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Vaccines

Section edited by Susanna Esposito

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. The protective capacities of antibodies induced with Haemophilus influenzae type b (Hib) vaccines can be directly assessed in vitro with a Hib-specific serum bactericidal assay (SBA). However, the conventional SB...

    Authors: Han Wool Kim, Kyung-Hyo Kim, JiHye Kim and Moon H. Nahm

    Citation: BMC Infectious Diseases 2016 16:473

    Content type: Research article

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  2. The effect of previous natural pandemic H1N1 (H1N1 pdm09) influenza infection on the immunogenicity to subsequent inactivated influenza vaccination in children has not been well studied. We aimed to evaluate t...

    Authors: Eun Kyeong Kang, Byung Wook Eun, Nam Hee Kim, Jung Sub Lim, Jun Ah Lee and Dong Ho Kim

    Citation: BMC Infectious Diseases 2016 16:438

    Content type: Research article

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  3. Like other countries in Asia, measles-rubella (MR) vaccine coverage in Bangladesh is suboptimal whereas 90–95 % coverage is needed for elimination of these diseases. The Ministry of Health and Family Welfare (...

    Authors: Md Jasim Uddin, Gourab Adhikary, Md Wazed Ali, Shahabuddin Ahmed, Md Shamsuzzaman, Chris Odell, Lauren Hashiguchi, Stephen S. Lim and Nurul Alam

    Citation: BMC Infectious Diseases 2016 16:411

    Content type: Research article

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  4. The effect of pneumococcal conjugate vaccines (PCV) on invasive pneumococcal disease is frequently reported, but the impact on upper respiratory tract infections in a clinical setting is less documented. Our a...

    Authors: Nils Littorin, Jonas Ahl, Fabian Uddén, Fredrik Resman and Kristian Riesbeck

    Citation: BMC Infectious Diseases 2016 16:407

    Content type: Research article

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  5. Despite the successes of routine national childhood vaccination programmes, measles remains a public health concern. The purpose of this paper is to investigate how patterns of parental attitudes are linked to...

    Authors: Carine Weiss, Daniel Schröpfer and Sonja Merten

    Citation: BMC Infectious Diseases 2016 16:400

    Content type: Research article

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  6. Scotland introduced PCV7 and PCV13 immunisation in young children in 2006 and 2010 respectively. One recent study from the United States reported a decrease in hospitalisation rates for all-cause pneumonia mos...

    Authors: Harish Nair, Arun Thor Watts, Linda J. Williams, Saad B. Omer, Colin R. Simpson, Lorna J. Willocks, J. Claire Cameron and Harry Campbell

    Citation: BMC Infectious Diseases 2016 16:390

    Content type: Research article

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  7. Vaccine-associated paralytic poliomyelitis (VAPP) and immunodeficient long-term polio excretors constitute a significant public health burden and are a major concern for the WHO global polio eradication endgame.

    Authors: Thomas Foiadelli, Salvatore Savasta, Andrea Battistone, Majlinda Kota, Carolina Passera, Stefano Fiore, Silvia Bino, Concetta Amato, Alessandro Lozza, Gian Luigi Marseglia and Lucia Fiore

    Citation: BMC Infectious Diseases 2016 16:277

    Content type: Case report

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  8. The endgame for polio eradication includes coordinated global cessation of oral poliovirus vaccine (OPV), starting with the cessation of vaccine containing OPV serotype 2 (OPV2) by switching all trivalent OPV ...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:237

    Content type: Research article

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  9. The endgame for polio eradication involves coordinated global cessation of oral poliovirus vaccine (OPV) with cessation of serotype 2 OPV (OPV2 cessation) implemented in late April and early May 2016 and cessa...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:231

    Content type: Research article

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  10. Migrant travellers who return to their country of origin to visit family and friends (VFR) are less likely to seek travel-related medical care and are less likely to adhere to recommended medications and trave...

    Authors: Holly Seale, Rajneesh Kaur, Abela Mahimbo, C. Raina MacIntyre, Nicholas Zwar, Mitchell Smith, Heather Worth and Anita E Heywood

    Citation: BMC Infectious Diseases 2016 16:213

    Content type: Research article

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  11. The present study aimed to identify factors affecting vaccination against influenza among health professionals.

