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Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss and Eyal Oren 

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Content type: Research article

    Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens. The aim of this study was to investigate the prevalence and molecu...

    Authors: Yu Pang, Damian Zhu, Huiwen Zheng, Jing Shen, Yan Hu, Jie Liu and Yanlin Zhao

    Citation: BMC Infectious Diseases 2017 17:711

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  2. Content type: Research article

    Forkhead box protein 3 (FoxP3) is an important factor for development and function of Regulatory T cells (Treg). Studies have found an association between common gene polymorphisms in FoxP3 and some infectious di...

    Authors: Elham Beiranvand, Saeid Abediankenari, Soghra Khani, Hamideh Mahmoodzadeh Hosseini, Sirous Zeinali, Behnoush Beiranvand, Mehdi Goudarzi and Sima Sadat Seyedjavadi

    Citation: BMC Infectious Diseases 2017 17:673

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  3. Content type: Commentary

    A recently published Ugandan study on tuberculosis (TB) diagnosis in HIV-positive patients with presumptive smear-negative TB, which showed that out of 90 patients who started TB treatment, 20% (18/90) had a p...

    Authors: Tom Decroo, Aquiles R. Henríquez-Trujillo, Anja De Weggheleire and Lutgarde Lynen

    Citation: BMC Infectious Diseases 2017 17:674

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  4. Content type: Research article

    Reported tuberculosis (TB) incidence globally continues to be heavily influenced by expert opinion of case detection rates and ecological estimates of disease duration. Both approaches are recognised as having...

    Authors: Debebe Shaweno, James M. Trauer, Justin T. Denholm and Emma S. McBryde

    Citation: BMC Infectious Diseases 2017 17:662

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  5. Content type: Technical advance

    Maintaining the quality of clinical specimens for tuberculosis (TB) testing is a major challenge in many high TB burden-limited resources countries. Sample referral systems in low and middle income countries a...

    Authors: Elisa Tagliani, Riccardo Alagna, Silva Tafaj, Hasan Hafizi and Daniela Maria Cirillo

    Citation: BMC Infectious Diseases 2017 17:663

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  6. Content type: Research article

    Interim treatment outcomes at 6-months for multidrug-resistant tuberculosis (MDR-TB) treatment are among the most basic performance monitoring and key evaluation indicators in the Stop and End TB strategy of t...

    Authors: Muhammad Atif, Arslan Bashir, Nafees Ahmad, Razia Kaneez Fatima, Sehar Saba and Shane Scahill

    Citation: BMC Infectious Diseases 2017 17:655

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  7. Content type: Research article

    Since the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literatu...

    Authors: Sepiso K. Masenga, Harrison Mubila and Benson M. Hamooya

    Citation: BMC Infectious Diseases 2017 17:640

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  8. Content type: Research article

    Sub-Saharan Africa continues to document high pediatric tuberculosis (TB) burden, especially among the urban poor. One recommended preventive strategy involves tracking and isoniazid preventive therapy (IPT) f...

    Authors: Florence Nafula Okwara, John Paul Oyore, Fred Nabwire Were and Samson Gwer

    Citation: BMC Infectious Diseases 2017 17:623

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  9. Content type: Research article

    The relatively simple and cheaper light-emitting diode fluorescent microscopy (LED-FM) was recommended by the World Health Organization (WHO) to replace the conventional tuberculosis (TB) microscopy in both hi...

    Authors: Alemu Gadissa Gelalcha, Abebaw Kebede and Hassen Mamo

    Citation: BMC Infectious Diseases 2017 17:613

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  10. Content type: Research article

    Concurrent diabetes mellitus and tuberculosis represent a significant health problem worldwide. Patients with diabetes mellitus have a high risk of tuberculosis, which may be mediated by an abnormal innate imm...

    Authors: María Teresa Herrera, Yolanda Gonzalez, Fernando Hernández-Sánchez, Guadalupe Fabián-San Miguel and Martha Torres

    Citation: BMC Infectious Diseases 2017 17:610

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  11. Content type: Research article

    Every year, over 1 million people develop isoniazid (INH) resistant tuberculosis (TB). Yet, the optimal treatment regimen remains unclear. Given increasing prevalence, the clinical efficacy of regimens used by...

    Authors: Kamila Romanowski, Leslie Y. Chiang, David Z. Roth, Mel Krajden, Patrick Tang, Victoria J. Cook and James C. Johnston

    Citation: BMC Infectious Diseases 2017 17:604

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  12. Content type: Research article

    In the search for fast, simple and better ways for diagnosis of tuberculosis (TB), there is need to discover and evaluate new biomarkers that are found in samples other than sputum to determine their effective...

