavirus gastroenteritis (RGE) is the leading cause of diarrhea in young children in Oman, incurring substantial healthcare and economic burden. We propose to formally assess the potential cost effectiveness ...

    Authors: Salah Thabit Al Awaidy, Berhanu G Gebremeskel, Idris Al Obeidani, Said Al Baqlani, Wisam Haddadin and Megan A O’Brien

    Citation: BMC Infectious Diseases 2014 14:334

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  12. Content type: Research article

    Previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic H1N1 influenza strain. Qualitative a...

    Authors: Isabelle Magalhaes, Mikael Eriksson, Charlotte Linde, Rashid Muhammad, Lalit Rane, Aditya Ambati, Rebecca Axelsson-Robertson, Bahareh Khalaj, Nancy Alvarez-Corrales, Giulia Lapini, Emanuele Montomoli, Annika Linde, Nancy L Pedersen and Markus Maeurer

    Citation: BMC Infectious Diseases 2014 14:319

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  13. Content type: Research article

    Tuberculosis (TB) remains a global health problem, with vaccination likely to be a necessary part of a successful control strategy. Results of the first Phase 2b efficacy trial of a candidate vaccine, MVA85A, ...

    Authors: Magali Matsumiya, Stephanie A Harris, Iman Satti, Lisa Stockdale, Rachel Tanner, Matthew K O’Shea, Michelle Tameris, Hassan Mahomed, Mark Hatherill, Thomas J Scriba, Willem A Hanekom, Helen McShane and Helen A Fletcher

    Citation: BMC Infectious Diseases 2014 14:314

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  14. Content type: Research article

    Over the past decade, there has been sustained interest and efforts to develop a S. aureus vaccine. There is a need to better evaluate the potential public health impact of S. aureus vaccination, particularly giv...

    Authors: Cosmina Hogea, Thierry Van Effelterre and Adrian Cassidy

    Citation: BMC Infectious Diseases 2014 14:291

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  15. Content type: Research article

    Meningococcal C (MenC) conjugate vaccines have controlled invasive diseases associated with this serogroup in countries where they are included in National Immunization Programs and also in an extensive catch-...

    Authors: Lina Pérez-Breva, Rafael J Villanueva, Javier Villanueva-Oller, Luis Acedo, Francisco Santonja, José A Moraño, Raquel Abad, Julio A Vázquez and Javier Díez-Domingo

    Citation: BMC Infectious Diseases 2014 14:280

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  16. Content type: Research article

    Schistosomiasis is one of the most important neglected diseases found in developing countries and affects 249 million people worldwide. The development of an efficient vaccination strategy is essential for the...

    Authors: Milena Sobral Espíndola, Fabiani Gai Frantz, Luana Silva Soares, Ana Paula Masson, Cristiane Tefé-Silva, Claudia Silva Bitencourt, Sérgio Costa Oliveira, Vanderlei Rodrigues, Simone Gusmão Ramos, Célio Lopes Silva and Lúcia Helena Faccioli

    Citation: BMC Infectious Diseases 2014 14:263

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  17. Content type: Research article

    Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes serious problems in immunocompromised or immunologically immature hosts. Vaccination is the preferred approach for prevention of HCMV infection...

    Authors: Huadong Wang, Yanfeng Yao, Chaoyang Huang, Xingxing Fu, Quanjiao Chen, Hongbo Zhang, Jianjun Chen, Fang Fang, Zhenyuan Xie and Ze Chen

    Citation: BMC Infectious Diseases 2014 14:195

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  18. Content type: Research article

    BCG immunogenicity in infants differs between populations and these differences have been attributed to various factors. In this study, the influence of geographical location, season of birth, timing of vaccin...

    Authors: Yun-Gyoung Hur, Patricia Gorak-Stolinska, Maeve K Lalor, Hazzie Mvula, Sian Floyd, John Raynes, Anne Ben-Smith, Joseph R Fitchett, Katie L Flanagan, Sarah Burl, Martin O Ota, Amelia C Crampin, Steven G Smith and Hazel M Dockrell

    Citation: BMC Infectious Diseases 2014 14:184

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  19. Content type: Research article

    During clinical development of the licensed Japanese encephalitis chimeric virus vaccine (JE-CV), the neutralization capacity of vaccine-induced antibodies was assessed against the vaccine virus and against we...

