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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of treatment are extremely rar...

    Authors: Akira Machida, Tasuku Ishihara, Eiichiro Amano and Shinichi Otsu

    Citation: BMC Infectious Diseases 2018 18:313

    Content type: Case report

    Published on:

  2. Nontuberculous mycobacteria (NTM) infections in patients with cystic fibrosis (CF) is increasing globally. However, the related epidemiology, comorbidities, and clinical impact of NTM infection remains unclear...

    Authors: Maxine S. Eikani, Melodee Nugent, Arash Poursina, Pippa Simpson and Hara Levy

    Citation: BMC Infectious Diseases 2018 18:311

    Content type: Research article

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  3. Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitu...

    Authors: Sileshi Abdissa, Tamrat Abebe, Gobena Ameni, Sisay Teklu, Yonas Bekuretsion, Markos Abebe and Adane Mihret

    Citation: BMC Infectious Diseases 2018 18:304

    Content type: Research article

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  4. We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum cultu...

    Authors: Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S. M. Mostafa Kamal, Annemarie van Schadewijk, Pieter S. Hiemstra, Gudmundur H. Gudmundsson, Birgitta Agerberth and Rubhana Raqib

    Citation: BMC Infectious Diseases 2018 18:303

    Content type: Research article

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  5. Efficient and effective strategies for identifying cases of active tuberculosis (TB) in rural sub-Saharan Africa are lacking. Household contact tracing offers a potential approach to diagnose more TB cases, an...

    Authors: Kristen M. Little, Reginah Msandiwa, Neil Martinson, Jonathan Golub, Richard Chaisson and David Dowdy

    Citation: BMC Infectious Diseases 2018 18:299

    Content type: Research article

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  6. Tuberculous (TB) pneumonia can induce acute respiratory distress syndrome (ARDS). Although TB pneumonia is one of the causes of disease and death among children worldwide, the literature on TB pneumonia-induce...

    Authors: Dong Tien Ngo, Phuc Huu Phan, Shoji Kawachi, Noriko Nakajima, Naoyuki Hirata, Akira Ainai, Thuy Thi Bich Phung, Dien Minh Tran and Hai Thanh Le

    Citation: BMC Infectious Diseases 2018 18:294

    Content type: Case report

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  7. Although intravesical bacille Calmette-Guérin (BCG) therapy is accepted as an effective treatment for bladder cancer, serious complications may occur in rare cases. To date, only 4 cases have been reported in ...

    Authors: Takuya Kusakabe, Kenji Endo, Itaru Nakamura, Hidekazu Suzuki, Hirosuke Nishimura, Shinji Fukushima and Kengo Yamamoto

    Citation: BMC Infectious Diseases 2018 18:290

    Content type: Case report

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  8. The recurrence of tuberculosis (TB) disease in treated patients can serve as a marker of the efficacy of TB control programs. Recurrent disease represents either endogenous reactivation with the same strain of My...

    Authors: Laila Parvaresh, Taryn Crighton, Elena Martinez, Andrea Bustamante, Sharon Chen and Vitali Sintchenko

    Citation: BMC Infectious Diseases 2018 18:265

    Content type: Research article

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  9. Tuberculosis (TB) case finding is an important component of TB control because it can reduce transmission of Mycobacterium tuberculosis (MTB) through prompt detection and treatment of infectious patients.

    Authors: Godfrey Bigogo, Kevin Cain, Diana Nyole, Geoffrey Masyongo, Joshua Auko Auko, Newton Wamola, Albert Okumu, Janet Agaya, Joel Montgomery, Martien Borgdorff and Deron Burton

    Citation: BMC Infectious Diseases 2018 18:262

    Content type: Research article

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  10. Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely under...

    Authors: Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang and Jing Zhou

    Citation: BMC Infectious Diseases 2018 18:261

    Content type: Research article

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  11. Tuberculosis is among the top ten cause of death (9th) from a single infectious agent worldwide. It even ranks above HIV/AIDS. It is among the top 10 causes of death among children. Globally there are estimate...