    Authors: Anna Ritah Namuganga, Novel N. Chegou, Paul Mubiri, Gerhard Walzl and Harriet Mayanja-Kizza

    Citation: BMC Infectious Diseases 2017 17:600

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  13. Content type: Research article

    The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child household contacts...

    Authors: Vera Golla, Kathryn Snow, Anna M. Mandalakas, H. Simon Schaaf, Karen Du Preez, Anneke C. Hesseling and James A. Seddon

    Citation: BMC Infectious Diseases 2017 17:593

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    The Correction to this article has been published in BMC Infectious Diseases 2017 17:713

  14. Content type: Research article

    Globally, almost 40% of tuberculosis (TB) patients remain undiagnosed, and those that are diagnosed often experience prolonged delays before initiating correct treatment, leading to ongoing transmission. While...

    Authors: Richard James, Keovathanak Khim, Lydia Boudarene, Joanne Yoong, Chea Phalla, Saly Saint, Pichenda Koeut, Tan Eang Mao, Richard Coker and Mishal Sameer Khan

    Citation: BMC Infectious Diseases 2017 17:580

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  15. Content type: Research article

    Emergence of Multidrug-resistant (MDR) strains constitutes a significant public health problem worldwide. Prevalence of MDR tuberculosis from Chad is unavailable to date.

    Authors: Awa Ba Diallo, Gedeon W. Ossoga, Geraldine Daneau, Seynabou Lo, Richard Ngandolo, Colette Diguimbaye Djaibé, Barou Djouater, Souleymane Mboup, Bouke C. de Jong, Aissatou G. Diallo and Florian Gehre

    Citation: BMC Infectious Diseases 2017 17:579

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  16. Content type: Research article

    Although the incidence of tuberculosis (TB) in most parts of China are well under control now, in less developed areas such as Qinghai, TB still remains a major public health problem. This study aims to reveal...

    Authors: Huaxiang Rao, Xinyu Shi and Xi Zhang

    Citation: BMC Infectious Diseases 2017 17:578

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  17. Content type: Research article

    In household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversio...

    Authors: Edward C. Jones-López, Carlos Acuña-Villaorduña, Geisa Fregona, Patricia Marques-Rodrigues, Laura F. White, David Jamil Hadad, Lucilia Pereira Dutra-Molina, Solange Vinhas, Avery I. McIntosh, Mary Gaeddert, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J. Ellner and Reynaldo Dietze

    Citation: BMC Infectious Diseases 2017 17:576

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  18. Content type: Research article

    The worldwide emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has posed additional challenges for global tuberculosis (TB) control efforts, as limite...

    Authors: Kefyalew Addis Alene, Hengzhong Yi, Kerri Viney, Emma S. McBryde, Kunyun Yang, Liqiong Bai, Darren J. Gray, Archie C. A. Clements and Zuhui Xu

    Citation: BMC Infectious Diseases 2017 17:573

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  19. Content type: Research article

    The implementation of rapid drug susceptibility testing (DST) is a current global priority for TB control. However, data are scarce on patient-relevant outcomes for presumptive diagnosis of drug-resistant tube...

    Authors: D. M. P. Ramalho, P. F. C. Miranda, M. K. Andrade, T. Brígido, M. P. Dalcolmo, E. Mesquita, C. F. Dias, A. N. Gambirasio, J. Ueleres Braga, A. Detjen, P. P. J. Phillips, I. Langley, P. I. Fujiwara, S. B. Squire, M. M. Oliveira and A. L. Kritski

    Citation: BMC Infectious Diseases 2017 17:571

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  20. Content type: Research article

    Reducing delay to accessing care is necessary to reduce the Tuberculosis (TB) burden in high incidence countries such as India. This study aimed to identify factors associated with delays in seeking care for T...

    Authors: Sarah E. Van Ness, Ankit Chandra, Sonali Sarkar, Jane Pleskunas, Jerrold J. Ellner, Gautam Roy, Subitha Lakshminarayanan, Swaroop Sahu, C. Robert Horsburgh Jr, Helen E. Jenkins and Natasha S. Hochberg

    Citation: BMC Infectious Diseases 2017 17:567

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  21. Content type: Research article

    The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk...

    Authors: Lauren Philips, Janicke Visser, Daan Nel and Renée Blaauw

    Citation: BMC Infectious Diseases 2017 17:570

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  22. Content type: Research article

    Tuberculosis (TB) remains a public health problem in Madagascar. A crucial element of TB control is the development of an easy and rapid method for the orientation of TB control strategies in the country. Our ...