    Authors: Matthew Bonaparte, Bashir Dweik, Emmanuel Feroldi, Claude Meric, Alain Bouckenooghe, Stephen Hildreth, Branda Hu, Sutee Yoksan and Mark Boaz

    Citation: BMC Infectious Diseases 2014 14:156

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  20. Content type: Research article

    The pandemic potential of avian influenza A/H5N1 should not be overlooked, and the continued development of vaccines against these highly pathogenic viruses is a public health priority.

    Authors: Paul Gillard, Daniel Wai Sing Chu, Shinn-Jang Hwang, Pan-Chyr Yang, Prasert Thongcharoen, Fong Seng Lim, Mamadou Dramé, Karl Walravens and François Roman

    Citation: BMC Infectious Diseases 2014 14:142

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  21. Content type: Research article

    An inactivated quadrivalent influenza vaccine (QIV) was recently licenced in the US as a thimerosal-free formulation presented in a pre-filled syringe. A multidose presentation is preferred in some settings du...

    Authors: Varsha K Jain, Vijayalakshmi Chandrasekaran, Long Wang, Ping Li, Aixue Liu and Bruce L Innis

    Citation: BMC Infectious Diseases 2014 14:133

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  22. Content type: Research article

    In many GAVI-eligible countries, effectiveness of new vaccines will be evaluated by case-control methodology. To inform the design and assess selection bias of a future case-control study of rotavirus vaccine ...

    Authors: Sammy Khagayi, Jacqueline E Tate, Reuben Onkoba, Umesh Parashar, Frank Odhiambo, Deron Burton, Kayla Laserson and Daniel R Feikin

    Citation: BMC Infectious Diseases 2014 14:77

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  23. Content type: Research article

    Global efforts to eradicate wild polioviruses (WPVs) continue to face challenges due to uninterrupted endemic WPV transmission in three countries and importation-related outbreaks into previously polio-free co...

    Authors: Radboud J Duintjer Tebbens, Dominika A Kalkowska, Steven GF Wassilak, Mark A Pallansch, Stephen L Cochi and Kimberly M Thompson

    Citation: BMC Infectious Diseases 2014 14:45

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  24. Content type: Research article

    Routine annual influenza vaccination is primarily recommended for all persons aged 60 and above and for people with underlying chronic conditions in Germany. Other countries have already adopted additional chi...

    Authors: Markus A Rose, Oliver Damm, Wolfgang Greiner, Markus Knuf, Peter Wutzler, Johannes G Liese, Hagen Krüger, Ulrich Wahn, Tom Schaberg, Markus Schwehm, Thomas F Kochmann and Martin Eichner

    Citation: BMC Infectious Diseases 2014 14:40

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  25. Content type: Research article

    Gambian infants were not routinely vaccinated against hepatitis B virus (HBV) before 1986. During 1986–90 the Gambia Hepatitis Intervention Study (GHIS) allocated 125,000 infants, by area, to vaccination or no...

    Authors: Thomas J Peto, Maimuma E Mendy, Yamundow Lowe, Emily L Webb, Hilton C Whittle and Andrew J Hall

    Citation: BMC Infectious Diseases 2014 14:7

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  26. Content type: Research article

    The epidemiology of bacterial meningitis in the African ‘meningitis belt’ changes periodically. In order to design an effective vaccination strategy, we have examined the epidemiological and microbiological pa...

    Authors: Jean-Marc Collard, Bassira Issaka, Maman Zaneidou, Stéphane Hugonnet, Pierre Nicolas, Muhamed-Kheir Taha, Brian Greenwood and Jean-François Jusot

    Citation: BMC Infectious Diseases 2013 13:576

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  27. Content type: Research article

    Human Papillomavirus (HPV) is the most common sexually transmitted infection. In Italy, HPV vaccination is now offered free of charge to 12-year-old females. However, some regional health authorities have exte...

    Authors: Donatella Panatto, Daniela Amicizia, Elisabetta Tanzi, Silvia Bianchi, Elena Rosanna Frati, Carla Maria Zotti, Piero Luigi Lai, Angela Bechini, Stefania Rossi and Roberto Gasparini

    Citation: BMC Infectious Diseases 2013 13:575

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  28. Content type: Research article

    Recommendations for diphtheria immunization are to apply an effective primary immunization in infancy and to maintain immunity throughout life. Immunity against diphtheria depends primarily on antibody to the ...