    Authors: Bereket Gebremichael, Tsega-Ab Abebaw, Tsedey Moges, Admas Abera Abaerei and Nadia Worede

    Citation: BMC Infectious Diseases 2018 18:252

    Content type: Research article

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  12. Ethiopia is one of the world health organization defined higher tuberculosis (TB) burden countries where the disease remains a massive public health threat. This study aimed to identify the prevalence and asso...

    Authors: Biresaw Demile, Amare Zenebu, Haile Shewaye, Siqing Xia and Awoke Guadie

    Citation: BMC Infectious Diseases 2018 18:249

    Content type: Research article

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  13. Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) i...

    Authors: Song Yee Kim, Jungho Kim, Deok Ryun Kim, Young Ae Kang, Sungyoung Bong, Jonghee Lee, Suyeon Kim, Nam Suk Lee, Bora Sim, Sang-Nae Cho, Young Sam Kim and Hyejon Lee

    Citation: BMC Infectious Diseases 2018 18:240

    Content type: Research article

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  14. Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral...

    Authors: Megan E. Gray, Peter W. Liu and Brian Wispelwey

    Citation: BMC Infectious Diseases 2018 18:235

    Content type: Case report

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  15. With the widespread use of rifampicin and isoniazid, bacterial resistance has become a growing problem. Additionally, the lack of relevant baseline information for the frequency of drug-resistant tuberculosis ...

    Authors: Ming-Jin Zhang, Wen-Zhi Ren, Xue-Juan Sun, Yang Liu, Ke-Wei Liu, Zhong-Hao Ji, Wei Gao and Bao Yuan

    Citation: BMC Infectious Diseases 2018 18:234

    Content type: Research article

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  16. Mycobacterium arupense, first identified in 2006, is a slow-growing nontuberculous mycobacterium (NTM) and an emerging cause of tenosynovitis, potentially associated with immunosuppression. However, unlike the di...

    Authors: Xian Zhou, Qiaoling Ruan, Weimin Jiang, Xinyu Wang, Yuan Jiang, Shenglei Yu, Yu Xu, Jing Li, Yangyi Zhang, Wenhong Zhang and Yuekai Hu

    Citation: BMC Infectious Diseases 2018 18:221

    Content type: Case report

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  17. Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Severa...

    Authors: Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J. Ellner, Yukari C. Manabe and Padmini Salgame

    Citation: BMC Infectious Diseases 2018 18:220

    Content type: Research article

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  18. TB outbreaking in schools is extremely complex, and presents a major challenge for public health. Understanding the knowledge, attitudes and practices among student TB patients in such settings is fundamental ...

    Authors: Yahui Fan, Shaoru Zhang, Yan Li, Yuelu Li, Tianhua Zhang, Weiping Liu and Hualin Jiang

    Citation: BMC Infectious Diseases 2018 18:213

    Content type: Research article

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  19. India plans to eliminate tuberculosis (TB) by 2025, and has identified screening and prevention as key activities. Household contacts (HHCs) of index TB cases are a high-risk population that would benefit from...

    Authors: Andrea DeLuca, Gauri Dhumal, Mandar Paradkar, Nishi Suryavanshi, Vidya Mave, Rewa Kohli, Shri Vijay Bala Yogendra Shivakumar, Vidula Hulyolkar, Archana Gaikwad, Ashwini Nangude, Geeta Pardeshi, Dileep Kadam and Amita Gupta

    Citation: BMC Infectious Diseases 2018 18:202

    Content type: Research article

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  20. The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to preve...

    Authors: N. Bionghi, A. Daftary, B. Maharaj, Z. Msibi, K. R. Amico, G. Friedland, C. Orrell, N. Padayatchi and M. R. O’Donnell

    Citation: BMC Infectious Diseases 2018 18:171

    Content type: Research article

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  21. Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical eff...