    Authors: Noël Harijaona Ratovonirina, Niaina Rakotosamimanana, Solohery Lalaina Razafimahatratra, Mamy Serge Raherison, Guislaine Refrégier, Christophe Sola, Fanjasoa Rakotomanana and Voahangy Rasolofo Razanamparany

    Citation: BMC Infectious Diseases 2017 17:562

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  23. Content type: Research article

    In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, ...

    Authors: Kazuma Yagi, Makoto Ishii, Ho Namkoong, Takahiro Asami, Osamu Iketani, Takanori Asakura, Shoji Suzuki, Hiroaki Sugiura, Yoshitake Yamada, Tomoyasu Nishimura, Hiroshi Fujiwara, Yohei Funatsu, Yoshifumi Uwamino, Tetsuro Kamo, Sadatomo Tasaka, Tomoko Betsuyaku…

    Citation: BMC Infectious Diseases 2017 17:558

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  24. Content type: Research article

    Extensively Drug-Resistant (XDR) Tuberculosis (TB) has posed a great threat to global health and finance systems, especially for developing countries with high TB and Multidrug-Resistant (MDR) TB burden.

    Authors: Xiao-chun He, Ning-ning Tao, Yao Liu, Xian-xin Zhang and Huai-chen Li

    Citation: BMC Infectious Diseases 2017 17:555

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  25. Content type: Research article

    Health workers (HWs) in resource-limited settings are at high-risk of exposure to tuberculosis (TB) at work. The aim of this study was to estimate the rate of TB disease among HWs in the Free State Province of...

    Authors: Lyndsay M. O’Hara, Annalee Yassi, Muzimkhulu Zungu, Molebogeng Malotle, Elizabeth A. Bryce, Stephen J. Barker, Lincoln Darwin and J. Mark FitzGerald

    Citation: BMC Infectious Diseases 2017 17:547

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  26. Content type: Software

    Tuberculosis (TB) is now the world’s leading infectious killer and major programmatic advances will be needed if we are to meet the ambitious new End TB Targets. Although mathematical models are powerful tools...

    Authors: James McCracken Trauer, Romain Ragonnet, Tan Nhut Doan and Emma Sue McBryde

    Citation: BMC Infectious Diseases 2017 17:546

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  27. Content type: Research article

    Rapid diagnosis of drug resistance in tuberculosis (TB) is pivotal for the timely initiation of effective antibiotic treatment to prevent the spread of drug-resistant strains. The development of low-cost, rapi...

    Authors: El Mehdi Bentaleb, My Driss El Messaoudi, Mohammed Abid, Malika Messaoudi, Ali K. Yetisen, Hassan Sefrioui, Saaïd Amzazi and Hassan Ait Benhassou

    Citation: BMC Infectious Diseases 2017 17:548

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  28. Content type: Research article

    Since 20% of pulmonary tuberculosis (PTB) patients are asymptomatic, the early detection of PTB is a challenge particularly in sputum-scarce patients and diagnostic accuracy based solely on clinical characteri...

    Authors: Liping Yan, Qing Zhang and Heping Xiao

    Citation: BMC Infectious Diseases 2017 17:545

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  29. Content type: Research article

    Culture contamination with environmental bacteria is a major challenge in tuberculosis (TB) laboratories in hot and humid climate zones. We studied the effect of cetylpyridinium chloride (CPC) preservation on ...

    Authors: Hellen Hiza, Basra Doulla, Mohamed Sasamalo, Jerry Hella, Lujeko Kamwela, Francis Mhimbira, Klaus Reither, Sebastien Gagneux, Levan Jugheli and Lukas Fenner

    Citation: BMC Infectious Diseases 2017 17:542

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  30. Content type: Research article

    There are very few studies on reasons for loss to follow-up from TB treatment in Central Asia. This study assessed risk factors for LTFU and compared their occurrence with successfully treated (ST) patients in...

    Authors: Jessica Wohlleben, Mavluda Makhmudova, Firuza Saidova, Shahnoza Azamova, Christina Mergenthaler and Suzanne Verver

    Citation: BMC Infectious Diseases 2017 17:543

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  31. Content type: Research article

    The Bacillus Calmette-Guérin vaccine (BCG) against tuberculosis is administered intradermally, and vaccination is often followed by a scar at the injection site. Among BCG-vaccinated individuals, having a scar...