    Authors: Aleksandra A Zasada, Waldemar Rastawicki, Natalia Rokosz and Marek Jagielski

    Citation: BMC Infectious Diseases 2013 13:551

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  29. Content type: Research article

    The efficacy of the H1N1 influenza vaccine relies on the induction of both humoral and cellular responses. This study evaluated the humoral and cellular responses to a monovalent non-adjuvanted pandemic influe...

    Authors: Ma Teresa Herrera, Yolanda Gonzalez, Esmeralda Juárez, Fernando Hernández-Sánchez, Claudia Carranza, Carmen Sarabia, Silvia Guzman-Beltran, Ma Eugenia Manjarrez, Marcela Muñoz-Torrico, Lourdes Garcia-Garcia, Eduardo Sada and Martha Torres

    Citation: BMC Infectious Diseases 2013 13:544

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  30. Content type: Research article

    The introduction of universal pertussis immunization and the high coverage achieved in most developed countries have largely changed the epidemiology of the disease. Although vaccination rates are high in the ...

    Authors: Silvio Tafuri, Maria Serena Gallone, Domenico Martinelli, Rosa Prato, Maria Chironna and Cinzia Germinario

    Citation: BMC Infectious Diseases 2013 13:541

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  31. Content type: Research article

    Toxoplasma gondii can infect almost all warm-blood animals including human beings. The plant-like calcium-dependent protein kinases (CDPKs) harbored by T. gondii are involved in gliding motility, cell invasion, ...

    Authors: Nian-Zhang Zhang, Si-Yang Huang, Dong-Hui Zhou, Jia Chen, Ying Xu, Wei-Peng Tian, Jing Lu and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2013 13:512

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  32. Content type: Research article

    The World Health Organization reported in 2007 that inclusion of PCV7 in national immunization programs should be seen as a priority, also encouraging countries to conduct appropriate surveillances for monitor...

    Authors: Juan Picazo, Joaquin Dueñas, Antonio Ramirez, Andres-Ricardo Perez, Emma Padilla, Susana Herrero, Carmen Gallegos, Esther Culebras, Cesar Balseiro and Cristina Mendez

    Citation: BMC Infectious Diseases 2013 13:503

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  33. Content type: Research article

    Toxoplasma gondii is a widespread intracellular parasite, which infects most vertebrate animal hosts and causes zoonotic infection in humans. Vaccine strategy remains a promising method for the prevention and co...

    Authors: Min Meng, Aihua Zhou, Gang Lu, Lin Wang, Guanghui Zhao, Yali Han, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu and Shenyi He

    Citation: BMC Infectious Diseases 2013 13:494

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  34. Content type: Research article

    A high prevalence of bacterial nasopharyngeal co-infections has been reported in children, however, such data is limited in adults. We examined the interaction of Haemophilus influenzae, Staphylococcus aureus and...

    Authors: Tinevimbo Shiri, Marta C Nunes, Peter V Adrian, Nadia Van Niekerk, Keith P Klugman and Shabir A Madhi

    Citation: BMC Infectious Diseases 2013 13:483

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  35. Content type: Research article

    We investigated the immune response to serogroup 6 with the opsonophagocytic killing assay (OPKA) in children aged 12–23 months of age after immunization with the 7-valent pneumococcal conjugate vaccine (PCV7)...

    Authors: Hyunju Lee, Jung Hwa Cha, Moon H Nahm, Robert L Burton and Kyung-Hyo Kim

    Citation: BMC Infectious Diseases 2013 13:474

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  36. Content type: Study protocol

    Despite almost 30 years of effective chemotherapy with MDT, the global new case detection rate of leprosy has remained quite constant over the past years. New tools and methodologies are necessary to interrupt...

    Authors: Renate A Richardus, Khorshed Alam, David Pahan, Sabiena G Feenstra, Annemieke Geluk and Jan H Richardus

    Citation: BMC Infectious Diseases 2013 13:456

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  37. Content type: Research article

    In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance Sy...

    Authors: Silvia Jiménez-Jorge, Salvador de Mateo, Concha Delgado-Sanz, Francisco Pozo, Inmaculada Casas, Manuel Garcia-Cenoz, Jesús Castilla, Esteban Pérez, Virtudes Gallardo, Carolina Rodriguez, Tomás Vega, Carmen Quiñones, Eva Martínez, Juana María Vanrell, Jaume Giménez, Daniel Castrillejo…

    Citation: BMC Infectious Diseases 2013 13:441

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  38. Content type: Research article

    Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity betwe...