    Authors: Süheyl Asma, Hülya Akan, Yücel Uysal, A. Gürhan Poçan, Mustafa Haki Sucaklı, Erhan Yengil, Çiğdem Gereklioğlu, Aslı Korur, İbrahim Başhan, A. Ferit Erdogan, A. Kürşat Özşahin and Altuğ Kut

    Citation: BMC Infectious Diseases 2016 16:192

    Content type: Research article

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  12. After the global implementation of national immunization programs for prevention of measles, mumps, and rubella (MMR), the prevalences of protective antibodies to these viruses are high in general population. ...

    Authors: Romanee Chaiwarith, Jutarat Praparattanapan, Khanuengnit Nuket, Wilai Kotarathitithum and Khuanchai Supparatpinyo

    Citation: BMC Infectious Diseases 2016 16:190

    Content type: Research article

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  13. Toxoplasmosis is a worldwide zoonosis caused by the intracellular parasite Toxoplasma gondii. However, no effective vaccine is yet available. Poly(lactide-co-glycolide) polymers can reduce protein degradation and...

    Authors: Nian-Zhang Zhang, Ying Xu, Meng Wang, Jia Chen, Si-Yang Huang, Qi Gao and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2016 16:168

    Content type: Research article

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  14. HPV is a major cancer-causing factor in both sexes in the cervix, vulva, vagina, anus, penis, oropharynx as well as the causal factor in other diseases such as genital warts and recurrent respiratory papilloma...

    Authors: L. Boiron, E. Joura, N. Largeron, B. Prager and M. Uhart

    Citation: BMC Infectious Diseases 2016 16:153

    Content type: Research article

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  15. The bacteria Streptococcus pneumoniae (pneumococcus) and Haemophilus influenzae type b (Hib) are leading causes of childhood pneumonia and meningitis and are major contributors to worldwide mortality in children ...

    Authors: Jiayu Hu, Xiaodong Sun, Zhuoying Huang, Abram L. Wagner, Bradley Carlson, Jianping Yang, Suwen Tang, Yunyi Li, Matthew L. Boulton and Zhengan Yuan

    Citation: BMC Infectious Diseases 2016 16:149

    Content type: Research article

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  16. Following successful eradication of wild polioviruses and planned globally-coordinated cessation of oral poliovirus vaccine (OPV), national and global health leaders may need to respond to outbreaks from reint...

    Authors: Radboud J. Duintjer Tebbens, Mark A. Pallansch, Steven G. F. Wassilak, Stephen L. Cochi and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:137

    Content type: Research article

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  17. Prior to introduction of universal varicella vaccination, it is crucial to gain insight into the willingness to vaccinate among the population. This is because suboptimal national vaccination coverage might in...

    Authors: Alies van Lier, Alma Tostmann, Irene A. Harmsen, Hester E. de Melker, Jeannine L. A. Hautvast and Wilhelmina L. M. Ruijs

    Citation: BMC Infectious Diseases 2016 16:127

    Content type: Research article

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  18. Schistosomiasis is the most important human helminth infection due to its impact on public health. The clinical manifestations are chronic and significantly decrease an individual’s quality of life. Infected i...

    Authors: Alessandra Ricciardi, Kittipos Visitsunthorn, John P. Dalton and Momar Ndao

    Citation: BMC Infectious Diseases 2016 16:112

    Content type: Research article

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  19. Although pertussis has been considered a disease of childhood, it is also recognized as an important respiratory tract infection in adolescents and adults. However, in countries with routine vaccination agains...

    Authors: Nirada Siriyakorn, Pornvimol Leethong, Terapong Tantawichien, Saowalak Sripakdee, Anusak Kerdsin, Surang Dejsirilert and Leilani Paitoonpong

    Citation: BMC Infectious Diseases 2016 16:25

    Content type: Research article

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  20. In Canada both bivalent (bHPV) vaccine and quadrivalent HPV vaccine (qHPV) are authorized for use. In Alberta, while both vaccines are available for private purchase, only qHPV is publicly funded for school gi...

