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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. The objectives of this study wer...

    Authors: Nawal Salahuddin, Farheen Ali, Zahra Hasan, Nisar Rao, Masooma Aqeel and Faisal Mahmood

    Citation: BMC Infectious Diseases 2013 13:22

    Content type: Research article

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  2. Knowledge about symptoms and transmission of tuberculosis determines health seeking behavior and helps in prevention of tuberculosis transmission in the community. Such data is useful for policy makers to form...

    Authors: Chandrashekhar T Sreeramareddy, H N Harsha Kumar and John T Arokiasamy

    Citation: BMC Infectious Diseases 2013 13:16

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2013 13:542

  3. Appropriate immune activation of T cells and macrophages is central for the control of Mycobacterium tuberculosis infections. IFN-γ stimulated responses are lowered in tuberculosis (TB), while expression of Suppr...

    Authors: Kiran I Masood, Martin E Rottenberg, Naseem Salahuddin, Muhammad Irfan, Nisar Rao, Berit Carow, Muniba Islam, Rabia Hussain and Zahra Hasan

    Citation: BMC Infectious Diseases 2013 13:13

    Content type: Research article

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  4. The pathogenesis of primary tuberculous pleurisy is a delayed-type hypersensitivity immunogenic reaction to a few mycobacterial antigens entering the pleural space rather than direct tissue destruction by myco...

    Authors: Tsutomu Shinohara, Naoki Shiota, Motohiko Kume, Norihiko Hamada, Keishi Naruse and Fumitaka Ogushi

    Citation: BMC Infectious Diseases 2013 13:12

    Content type: Case report

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  5. To describe the epidemiology and possible risk factors for the development of multidrug-resistant tuberculosis (MDR-TB) in Namibia.

    Authors: Philip M Ricks, Farai Mavhunga, Surbhi Modi, Rosalia Indongo, Abbas Zezai, Lauren A Lambert, Nick DeLuca, Jamie S Krashin, Allyn K Nakashima and Timothy H Holtz

    Citation: BMC Infectious Diseases 2012 12:385

    Content type: Research article

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  6. Pulmonary tuberculosis (TB) is a highly lethal infectious disease and early diagnosis of TB is critical for the control of disease progression. The objective of this study was to profile a panel of serum micro...

    Authors: Yuhua Qi, Lunbiao Cui, Yiyue Ge, Zhiyang Shi, Kangchen Zhao, Xiling Guo, Dandan Yang, Hao Yu, Lan Cui, Yunfeng Shan, Minghao Zhou, Hua Wang and Zuhong Lu

    Citation: BMC Infectious Diseases 2012 12:384

    Content type: Research article

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  7. False negative and indeterminate Interferon Gamma Release Assay (IGRA) results are a well documented problem. Cigarette smoking is known to increase the risk of tuberculosis (TB) and to impair Interferon-gamma...

    Authors: Martine G Aabye, Thomas Stig Hermansen, Morten Ruhwald, George PrayGod, Daniel Faurholt-Jepsen, Kidola Jeremiah, Maria Faurholt-Jepsen, Nyagosya Range, Henrik Friis, John Changalucha, Aase B Andersen and Pernille Ravn

    Citation: BMC Infectious Diseases 2012 12:379

    Content type: Research article

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  8. Tuberculosis is one of the most infectious diseases in the world. Molecular typing methods such as spoligotyping, and VNTR (variable number tandem repeats), IS6110 in the NTF region and LSP (large sequence polymo...

    Authors: Bing Lu, Ping Zhao, Binbin Liu, Haiyan Dong, Qin Yu, Xiuqin Zhao and Kanglin Wan

    Citation: BMC Infectious Diseases 2012 12:372

    Content type: Research article

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  9. The increasing problem of multi-drug-resistant (MDR) tuberculosis (TB) [ie resistant to at least isoniazid (INH) and rifampicin (RIF)] is becoming a global problem. Successful treatment outcome for MDR-TB depe...