    Authors: Rafael Silva Gama, Thalisson Artur Ribeiro Gomides, Chaiana Fróes Magalhães Gama, Suelen Justo Maria Moreira, Fernanda Saloum de Neves Manta, Lorena Bruna P. de Oliveira, Pedro Henrique Ferreira Marçal, Euzenir Nunes Sarno, Milton Ozório Moraes, Raúl Marcel González Garcia and Lucia Alves de Oliveira Fraga

    Citation: BMC Infectious Diseases 2018 18:153

    Content type: Research article

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  22. Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequen...

    Authors: Audrey Forson, Awewura Kwara, Samuel Kudzawu, Michael Omari, Jacob Otu, Florian Gehre, Bouke de Jong and Martin Antonio

    Citation: BMC Infectious Diseases 2018 18:149

    Content type: Research article

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  23. Pretreatment loss to follow-up (PTLFU) is a barrier to tuberculosis (TB) control in India’s Revised National TB Control Programme (RNTCP). PTLFU studies have not been conducted in India’s mega-cities, where pa...

    Authors: Beena E. Thomas, Ramnath Subbaraman, Senthil Sellappan, Chandra Suresh, J. Lavanya, Savari Lincy, Agnes Lawrence Raja, B. Javeed, S. Kokila, S. Arumugam, Soumya Swaminathan and Kenneth H. Mayer

    Citation: BMC Infectious Diseases 2018 18:142

    Content type: Research article

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  24. Since 2006, the Peruvian National TB program (NTP) recommends voluntary counseling and testing (VCT) for all tuberculosis (TB) patients. Responding to the differential burden of both diseases in Peru, TB is ma...

    Authors: Suzanne Ramírez, Fernando Mejía, Marlene Rojas, Carlos Seas, Patrick Van der Stuyft, Eduardo Gotuzzo and Larissa Otero

    Citation: BMC Infectious Diseases 2018 18:136

    Content type: Research article

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  25. Precise designation of high risk forms of latent Mycobacterium tuberculosis-M.tb infections (LTBI) is impossible. Delineation of high-risk LTBI can, however, allow for chemoprophylaxis and curtail majority cases ...

    Authors: Misaki Wayengera, David P. Kateete, Benon Asiimwe and Moses L. Joloba

    Citation: BMC Infectious Diseases 2018 18:133

    Content type: Research article

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  26. Few prospective cohort studies, none in China, have investigated the relationship between treatment outcomes of multidrug-resistant tuberculosis (MDR-TB) patients and sputum culture conversion. Factors affecti...

    Authors: Qiao Liu, Peng Lu, Leonardo Martinez, Haitao Yang, Wei Lu, Xiaoyan Ding and Limei Zhu

    Citation: BMC Infectious Diseases 2018 18:114

    Content type: Research article

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  27. Drug resistant tuberculosis (TB) is increasing in prevalence worldwide. Treatment failure and relapse is known to be high for patients with isoniazid resistant TB treated with standard first line regimens. How...

    Authors: Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thi Hanh, Jeremy Day, Sarah Dunstan, Nguyen Thi Quynh Nhu, Vo Sy Kiet, Nguyen Huu Lan, Nguyen Huy Dung, Nguyen Thi Ngoc Lan, Nguyen Thuong Thuong, Nguyen Ngoc Lan, Phạm Thị Thúy Liễu, Nguyễn Thị Hồng, Đào Công Điệp, Nguyễn Thị Kim Thanh…

    Citation: BMC Infectious Diseases 2018 18:112

    Content type: Research article

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  28. Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there is una...

    Authors: Medard Beyanga, Benson R. Kidenya, Lisa Gerwing-Adima, Eleanor Ochodo, Stephen E. Mshana and Christa Kasang

    Citation: BMC Infectious Diseases 2018 18:110

    Content type: Research article

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  29. In 2012, the World Health Organization launched guidelines for systematically investigating contacts of persons with infectious tuberculosis (TB) in low- and middle-income countries. As such, it is necessary t...

