Section edited by Susanna Esposito

This section aims to publish studies looking at the development and application of vaccines, including efficacy, safety, population coverage and barriers to vaccination.

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  1. Research article

    Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine

    Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes ...

    Marta Inês Cazentini Medeiros, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo Silva Guerra, Paulo da Silva, Ana Maria Machado Carneiro and Denise de Andrade

    BMC Infectious Diseases 2017 17:590

    Published on: 25 August 2017

  2. Research article

    Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial

    We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vac...

    Abdoulie Bojang, Lindsay Kendall, Effua Usuf, Uzochukwu Egere, Sarah Mulwa, Martin Antonio, Brian Greenwood, Philip C. Hill and Anna Roca

    BMC Infectious Diseases 2017 17:588

    Published on: 25 August 2017

  3. Research article

    Population effectiveness of the pentavalent and monovalent rotavirus vaccines: a systematic review and meta-analysis of observational studies

    Rotavirus was the leading cause of acute gastroenteritis (AGE) in infants and young children prior to the introduction of routine vaccination. Since 2006 there have been two licensed vaccines available; with s...

    Daniel Hungerford, Katie Smith, Angela Tucker, Miren Iturriza-Gómara, Roberto Vivancos, Catherine McLeonard, Nigel A Cunliffe and Neil French

    BMC Infectious Diseases 2017 17:569

    Published on: 15 August 2017

  4. Research article

    Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine—an interrupted time series analysis from 2005 to 2010 using health insurance data

    Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital war...

    Kathrin Thöne, Johannes Horn and Rafael Mikolajczyk

    BMC Infectious Diseases 2017 17:564

    Published on: 14 August 2017

  5. Research article

    Cost-effectiveness analysis of different types of human papillomavirus vaccination combined with a cervical cancer screening program in mainland China

    China has a high prevalence of human papillomavirus (HPV) and a consequently high burden of disease with respect to cervical cancer. The HPV vaccine has proved to be effective in preventing cervical cancer and...

    Xiuting Mo, Ruoyan Gai Tobe, Lijie Wang, Xianchen Liu, Bin Wu, Huiwen Luo, Chie Nagata, Rintaro Mori and Takeo Nakayama

    BMC Infectious Diseases 2017 17:502

    Published on: 18 July 2017

  6. Case report

    A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination

    We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfun...

    Josef Singer, Christoph Testori, Peter Schellongowski, Ammon Handisurya, Catharina Müller, Eva-Maria Reitter, Wolfgang Graninger, Paul Knöbl, Thomas Staudinger, Stefan Winkler and Florian Thalhammer

    BMC Infectious Diseases 2017 17:442

    Published on: 22 June 2017

  7. Research article

    Immunization with a DNA vaccine encoding Toxoplasma gondii Superoxide dismutase (TgSOD) induces partial immune protection against acute toxoplasmosis in BALB/c mice

    Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects all warm-blooded animals including humans and causes toxoplasmosis. An effective vaccine coul...

    Yuan Liu, Aiping Cao, Yawen Li, Xun Li, Hua Cong, Shenyi He and Huaiyu Zhou

    BMC Infectious Diseases 2017 17:403

    Published on: 7 June 2017

  8. Research article

    Direct and indirect effects of influenza vaccination

    After vaccination, vaccinees acquire some protection against infection and/or disease. Vaccination, therefore, reduces the number of infections in the population. Due to this herd protection, not everybody nee...

    Martin Eichner, Markus Schwehm, Linda Eichner and Laetitia Gerlier

    BMC Infectious Diseases 2017 17:308

    Published on: 26 April 2017

  9. Research article

    Is the impact of childhood influenza vaccination less than expected: a transmission modelling study

    To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spre...

    Felix Weidemann, Cornelius Remschmidt, Silke Buda, Udo Buchholz, Bernhard Ultsch and Ole Wichmann

    BMC Infectious Diseases 2017 17:258

    Published on: 11 April 2017

  10. Research article

    Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain

    Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hosp...

    Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar and Javier Díez-Domingo

    BMC Infectious Diseases 2017 17:267

    Published on: 11 April 2017

  11. Study protocol

    Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial

    Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population h...

    Eva van Doorn, Olga Pleguezuelos, Heng Liu, Ana Fernandez, Robin Bannister, Gregory Stoloff, Fredrik Oftung, Stephen Norley, Anke Huckriede, Henderik W. Frijlink and Eelko Hak

    BMC Infectious Diseases 2017 17:241

    Published on: 4 April 2017

  12. Research article

    Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model

    Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in ...

    Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn and Jin Han Kang

    BMC Infectious Diseases 2017 17:247

    Published on: 4 April 2017

  13. Research article

    Comparison of a novel microcrystalline tyrosine adjuvant with aluminium hydroxide for enhancing vaccination against seasonal influenza

    Vaccination against seasonal influenza strains is recommended for “high risk” patient groups such as infants, elderly and those with respiratory or circulatory diseases. However, efficacy of the trivalent infl...

    M. D Heath, N. J. Swan, A. C. Marriott, N. J. Silman, B. Hallis, C. Prevosto, K. E. Gooch and M. A. Skinner

    BMC Infectious Diseases 2017 17:232

    Published on: 27 March 2017

  14. Research article

    Lack of immunity against rubella among Italian young adults

    To support the evaluation of the 2010-15 National Plan for Measles and Congenital Rubella Elimination, the authors designed and performed a serosurveillance survey to verify the immunity/susceptibility rate ag...

    Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio

    BMC Infectious Diseases 2017 17:199

    Published on: 7 March 2017

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:630

  15. Research article

    Transcriptome profiling of gene expression during immunisation trial against Fasciola hepatica: identification of genes and pathways involved in conferring immunoprotection in a murine model

    Fasciolosis remains a significant food-borne trematode disease causing high morbidity around the world and affecting grazing animals and humans. A deeper understanding concerning the molecular mechanisms by wh...

    Jose Rojas-Caraballo, Julio López-Abán, Darwin Andrés Moreno-Pérez, Belén Vicente, Pedro Fernández-Soto, Esther del Olmo, Manuel Alfonso Patarroyo and Antonio Muro

    BMC Infectious Diseases 2017 17:94

    Published on: 23 January 2017

  16. Research article

    Mumps transmission in social networks: a cohort study

    Mumps emerged among highly vaccinated populations in the Netherlands. This offered a unique opportunity to study mumps virus transmission. In particular the extent to which asymptomatic infections in vaccinate...

    Susan Hahné, Tessa Schurink, Jacco Wallinga, Jeroen Kerkhof, Marianne van der Sande, Rob van Binnendijk and Hester de Melker

    BMC Infectious Diseases 2017 17:56

    Published on: 10 January 2017

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