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Vaccines

Section edited by Susanna Esposito

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. Toxoplasma gondii is an obligate intracellular parasite that can infect almost all warm-blooded animals, avian species and humans. Toxoplasmosis is asymptomatic in healthy individuals, whereas it may lead to deat...

    Authors: Esra Atalay Şahar, Hüseyin Can, Sultan Gülçe İz, Aysu Değirmenci Döşkaya, Mina Kalantari-Dehaghi, Remziye Deveci, Adnan Yüksel Gürüz and Mert Döşkaya

    Citation: BMC Infectious Diseases 2020 20:493

    Content type: Research article

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  2. Persistent high-risk human papillomavirus (HPV) infection is endorsed by the World Health Organization as an intermediate endpoint for evaluating HPV vaccine effectiveness/efficacy. There are different approac...

    Authors: R. Donken, J. Hoes, M. J. Knol, G. S. Ogilvie, S. Dobson, A. J. King, J. Singer, P. J. Woestenberg, J. A. Bogaards, C. J. L. M. Meijer and H. E. de Melker

    Citation: BMC Infectious Diseases 2020 20:482

    Content type: Research article

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  3. Ethiopia has low measles immunization coverage and little is known about the disparities surrounding what coverage is provided. This study assessed disparities in measles immunization and its change over time ...

    Authors: Gebretsadik Shibre, Betregiorgis Zegeye, Dina Idriss-Wheeler and Sanni Yaya

    Citation: BMC Infectious Diseases 2020 20:481

    Content type: Research article

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  4. A previous phase 2 study demonstrated the immunogenicity of a single dose of meningococcal A, C, W, Y-tetanus toxoid conjugate (MenACWY-TT) or polysaccharide (MenACWY-PS) vaccine for up to 5 years in individua...

    Authors: Charissa Fay Corazon Borja-Tabora, Paula Peyrani, Chris Webber, Marie Van der Wielen, Brigitte Cheuvart, Nathalie De Schrevel, Veronique Bianco, Emmanuel Aris, Mark Cutler, Ping Li and John L. Perez

    Citation: BMC Infectious Diseases 2020 20:426

    Content type: Research article

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  5. Most individuals are infected with human papillomavirus (HPV) at least once in their lifetime. Infections with low-risk types can cause genital warts, whereas high-risk types can cause malignant tumors. The ai...

    Authors: Miriam Reuschenbach, Sarah Mihm, Regine Wölle, Kim Maren Schneider, Christian Jacob, Sebastian Braun, Wolfgang Greiner and Monika Hampl

    Citation: BMC Infectious Diseases 2020 20:297

    Content type: Research article

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  6. The objectives of this review were to evaluate the effect of age at administration of the first dose of a measles-containing vaccine (MCV1) on protection against measles and on antibody response after one- and...

    Authors: Sara Carazo, Marie-Noëlle Billard, Amélie Boutin and Gaston De Serres

    Citation: BMC Infectious Diseases 2020 20:251

    Content type: Research article

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  7. The current national influenza vaccination schedule in Mexico does not recommend vaccination in the school-aged population (5–11 years). Currently, there are limited data from middle-income countries analysing...

    Authors: Jorge Abelardo Falcón-Lezama, Rodrigo Saucedo-Martínez, Miguel Betancourt-Cravioto, Myrna María Alfaro-Cortes, Roberto Isaac Bahena-González and Roberto Tapia-Conyer

    Citation: BMC Infectious Diseases 2020 20:240

    Content type: Research article

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  8. Kiribati introduced rotavirus vaccine in 2015. To estimate the impact of rotavirus vaccine on acute gastroenteritis (AGE) and severe acute malnutrition (SAM) among children under 5 in Kiribati, a retrospective...

    Authors: Jana Lai, Cattram Nguyen, Beia Tabwaia, Agnes Nikuata, Nikarawa Baueri, Eretii Timeon, Mohammed Diaaldeen, Tinai Iuta, Murat Hakan Ozturk, Aaron Moore, Alice Hall, Batmunkh Nyambat, Stephanie Davis, Ataur Rahman, Wendy Erasmus, Kimberley Fox…

    Citation: BMC Infectious Diseases 2020 20:207

    Content type: Research article

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  9. Infants < 3 months of age are at highest risk for developing severe complications after pertussis. The majority of pregnant women has low concentrations of pertussis-specific antibodies and thus newborns are i...