    Authors: Gladys Kigozi, Michelle Engelbrecht, Christo Heunis and André Janse van Rensburg

    Citation: BMC Infectious Diseases 2018 18:106

    Content type: Research article

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  30. Mycobacterium tuberculosis (M. tuberculosis) disease is a generally well-known problem among immunocompromised adults and children. In pediatric oncology, only few cases of M. tuberculosis disease are reported so...

    Authors: Karoline van de Loo, Stefan Balzer, Colin R. MacKenzie, Thomas M. Boemers, Monika Ortmann, Jörg Schaper, Arndt Borkhardt, Hans-Jürgen Laws and Michaela Kuhlen

    Citation: BMC Infectious Diseases 2018 18:105

    Content type: Case report

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  31. Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program...

    Authors: Yufeng Wen, Zhiping Zhang, Xianxiang Li, Dan Xia, Jun Ma, Yuanyuan Dong and Xinwei Zhang

    Citation: BMC Infectious Diseases 2018 18:104

    Content type: Research article

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  32. Growth-based drug susceptibility testing (DST) is the reference standard for diagnosing drug-resistant tuberculosis (TB), but standard time to result (TTR) is typically ≥ 3 weeks. Rapid tests can reduce that T...

    Authors: Erik J. Groessl, Theodore G. Ganiats, Naomi Hillery, Andre Trollip, Roberta L. Jackson, Donald G. Catanzaro, Timothy C. Rodwell, Richard S. Garfein, Camilla Rodrigues, Valeriu Crudu, Thomas C. Victor and Antonino Catanzaro

    Citation: BMC Infectious Diseases 2018 18:102

    Content type: Research article

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  33. The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic ...

    Authors: Amal Oudghiri, Hind Karimi, Fouad Chetioui, Fathiah Zakham, Jamal Eddine Bourkadi, My Driss Elmessaoudi, Amin Laglaoui, Imane Chaoui and Mohammed El Mzibri

    Citation: BMC Infectious Diseases 2018 18:98

    Content type: Research article

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  34. Tuberculosis (TB) recurrence represents a challenge to control programs. In low incidence countries, the prevailing risk factors leading to recurrence are poorly characterised.

    Authors: Andrew Rosser, Matthew Richardson, Martin J. Wiselka, Robert C. Free, Gerrit Woltmann, Galina V. Mukamolova and Manish Pareek

    Citation: BMC Infectious Diseases 2018 18:94

    Content type: Research article

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  35. Smear microscopy lacks sensitivity especially in HIV co-infection, resulting in undiagnosed tuberculosis (TB) and high mortality. The loop-mediated isothermal amplification (TB-LAMP) assay can be staged with m...

    Authors: Lydia Nakiyingi, Prossy Nakanwagi, Jessica Briggs, Tifu Agaba, Frank Mubiru, Mark Mugenyi, Willy Ssengooba, Moses L. Joloba and Yukari C. Manabe

    Citation: BMC Infectious Diseases 2018 18:87

    Content type: Research article

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  36. Tuberculosis (TB) transmission is influenced by patient-related risk, environment and bacteriological factors. We determined the risk factors associated with cluster size of IS6110 RFLP based genotypes of Mycobac...

    Authors: Renata Lyrio Peres, Solange Alves Vinhas, Fabíola Karla Correa Ribeiro, Moisés Palaci, Thiago Nascimento do Prado, Bárbara Reis-Santos, Eliana Zandonade, Philip Noel Suffys, Jonathan E. Golub, Lee W. Riley and Ethel Leonor Maciel

    Citation: BMC Infectious Diseases 2018 18:71

    Content type: Research article

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  37. Although atypical mycobacteria had been increasingly found in various ocular infections in the past decades, a slow-growing Mycobacterium haemophilum (M. haemophilum) was scarcely reported. Similar to tuberculous...

