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Vaccines

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. There is great interest in the use of reduced dosing schedules for pneumococcal conjugate vaccines, a strategy premised on maintaining an acceptable level of protection against disease and carriage of the orga...

    Authors: Alan Yang, Francisco Cai and Marc Lipsitch

    Citation: BMC Infectious Diseases 2019 19:227

    Content type: Research article

    Published on:

  2. Delayed vaccination increases the time infants are at risk for acquiring vaccine-preventable diseases. Factors associated with incomplete vaccination are relatively well characterized in resource-limited setti...

    Authors: Pranay Nadella, Emily R. Smith, Alfa Muhihi, Ramadhani A. Noor, Honorati Masanja, Wafaie W. Fawzi and Christopher R. Sudfeld

    Citation: BMC Infectious Diseases 2019 19:188

    Content type: Research article

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  3. The direct effectiveness of infant rotavirus vaccination implemented in 2006 in the United States has been evaluated extensively, however, understanding of population-level vaccine effectiveness (VE) is still ...

    Authors: Julia M. Baker, Rebecca M. Dahl, Justin Cubilo, Umesh D. Parashar and Benjamin A. Lopman

    Citation: BMC Infectious Diseases 2019 19:186

    Content type: Research article

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  4. Influenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased...

    Authors: Lin Yang, King Pan Chan, Chit Ming Wong, Susan Shui Seng Chiu, Ricardo J. Soares Magalhaes, Thuan Quoc Thach, Joseph Syrial Malik Peiris, Archie C. A. Clements and Wenbiao Hu

    Citation: BMC Infectious Diseases 2019 19:162

    Content type: Research article

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  5. A controversy exists about the potential effect of childhood varicella vaccination on Herpes Zoster (HZ) incidence. Mathematical models projected temporary HZ incidence increase after vaccine introduction that...

    Authors: Christophe Sauboin, Katsiaryna Holl, Paolo Bonanni, Anne A. Gershon, Bernd Benninghoff, Stephane Carryn, Margaret A. Burgess and Peter Wutzler

    Citation: BMC Infectious Diseases 2019 19:126

    Content type: Research article

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  6. In Japan, freeze-dried live attenuated varicella-zoster vaccine is available for adults aged ≥50 years to prevent herpes zoster. However, limited evidence has been accumulated regarding vaccine safety for pati...

    Authors: Satoko Ohfuji, Kazuya Ito, Megumi Inoue, Motoki Ishibashi, Hiroko Kumashiro, Yoshio Hirota, Eiji Kayano and Naoshi Ota

    Citation: BMC Infectious Diseases 2019 19:95

    Content type: Research article

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  7. Benefits of pneumococcal conjugate vaccine programs have been linked to the vaccine’s ability to disrupt nasopharyngeal carriage and transmission. The 10-valent pneumococcal vaccine (PCV10) was included in the...

    Authors: Muhammad Imran Nisar, Kanwal Nayani, Tauseef Akhund, Atif Riaz, Omar Irfan, Sadia Shakoor, Sehrish Muneer, Sana Muslim, Aneeta Hotwani, Furqan Kabir, Cynthia Whitney, Lindsay Kim, Velusamy Srinivasan, Asad Ali, Anita K. M. Zaidi and Fyezah Jehan

    Citation: BMC Infectious Diseases 2018 18:672

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:114

  8. When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction.

    Authors: Joon Young Song, Hee Jin Cheong, Ji Yun Noh, Min Joo Choi, Jin Gu Yoon, Saem Na Lee, Seong Hui Kang, Eun Joo Jeong, Yu Mi Jo and Woo Joo Kim

    Citation: BMC Infectious Diseases 2018 18:628

    Content type: Research article

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  9. Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a...

    Authors: Zhifeng Chen, Kara S. Cox, Aimin Tang, Jeanette Roman, Malorie Fink, Robin M. Kaufhold, Liming Guan, Andy Xie, Melissa A. Boddicker, Debra Mcguinness, Xiao Xiao, Hualin Li, Julie M. Skinner, Thorsten Verch, Mary Retzlaff and Kalpit A. Vora

    Citation: BMC Infectious Diseases 2018 18:613

    Content type: Research article

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  10. Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have...