    Authors: Halima M Said, Marleen M Kock, Nazir A Ismail, Kamaldeen Baba, Shaheed V Omar, Ayman G Osman, Anwar A Hoosen and Marthie M Ehlers

    Citation: BMC Infectious Diseases 2012 12:369

    Content type: Research article

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  10. The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore C...

    Authors: Maunank Shah, Kathryn Miele, Howard Choi, Danielle DiPietro, Maria Martins-Evora, Vincent Marsiglia and Susan Dorman

    Citation: BMC Infectious Diseases 2012 12:360

    Content type: Research article

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  11. Beijing genotype strains are the most predominant strains in China. The aim of this study was to explore risk factors and clinical phenotypes associated with infection with Beijing genotype strains among tuber...

    Authors: Yu Pang, Yuanyuan Song, Hui Xia, Yang Zhou, Bing Zhao and Yanlin Zhao

    Citation: BMC Infectious Diseases 2012 12:354

    Content type: Research article

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  12. People concentrated in congregated systems, such as prisons, are important but often neglected reservoirs for TB transmission, and threaten those in the outside community. Therefore, this study was conducted t...

    Authors: Beyene Moges, Bemnet Amare, Fanaye Asfaw, Wogahta Tesfaye, Moges Tiruneh, Yeshambel Belyhun, Andargachew Mulu and Afework Kassu

    Citation: BMC Infectious Diseases 2012 12:352

    Content type: Research article

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  13. Background rates of latent tuberculosis infection in low prevalence regions of Britain are unknown. These would be valuable data for interpreting positive IGRA results, and guiding cost-benefit analyses. The m...

    Authors: Timothy SC Hinks, Nimu Varsani, David T Godsiff, Thomas C Bull, Katherine L Nash, Lisa McLuckie, Catherine Maule, Tessa Flower and Anthony Warley

    Citation: BMC Infectious Diseases 2012 12:339

    Content type: Research article

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  15. DNA microarrays can detect tuberculosis and its multi-drug resistant form in M. tuberculosis isolates and sputum specimens with high sensitivity and specificity. However, no performance data currently exists for ...

    Authors: Zehua Zhang, Litao Li, Fei Luo, Peng Cheng, Feng Wu, Zheng Wu, Tianyong Hou, Min Zhong and Jianzhong Xu

    Citation: BMC Infectious Diseases 2012 12:303

    Content type: Research article

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  16. Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objec...

    Authors: Apostolos Sarivalasis, Jean-Pierre Zellweger, Mohamed Faouzi, Oscar Daher, Charlotte Deslarzes and Patrick Bodenmann

    Citation: BMC Infectious Diseases 2012 12:285

    Content type: Research article

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  18. Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB dis...

    Authors: Assel Terlikbayeva, Sabrina Hermosilla, Sandro Galea, Neil Schluger, Saltanat Yegeubayeva, Tleukhan Abildayev, Talgat Muminov, Farida Akiyanova, Laura Bartkowiak, Zhaksybay Zhumadilov, Almaz Sharman and Nabila El-Bassel

    Citation: BMC Infectious Diseases 2012 12:262

    Content type: Research article

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  21. In most of the world, microbiologic diagnosis of tuberculosis (TB) is limited to microscopy. Recent guidelines recommend culture-based diagnosis where feasible.

    Authors: Anne-Marie Demers, Suzanne Verver, Andrew Boulle, Robin Warren, Paul van Helden, Marcel A Behr and David Coetzee

    Citation: BMC Infectious Diseases 2012 12:218

    Content type: Research article

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  22. M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate w...

    Authors: Nelda van Soelen, Anna M Mandalakas, H Lester Kirchner, Gerhard Walzl, Harleen M S Grewal, Marc Jacobsen and Anneke C Hesseling

    Citation: BMC Infectious Diseases 2012 12:211

    Content type: Research article

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  23. The delay in initiating treatment for tuberculosis (TB) in HIV-infected individuals may lead to the development of a more severe form of the disease, with higher rates of morbidity, mortality and transmissibil...

