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Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss and Eyal Oren 

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. The understanding of early events following TB exposure is limited by traditional tests that rely on detection of an immune response to infection, which is delayed, or on imaging tests with low sensitivity for...

    Authors: James S. Molton, Benjamin A. Thomas, Yan Pang, Lih Kin Khor, James Hallinan, Claire M. Naftalin, John J. Totman, David W. Townsend, Tow Keang Lim, Cynthia Bin Eng Chee, Yee Tang Wang and Nicholas I. Paton

    Citation: BMC Infectious Diseases 2019 19:83

    Content type: Research article

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  2. Understanding the explanations behind unsuccessful treatment outcomes in tuberculosis (TB) patients is important to improve treatment success. Treatment completion for TB is the mainstay of TB prevention and c...

    Authors: Madeeha Laghari, Syed Azhar Syed Sulaiman, Amer Hayat Khan and Naheed Memon

    Citation: BMC Infectious Diseases 2019 19:82

    Content type: Research article

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  3. Every year around 4 million people with tuberculosis (TB) are not detected. Thus may not get the medical care that they need and deserve from their respective health systems. Ethiopia is included in the 12 cou...

    Authors: Dawit Assefa, Feleke Belachew, Getachew Wondimagegn and Eveline Klinkenberg

    Citation: BMC Infectious Diseases 2019 19:60

    Content type: Research article

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  4. Tuberculosis (TB) remains a major public health concern on a global scale, especially in developing nations. So far, no formal guidelines are available for the diagnosis and treatment of tuberculosis pleurisy....

    Authors: Yimin Tang, Juanjuan Zhang, Huarong Huang, Xing He, Jiaohong Zhang, Min Ou, Guobao Li, Changchun Zeng, Taosheng Ye, Lili Ren, Yingxia Liu and Guoliang Zhang

    Citation: BMC Infectious Diseases 2019 19:55

    Content type: Research article

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  5. Leprosy is an ideal human disease to study T cell regulation as patients show correlation between cytokine skewed Th1-Th2 responses and clinical forms of the disease. The Role of transcription factors on the m...

    Authors: Rajni Upadhyay, Bhavyata Dua, Bhawna Sharma, Mohan Natrajan, Ajai Kumar Jain, Balaji Kithiganahalli Narayanaswamy and Beenu Joshi

    Citation: BMC Infectious Diseases 2019 19:52

    Content type: Research article

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  6. Nigeria accounts for a significant proportion of the global drug-resistant tuberculosis (DR-TB) burden, a large proportion of which goes untreated. Different models for managing DR-TB treatment with varying le...

    Authors: Florence O. Bada, Evaezi Okpokoro, Nick Blok, Emmanuel Meribole, Saswata Dutt, Patrick Dakum, Alash’le Abimiku, Alice Zwerling and Sandra V. Kik

    Citation: BMC Infectious Diseases 2019 19:41

    Content type: Research article

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  7. Bovine tuberculosis is among the primary zoonotic disease caused by Mycobacterium bovis which has significant impact on the health of livestock and human. It has been significantly a cause for great economic loss...

    Authors: Jelalu Kemal, Berhanu Sibhat, Aklilu Abraham, Yitagele Terefe, Ketema Tafess Tulu, Kiros Welay and Nejib Getahun

    Citation: BMC Infectious Diseases 2019 19:39

    Content type: Research article

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  8. Transmission patterns in high tuberculosis incidence areas in England are poorly understood but need elucidating to focus contact tracing. We study transmission within and between age, ethnic and immigrant gro...

    Authors: Emilia Vynnycky, Adrienne R. Keen, Jason T. Evans, Shaina Khanom, Peter M. Hawkey, Richard G. White and Ibrahim Abubakar

    Citation: BMC Infectious Diseases 2019 19:26

    Content type: Research article

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  9. Crohn’s disease is a chronic enteritis of humans that affects the gastrointestinal tract, especially the terminal ileum, cecum and colon. The etiology of this disease is still unknown but seems to be multifact...

    Authors: Forough Zarei-Kordshouli, Bita Geramizadeh and Azizollah Khodakaram-Tafti

    Citation: BMC Infectious Diseases 2019 19:23

    Content type: Research article

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  10. Early detection of leprosy and multidrug therapy are crucial to achieve zero transmission and zero grade II incapacities goals of World Health Organization. Leprosy is difficult to diagnose because clinical fo...

    Authors: André Luiz Leturiondo, Ariani Batista Noronha, Monik Oney Oliveira do Nascimento, Cynthia de Oliveira Ferreira, Fabíola da Costa Rodrigues, Milton Ozório Moraes and Carolina Talhari

    Citation: BMC Infectious Diseases 2019 19:22

    Content type: Research article

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  11. The GeneXpert MTB/RIF Assay (Xpert®) is known to be a feasible, effective and a hopeful tool for rapid tuberculosis (TB) diagnosis and treatment. However, little is known about the time delay caused by initial...