    Authors: Sabine Vygen-Bonnet, Wiebke Hellenbrand, Edeltraut Garbe, Rüdiger von Kries, Christian Bogdan, Ulrich Heininger, Marianne Röbl-Mathieu and Thomas Harder

    Citation: BMC Infectious Diseases 2020 20:136

    Content type: Research article

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  10. Yellow fever vaccine exists for over 80 years and is considered to be relatively safe. However, in rare cases it can produce serious neurotropic and viscerotropic complications. We report a case of a patient w...

    Authors: Lev Volkov, Gilda Grard, Pierre-Edouard Bollaert, Guillaume A. Durand, Aurélie Cravoisy, Marie Conrad, Lionel Nace, Guilhem Courte, Rémy Marnai, Isabelle Leparc-Goffart and Sébastien Gibot

    Citation: BMC Infectious Diseases 2020 20:116

    Content type: Case report

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  11. Streptococcus pneumoniae carriage is often asymptomatic but can cause invasive pneumococcal disease. Pneumococcal carriage is a prerequisite for disease, with children as main reservoir and transmitters. Childhoo...

    Authors: A. Løvlie, D. F. Vestrheim, I. S. Aaberge and A. Steens

    Citation: BMC Infectious Diseases 2020 20:29

    Content type: Research article

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  12. Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Au...

    Authors: Raúl Pérez-Ortín, Cristina Santiso-Bellón, Susana Vila-Vicent, Noelia Carmona-Vicente, Jesús Rodríguez-Díaz and Javier Buesa

    Citation: BMC Infectious Diseases 2019 19:998

    Content type: Research article

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  14. Although DAAs hold promise to significantly reduce rates of chronic HCV infections, its eradication still requires development of an effective vaccine. Prolonged T cell responses and cross neutralizing antibod...

    Authors: Reham M. Dawood, Rehab I. Moustafa, Tawfeek H. Abdelhafez, Reem El-Shenawy, Yasmine El-Abd, Noha G. Bader El Din, Jean Dubuisson and Mostafa K. El Awady

    Citation: BMC Infectious Diseases 2019 19:932

    Content type: Research article

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  15. To prospectively analyze the efficacy of uromune® in the prevention of uncomplicated recurrent urinary tract infections at 3 and 6 months, and according to gender and menopause.

    Authors: Cristóbal Ramírez Sevilla, Esther Gómez Lanza, Juan Llopis Manzanera, Jose Antonio Romero Martín and Miguel Ángel Barranco Sanz

    Citation: BMC Infectious Diseases 2019 19:901

    Content type: Research article

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  16. Early Childhood Education Centre (ECEC) staff are strongly recommended to receive several immunizations including influenza and pertussis. However, evidence regarding the uptake is either old or lacking across...

    Authors: Holly Seale, Stephanie Dwyer, Alamgir Kabir and Rajneesh Kaur

    Citation: BMC Infectious Diseases 2019 19:805

    Content type: Research article

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  17. Dengue is an arbovirus that has rapidly spread worldwide, and the incidence of dengue has greatly increased in recent decades. The actual numbers of dengue cases are underreported, and many cases are not class...

    Authors: Lucia Teresa Côrtes da Silveira, Bernardo Tura and Marisa Santos

    Citation: BMC Infectious Diseases 2019 19:750

    Content type: Research article

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  18. Female sex workers (FSWs) at substantial risk of HIV are potentially a suitable group for HIV prevention trials including vaccine trials. Few HIV vaccine preparatory studies have been conducted among FSWs in S...

    Authors: Yunia Mayanja, Andrew Abaasa, Gertrude Namale, Gershim Asiki, Matthew A. Price and Anatoli Kamali

    Citation: BMC Infectious Diseases 2019 19:725

    Content type: Research article

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  19. The immune response to seasonal influenza vaccines decreases with advancing age. Therefore, an adjuvanted inactivated trivalent influenza vaccine (Fluad®) exists for elderly individuals. Fluad® is more immunog...

    Authors: Manas K. Akmatov, Peggy Riese, Stephanie Trittel, Marcus May, Jana Prokein, Thomas Illig, Christoph Schindler, Carlos A. Guzmán and Frank Pessler

    Citation: BMC Infectious Diseases 2019 19:656

    Content type: Research article

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  20. Streptococcus pneumoniae is a major cause of pneumonia, meningitis, and other serious infections among children in India. India introduced the 13-valent pneumococcal conjugate vaccine (PCV) in several states in 2...