    Authors: Xianfang C. Liu, Christopher A. Bell, Kimberley A. Simmonds, Margaret L. Russell and Lawrence W. Svenson

    Citation: BMC Infectious Diseases 2016 16:15

    Content type: Research article

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  21. The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pn...

    Authors: Susanna Esposito, Leonardo Terranova, Maria Francesca Patria, Gian Luigi Marseglia, Michele Miraglia del Giudice, Alessandro Bodini, Alberto Martelli, Eugenio Baraldi, Oscar Mazzina, Claudia Tagliabue, Amelia Licari, Valentina Ierardi, Mara Lelii and Nicola Principi

    Citation: BMC Infectious Diseases 2016 16:12

    Content type: Research article

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  22. Over 20 000 people die from rabies each year in India. At least 95 % of people contract rabies from an infected dog. Annual vaccination of over 70 % of the dog population has eliminated both canine and human r...

    Authors: Andrew D. Gibson, Praveen Ohal, Kate Shervell, Ian G. Handel, Barend M. Bronsvoort, Richard J. Mellanby and Luke Gamble

    Citation: BMC Infectious Diseases 2015 15:589

    Content type: Research article

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  23. The availability of new vaccines can prompt policy makers to consider changes to the routine childhood immunisation programme in the UK. Alterations to one aspect of the schedule may have implications for othe...

    Authors: Sonya Crowe, Martin Utley, Guy Walker, Jasmina Panovska-Griffiths, Peter Grove and Christina Pagel

    Citation: BMC Infectious Diseases 2015 15:585

    Content type: Research article

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  24. During the 2009 influenza A (H1N1) pandemic, a monovalent pandemic strain vaccine containing the oil-in-water adjuvant AS03 (Pandemrix®) was offered to the Norwegian population. The coverage among children rea...

    Authors: Inger Johanne Bakken, Kari Modalsli Aaberg, Sara Ghaderi, Nina Gunnes, Lill Trogstad, Per Magnus and Siri Eldevik Håberg

    Citation: BMC Infectious Diseases 2015 15:506

    Content type: Research article

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  25. The use of molecular diagnostic techniques for the evaluation of the impact of pneumococcal conjugate vaccines (PCVs) has not been documented. We aimed to evaluate the impact of PCVs on invasive pneumococcal d...

    Authors: Stefano Tempia, Nicole Wolter, Cheryl Cohen, Sibongile Walaza, Claire von Mollendorf, Adam L. Cohen, Jocelyn Moyes, Linda de Gouveia, Susan Nzenze, Florette Treurnicht, Marietjie Venter, Michelle J. Groome, Shabir A. Madhi and Anne von Gottberg

    Citation: BMC Infectious Diseases 2015 15:450

    Content type: Research article

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  27. Pneumococcal diseases remain a leading cause of vaccine-preventable death worldwide in children <5 years of age. The seven-valent pneumococcal conjugate vaccine (PCV7) was approved in 2001 in Europe and was in...

    Authors: Myint Tin Tin Htar, Dina Christopoulou and Heinz-Josef Schmitt

    Citation: BMC Infectious Diseases 2015 15:419

    Content type: Debate

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  29. Little is known about factors associated with maintenance of hemagglutinin inhibition (HAI) antibodies after influenza vaccination in older adults.

    Authors: H Keipp Talbot, Laura A Coleman, Yuwei Zhu, Sarah Spencer, Mark Thompson, Po-Yung Cheng, Maria E Sundaram, Edward A Belongia and Marie R Griffin

    Citation: BMC Infectious Diseases 2015 15:195

    Content type: Research article

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  30. Influenza vaccination is recommended for all healthcare personnel (HCP) and most institutions offer vaccination for free and on site. However, medical students do not always have such easy access, and the pred...

    Authors: Birthe A Lehmann, Robert AC Ruiter, Sabine Wicker, Gretchen Chapman and Gerjo Kok

    Citation: BMC Infectious Diseases 2015 15:185

    Content type: Research article

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  31. Several studies suggested that vaccines could have non-specific effects on mortality depending on the type of vaccine. Non-specific effects seem to be different in boys and girls. In this study we want to inve...

