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Vaccines

Section edited by Susanna Esposito

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. Children who receive all doses of scheduled vaccines reduce their susceptibility to vaccine-preventable diseases. In India, full immunization coverage has increased significantly. However, only a small proport...

    Authors: Manojkumar Choudhary, Roma Solomon, Jitendra Awale and Rina Dey

    Citation: BMC Infectious Diseases 2018 18:222

    Content type: Research article

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  2. Benefits using the 13-valent pneumococcal conjugate vaccine (PCV13) in adults are controversial. This study investigated clinical effectiveness of PCV13 vaccination in preventing hospitalisation from pneumonia...

    Authors: Angel Vila-Corcoles, Olga Ochoa-Gondar, Cinta de Diego, Eva Satue, María Aragón, Angel Vila-Rovira, Frederic Gomez-Bertomeu, Ramon Magarolas, Enric Figuerola-Massana, Xavier Raga, Mar O. Perez and Frederic Ballester

    Citation: BMC Infectious Diseases 2018 18:196

    Content type: Research article

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  3. Staphylococcus aureus (S. aureus) causes a wide range of infectious diseases in human and animals. The emergence of antibiotic-resistant strains demands novel strategies for prophylactic vaccine development. In t...

    Authors: Chen Xu, Bao-zhong Zhang, Qiubin Lin, Jian Deng, Bin Yu, Smriti Arya, Kwok-Yung Yuen and Jian-Dong Huang

    Citation: BMC Infectious Diseases 2018 18:195

    Content type: Research article

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  4. GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an incr...

    Authors: Carine Claeys, Mamadou Drame, José García-Sicilia, Khalequ Zaman, Alfonso Carmona, Phu My Tran, Mariano Miranda, Federico Martinón-Torres, Franck Thollot, Michael Horn, Tino F. Schwarz, Ulrich Behre, José M. Merino, Iwona Sadowska-Krawczenko, Henryk Szymański, Peter Schu…

    Citation: BMC Infectious Diseases 2018 18:186

    Content type: Research article

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  5. Oral polio vaccine (OPV) containing attenuated serotype 2 polioviruses was globally withdrawn in 2016, and bivalent OPV (bOPV) containing attenuated serotype 1 and 3 polioviruses needs to be withdrawn after th...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2018 18:165

    Content type: Research article

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  6. Limited data are available on the effectiveness of 13-valent pneumococcal conjugate vaccine (PCV13) in resource-poor settings and PCV naïve populations. The Dominican Republic introduced PCV13 in September 201...

    Authors: Sara Tomczyk, Fernanda C. Lessa, Jacqueline Sánchez, Chabela Peña, Josefina Fernández, M. Gloria Carvalho, Fabiana Pimenta, Doraliza Cedano, Cynthia G. Whitney, Jennifer R. Verani, Hilma Coradin, Zacarías Garib, Lucia Helena De Oliveira and Jesús Feris-Iglesias

    Citation: BMC Infectious Diseases 2018 18:152

    Content type: Research article

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  7. Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among...

    Authors: Qinghong Meng, Jie Luo, Lijun Li, Wei Shi, Jinqian Yu, Yingjie Shen, Li Li, Yajuan Wang and Kaihu Yao

    Citation: BMC Infectious Diseases 2018 18:130

    Content type: Research article

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  8. Influenza virus transmission may be prevented by infection control measures, including vaccination, wearing a mask, gargling with water, and hand washing. It is unclear, however, whether these measures affect ...

    Authors: Mitsuo Uchida, Minoru Kaneko, Yoshihiko Hidaka, Hiroshi Yamamoto, Takayuki Honda, Shouhei Takeuchi, Masaya Saito and Shigeyuki Kawa

    Citation: BMC Infectious Diseases 2018 18:128

    Content type: Research article

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  9. Toxoplasma gondii is an obligate intracellular parasite that can infect almost all warm-blooded animals. T. gondii profilin (TgPF) plays a crucial role in parasite motility and host cell invasion, and has shown p...

