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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine w...

    Authors: Ming-Gui Wang, Miao-Miao Zhang, Yu Wang, Shou-Quan Wu, Meng Zhang and Jian-Qing He

    Citation: BMC Infectious Diseases 2018 18:561

    Content type: Research article

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  2. Globally recommended measures for comprehensive tuberculosis (TB) infection control (IC) are inadequately practiced in most health care facilities in Ethiopia. The aim of this study was to assess the extent of...

    Authors: Asfaw Ayalew, Zewdu Gashu, Tadesse Anteneh, Nebiyu Hiruy, Dereje Habte, Degu Jerene, Genetu Alem, Ilili Jemal, Muluken Melese and Pedro G. Suarez

    Citation: BMC Infectious Diseases 2018 18:557

    Content type: Research article

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  3. China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review ...

    Authors: Yun Qian, Qixin Han, Wenjun Liu, Wei-En Yuan and Cunyi Fan

    Citation: BMC Infectious Diseases 2018 18:543

    Content type: Research article

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  4. The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains un...

    Authors: Che-Liang Chung, Yen-Fu Chen, Yen-Ting Lin, Jann-Yuan Wang, Shuenn-Wen Kuo and Jin-Shing Chen

    Citation: BMC Infectious Diseases 2018 18:530

    Content type: Research article

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  5. The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve ...

    Authors: Alireza Neshani, Reza Kamali Kakhki, Mojtaba Sankian, Hosna Zare, Amin Hooshyar Chichaklu, Mahsa Sayyadi and Kiarash Ghazvini

    Citation: BMC Infectious Diseases 2018 18:517

    Content type: Research article

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  6. Early diagnosis of tuberculosis (TB) and involvement of the public-private partnership are critical to eradicate TB. Patients need to receive proper treatment through the National Tuberculosis Control Programm...

    Authors: K. A. T. M. Ehsanul Huq, Michiko Moriyama, Khalequ Zaman, Mohammod Jobayer Chisti, Julie Long, Akramul Islam, Shahed Hossain, Habiba Shirin, Mohammad Jyoti Raihan, Sajeda Chowdhury and Md Moshiur Rahman

    Citation: BMC Infectious Diseases 2018 18:515

    Content type: Research article

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  7. The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-expo...

    Authors: Liesbeth F Mieras, Anna T Taal, Wim H van Brakel, Emmanuelle Cambau, Paul R Saunderson, W Cairns S Smith, Cita Rosita S Prakoeswa, Linda Astari, David M Scollard, Dejair Caitano do Nascimento, Jacques Grosset, Hemanta K Kar, Shinzo Izumi, Laura Gillini, Marcos C L Virmond and Marieke G G Sturkenboom

    Citation: BMC Infectious Diseases 2018 18:506

    Content type: Debate

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  8. The depletion of CD4 cell is the underlying reason for TB hyper-susceptibility among people with HIV. Consequently, the trend of TB dynamics is usually hidden by the HIV outbreak.

    Authors: Dao Nguyen Vinh, Dang Thi Minh Ha, Nguyen Thi Hanh, Guy Thwaites, Maciej F. Boni, Hannah E. Clapham and Nguyen Thuy Thuong Thuong

    Citation: BMC Infectious Diseases 2018 18:494

    Content type: Research article

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  9. An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not cle...

    Authors: Bronwyn Myers, Tara C Bouton, Elizabeth J Ragan, Laura F White, Helen McIlleron, Danie Theron, Charles D H Parry, C Robert Horsburgh, Robin M Warren and Karen R Jacobson

    Citation: BMC Infectious Diseases 2018 18:488

    Content type: Study protocol

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  10. The programmatic management of Multidrug-resistant tuberculosis (MDR-TB) is entirely based on a WHO recommended long-term, 18–24 month lasting treatment regimen. However, growing evidence shows that low treatm...

    Authors: Setegn Eshetie, Animut Alebel, Fasil Wagnew, Demeke Geremew, Alebachew Fasil and Ulrich Sack

    Citation: BMC Infectious Diseases 2018 18:486

    Content type: Research article

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  11. HIV is a major driver of the tuberculosis epidemic in sub-Saharan Africa. The population-level impact of antiretroviral therapy (ART) scale-up on tuberculosis rates in this region has not been well studied. We...