    Authors: Miguelhete Lisboa, Inês Fronteira, Estefano Colove, Marques Nhamonga and Maria do Rosário O. Martins

    Citation: BMC Infectious Diseases 2019 19:18

    Content type: Research article

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  12. Subclinical tuberculosis is an asymptomatic disease phase with important relevance to persons living with HIV. We describe the prevalence, clinical characteristics, and risk of mortality for HIV-infected adult...

    Authors: Kristina L. Bajema, Ingrid V. Bassett, Sharon M. Coleman, Douglas Ross, Kenneth A. Freedberg, Anna Wald and Paul K. Drain

    Citation: BMC Infectious Diseases 2019 19:14

    Content type: Research article

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  13. Making an accurate prognosis for mortality during tuberculosis (TB) treatment in TB-diabetes (TB-DM) comorbid patients remains a challenge for health professionals, especially in low TB prevalent populations, ...

    Authors: Duc T. Nguyen and Edward A. Graviss

    Citation: BMC Infectious Diseases 2019 19:10

    Content type: Research article

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  14. To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality.

    Authors: Jaime Soria, Tatiana Metcalf, Nicanor Mori, Renee E. Newby, Silvia M. Montano, Luz Huaroto, Eduardo Ticona and Joseph R. Zunt

    Citation: BMC Infectious Diseases 2019 19:9

    Content type: Research article

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  15. Accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis in clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and management of multidrug-resistant tuberculosis ...

    Authors: Noura M. Al-Mutairi, Suhail Ahmad, Eiman Mokaddas, Hanaa S. Eldeen and Susan Joseph

    Citation: BMC Infectious Diseases 2019 19:3

    Content type: Research article

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  16. Lebanon hosts a heterogeneous population coming from underdeveloped and developing countries, resulting in increasing incidences of tuberculosis over the past years. The genetic heterogeneity and lineages asso...

    Authors: Balig Panossian, Tamara Salloum, George F. Araj, Georges Khazen and Sima Tokajian

    Citation: BMC Infectious Diseases 2018 18:710

    Content type: Research article

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  17. Abdominal tuberculosis (TB) is an uncommon form of infection with Mycobacterium tuberculosis in Korea. In this study, we aimed to highlight the clinical features, diagnostic methods, and outcomes of abdominal TB ...

    Authors: Jin-Kyu Cho, Young Min Choi, Sang Soo Lee, Hye Kyong Park, Ra Ri Cha, Wan Soo Kim, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok Jae Lee

    Citation: BMC Infectious Diseases 2018 18:699

    Content type: Research article

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  18. Prompt diagnosis of active tuberculosis (TB) has paramount importance to reduce TB morbidity and mortality and to prevent the spread of Mycobacterium tuberculosis. Few studies so far have assessed the diagnostic ...

    Authors: Anna Maria Peri, Davide Paolo Bernasconi, Nadia Galizzi, Alberto Matteelli, Luigi Codecasa, Vincenza Giorgio, Antonio Di Biagio, Fabio Franzetti, Antonella Cingolani, Andrea Gori and Giuseppe Lapadula

    Citation: BMC Infectious Diseases 2018 18:690

    Content type: Research article

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  19. Contact tracing for tuberculosis (TB) is a recommended measure to improve the case detection rate; however, actual implementation in Myanmar is limited and low detection rates have been reported. Household con...

    Authors: Kyaw Ko Ko Htet, Tippawan Liabsuetrakul, Saw Thein, Edward B. McNeil and Virasakdi Chongsuvivatwong

    Citation: BMC Infectious Diseases 2018 18:660

    Content type: Research article

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  20. Nontuberculous mycobacteria (NTM) lung diseases are increasingly recognized as chronic opportunistic infections, occurring in individuals with a wide variety of underlying conditions. In the absence of systemi...

    Authors: Judith Provoost, Florent Valour, Delphine Gamondes, Sandrine Roux, Nathalie Freymond, Emilie Perrot, Pierre-Jean Souquet, Lize Kiakouama-Maleka, Christian Chidiac, Gérard Lina, Oana Dumitrescu, Agathe Sénéchal and Florence Ader

    Citation: BMC Infectious Diseases 2018 18:659

    Content type: Research article

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  21. The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the associ...

    Authors: Yi Liu, Xuxia Zhang, Yuqing Zhang, Yong Sun, Cong Yao, Wei Wang and Chuanyou Li

    Citation: BMC Infectious Diseases 2018 18:658

    Content type: Research article

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  22. This study investigated the treatment outcomes, and factors affecting the outcomes, of new tuberculosis (TB) patients in Busan, South Korea.