    Authors: Odile Launay, Xavier Duval, Serge Fitoussi, Wolfgang Jilg, Angkool Kerdpanich, May Montellano, Tino F Schwarz, Veerachai Watanveerade, Jürgen J Wenzel, Gerard Zalcman, Vinod Bambure, Ping Li, Adrian Caplanusi, Anuradha Madan, Paul Gillard and David W Vaughn

    Citation: BMC Infectious Diseases 2013 13:435

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  39. Content type: Research article

    Interruption of measles transmission was achieved in Catalonia (Spain) in 2000. Six years later, a measles outbreak occurred between August 2006 and June 2007 with 381 cases, 11 of whom were health care worker...

    Authors: Luis Urbiztondo, Eva Borràs, Josep Costa, Sonia Broner, Magda Campins, José María Bayas, María Esteve and Angela Domínguez

    Citation: BMC Infectious Diseases 2013 13:391

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  40. Content type: Research article

    The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, was first introduced in mass vaccination campaigns of the 1-29-year-olds in Burkina Faso in 2010. The aim of this study was to g...

    Authors: Paul A Kristiansen, Absatou Ky Ba, Idrissa Sanou, Abdoul-Salam Ouédraogo, Rasmata Ouédraogo, Lassana Sangaré, Fabien Diomandé, Denis Kandolo, Jennifer Dolan Thomas, Thomas A Clark, Marc LaForce and Dominique A Caugant

    Citation: BMC Infectious Diseases 2013 13:363

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  41. Content type: Research article

    Countries of the Americas have been working towards rubella elimination since 2003 and endemic rubella virus transmission appears to have been interrupted since 2009. To contribute towards monitoring of rubell...

    Authors: Gillian H Lim, Tara Harris, Shalini Desai, Natasha S Crowcroft, Tony Mazzulli, Tina Kozlowski and Shelley L Deeks

    Citation: BMC Infectious Diseases 2013 13:362

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  42. Content type: Research article

    Community-acquired pneumonia (CAP) is a serious cause of morbidity among children in developed countries. The real impact of 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal pneumonia is difficul...

    Authors: Hélène Chappuy, Kristina Keitel, Mario Gehri, René Tabin, Lynda Robitaille, Frederic Raymond, Jacques Corbeil, Veronica Maspoli, Naim Bouazza, Gabriel Alcoba, Laurence Lacroix, Sergio Manzano, Annick Galetto-Lacour and Alain Gervaix

    Citation: BMC Infectious Diseases 2013 13:357

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  43. Content type: Research article

    Improved influenza vaccines are needed to reduce influenza-associated complications in older adults. The aim of this study was to identify the optimal formulation of adjuvanted seasonal influenza vaccine for u...

    Authors: Hans C Rümke, Jan Hendrik Richardus, Lars Rombo, Karlis Pauksens, Georg Plaßmann, Christelle Durand, Jeanne-Marie Devaster, Walthère Dewé and Lidia Oostvogels

    Citation: BMC Infectious Diseases 2013 13:348

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  44. Content type: Research article

    Two antigenically distinct influenza B lineages have co-circulated since the 1980s, yet inactivated trivalent influenza vaccines (TIVs) include strains of influenza A/H1N1, A/H3N2, and only one influenza B fro...

    Authors: Dorothee Kieninger, Eric Sheldon, Wen-Yuan Lin, Chong-Jen Yu, Jose M Bayas, Julian J Gabor, Meral Esen, Jose Luis Fernandez Roure, Silvia Narejos Perez, Carmen Alvarez Sanchez, Yang Feng, Carine Claeys, Mathieu Peeters, Bruce L Innis and Varsha Jain

    Citation: BMC Infectious Diseases 2013 13:343

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  45. Content type: Research article

    Streptococcus pneumoniae remains a major cause of childhood morbidity and mortality worldwide. Nasopharyngeal colonization plays an important role in the development and transmission of pneumococcal diseases, an...

    Authors: Felipe Piedade Gonçalves Neves, Tatiana Castro Abreu Pinto, Mariane Alves Corrêa, Roberta dos Anjos Barreto, Laís de Souza Gouveia Moreira, Havana Gomes Rodrigues, Claudete Araújo Cardoso, Rosana Rocha Barros and Lúcia Martins Teixeira

    Citation: BMC Infectious Diseases 2013 13:318

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