    Authors: Diya Surie, Martien W. Borgdorff, Kevin P. Cain, Eleanor S. Click, Kevin M. DeCock and Courtney M. Yuen

    Citation: BMC Infectious Diseases 2018 18:481

    Content type: Research article

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  12. Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of ...

    Authors: Youn Jeong Kim, Ji Young Kang, Sang Il Kim, Mee Soo Chang, Yang Ree Kim and Yeon Joon Park

    Citation: BMC Infectious Diseases 2018 18:457

    Content type: Research article

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  13. It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of periphera...

    Authors: Liping Yan, Hongbo Shen and Heping Xiao

    Citation: BMC Infectious Diseases 2018 18:453

    Content type: Research article

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  14. Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycob...

    Authors: Jie Shi, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li and Jin Xing

    Citation: BMC Infectious Diseases 2018 18:447

    Content type: Research article

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  15. Multidrug resistant-tuberculosis (MDR-TB) is a major global health concern. Its treatment requires toxic medications, is longer and costlier than drug-susceptible TB, and often results in productivity losses a...

    Authors: Lisa Kawatsu, Kazuhiro Uchimura, Kiyohiko Izumi, Akihiro Ohkado and Takashi Yoshiyama

    Citation: BMC Infectious Diseases 2018 18:445

    Content type: Research article

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  16. Tuberculosis (TB), especially extrapulmonary tuberculosis (EPTB), is an important cause of fever of unknown origin (FUO) in TB-burdened areas. Little information is known about patients with EPTB with clinical...

    Authors: Jeong-Han Kim, Eu Suk Kim, Kang-Il Jun, Hyun gul Jung, Ji Hwan Bang, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh and Sang-Won Park

    Citation: BMC Infectious Diseases 2018 18:426

    Content type: Research article

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  17. The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions ha...

    Authors: Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci and Milton Ozório Moraes

    Citation: BMC Infectious Diseases 2018 18:422

    Content type: Research article

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  18. Diabetes is associated with increased risk of tuberculosis (TB) treatment failure, death, and relapse compared to patients without diabetes. Current TB regimens are available as fixed dose combination (FDC) an...

    Authors: Mohammad H. Al-Shaer, Hazem Elewa, Yosra Alkabab, Lama H. Nazer and Scott K. Heysell

    Citation: BMC Infectious Diseases 2018 18:384

    Content type: Research article

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  19. In Cape Town, the roll-out of antiretroviral therapy (ART) has increased over the last decade with an estimated coverage of 63% of HIV- positive patients in 2013. The influence of ART on the characteristics of...

    Authors: Richard Kaplan, Sabine Hermans, Judy Caldwell, Karen Jennings, Linda-Gail Bekker and Robin Wood

    Citation: BMC Infectious Diseases 2018 18:356

    Content type: Research article

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  20. Matrix metalloproteinases (MMPs) are considered to be key mediators of tuberculosis (TB) pathology but their role in tuberculosis – diabetes comorbidity (TB-DM) is not well understood.

    Authors: Nathella P. Kumar, Kadar Moideen, Vijay Viswanathan, Basavaradhya S. Shruthi, Shanmugam Sivakumar, Pradeep A. Menon, Hardy Kornfeld and Subash Babu

    Citation: BMC Infectious Diseases 2018 18:345

    Content type: Research article

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  21. Increasing case notifications is one of the top programmatic priorities of National TB Control Programmes (NTPs). To find more cases, NTPs often need to consider expanding TB case-detection activities to popul...

    Authors: Marek Lalli, Matthew Hamilton, Carel Pretorius, Debora Pedrazzoli, Richard G. White and Rein M. G. J. Houben

    Citation: BMC Infectious Diseases 2018 18:340

    Content type: Research article

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  22. Globally, 40% of all tuberculosis (TB) cases, 65% paediatric cases and 75% multi-drug resistant TB (MDR-TB) cases are missed due to underreporting and/or under diagnosis. A recent Kenyan TB prevalence survey f...

    Authors: J. N. Oliwa, J. Maina, P. Ayieko, D. Gathara, I. A. Kathure, E. Masini, A. H. van’t Hoog, M. B. van Hensbroek and M. English

    Citation: BMC Infectious Diseases 2018 18:328

    Content type: Research article

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  23. Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. ‘Blanket approach’ is an operational strategy for leprosy po...