    Authors: Warinyupa Pinitpuwadol, Sucheera Sarunket, Sutasinee Boonsopon, Nattaporn Tesavibul and Pitipol Choopong

    Citation: BMC Infectious Diseases 2018 18:70

    Content type: Case report

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  38. Tuberculosis (TB) remains one of the major infectious diseases worldwide. Adverse reactions are common during TB treatment. Few reports, however, are available on treatment-related acute biliary events (ABEs),...

    Authors: Lih-Yu Chang, Chih-Hsin Lee, Chia-Hao Chang, Ming-Chia Lee, Meng-Rui Lee, Jann-Yuan Wang and Li-Na Lee

    Citation: BMC Infectious Diseases 2018 18:64

    Content type: Research article

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  39. Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for...

    Authors: Teresa Rito, Carlos Matos, Carlos Carvalho, Henrique Machado, Gabriela Rodrigues, Olena Oliveira, Eduarda Ferreira, Jorge Gonçalves, Lurdes Maio, Clara Morais, Helena Ramos, João Tiago Guimarães, Catarina L. Santos, Raquel Duarte and Margarida Correia-Neves

    Citation: BMC Infectious Diseases 2018 18:53

    Content type: Research article

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  40. Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation co...

    Authors: Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Ebekalisai Piten, Marcus Beissner, Yiragnima Kobara, Komlan Kossi, Kossi Badziklou, Franz Xaver Wiedemann, Komi Amekuse, Gisela Bretzel and Damintoti Simplice Karou

    Citation: BMC Infectious Diseases 2018 18:48

    Content type: Research article

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  41. Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical sym...

    Authors: Leonar Arroyo, Diana Marín, Kees L. M. C. Franken, Tom H. M. Ottenhoff and Luis F. Barrera

    Citation: BMC Infectious Diseases 2018 18:26

    Content type: Research article

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  42. The non-tuberculous mycobacteria include those mycobacterium species that are not members of the Mycobacterium tuberculosis complex, the causative agent of pulmonary tuberculosis and Mycobacterium leprae. In Zamb...

    Authors: Ngula Monde, Musso Munyeme, Adrian Muwonge, John Bwalya Muma and Sydney Malama

    Citation: BMC Infectious Diseases 2018 18:20

    Content type: Research article

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  43. Presence of Mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs in patients with gastroesophageal disease. However, li...

    Authors: Satoshi Okamori, Takanori Asakura, Tomoyasu Nishimura, Eiko Tamizu, Makoto Ishii, Mitsunori Yoshida, Hanako Fukano, Yuichiro Hayashi, Masaki Fujita, Yoshihiko Hoshino, Tomoko Betsuyaku and Naoki Hasegawa

    Citation: BMC Infectious Diseases 2018 18:1

    Content type: Case report

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  44. The introduction of Xpert MTB/RIF assay (Xpert) has significantly improved diagnosis of Tuberculosis (TB) in resource limited human immunodeficiency virus (HIV) endemic settings. We aimed to modify the Xpert p...

    Authors: Peter M. Mbelele, Said Aboud, Stellah G. Mpagama and Mecky I. Matee

    Citation: BMC Infectious Diseases 2017 17:808

    Content type: Technical advance

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  45. Up to one third of HIV-infected individuals with suspected TB are sputum-scarce. The Alere Determine™ TB LAM Ag lateral flow strip test can be used to diagnose TB in HIV-infected patients with advanced immunos...

    Authors: Natasha F. Sabur, Aliasgar Esmail, Mantaj S. Brar and Keertan Dheda

    Citation: BMC Infectious Diseases 2017 17:803

    Content type: Research article

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  46. Nontuberculous mycobacterial (NTM) infection in immunocompromized patients is currently a growing health concern, and we aimed to examine the relative risk of NTM infection in patients with Sjögren’s syndrome ...

    Authors: Wen-Cheng Chao, Ching-Heng Lin, Tsai-Ling Liao, Yi-Ming Chen, Chiann-Yi Hsu, Jun-Peng Chen, Der-Yuan Chen and Hsin-Hua Chen

    Citation: BMC Infectious Diseases 2017 17:796

    Content type: Research article

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.