    Authors: Qi Gao, Nian-Zhang Zhang, Fu-Kai Zhang, Meng Wang, Ling-Ying Hu and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2018 18:117

    Content type: Research article

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  10. Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadri...

    Authors: Carlo Giaquinto, Giovanni Gabutti, Vincenzo Baldo, Marco Villa, Lara Tramontan, Nadia Raccanello, Francesca Russo, Chiara Poma, Antonio Scamarcia, Luigi Cantarutti, Rebecca Lundin, Emilia Perinetti, Xavier Cornen, Stéphane Thomas, Céline Ballandras, Audrey Souverain…

    Citation: BMC Infectious Diseases 2018 18:103

    Content type: Research article

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  11. Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes could he...

    Authors: Youyi Fong, M. Elizabeth Halloran, Jin Kyung Park, Florian Marks, John D. Clemens and Dennis L. Chao

    Citation: BMC Infectious Diseases 2018 18:84

    Content type: Research article

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  12. The globally synchronized switch from trivalent Oral Polio Vaccine (tOPV) to bivalent Oral Polio Vaccine (bOPV) took place in Nigeria on April 18th 2016. The country is divided into six geopolitical zones. Thi...

    Authors: Bassey Enya Bassey, Fiona Braka, Rui Gama Vaz, William Komakech, Sylvester Toritseju Maleghemi, Richard Koko, Thompson Igbu, Faith Ireye, Sylvester Agwai, Godwin Ubong Akpan, Sisay Gashu Tegegne, Abdul-Aziz Garba Mohammed and Angela Okocha-Ejeko

    Citation: BMC Infectious Diseases 2018 18:57

    Content type: Research article

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  13. Adults aged 18–64 years with comorbid conditions are at high risk for complications of certain vaccine-preventable diseases, including influenza and pneumococcal disease. The 4 Pillars™ Practice Transformation...

    Authors: Angela R. Wateska, Mary Patricia Nowalk, Richard K. Zimmerman, Kenneth J. Smith and Chyongchiou J. Lin

    Citation: BMC Infectious Diseases 2018 18:52

    Content type: Research article

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  14. A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine a...

    Authors: Francesca Carozzi, Donella Puliti, Cristina Ocello, Pasquale Silvio Anastasio, Espedito Antonio Moliterni, Emilia Perinetti, Laurence Serradell, Elena Burroni, Massimo Confortini, Paola Mantellini, Marco Zappa and Géraldine Dominiak-Felden

    Citation: BMC Infectious Diseases 2018 18:38

    Content type: Research article

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  15. As China approaches the elimination of measles, outbreaks of measles continue to occur. Healthcare workers (HCWs) are known to be at high risk of infection and transmission of measles virus. A measles outbreak...

    Authors: Haimei Jia, Chao Ma, Mengting Lu, Jianping Fu, Lance E. Rodewald, Qiru Su, Huaqin Wang and Lixin Hao

    Citation: BMC Infectious Diseases 2018 18:36

    Content type: Research article

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  16. The Serious Outcomes Surveillance (SOS) Network was established to monitor seasonal influenza complications among hospitalized Canadian adults and to assess the effectiveness of influenza vaccination against s...

    Authors: Melissa K. Andrew, Vivek Shinde, Todd Hatchette, Ardith Ambrose, Guy Boivin, William Bowie, Ayman Chit, Gael Dos Santos, May ElSherif, Karen Green, François Haguinet, Scott A. Halperin, Barbara Ibarguchi, Jennie Johnstone, Kevin Katz, Joanne M. Langley…

    Citation: BMC Infectious Diseases 2017 17:805

    Content type: Research article

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  17. There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access a...