    Authors: Tessa M Schurink-van’t Klooster, Mirjam J Knol, Hester E de Melker and Marianne AB van der Sande

    Citation: BMC Infectious Diseases 2015 15:148

    Content type: Research article

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  32. Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to...

    Authors: Cornelius Remschmidt, Thorsten Rieck, Birte Bödeker and Ole Wichmann

    Citation: BMC Infectious Diseases 2015 15:137

    Content type: Research article

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  33. The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune responses against the parasite, as well as a valuable tool for vaccine development. We have pre...

    Authors: Xiu-Zhen Li, Xiao-Hu Wang, Li-Jun Xia, Ya-Biao Weng, Jorge A Hernandez, Li-Qing Tu, Lu-Tao Li, Shou-Jun Li and Zi-Guo Yuan

    Citation: BMC Infectious Diseases 2015 15:114

    Content type: Research article

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  34. H1N1 influenza viruses mutate rapidly, rendering vaccines developed in any given year relatively ineffective in subsequent years. Thus it is necessary to generate new vaccines every year, but this is time-cons...

    Authors: Owen Proudfoot, Sandra Esparon, Choon-Kit Tang, Karen Laurie, Ian Barr and Geoffrey Pietersz

    Citation: BMC Infectious Diseases 2015 15:101

    Content type: Research article

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  35. Although rotavirus vaccines have been licensed in Spain for over 8 years, they are not funded by its public health systems. The analysis of their effectiveness in the Valencia Region could better inform decisi...

    Authors: Silvia Pérez-Vilar, Javier Díez-Domingo, Mónica López-Lacort, Sergio Martínez-Úbeda and Miguel A Martinez-Beneito

    Citation: BMC Infectious Diseases 2015 15:92

    Content type: Research article

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  36. Healthcare workers (HCWs) are at particular risk of acquiring pertussis and transmitting the infection to high-risk susceptible patients and colleagues. In this paper, the return on investment (ROI) of prevent...

    Authors: Luqman Tariq, Marie-Josée J Mangen, Anke Hövels, Gerard Frijstein and Hero de Boer

    Citation: BMC Infectious Diseases 2015 15:75

    Content type: Research article

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  38. The success of 7-valent pneumococcal conjugate vaccination (PCV-7) introduced to the US childhood immunization schedule in 2000 was partially offset by increases in invasive pneumococcal disease (IPD) and pneu...

    Authors: Qiuzhi Chang, Abbie E Stevenson, Nicholas J Croucher, Grace M Lee, Stephen I Pelton, Marc Lipsitch, Jonathan A Finkelstein and William P Hanage

    Citation: BMC Infectious Diseases 2015 15:68

    Content type: Research article

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  39. Most poliovirus infections occur with no symptoms and this leads to the possibility of silent circulation, which complicates the confirmation of global goals to permanently end poliovirus transmission. Previou...

    Authors: Dominika A Kalkowska, Radboud J Duintjer Tebbens, Mark A Pallansch, Stephen L Cochi, Steven G F Wassilak and Kimberly M Thompson

    Citation: BMC Infectious Diseases 2015 15:66

    Content type: Research article

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  40. Long-term complications and a case mortality rate of 7.5% make meningitis caused by Streptococcus pneumoniae a serious clinical threat. In 2006, a general pneumococcal conjugate vaccination (PCV) recommendation w...

    Authors: Matthias Imöhl, Jens Möller, Ralf René Reinert, Stephanie Perniciaro, Mark van der Linden and Orhan Aktas

    Citation: BMC Infectious Diseases 2015 15:61

    Content type: Research article

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  41. Recent studies worldwide have reported increasing numbers of adults diagnosed with Bordetella pertussis despite receiving childhood vaccinations. This study describes a pertussis outbreak at a university medical ...