    Authors: Nina Marie Birk, Thomas Nørrelykke Nissen, Monica Ladekarl, Vera Zingmark, Jesper Kjærgaard, Trine Mølbæk Jensen, Signe Kjeldgaard Jensen, Lisbeth Marianne Thøstesen, Poul-Erik Kofoed, Lone Graff Stensballe, Andreas Andersen, Ole Pryds, Susanne Dam Nielsen, Christine Stabell Benn and Dorthe Lisbeth Jeppesen

    Citation: BMC Infectious Diseases 2017 17:540

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  32. Content type: Research article

    Understanding the immune response to combination antiretroviral therapy (cART) is essential for a clear approach to tuberculosis (TB) preventive therapy. We investigated the immunological recovery in cART-trea...

    Authors: Basel Karo, Gérard Krause, Stefanie Castell, Christian Kollan, Osamah Hamouda and Walter Haas

    Citation: BMC Infectious Diseases 2017 17:517

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  33. Content type: Research article

    Stigma associated with tuberculosis (TB) has been an object of interest in several regions of the world. The behaviour presented by patients as a result of social discrimination has contributed to delays in di...

    Authors: Juliane de Almeida Crispim, Laís Mara Caetano da Silva, Mellina Yamamura, Marcela Paschoal Popolin, Antônio Carlos Vieira Ramos, Luiz Henrique Arroyo, Ana Angélica Rêgo de Queiroz, Aylana de Souza Belchior, Danielle Talita dos Santos, Flávia Meneguetti Pieri, Ludmila Barbosa Bandeira Rodrigues, Simone Terezinha Protti, Ione Carvalho Pinto, Pedro Fredemir Palha and Ricardo Alexandre Arcêncio

    Citation: BMC Infectious Diseases 2017 17:510

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  34. Content type: Research article

    The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is current...

    Authors: Sarah Sengstake, Indra L Bergval, Anja R Schuitema, Jessica L de Beer, Jody Phelan, Rina de Zwaan, Taane G Clark, Dick van Soolingen and Richard M Anthony

    Citation: BMC Infectious Diseases 2017 17:491

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  35. Content type: Research article

    Gene polymorphisms impact greatly on a person’s susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recogn...

    Authors: Wenting Lao, Hui Kang, Guojiang Jin, Li Chen, Yang Chu, Jiao Sun and Bingqi Sun

    Citation: BMC Infectious Diseases 2017 17:488

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  36. Content type: Research article

    Studies focusing on pulmonary tuberculosis in advanced age (≥80 years) are lacking. This study aimed to explore treatment delay, outcomes and their predictors in this group.

    Authors: Chih-Hsin Lee, Jann-Yuan Wang, Hsien-Chun Lin, Pai-Yang Lin, Jer-Hwa Chang, Chi-Won Suk, Li-Na Lee, Chou-Chin Lan and Kuan-Jen Bai

    Citation: BMC Infectious Diseases 2017 17:449

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  37. Content type: Study protocol

    Shortening the standard 6-month treatment for drug-susceptible pulmonary tuberculosis (DS-PTB) would be a major improvement for TB case management and disease control.

    Authors: Mengqiu Gao, Jingtao Gao, Jian Du, Yuhong Liu, Yao Zhang, Liping Ma, Fengling Mi, Liang Li and Shenjie Tang

    Citation: BMC Infectious Diseases 2017 17:435

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  38. Content type: Research article

    Patients with Mycobacterium avium complex (MAC) lung disease (LD) have a heterogeneous prognosis. This study aimed to develop and validate a prognostic scoring model for these patients using independent risk fact...

    Authors: Shogo Kumagai, Akihiro Ito, Toru Hashimoto, Satoshi Marumo, Hironobu Tokumasu, Aya Kotani, Haruka Yamaki, Masahiro Shirata, Koji Furuuchi, Motonari Fukui and Tadashi Ishida

    Citation: BMC Infectious Diseases 2017 17:436

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  39. Content type: Research article

    The incidence of nontuberculous mycobacteria (NTM) infections is increasing worldwide, however formal evaluations of the epidemiology of NTM infections are limited. Understanding the trends and true prevalence...

    Authors: Hee Jung Yoon, Hwa Young Choi and Moran Ki

    Citation: BMC Infectious Diseases 2017 17:432

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  40. Content type: Research article

    Residents in long-term care facilities (LTCFs) are vulnerable to tuberculosis (TB) transmission; however, to delineate possible routes of TB transmission in LTCFs is difficult. This study aimed to address the ...