    Authors: Lisa Lindsay, Herbert L. DuPont, Christine L. Moe, Martin Alberer, Christoph Hatz, Amy E. Kirby, Henry M. Wu, Thomas Verstraeten and Robert Steffen

    Citation: BMC Infectious Diseases 2018 18:605

    Content type: Study protocol

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  11. In recent years, outbreaks of varicella have continued to occur, and the coverage rate of varicella vaccine in Jiangsu Province, China, remains unclear. This study aims to analyse the levels of immune antibody...

    Authors: Lei Zhang, Wang Ma, Yuanbao Liu, Yong Wang, Xiang Sun, Ying Hu, Xiuying Deng, Peishan Lu, Fenyang Tang, Zhiguo Wang and Minghao Zhou

    Citation: BMC Infectious Diseases 2018 18:563

    Content type: Research article

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  12. The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the fr...

    Authors: Avital Hirsch, Mark A. Katz, Alon Laufer Peretz, David Greenberg, Rachael Wendlandt, Yonat Shemer Avni, Gabriella Newes-Adeyi, Ilan Gofer, Maya Leventer-Roberts, Nadav Davidovitch, Anat Rosenthal, Rachel Gur-Arie, Tomer Hertz, Aharona Glatman-Freedman, Arnold S. Monto, Eduardo Azziz-Baumgartner…

    Citation: BMC Infectious Diseases 2018 18:550

    Content type: Study protocol

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  13. Antimicrobial resistance is a public-health threat and antimicrobial consumption is the main contributor. The ten-valent pneumococcal conjugate vaccine (PHiD-CV10) was introduced into the Icelandic vaccination...

    Authors: Elias Eythorsson, Samuel Sigurdsson, Birgir Hrafnkelsson, Helga Erlendsdóttir, Ásgeir Haraldsson and Karl G Kristinsson

    Citation: BMC Infectious Diseases 2018 18:505

    Content type: Research article

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  14. Vaccine regulation in China meets World Health Organization standards, but China’s vaccine industry and immunization program have some characteristics that differ from other countries. We described the history...

    Authors: Yaming Zheng, Lance Rodewald, Juan Yang, Ying Qin, Mingfan Pang, Luzhao Feng and Hongjie Yu

    Citation: BMC Infectious Diseases 2018 18:502

    Content type: Research article

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  15. Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumoc...

    Authors: Dongmu Zhang, Tanaz Petigara and Xiaoqin Yang

    Citation: BMC Infectious Diseases 2018 18:436

    Content type: Research article

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  16. Invasive bacterial diseases (IBD) are a serious cause of hospitalization, sequelae and mortality. Albeit a low incidence, an increase in cases due to H. influenzae was registered in the past 4 years and, in the T...

    Authors: Elena Chiappini, Federica Inturrisi, Elisa Orlandini, Maurizio de Martino and Chiara de Waure

    Citation: BMC Infectious Diseases 2018 18:396

    Content type: Research article

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  17. Some children are prone to recurrent invasive pneumococcal disease (rIPD) and of these, some respond insufficiently to standard pneumococcal vaccination. Little is known about how to handle these children and ...

    Authors: Helene A. S. Ingels, Bjørn Kantsø and Hans-Christian Slotved

    Citation: BMC Infectious Diseases 2018 18:366

    Content type: Research article

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  18. Stenotrophomonas maltophilia (S. maltophilia) is an emerging global multiple-drug-resistant organism. It becomes increasingly challenging to treat S. maltophilia infection effectively. Novel therapeutic and preve...

    Authors: Guangyang Xu, Xueping Tang, Xueyi Shang, Yan Li, Jing Wang, Junjie Yue and Yan Li

    Citation: BMC Infectious Diseases 2018 18:347

    Content type: Research article

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  19. Children who receive all doses of scheduled vaccines reduce their susceptibility to vaccine-preventable diseases. In India, full immunization coverage has increased significantly. However, only a small proport...