    Authors: Jennifer Forshaw, Sarah M. Gerver, Moneet Gill, Emily Cooper, Logan Manikam and Helen Ward

    Citation: BMC Infectious Diseases 2017 17:801

    Content type: Research article

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  18. Gardasil®, a quadrivalent vaccine targeting low-risk (6, 11) and high-risk (16, 18) human papillomaviruses (HPV), has been offered to 11–14 year-old schoolgirls in Switzerland since 2008. To evaluate its succe...

    Authors: Martine Jacot-Guillarmod, Jérôme Pasquier, Gilbert Greub, Massimo Bongiovanni, Chahin Achtari and Roland Sahli

    Citation: BMC Infectious Diseases 2017 17:790

    Content type: Research article

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  19. Cholera is a diarrheal disease that produces rapid dehydration. The infection is a significant cause of mortality and morbidity. Oral cholera vaccine (OCV) has been propagated for the prevention of cholera. Ev...

    Authors: Patrick G. Ilboudo and Jean-Bernard Le Gargasson

    Citation: BMC Infectious Diseases 2017 17:779

    Content type: Research article

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  20. As annual influenza vaccination is recommended for all U.S. persons aged 6 months or older, it is unethical to conduct randomized clinical trials to estimate influenza vaccine effectiveness (VE). Observational...

    Authors: Meng Shi, Qian An, Kylie E. C. Ainslie, Michael Haber and Walter A. Orenstein

    Citation: BMC Infectious Diseases 2017 17:757

    Content type: Research article

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  21. Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes ...

    Authors: Marta Inês Cazentini Medeiros, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo Silva Guerra, Paulo da Silva, Ana Maria Machado Carneiro and Denise de Andrade

    Citation: BMC Infectious Diseases 2017 17:590

    Content type: Research article

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  22. We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vac...

    Authors: Abdoulie Bojang, Lindsay Kendall, Effua Usuf, Uzochukwu Egere, Sarah Mulwa, Martin Antonio, Brian Greenwood, Philip C. Hill and Anna Roca

    Citation: BMC Infectious Diseases 2017 17:588

    Content type: Research article

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  23. Rotavirus was the leading cause of acute gastroenteritis (AGE) in infants and young children prior to the introduction of routine vaccination. Since 2006 there have been two licensed vaccines available; with s...

    Authors: Daniel Hungerford, Katie Smith, Angela Tucker, Miren Iturriza-Gómara, Roberto Vivancos, Catherine McLeonard, Nigel A Cunliffe and Neil French

    Citation: BMC Infectious Diseases 2017 17:569

    Content type: Research article

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  24. Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital war...

    Authors: Kathrin Thöne, Johannes Horn and Rafael Mikolajczyk

    Citation: BMC Infectious Diseases 2017 17:564

    Content type: Research article

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  26. China has a high prevalence of human papillomavirus (HPV) and a consequently high burden of disease with respect to cervical cancer. The HPV vaccine has proved to be effective in preventing cervical cancer and...

    Authors: Xiuting Mo, Ruoyan Gai Tobe, Lijie Wang, Xianchen Liu, Bin Wu, Huiwen Luo, Chie Nagata, Rintaro Mori and Takeo Nakayama

    Citation: BMC Infectious Diseases 2017 17:502

    Content type: Research article

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  27. Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effecti...

    Authors: Z. Meszner, Z. Molnar, E. Rampakakis, H. K. Yang, B. J. Kuter and Lara J. Wolfson

    Citation: BMC Infectious Diseases 2017 17:495

    Content type: Research article

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  28. We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfun...

    Authors: Josef Singer, Christoph Testori, Peter Schellongowski, Ammon Handisurya, Catharina Müller, Eva-Maria Reitter, Wolfgang Graninger, Paul Knöbl, Thomas Staudinger, Stefan Winkler and Florian Thalhammer

    Citation: BMC Infectious Diseases 2017 17:442

    Content type: Case report

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  29. Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects all warm-blooded animals including humans and causes toxoplasmosis. An effective vaccine coul...