    Authors: Jeongha Mok, Daeseong An, Seoungjin Kim, Miyoung Lee, Changhoon Kim and Hyunjin Son

    Citation: BMC Infectious Diseases 2018 18:655

    Content type: Research article

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  23. Tuberculosis (TB) caused an estimated 1.4 million deaths and 10.4 million new cases globally in 2015. TB rates in the United States continue to steadily decline, yet rates in the State of Hawaii are perenniall...

    Authors: Kent J. Koster, Angela Largen, Jeffrey T. Foster, Kevin P. Drees, Lishi Qian, Ed Desmond, Xuehua Wan, Shaobin Hou and James T. Douglas

    Citation: BMC Infectious Diseases 2018 18:608

    Content type: Research article

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  24. Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of ...

    Authors: N. B. Hoa, P. D. Phuc, N. T. Hien, V. Q. Hoa, P. H. Thuong, P. T. Anh and N. V. Nhung

    Citation: BMC Infectious Diseases 2018 18:603

    Content type: Research article

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  25. Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of non-c...

    Authors: Yvette Louise Schein, Tesfaye Madebo, Hilde Elise Andersen, Trude Margrete Arnesen, Anne Ma Dyrhol-Riise, Hallgeir Tveiten, Richard A. White and Brita Askeland Winje

    Citation: BMC Infectious Diseases 2018 18:587

    Content type: Research article

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  26. In developing countries, tuberculosis (TB) is a major public health problem and the leading cause of death among patients with HIV (Human Immunodeficiency Virus). Until 2001, the tuberculin skin test (TST) was...

    Authors: Giselle Burlamaqui Klautau, Nadijane Valéria Ferreira da Mota, Mauro José Costa Salles, Marcelo Nascimento Burattini and Denise Silva Rodrigues

    Citation: BMC Infectious Diseases 2018 18:585

    Content type: Research article

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  27. Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages...

    Authors: Jorge Rodrigues de Sousa, Francisco Dias Lucena Neto, Mirian Nacagami Sotto and Juarez Antonio Simões Quaresma

    Citation: BMC Infectious Diseases 2018 18:576

    Content type: Research article

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  28. The enteric string test can be used to obtain a specimen for microbiological confirmation of tuberculosis in children, but it is not widely used for this. The aim of this analysis to evaluate this approach in ...

    Authors: Karla T. Tafur, Julia Coit, Segundo R. Leon, Cynthia Pinedo, Silvia S. Chiang, Carmen Contreras, Roger Calderon, Milagros J. Mendoza, Leonid Lecca and Molly F. Franke

    Citation: BMC Infectious Diseases 2018 18:574

    Content type: Research article

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  29. By 2014 although tuberculosis (TB) incidence had fallen by an average of 1.5% per year since 2000 and was 18% lower than the level of in 2000, 1.5 million people died for TB in that year. One of reason was tha...

    Authors: Tao Shi, Tongxin Li, Jungang Li, Jing Wang and Zehua Zhang

    Citation: BMC Infectious Diseases 2018 18:565

    Content type: Research article

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  30. Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine w...

    Authors: Ming-Gui Wang, Miao-Miao Zhang, Yu Wang, Shou-Quan Wu, Meng Zhang and Jian-Qing He

    Citation: BMC Infectious Diseases 2018 18:561

    Content type: Research article

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  31. Globally recommended measures for comprehensive tuberculosis (TB) infection control (IC) are inadequately practiced in most health care facilities in Ethiopia. The aim of this study was to assess the extent of...

    Authors: Asfaw Ayalew, Zewdu Gashu, Tadesse Anteneh, Nebiyu Hiruy, Dereje Habte, Degu Jerene, Genetu Alem, Ilili Jemal, Muluken Melese and Pedro G. Suarez

    Citation: BMC Infectious Diseases 2018 18:557

    Content type: Research article

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  32. China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review ...

    Authors: Yun Qian, Qixin Han, Wenjun Liu, Wei-En Yuan and Cunyi Fan

    Citation: BMC Infectious Diseases 2018 18:543

    Content type: Research article

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  33. The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains un...

    Authors: Che-Liang Chung, Yen-Fu Chen, Yen-Ting Lin, Jann-Yuan Wang, Shuenn-Wen Kuo and Jin-Shing Chen

    Citation: BMC Infectious Diseases 2018 18:530

    Content type: Research article

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  34. The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve ...