    Authors: Manojkumar Choudhary, Roma Solomon, Jitendra Awale and Rina Dey

    Citation: BMC Infectious Diseases 2018 18:222

    Content type: Research article

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  20. Benefits using the 13-valent pneumococcal conjugate vaccine (PCV13) in adults are controversial. This study investigated clinical effectiveness of PCV13 vaccination in preventing hospitalisation from pneumonia...

    Authors: Angel Vila-Corcoles, Olga Ochoa-Gondar, Cinta de Diego, Eva Satue, María Aragón, Angel Vila-Rovira, Frederic Gomez-Bertomeu, Ramon Magarolas, Enric Figuerola-Massana, Xavier Raga, Mar O. Perez and Frederic Ballester

    Citation: BMC Infectious Diseases 2018 18:196

    Content type: Research article

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  21. Staphylococcus aureus (S. aureus) causes a wide range of infectious diseases in human and animals. The emergence of antibiotic-resistant strains demands novel strategies for prophylactic vaccine development. In t...

    Authors: Chen Xu, Bao-zhong Zhang, Qiubin Lin, Jian Deng, Bin Yu, Smriti Arya, Kwok-Yung Yuen and Jian-Dong Huang

    Citation: BMC Infectious Diseases 2018 18:195

    Content type: Research article

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  22. GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an incr...

    Authors: Carine Claeys, Mamadou Drame, José García-Sicilia, Khalequ Zaman, Alfonso Carmona, Phu My Tran, Mariano Miranda, Federico Martinón-Torres, Franck Thollot, Michael Horn, Tino F. Schwarz, Ulrich Behre, José M. Merino, Iwona Sadowska-Krawczenko, Henryk Szymański, Peter Schu…

    Citation: BMC Infectious Diseases 2018 18:186

    Content type: Research article

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  23. Oral polio vaccine (OPV) containing attenuated serotype 2 polioviruses was globally withdrawn in 2016, and bivalent OPV (bOPV) containing attenuated serotype 1 and 3 polioviruses needs to be withdrawn after th...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2018 18:165

    Content type: Research article

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  24. Limited data are available on the effectiveness of 13-valent pneumococcal conjugate vaccine (PCV13) in resource-poor settings and PCV naïve populations. The Dominican Republic introduced PCV13 in September 201...

    Authors: Sara Tomczyk, Fernanda C. Lessa, Jacqueline Sánchez, Chabela Peña, Josefina Fernández, M. Gloria Carvalho, Fabiana Pimenta, Doraliza Cedano, Cynthia G. Whitney, Jennifer R. Verani, Hilma Coradin, Zacarías Garib, Lucia Helena De Oliveira and Jesús Feris-Iglesias

    Citation: BMC Infectious Diseases 2018 18:152

    Content type: Research article

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  25. Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among...

    Authors: Qinghong Meng, Jie Luo, Lijun Li, Wei Shi, Jinqian Yu, Yingjie Shen, Li Li, Yajuan Wang and Kaihu Yao

    Citation: BMC Infectious Diseases 2018 18:130

    Content type: Research article

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  26. Influenza virus transmission may be prevented by infection control measures, including vaccination, wearing a mask, gargling with water, and hand washing. It is unclear, however, whether these measures affect ...

    Authors: Mitsuo Uchida, Minoru Kaneko, Yoshihiko Hidaka, Hiroshi Yamamoto, Takayuki Honda, Shouhei Takeuchi, Masaya Saito and Shigeyuki Kawa

    Citation: BMC Infectious Diseases 2018 18:128

    Content type: Research article

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  27. Toxoplasma gondii is an obligate intracellular parasite that can infect almost all warm-blooded animals. T. gondii profilin (TgPF) plays a crucial role in parasite motility and host cell invasion, and has shown p...

    Authors: Qi Gao, Nian-Zhang Zhang, Fu-Kai Zhang, Meng Wang, Ling-Ying Hu and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2018 18:117

    Content type: Research article

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  28. Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadri...