    Authors: Yuan Liu, Aiping Cao, Yawen Li, Xun Li, Hua Cong, Shenyi He and Huaiyu Zhou

    Citation: BMC Infectious Diseases 2017 17:403

    Content type: Research article

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  30. After vaccination, vaccinees acquire some protection against infection and/or disease. Vaccination, therefore, reduces the number of infections in the population. Due to this herd protection, not everybody nee...

    Authors: Martin Eichner, Markus Schwehm, Linda Eichner and Laetitia Gerlier

    Citation: BMC Infectious Diseases 2017 17:308

    Content type: Research article

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  31. Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hosp...

    Authors: Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar and Javier Díez-Domingo

    Citation: BMC Infectious Diseases 2017 17:267

    Content type: Research article

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  32. To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spre...

    Authors: Felix Weidemann, Cornelius Remschmidt, Silke Buda, Udo Buchholz, Bernhard Ultsch and Ole Wichmann

    Citation: BMC Infectious Diseases 2017 17:258

    Content type: Research article

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  33. Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in ...

    Authors: Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn and Jin Han Kang

    Citation: BMC Infectious Diseases 2017 17:247

    Content type: Research article

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  34. Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population h...

    Authors: Eva van Doorn, Olga Pleguezuelos, Heng Liu, Ana Fernandez, Robin Bannister, Gregory Stoloff, Fredrik Oftung, Stephen Norley, Anke Huckriede, Henderik W. Frijlink and Eelko Hak

    Citation: BMC Infectious Diseases 2017 17:241

    Content type: Study protocol

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  35. Vaccination against seasonal influenza strains is recommended for “high risk” patient groups such as infants, elderly and those with respiratory or circulatory diseases. However, efficacy of the trivalent infl...

    Authors: M. D Heath, N. J. Swan, A. C. Marriott, N. J. Silman, B. Hallis, C. Prevosto, K. E. Gooch and M. A. Skinner

    Citation: BMC Infectious Diseases 2017 17:232

    Content type: Research article

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  36. To support the evaluation of the 2010-15 National Plan for Measles and Congenital Rubella Elimination, the authors designed and performed a serosurveillance survey to verify the immunity/susceptibility rate ag...

    Authors: Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio

    Citation: BMC Infectious Diseases 2017 17:199

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:630

  38. Fasciolosis remains a significant food-borne trematode disease causing high morbidity around the world and affecting grazing animals and humans. A deeper understanding concerning the molecular mechanisms by wh...

    Authors: Jose Rojas-Caraballo, Julio López-Abán, Darwin Andrés Moreno-Pérez, Belén Vicente, Pedro Fernández-Soto, Esther del Olmo, Manuel Alfonso Patarroyo and Antonio Muro

    Citation: BMC Infectious Diseases 2017 17:94

    Content type: Research article

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  39. Mumps emerged among highly vaccinated populations in the Netherlands. This offered a unique opportunity to study mumps virus transmission. In particular the extent to which asymptomatic infections in vaccinate...

    Authors: Susan Hahné, Tessa Schurink, Jacco Wallinga, Jeroen Kerkhof, Marianne van der Sande, Rob van Binnendijk and Hester de Melker

    Citation: BMC Infectious Diseases 2017 17:56

    Content type: Research article

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  41. A widely prevalent disease, toxoplasmosis poses serious health threats to both humans and animals; therefore, development of an ideal DNA vaccine against Toxoplasma gondii is needed eagerly. The purpose of the pr...

    Authors: Pengxia Song, Shenyi He, Aihua Zhou, Gang Lv, Jingjing Guo, Jian Zhou, Yali Han, Huaiyu Zhou, Zhen Hao and Hua Cong

    Citation: BMC Infectious Diseases 2017 17:19

    Content type: Research article

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  42. In Sri Lanka pertussis continues to circulate in the community and cases among adolescents and adults have been reported despite 95% coverage of the four dose pertussis vaccination during early childhood. Wani...