    Authors: Anuj Tiwari, Steaven Dandel, Rita Djupuri, Liesbeth Mieras and Jan Hendrik Richardus

    Citation: BMC Infectious Diseases 2018 18:324

    Content type: Research article

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  24. The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the sta...

    Authors: Conor D. Tweed, Angela M. Crook, Evans I. Amukoye, Rodney Dawson, Andreas H. Diacon, Madeline Hanekom, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Michael E. Murphy, Saraswathi E. Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Genevieve H. Wills…

    Citation: BMC Infectious Diseases 2018 18:317

    Content type: Research article

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  25. Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of treatment are extremely rar...

    Authors: Akira Machida, Tasuku Ishihara, Eiichiro Amano and Shinichi Otsu

    Citation: BMC Infectious Diseases 2018 18:313

    Content type: Case report

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  26. Nontuberculous mycobacteria (NTM) infections in patients with cystic fibrosis (CF) is increasing globally. However, the related epidemiology, comorbidities, and clinical impact of NTM infection remains unclear...

    Authors: Maxine S. Eikani, Melodee Nugent, Arash Poursina, Pippa Simpson and Hara Levy

    Citation: BMC Infectious Diseases 2018 18:311

    Content type: Research article

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  27. Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitu...

    Authors: Sileshi Abdissa, Tamrat Abebe, Gobena Ameni, Sisay Teklu, Yonas Bekuretsion, Markos Abebe and Adane Mihret

    Citation: BMC Infectious Diseases 2018 18:304

    Content type: Research article

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  28. We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum cultu...

    Authors: Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S. M. Mostafa Kamal, Annemarie van Schadewijk, Pieter S. Hiemstra, Gudmundur H. Gudmundsson, Birgitta Agerberth and Rubhana Raqib

    Citation: BMC Infectious Diseases 2018 18:303

    Content type: Research article

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  29. Efficient and effective strategies for identifying cases of active tuberculosis (TB) in rural sub-Saharan Africa are lacking. Household contact tracing offers a potential approach to diagnose more TB cases, an...

    Authors: Kristen M. Little, Reginah Msandiwa, Neil Martinson, Jonathan Golub, Richard Chaisson and David Dowdy

    Citation: BMC Infectious Diseases 2018 18:299

    Content type: Research article

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  30. Tuberculous (TB) pneumonia can induce acute respiratory distress syndrome (ARDS). Although TB pneumonia is one of the causes of disease and death among children worldwide, the literature on TB pneumonia-induce...

    Authors: Dong Tien Ngo, Phuc Huu Phan, Shoji Kawachi, Noriko Nakajima, Naoyuki Hirata, Akira Ainai, Thuy Thi Bich Phung, Dien Minh Tran and Hai Thanh Le

    Citation: BMC Infectious Diseases 2018 18:294

    Content type: Case report

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  31. Although intravesical bacille Calmette-Guérin (BCG) therapy is accepted as an effective treatment for bladder cancer, serious complications may occur in rare cases. To date, only 4 cases have been reported in ...

    Authors: Takuya Kusakabe, Kenji Endo, Itaru Nakamura, Hidekazu Suzuki, Hirosuke Nishimura, Shinji Fukushima and Kengo Yamamoto

    Citation: BMC Infectious Diseases 2018 18:290

    Content type: Case report

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  32. The recurrence of tuberculosis (TB) disease in treated patients can serve as a marker of the efficacy of TB control programs. Recurrent disease represents either endogenous reactivation with the same strain of My...

    Authors: Laila Parvaresh, Taryn Crighton, Elena Martinez, Andrea Bustamante, Sharon Chen and Vitali Sintchenko

    Citation: BMC Infectious Diseases 2018 18:265

    Content type: Research article

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  33. Tuberculosis (TB) case finding is an important component of TB control because it can reduce transmission of Mycobacterium tuberculosis (MTB) through prompt detection and treatment of infectious patients.

    Authors: Godfrey Bigogo, Kevin Cain, Diana Nyole, Geoffrey Masyongo, Joshua Auko Auko, Newton Wamola, Albert Okumu, Janet Agaya, Joel Montgomery, Martien Borgdorff and Deron Burton

    Citation: BMC Infectious Diseases 2018 18:262

    Content type: Research article

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  34. Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely under...