    Authors: Carlo Giaquinto, Giovanni Gabutti, Vincenzo Baldo, Marco Villa, Lara Tramontan, Nadia Raccanello, Francesca Russo, Chiara Poma, Antonio Scamarcia, Luigi Cantarutti, Rebecca Lundin, Emilia Perinetti, Xavier Cornen, Stéphane Thomas, Céline Ballandras, Audrey Souverain…

    Citation: BMC Infectious Diseases 2018 18:103

    Content type: Research article

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  29. Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes could he...

    Authors: Youyi Fong, M. Elizabeth Halloran, Jin Kyung Park, Florian Marks, John D. Clemens and Dennis L. Chao

    Citation: BMC Infectious Diseases 2018 18:84

    Content type: Research article

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  30. The globally synchronized switch from trivalent Oral Polio Vaccine (tOPV) to bivalent Oral Polio Vaccine (bOPV) took place in Nigeria on April 18th 2016. The country is divided into six geopolitical zones. Thi...

    Authors: Bassey Enya Bassey, Fiona Braka, Rui Gama Vaz, William Komakech, Sylvester Toritseju Maleghemi, Richard Koko, Thompson Igbu, Faith Ireye, Sylvester Agwai, Godwin Ubong Akpan, Sisay Gashu Tegegne, Abdul-Aziz Garba Mohammed and Angela Okocha-Ejeko

    Citation: BMC Infectious Diseases 2018 18:57

    Content type: Research article

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  31. Adults aged 18–64 years with comorbid conditions are at high risk for complications of certain vaccine-preventable diseases, including influenza and pneumococcal disease. The 4 Pillars™ Practice Transformation...

    Authors: Angela R. Wateska, Mary Patricia Nowalk, Richard K. Zimmerman, Kenneth J. Smith and Chyongchiou J. Lin

    Citation: BMC Infectious Diseases 2018 18:52

    Content type: Research article

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  32. A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine a...

    Authors: Francesca Carozzi, Donella Puliti, Cristina Ocello, Pasquale Silvio Anastasio, Espedito Antonio Moliterni, Emilia Perinetti, Laurence Serradell, Elena Burroni, Massimo Confortini, Paola Mantellini, Marco Zappa and Géraldine Dominiak-Felden

    Citation: BMC Infectious Diseases 2018 18:38

    Content type: Research article

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  33. As China approaches the elimination of measles, outbreaks of measles continue to occur. Healthcare workers (HCWs) are known to be at high risk of infection and transmission of measles virus. A measles outbreak...

    Authors: Haimei Jia, Chao Ma, Mengting Lu, Jianping Fu, Lance E. Rodewald, Qiru Su, Huaqin Wang and Lixin Hao

    Citation: BMC Infectious Diseases 2018 18:36

    Content type: Research article

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  34. The Serious Outcomes Surveillance (SOS) Network was established to monitor seasonal influenza complications among hospitalized Canadian adults and to assess the effectiveness of influenza vaccination against s...

    Authors: Melissa K. Andrew, Vivek Shinde, Todd Hatchette, Ardith Ambrose, Guy Boivin, William Bowie, Ayman Chit, Gael Dos Santos, May ElSherif, Karen Green, François Haguinet, Scott A. Halperin, Barbara Ibarguchi, Jennie Johnstone, Kevin Katz, Joanne M. Langley…

    Citation: BMC Infectious Diseases 2017 17:805

    Content type: Research article

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  35. There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access a...

    Authors: Jennifer Forshaw, Sarah M. Gerver, Moneet Gill, Emily Cooper, Logan Manikam and Helen Ward

    Citation: BMC Infectious Diseases 2017 17:801

    Content type: Research article

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  36. Gardasil®, a quadrivalent vaccine targeting low-risk (6, 11) and high-risk (16, 18) human papillomaviruses (HPV), has been offered to 11–14 year-old schoolgirls in Switzerland since 2008. To evaluate its succe...

    Authors: Martine Jacot-Guillarmod, Jérôme Pasquier, Gilbert Greub, Massimo Bongiovanni, Chahin Achtari and Roland Sahli

    Citation: BMC Infectious Diseases 2017 17:790

    Content type: Research article

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  37. Cholera is a diarrheal disease that produces rapid dehydration. The infection is a significant cause of mortality and morbidity. Oral cholera vaccine (OCV) has been propagated for the prevention of cholera. Ev...