    Authors: Alireza Neshani, Reza Kamali Kakhki, Mojtaba Sankian, Hosna Zare, Amin Hooshyar Chichaklu, Mahsa Sayyadi and Kiarash Ghazvini

    Citation: BMC Infectious Diseases 2018 18:517

    Content type: Research article

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  35. Early diagnosis of tuberculosis (TB) and involvement of the public-private partnership are critical to eradicate TB. Patients need to receive proper treatment through the National Tuberculosis Control Programm...

    Authors: K. A. T. M. Ehsanul Huq, Michiko Moriyama, Khalequ Zaman, Mohammod Jobayer Chisti, Julie Long, Akramul Islam, Shahed Hossain, Habiba Shirin, Mohammad Jyoti Raihan, Sajeda Chowdhury and Md Moshiur Rahman

    Citation: BMC Infectious Diseases 2018 18:515

    Content type: Research article

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  36. The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-expo...

    Authors: Liesbeth F Mieras, Anna T Taal, Wim H van Brakel, Emmanuelle Cambau, Paul R Saunderson, W Cairns S Smith, Cita Rosita S Prakoeswa, Linda Astari, David M Scollard, Dejair Caitano do Nascimento, Jacques Grosset, Hemanta K Kar, Shinzo Izumi, Laura Gillini, Marcos C L Virmond and Marieke G G Sturkenboom

    Citation: BMC Infectious Diseases 2018 18:506

    Content type: Debate

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  37. The depletion of CD4 cell is the underlying reason for TB hyper-susceptibility among people with HIV. Consequently, the trend of TB dynamics is usually hidden by the HIV outbreak.

    Authors: Dao Nguyen Vinh, Dang Thi Minh Ha, Nguyen Thi Hanh, Guy Thwaites, Maciej F. Boni, Hannah E. Clapham and Nguyen Thuy Thuong Thuong

    Citation: BMC Infectious Diseases 2018 18:494

    Content type: Research article

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  38. An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not cle...

    Authors: Bronwyn Myers, Tara C Bouton, Elizabeth J Ragan, Laura F White, Helen McIlleron, Danie Theron, Charles D H Parry, C Robert Horsburgh, Robin M Warren and Karen R Jacobson

    Citation: BMC Infectious Diseases 2018 18:488

    Content type: Study protocol

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  39. The programmatic management of Multidrug-resistant tuberculosis (MDR-TB) is entirely based on a WHO recommended long-term, 18–24 month lasting treatment regimen. However, growing evidence shows that low treatm...

    Authors: Setegn Eshetie, Animut Alebel, Fasil Wagnew, Demeke Geremew, Alebachew Fasil and Ulrich Sack

    Citation: BMC Infectious Diseases 2018 18:486

    Content type: Research article

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  40. HIV is a major driver of the tuberculosis epidemic in sub-Saharan Africa. The population-level impact of antiretroviral therapy (ART) scale-up on tuberculosis rates in this region has not been well studied. We...

    Authors: Diya Surie, Martien W. Borgdorff, Kevin P. Cain, Eleanor S. Click, Kevin M. DeCock and Courtney M. Yuen

    Citation: BMC Infectious Diseases 2018 18:481

    Content type: Research article

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  41. Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of ...

    Authors: Youn Jeong Kim, Ji Young Kang, Sang Il Kim, Mee Soo Chang, Yang Ree Kim and Yeon Joon Park

    Citation: BMC Infectious Diseases 2018 18:457

    Content type: Research article

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  42. It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of periphera...

    Authors: Liping Yan, Hongbo Shen and Heping Xiao

    Citation: BMC Infectious Diseases 2018 18:453

    Content type: Research article

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  43. Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycob...

    Authors: Jie Shi, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li and Jin Xing

    Citation: BMC Infectious Diseases 2018 18:447

    Content type: Research article

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  44. Multidrug resistant-tuberculosis (MDR-TB) is a major global health concern. Its treatment requires toxic medications, is longer and costlier than drug-susceptible TB, and often results in productivity losses a...

    Authors: Lisa Kawatsu, Kazuhiro Uchimura, Kiyohiko Izumi, Akihiro Ohkado and Takashi Yoshiyama

    Citation: BMC Infectious Diseases 2018 18:445

    Content type: Research article

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  45. Tuberculosis (TB), especially extrapulmonary tuberculosis (EPTB), is an important cause of fever of unknown origin (FUO) in TB-burdened areas. Little information is known about patients with EPTB with clinical...

    Authors: Jeong-Han Kim, Eu Suk Kim, Kang-Il Jun, Hyun gul Jung, Ji Hwan Bang, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh and Sang-Won Park

    Citation: BMC Infectious Diseases 2018 18:426

    Content type: Research article

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  46. The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions ha...

    Authors: Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci and Milton Ozório Moraes

    Citation: BMC Infectious Diseases 2018 18:422

    Content type: Research article

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