    Authors: Catherine G. Sutcliffe, Anita Shet, Rosemol Varghese, Balaji Veeraraghavan, Anand Manoharan, Brian Wahl, Sara Chandy, Jack Sternal, Raziuddin Khan, Rakesh Kumar Singh, Mathuram Santosham and Narendra K. Arora

    Citation: BMC Infectious Diseases 2019 19:605

    Content type: Research article

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  21. In recent years Pakistan has faced frequent measles outbreaks killing hundreds of children despite the availability of vaccine for decades. This study was undertaken to determine the persistence of maternal tr...

    Authors: Najma Javed, Muhammad Arif Nadeem Saqib, Mir. Muhammad Hassan Bullo and Rana Jawad Asghar

    Citation: BMC Infectious Diseases 2019 19:587

    Content type: Research article

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  22. Influenza vaccination is recognized as a primary public health intervention which prevents the illness of patients and relieves the societal burdens of influenza for medical community as well as the economy. T...

    Authors: Natsumi Shibata, Shinya Kimura, Takahiro Hoshino and Hisashi Urushihara

    Citation: BMC Infectious Diseases 2019 19:586

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:709

  24. To describe patients with inherited and acquired complement deficiency who developed invasive meningococcal disease (IMD) in England over the last decade.

    Authors: Shamez N. Ladhani, Helen Campbell, Jay Lucidarme, Steve Gray, Sydel Parikh, Laura Willerton, Stephen A. Clark, Aiswarya Lekshmi, Andrew Walker, Sima Patel, Xilian Bai, Mary Ramsay and Ray Borrow

    Citation: BMC Infectious Diseases 2019 19:522

    Content type: Research article

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  25. Pneumococcal infections are major causes of morbidity and mortality worldwide. We use routine hospital admissions data and time-series modelling analysis to estimate the impact of the seven and thirteen valent...

    Authors: Tinevimbo Shiri, Noel D. McCarthy and Stavros Petrou

    Citation: BMC Infectious Diseases 2019 19:510

    Content type: Research article

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  26. Population immunity against hepatitis B virus (HBV) in Lao People’s Demographic Republic (PDR) has not been examined since the national HBV vaccination program was started in 2002. Vaccine has been observed to...

    Authors: Masataro Norizuki, Tomomi Kitamura, Kenichi Komada, Masaya Sugiyama, Masashi Mizokami, Anonh Xeuatvongsa, Vilasak Som-Oulay, Phengta Vongphrachanh, Munehito Machida, Koji Wada, Koji Ishii, Tomoko Kiyohara, Takaji Wakita and Masahiko Hachiya

    Citation: BMC Infectious Diseases 2019 19:507

    Content type: Research article

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  27. To assess the immune persistence conferred by a Chinese hamster ovary (CHO)-derived hepatitis B vaccine (HepB) 17 to 20 years after primary immunization during early life.

    Authors: Yu-Liang Zhao, Bi-Hua Han, Xin-Jiang Zhang, Lu-Lu Pan, Hai-Song Zhou, Zhao Gao, Zhi-Yong Hao, Zhi-Wei Wu, Tian-Li Ma, Feng Wang, Qi Li, Sheng-Li Bi and Jing-Chen Ma

    Citation: BMC Infectious Diseases 2019 19:482

    Content type: Research article

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  28. This paper outlines the methodology, study population and response rate of a third large Dutch population-based cross-sectional serosurvey carried-out in 2016/2017, primarily aiming to obtain insight into age-...

    Authors: Janneke Doortje Maria Verberk, Regnerus Albertus Vos, Liesbeth Mollema, Jeffrey van Vliet, Joanna Wilhelmina Maria van Weert, Hester Ellen de Melker and Fiona Regina Maria van der Klis

    Citation: BMC Infectious Diseases 2019 19:470

    Content type: Research article

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  29. High hemagglutination inhibition (HAI) and neuraminidase inhibition (NAI) titers are generally associated with reduced influenza risk. While repeated influenza vaccination reduces seroresponse, vaccine effecti...

    Authors: Peter B Gilbert, Youyi Fong, Michal Juraska, Lindsay N Carpp, Arnold S Monto, Emily T Martin and Joshua G Petrie

    Citation: BMC Infectious Diseases 2019 19:453

    Content type: Research article

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  30. Cholera increases the risk of harmful effects on foetuses. We prospectively followed pregnant women unaware of their pregnancy status who received a study agent in a clinical trial evaluating the association b...

    Authors: Ashraful Islam Khan, Mohammad Ali, Julia Lynch, Alamgir Kabir, Jean-Louis Excler, Md. Arifuzzaman Khan, Md. Taufiqul Islam, Afroza Akter, Fahima Chowdhury, Amit Saha, Iqbal Ansary Khan, Sachin N. Desai, Deok Ryun Kim, Nirod Chandra Saha, Ajit P. Singh, John D. Clemens…

    Citation: BMC Infectious Diseases 2019 19:422

    Content type: Research article

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  31. The Zambian Ministry of Health implemented a reactive one-dose Oral Cholera Vaccine (OCV) campaign in April 2016 in three Lusaka compounds, followed by a pre-emptive second-round in December. Understanding upt...