    Authors: Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang and Jing Zhou

    Citation: BMC Infectious Diseases 2018 18:261

    Content type: Research article

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  35. Tuberculosis is among the top ten cause of death (9th) from a single infectious agent worldwide. It even ranks above HIV/AIDS. It is among the top 10 causes of death among children. Globally there are estimate...

    Authors: Bereket Gebremichael, Tsega-Ab Abebaw, Tsedey Moges, Admas Abera Abaerei and Nadia Worede

    Citation: BMC Infectious Diseases 2018 18:252

    Content type: Research article

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  36. Ethiopia is one of the world health organization defined higher tuberculosis (TB) burden countries where the disease remains a massive public health threat. This study aimed to identify the prevalence and asso...

    Authors: Biresaw Demile, Amare Zenebu, Haile Shewaye, Siqing Xia and Awoke Guadie

    Citation: BMC Infectious Diseases 2018 18:249

    Content type: Research article

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  37. Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) i...

    Authors: Song Yee Kim, Jungho Kim, Deok Ryun Kim, Young Ae Kang, Sungyoung Bong, Jonghee Lee, Suyeon Kim, Nam Suk Lee, Bora Sim, Sang-Nae Cho, Young Sam Kim and Hyejon Lee

    Citation: BMC Infectious Diseases 2018 18:240

    Content type: Research article

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  38. Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral...

    Authors: Megan E. Gray, Peter W. Liu and Brian Wispelwey

    Citation: BMC Infectious Diseases 2018 18:235

    Content type: Case report

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  39. With the widespread use of rifampicin and isoniazid, bacterial resistance has become a growing problem. Additionally, the lack of relevant baseline information for the frequency of drug-resistant tuberculosis ...

    Authors: Ming-Jin Zhang, Wen-Zhi Ren, Xue-Juan Sun, Yang Liu, Ke-Wei Liu, Zhong-Hao Ji, Wei Gao and Bao Yuan

    Citation: BMC Infectious Diseases 2018 18:234

    Content type: Research article

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  40. Mycobacterium arupense, first identified in 2006, is a slow-growing nontuberculous mycobacterium (NTM) and an emerging cause of tenosynovitis, potentially associated with immunosuppression. However, unlike the di...

    Authors: Xian Zhou, Qiaoling Ruan, Weimin Jiang, Xinyu Wang, Yuan Jiang, Shenglei Yu, Yu Xu, Jing Li, Yangyi Zhang, Wenhong Zhang and Yuekai Hu

    Citation: BMC Infectious Diseases 2018 18:221

    Content type: Case report

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  41. Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Severa...

    Authors: Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J. Ellner, Yukari C. Manabe and Padmini Salgame

    Citation: BMC Infectious Diseases 2018 18:220

    Content type: Research article

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  42. TB outbreaking in schools is extremely complex, and presents a major challenge for public health. Understanding the knowledge, attitudes and practices among student TB patients in such settings is fundamental ...

    Authors: Yahui Fan, Shaoru Zhang, Yan Li, Yuelu Li, Tianhua Zhang, Weiping Liu and Hualin Jiang

    Citation: BMC Infectious Diseases 2018 18:213

    Content type: Research article

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  43. India plans to eliminate tuberculosis (TB) by 2025, and has identified screening and prevention as key activities. Household contacts (HHCs) of index TB cases are a high-risk population that would benefit from...

    Authors: Andrea DeLuca, Gauri Dhumal, Mandar Paradkar, Nishi Suryavanshi, Vidya Mave, Rewa Kohli, Shri Vijay Bala Yogendra Shivakumar, Vidula Hulyolkar, Archana Gaikwad, Ashwini Nangude, Geeta Pardeshi, Dileep Kadam and Amita Gupta

    Citation: BMC Infectious Diseases 2018 18:202

    Content type: Research article

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  44. The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to preve...

    Authors: N. Bionghi, A. Daftary, B. Maharaj, Z. Msibi, K. R. Amico, G. Friedland, C. Orrell, N. Padayatchi and M. R. O’Donnell

    Citation: BMC Infectious Diseases 2018 18:171

    Content type: Research article

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  45. Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequen...

    Authors: Audrey Forson, Awewura Kwara, Samuel Kudzawu, Michael Omari, Jacob Otu, Florian Gehre, Bouke de Jong and Martin Antonio

    Citation: BMC Infectious Diseases 2018 18:149

    Content type: Research article

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