    Authors: Megumi Hara, Mami Fukuoka, Katsuya Tashiro, Iwata Ozaki, Satoko Ohfuji, Kenji Okada, Takashi Nakano, Wakaba Fukushima and Yoshio Hirota

    Citation: BMC Infectious Diseases 2015 15:45

    Content type: Research article

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  42. China is approaching measles elimination, but indigenous measles still circulates. County L in China has reported measles-containing vaccine (MCV) coverage rates >95% since 2000. Despite high reported coverage...

    Authors: Chao Ma, Fangjun Li, Xiang Zheng, Hong Zhang, Mengjuan Duan, Yanhua Yang, Lixin Hao, Qiru Su, Lance Rodewald, Bosong Guo, Shanliang Xiao, Huaqing Wang, Li Li, Junhua Li, Huiming Luo and Lidong Gao

    Citation: BMC Infectious Diseases 2015 15:23

    Content type: Research article

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  43. Although mouse brain-derived, inactivated Japanese encephalitis vaccines (JE-MBs) have been successfully used for a long time, potential rare neurological complications have prompted the development of a Vero ...

    Authors: Ki Wook Yun, Hoan Jong Lee, Jin Han Kang, Byung Wook Eun, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim and Sung-Ho Cha

    Citation: BMC Infectious Diseases 2015 15:7

    Content type: Research article

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  44. Toxoplasmosis caused by the intracellular parasite Toxoplasma gondii (T. gondii) is a global epidemic parasitic disease. DNA vaccines play an important role in preventing the spread of toxoplasmosis. SAG family g...

    Authors: Gang Lu, Aihua Zhou, Min Meng, Lin Wang, Yali Han, Jingjing Guo, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu and Shenyi He

    Citation: BMC Infectious Diseases 2014 14:3862

    Content type: Research article

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  45. The natural (i.e. unvaccinated population) attack rate of an infectious disease is an important parameter required for understanding disease transmission. As such, it is an input parameter in infectious diseas...

    Authors: Kavisha Jayasundara, Charlene Soobiah, Edward Thommes, Andrea C Tricco and Ayman Chit

    Citation: BMC Infectious Diseases 2014 14:670

    Content type: Research article

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  46. The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, is currently being introduced throughout the African meningitis belt. In repeated multicentre cross-sectional studies in Burkina...

    Authors: Paul A Kristiansen, Absatou Ky Ba, Abdoul-Salam Ouédraogo, Idrissa Sanou, Rasmata Ouédraogo, Lassana Sangaré, Fabien Diomandé, Denis Kandolo, Inger Marie Saga, Lara Misegades, Thomas A Clark, Marie-Pierre Préziosi and Dominique A Caugant

    Citation: BMC Infectious Diseases 2014 14:663

    Content type: Research article

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  47. There is an urgent need for improved vaccines to protect against tuberculosis. The currently available vaccine Bacille Calmette-Guerin (BCG) has varying immunogenicity and efficacy across different populations...

    Authors: Rachel Tanner, Kristina Kakalacheva, Ellen Miller, Ansar A Pathan, Rod Chalk, Clare R Sander, Tom Scriba, Michelle Tameris, Tony Hawkridge, Hassan Mahomed, Greg Hussey, Willem Hanekom, Anna Checkley, Helen McShane and Helen A Fletcher

    Citation: BMC Infectious Diseases 2014 14:660

    Content type: Research article

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  49. Tétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history...

    Authors: Dieynaba S N'Diaye, Michaël Schwarzinger, Dorothée Obach, Julien Poissy, Sophie Matheron, Enrique Casalino and Yazdan Yazdanpanah

    Citation: BMC Infectious Diseases 2014 14:603

    Content type: Research article

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  50. World Health Organization (WHO) has recommended individuals with increased risk of contracting influenza A H5N1 infection to be immunized against the virus during the inter-pandemic period. Safety and immunoge...

    Authors: Sung-Hsi Wei, Ming-Tsan Liu, Yao-Chou Tsai, Chung-Hsin Liao, Chih-Ming Chen, Wei-Yao Wang, Yi-Lung Huang, Feng-Yee Chang and Pesus Chou

    Citation: BMC Infectious Diseases 2014 14:587

    Content type: Research article

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