    Authors: Leonard W. Heyerdahl, Miguel Pugliese-Garcia, Sharon Nkwemu, Taniya Tembo, Chanda Mwamba, Rachel Demolis, Roma Chilengi, Bradford D. Gessner, Elise Guillermet and Anjali Sharma

    Citation: BMC Infectious Diseases 2019 19:421

    Content type: Research article

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  32. Streptococcus pneumoniae is a major human pathogen, and nasopharyngeal colonization is the first step for transmission and pathogenesis of pneumococcal diseases. Ethiopia introduced the 10-valent pneumococcal con...

    Authors: Wondewosen Tsegaye Sime, Abraham Aseffa, Yimtubezenash Woldeamanuel, Sarah Brovall, Eva Morfeldt and Birgitta Henriques-Normark

    Citation: BMC Infectious Diseases 2019 19:409

    Content type: Research article

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  33. There is great interest in the use of reduced dosing schedules for pneumococcal conjugate vaccines, a strategy premised on maintaining an acceptable level of protection against disease and carriage of the orga...

    Authors: Alan Yang, Francisco Cai and Marc Lipsitch

    Citation: BMC Infectious Diseases 2019 19:227

    Content type: Research article

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  34. Delayed vaccination increases the time infants are at risk for acquiring vaccine-preventable diseases. Factors associated with incomplete vaccination are relatively well characterized in resource-limited setti...

    Authors: Pranay Nadella, Emily R. Smith, Alfa Muhihi, Ramadhani A. Noor, Honorati Masanja, Wafaie W. Fawzi and Christopher R. Sudfeld

    Citation: BMC Infectious Diseases 2019 19:188

    Content type: Research article

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  35. The direct effectiveness of infant rotavirus vaccination implemented in 2006 in the United States has been evaluated extensively, however, understanding of population-level vaccine effectiveness (VE) is still ...

    Authors: Julia M. Baker, Rebecca M. Dahl, Justin Cubilo, Umesh D. Parashar and Benjamin A. Lopman

    Citation: BMC Infectious Diseases 2019 19:186

    Content type: Research article

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  36. Influenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased...

    Authors: Lin Yang, King Pan Chan, Chit Ming Wong, Susan Shui Seng Chiu, Ricardo J. Soares Magalhaes, Thuan Quoc Thach, Joseph Syrial Malik Peiris, Archie C. A. Clements and Wenbiao Hu

    Citation: BMC Infectious Diseases 2019 19:162

    Content type: Research article

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  37. A controversy exists about the potential effect of childhood varicella vaccination on Herpes Zoster (HZ) incidence. Mathematical models projected temporary HZ incidence increase after vaccine introduction that...

    Authors: Christophe Sauboin, Katsiaryna Holl, Paolo Bonanni, Anne A. Gershon, Bernd Benninghoff, Stephane Carryn, Margaret A. Burgess and Peter Wutzler

    Citation: BMC Infectious Diseases 2019 19:126

    Content type: Research article

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  38. In Japan, freeze-dried live attenuated varicella-zoster vaccine is available for adults aged ≥50 years to prevent herpes zoster. However, limited evidence has been accumulated regarding vaccine safety for pati...

    Authors: Satoko Ohfuji, Kazuya Ito, Megumi Inoue, Motoki Ishibashi, Hiroko Kumashiro, Yoshio Hirota, Eiji Kayano and Naoshi Ota

    Citation: BMC Infectious Diseases 2019 19:95

    Content type: Research article

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  39. Benefits of pneumococcal conjugate vaccine programs have been linked to the vaccine’s ability to disrupt nasopharyngeal carriage and transmission. The 10-valent pneumococcal vaccine (PCV10) was included in the...

    Authors: Muhammad Imran Nisar, Kanwal Nayani, Tauseef Akhund, Atif Riaz, Omar Irfan, Sadia Shakoor, Sehrish Muneer, Sana Muslim, Aneeta Hotwani, Furqan Kabir, Cynthia Whitney, Lindsay Kim, Velusamy Srinivasan, Asad Ali, Anita K. M. Zaidi and Fyezah Jehan

    Citation: BMC Infectious Diseases 2018 18:672

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:114

  40. When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction.

    Authors: Joon Young Song, Hee Jin Cheong, Ji Yun Noh, Min Joo Choi, Jin Gu Yoon, Saem Na Lee, Seong Hui Kang, Eun Joo Jeong, Yu Mi Jo and Woo Joo Kim

    Citation: BMC Infectious Diseases 2018 18:628

    Content type: Research article

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  41. Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a...