    Authors: Wen-Cheng Chao, Pei-Chun Chuang, Don-Han Wu, Chieh-Liang Wu, Po-Yu Liu, Chi-Chang Shieh and Ruwen Jou

    Citation: BMC Infectious Diseases 2017 17:421

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  41. Content type: Case report

    Extensively drug-resistant (XDR) tuberculosis (TB) and multidrug resistant (MDR)-TB with additional resistance to injectable agents or fluoroquinolones are challenging to treat due to lack of available, effect...

    Authors: Aravind Swaminathan, Philipp du Cros, James A. Seddon, Shamsiya Mirgayosieva, Rajabov Asladdin and Zulfiya Dusmatova

    Citation: BMC Infectious Diseases 2017 17:417

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  42. Content type: Research article

    Genitourinary tuberculosis is the third most common form of extrapulmonary tuberculosis. Diagnosis is difficult because of unspecific clinical manifestations and low accuracy of conventional tests. Unfortunate...

    Authors: Carlos Altez-Fernandez, Victor Ortiz, Majid Mirzazadeh, Luis Zegarra, Carlos Seas and Cesar Ugarte-Gil

    Citation: BMC Infectious Diseases 2017 17:390

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  43. Content type: Research article

    Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is ...

    Authors: Vidya Mave, Smita Nimkar, Haridas Prasad, Dileep Kadam, Sushant Meshram, Rahul Lokhande, Nikhil Gupte, Divyashri Jain, Amita Gupta and Jonathan E. Golub

    Citation: BMC Infectious Diseases 2017 17:388

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  44. Content type: Research article

    Drug-resistant tuberculosis, especially multidrug-resistant tuberculosis (MDR-TB), is a major public health problem. Effective management of MDR-TB relies on accurate and rapid diagnosis. In this study, we ass...

    Authors: Ngu Njei Abanda, Josiane Yvonne Djieugoué, Eunjung Lim, Eric Walter Pefura-Yone, Wilfred Fon Mbacham, Guy Vernet, Veronique Mbeng Penlap, Sara Irene Eyangoh, Diane Wallace Taylor and Rose Gana Fomban Leke

    Citation: BMC Infectious Diseases 2017 17:379

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  45. Content type: Research article

    Harris County, Texas is the third most populous county in the United States and consistently has tuberculosis rates above the national average. Understanding jurisdictional epidemiologic characteristics for th...

    Authors: Saroochi Agarwal, Duc T. Nguyen, Larry D. Teeter and Edward A. Graviss

    Citation: BMC Infectious Diseases 2017 17:378

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  46. Content type: Correspondence

    Multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) represent an important challenge for global tuberculosis (TB) control. The high rates of MDR/RR-TB observed among re-treatment cases can ar...

    Authors: Romain Ragonnet, James M. Trauer, Justin T. Denholm, Ben J. Marais and Emma S. McBryde

    Citation: BMC Infectious Diseases 2017 17:374

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  47. Content type: Research article

    Foreign-born patients with tuberculosis (TB) may introduce globally disseminated isolates of Mycobacterium tuberculosis into large cities in Japan. The risk of dissemination of these isolates into local regions, ...

    Authors: Fuminori Mizukoshi, Tohru Miyoshi-Akiyama, Hiroki Iwai, Takako Suzuki, Reiko Kiritani, Teruo Kirikae and Keiji Funatogawa

    Citation: BMC Infectious Diseases 2017 17:365

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  48. Content type: Research article

    Whereas high risk groups such as asylum seekers are systematically screened for active tuberculosis (TB) upon entry in Switzerland, this strategy does not apply to homeless persons despite a reported high risk...

    Authors: Jean-Paul Janssens, Timothee Wuillemin, Dan Adler and Yves Jackson

    Citation: BMC Infectious Diseases 2017 17:347

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  49. Content type: Research article

    Strains of the Beijing genotype of Mycobacterium tuberculosis (MTB) are reportedly associated with the virulence of tuberculosis (TB) infection, unfavorable outcomes of anti-TB treatment, and the global TB pandem...

    Authors: Jingge Zhao, Takashi Matsuba, Xiaoyan Zhang, Susan Leano, Chie Nakajima, Haorile Chagan-Yasutan, Elizabeth Freda Telan, Yasuhiko Suzuki and Toshio Hattori

    Citation: BMC Infectious Diseases 2017 17:344

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  50. Content type: Research article

    Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We therefore examined the incremental diagnostic sensit...

    Authors: Phindile Gina, Philippa J. Randall, Tapuwa E. Muchinga, Anil Pooran, Richard Meldau, Jonny G. Peter and Keertan Dheda

    Citation: BMC Infectious Diseases 2017 17:339

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