    Authors: Patrick G. Ilboudo and Jean-Bernard Le Gargasson

    Citation: BMC Infectious Diseases 2017 17:779

    Content type: Research article

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  38. As annual influenza vaccination is recommended for all U.S. persons aged 6 months or older, it is unethical to conduct randomized clinical trials to estimate influenza vaccine effectiveness (VE). Observational...

    Authors: Meng Shi, Qian An, Kylie E. C. Ainslie, Michael Haber and Walter A. Orenstein

    Citation: BMC Infectious Diseases 2017 17:757

    Content type: Research article

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  39. Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes ...

    Authors: Marta Inês Cazentini Medeiros, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo Silva Guerra, Paulo da Silva, Ana Maria Machado Carneiro and Denise de Andrade

    Citation: BMC Infectious Diseases 2017 17:590

    Content type: Research article

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  40. We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vac...

    Authors: Abdoulie Bojang, Lindsay Kendall, Effua Usuf, Uzochukwu Egere, Sarah Mulwa, Martin Antonio, Brian Greenwood, Philip C. Hill and Anna Roca

    Citation: BMC Infectious Diseases 2017 17:588

    Content type: Research article

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  41. Rotavirus was the leading cause of acute gastroenteritis (AGE) in infants and young children prior to the introduction of routine vaccination. Since 2006 there have been two licensed vaccines available; with s...

    Authors: Daniel Hungerford, Katie Smith, Angela Tucker, Miren Iturriza-Gómara, Roberto Vivancos, Catherine McLeonard, Nigel A Cunliffe and Neil French

    Citation: BMC Infectious Diseases 2017 17:569

    Content type: Research article

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  42. Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital war...

    Authors: Kathrin Thöne, Johannes Horn and Rafael Mikolajczyk

    Citation: BMC Infectious Diseases 2017 17:564

    Content type: Research article

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  44. China has a high prevalence of human papillomavirus (HPV) and a consequently high burden of disease with respect to cervical cancer. The HPV vaccine has proved to be effective in preventing cervical cancer and...

    Authors: Xiuting Mo, Ruoyan Gai Tobe, Lijie Wang, Xianchen Liu, Bin Wu, Huiwen Luo, Chie Nagata, Rintaro Mori and Takeo Nakayama

    Citation: BMC Infectious Diseases 2017 17:502

    Content type: Research article

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  45. Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effecti...

    Authors: Z. Meszner, Z. Molnar, E. Rampakakis, H. K. Yang, B. J. Kuter and Lara J. Wolfson

    Citation: BMC Infectious Diseases 2017 17:495

    Content type: Research article

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  46. We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfun...

    Authors: Josef Singer, Christoph Testori, Peter Schellongowski, Ammon Handisurya, Catharina Müller, Eva-Maria Reitter, Wolfgang Graninger, Paul Knöbl, Thomas Staudinger, Stefan Winkler and Florian Thalhammer

    Citation: BMC Infectious Diseases 2017 17:442

    Content type: Case report

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  47. Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects all warm-blooded animals including humans and causes toxoplasmosis. An effective vaccine coul...

    Authors: Yuan Liu, Aiping Cao, Yawen Li, Xun Li, Hua Cong, Shenyi He and Huaiyu Zhou

    Citation: BMC Infectious Diseases 2017 17:403

    Content type: Research article

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  48. After vaccination, vaccinees acquire some protection against infection and/or disease. Vaccination, therefore, reduces the number of infections in the population. Due to this herd protection, not everybody nee...

    Authors: Martin Eichner, Markus Schwehm, Linda Eichner and Laetitia Gerlier

    Citation: BMC Infectious Diseases 2017 17:308

    Content type: Research article

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  49. Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hosp...

    Authors: Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar and Javier Díez-Domingo

    Citation: BMC Infectious Diseases 2017 17:267

    Content type: Research article

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  50. To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spre...

    Authors: Felix Weidemann, Cornelius Remschmidt, Silke Buda, Udo Buchholz, Bernhard Ultsch and Ole Wichmann

    Citation: BMC Infectious Diseases 2017 17:258

    Content type: Research article

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