    Authors: Shamithra Sigera, Jennifer Perera, Jeyanthakumar Rasarathinam, Dulani Samaranayake and Dileepa Ediriweera

    Citation: BMC Infectious Diseases 2016 16:729

    Content type: Research article

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  43. In order to control the spread of rubella and reduce the risk for congenital rubella syndrome, an additional rubella vaccination program was set up for all secondary school students since 2008 in Zhejiang, China.

    Authors: Hanqing He, Rui Yan, Xuewen Tang, Yang Zhou, Xuan Deng and Shuyun Xie

    Citation: BMC Infectious Diseases 2016 16:723

    Content type: Research article

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  44. In many industrialized countries routine vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV-23) is recommended to prevent pneumococcal disease in the elderly. However, vaccine-induced imm...

    Authors: Cornelius Remschmidt, Thomas Harder, Ole Wichmann, Christian Bogdan and Gerhard Falkenhorst

    Citation: BMC Infectious Diseases 2016 16:711

    Content type: Research article

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  45. Rotavirus infection causes considerable disease burden of acute gastroenteritis (AGE) hospitalization and death among children less than 5 years in China. Although two rotavirus vaccines (Rotarix and RotaTeq) ...

    Authors: Shuhui Cui, Ruoyan Gai Tobe, Xiuting Mo, Xiaoyan Liu, Lingzhong Xu and Shixue Li

    Citation: BMC Infectious Diseases 2016 16:677

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2018 18:487

  46. The demographic composition and the frequency and nature of social contacts may affect the spread of influenza virus in a population, resulting in distinct age-dependent immunity patterns. As demography and so...

    Authors: Ruprecht Schmidt-Ott, Markus Schwehm and Martin Eichner

    Citation: BMC Infectious Diseases 2016 16:646

    Content type: Research article

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  47. An evidence-based, step-by-step guide, the 4 Pillars™ Practice Transformation Program, was the foundation of an intervention to increase adult immunizations in primary care and was tested in a randomized contr...

    Authors: Chyongchiou J. Lin, Mary Patricia Nowalk, Valory N. Pavlik, Anthony E. Brown, Song Zhang, Jonathan M. Raviotta, Krissy K. Moehling, Mary Hawk, Edmund M. Ricci, Donald B. Middleton, Suchita Patel, Jeannette E. South-Paul and Richard K. Zimmerman

    Citation: BMC Infectious Diseases 2016 16:623

    Content type: Research article

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  48. Dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the genus Flavivirus, and infection with a virus within this genus induces antibodies that are cross-reactive to other flaviviruses. Particularl...

    Authors: Yuka Saito, Meng Ling Moi, Nozomi Takeshita, Chang-Kweng Lim, Hajime Shiba, Kuniaki Hosono, Masayuki Saijo, Ichiro Kurane and Tomohiko Takasaki

    Citation: BMC Infectious Diseases 2016 16:578

    Content type: Research article

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  49. Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are responsible for a significant disease burden amongst Māori and Pacific populations in New Zealand (NZ). However, contemporary data are lacking ...

    Authors: Deborah A Williamson, Pierre R Smeesters, Andrew C Steer, Julie Morgan, Mark Davies, Philip Carter, Arlo Upton, Stephen Y.C. Tong, John Fraser and Nicole J Moreland

    Citation: BMC Infectious Diseases 2016 16:561

    Content type: Research article

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  50. In the absence of an adult vaccination register, coverage estimates for influenza and pneumococcal vaccination come from surveys and other data sources.

    Authors: Amalie Dyda, Surendra Karki, Andrew Hayen, C. Raina MacIntyre, Robert Menzies, Emily Banks, John M. Kaldor and Bette Liu

    Citation: BMC Infectious Diseases 2016 16:515

    Content type: Research article

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