    Authors: Zhifeng Chen, Kara S. Cox, Aimin Tang, Jeanette Roman, Malorie Fink, Robin M. Kaufhold, Liming Guan, Andy Xie, Melissa A. Boddicker, Debra Mcguinness, Xiao Xiao, Hualin Li, Julie M. Skinner, Thorsten Verch, Mary Retzlaff and Kalpit A. Vora

    Citation: BMC Infectious Diseases 2018 18:613

    Content type: Research article

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  42. Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have...

    Authors: Lisa Lindsay, Herbert L. DuPont, Christine L. Moe, Martin Alberer, Christoph Hatz, Amy E. Kirby, Henry M. Wu, Thomas Verstraeten and Robert Steffen

    Citation: BMC Infectious Diseases 2018 18:605

    Content type: Study protocol

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  43. In recent years, outbreaks of varicella have continued to occur, and the coverage rate of varicella vaccine in Jiangsu Province, China, remains unclear. This study aims to analyse the levels of immune antibody...

    Authors: Lei Zhang, Wang Ma, Yuanbao Liu, Yong Wang, Xiang Sun, Ying Hu, Xiuying Deng, Peishan Lu, Fenyang Tang, Zhiguo Wang and Minghao Zhou

    Citation: BMC Infectious Diseases 2018 18:563

    Content type: Research article

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  44. The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the fr...

    Authors: Avital Hirsch, Mark A. Katz, Alon Laufer Peretz, David Greenberg, Rachael Wendlandt, Yonat Shemer Avni, Gabriella Newes-Adeyi, Ilan Gofer, Maya Leventer-Roberts, Nadav Davidovitch, Anat Rosenthal, Rachel Gur-Arie, Tomer Hertz, Aharona Glatman-Freedman, Arnold S. Monto, Eduardo Azziz-Baumgartner…

    Citation: BMC Infectious Diseases 2018 18:550

    Content type: Study protocol

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  45. Antimicrobial resistance is a public-health threat and antimicrobial consumption is the main contributor. The ten-valent pneumococcal conjugate vaccine (PHiD-CV10) was introduced into the Icelandic vaccination...

    Authors: Elias Eythorsson, Samuel Sigurdsson, Birgir Hrafnkelsson, Helga Erlendsdóttir, Ásgeir Haraldsson and Karl G Kristinsson

    Citation: BMC Infectious Diseases 2018 18:505

    Content type: Research article

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  46. Vaccine regulation in China meets World Health Organization standards, but China’s vaccine industry and immunization program have some characteristics that differ from other countries. We described the history...

    Authors: Yaming Zheng, Lance Rodewald, Juan Yang, Ying Qin, Mingfan Pang, Luzhao Feng and Hongjie Yu

    Citation: BMC Infectious Diseases 2018 18:502

    Content type: Research article

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  47. Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumoc...

    Authors: Dongmu Zhang, Tanaz Petigara and Xiaoqin Yang

    Citation: BMC Infectious Diseases 2018 18:436

    Content type: Research article

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  48. Invasive bacterial diseases (IBD) are a serious cause of hospitalization, sequelae and mortality. Albeit a low incidence, an increase in cases due to H. influenzae was registered in the past 4 years and, in the T...

    Authors: Elena Chiappini, Federica Inturrisi, Elisa Orlandini, Maurizio de Martino and Chiara de Waure

    Citation: BMC Infectious Diseases 2018 18:396

    Content type: Research article

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  49. Some children are prone to recurrent invasive pneumococcal disease (rIPD) and of these, some respond insufficiently to standard pneumococcal vaccination. Little is known about how to handle these children and ...

    Authors: Helene A. S. Ingels, Bjørn Kantsø and Hans-Christian Slotved

    Citation: BMC Infectious Diseases 2018 18:366

    Content type: Research article

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  50. Stenotrophomonas maltophilia (S. maltophilia) is an emerging global multiple-drug-resistant organism. It becomes increasingly challenging to treat S. maltophilia infection effectively. Novel therapeutic and preve...

    Authors: Guangyang Xu, Xueping Tang, Xueyi Shang, Yan Li, Jing Wang, Junjie Yue and Yan Li

    Citation: BMC Infectious Diseases 2018 18:347

    Content type: Research article

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