    Authors: Isabella Coimbra, Magda Maruza, Maria de Fátima Pessoa Militão-Albuquerque, Líbia Vilela Moura, George Tadeu Nunes Diniz, Demócrito de Barros Miranda-Filho, Heloísa Ramos Lacerda, Laura Cunha Rodrigues and Ricardo Arraes de Alencar Ximenes

    Citation: BMC Infectious Diseases 2012 12:208

    Content type: Research article

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  24. Patients with end-stage renal disease (ESRD) and Mycobacterium tuberculosis infection pose a high risk of developing active TB disease. It is therefore important to detect latent TB infection (LTBI) to be able to...

    Authors: Luis Anibarro, Matilde Trigo, Diana Feijoó, Mónica Ríos, Luisa Palomares, Alberto Pena, Marta Núñez, Carlos Villaverde and África González-Fernández

    Citation: BMC Infectious Diseases 2012 12:195

    Content type: Research article

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  25. For antiretroviral therapy (ART) naive human immunodeficiency virus (HIV) infected adults suffering from tuberculosis (TB), there is uncertainty about the optimal time to initiate highly active antiretroviral ...

    Authors: Sanjeev Sinha, Rahul C Shekhar, Gurjeet Singh, Nipam Shah, Hafiz Ahmad, Narendra Kumar, Surendra K Sharma, JC Samantaray, Sanjai Ranjan, Meera Ekka, Vishnu Sreenivas and Ronald T Mitsuyasu

    Citation: BMC Infectious Diseases 2012 12:168

    Content type: Research article

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  26. Early diagnosis of tuberculosis (TB) and multidrug resistant tuberculosis (MDR TB) is important for the elimination of TB. We evaluated the microscopic observation drug susceptibility (MODS) assay as a direct ...

    Authors: Dang Thi Minh Ha, Nguyen Thi Ngoc Lan, Marcel Wolbers, Vo sy Kiet, Hoang Thi Thanh Hang, Nguyen Hong Duc, To My Huong, Vuong Minh Bach, Nguyen Thi Phuong Thao, Tran Van Quyet, Nguyen Thi Bich Tuyen, Vo Thi Ha, Nguyen Thi Nho, Dai Viet Hoa, Phan Thi Hoang Anh, Nguyen Huy Dung…

    Citation: BMC Infectious Diseases 2012 12:49

    Content type: Research article

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  27. Detection of lipoarabinomannan (LAM), a Mycobacterium tuberculosis (Mtb) cell wall antigen, is a potentially attractive diagnostic. However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing...

    Authors: Robin Wood, Kimberly Racow, Linda-Gail Bekker, Keren Middelkoop, Monica Vogt, Barry N Kreiswirth and Stephen D Lawn

    Citation: BMC Infectious Diseases 2012 12:47

    Content type: Research article

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  28. Tuberculosis (TB) is an enduring health problem worldwide and the emerging threat of multidrug resistant (MDR) TB and extensively drug resistant (XDR) TB is of particular concern. A better understanding of bio...

    Authors: Raija K Ahmed, Zoyia Rohava, Kithiganahalli N Balaji, Sven E Hoffner, Hans Gaines, Isabelle Magalhaes, Alimuddin Zumla, Alena Skrahina and Markus J Maeurer

    Citation: BMC Infectious Diseases 2012 12:41

    Content type: Research article

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  29. The emergence of drug resistance is one of the most important threats to tuberculosis control programs. This study was aimed to analyze the frequency of gene mutations associated with resistance to isoniazid (...

    Authors: Belay Tessema, Joerg Beer, Frank Emmrich, Ulrich Sack and Arne C Rodloff

    Citation: BMC Infectious Diseases 2012 12:37

    Content type: Research article

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  30. Inter-rater agreement in the interpretation of chest X-ray (CXR) films is crucial for clinical and epidemiological studies of tuberculosis. We compared the readings of CXR films used for a survey of tuberculos...

    Authors: Shinsaku Sakurada, Nguyen TL Hang, Naoki Ishizuka, Emiko Toyota, Le D Hung, Pham T Chuc, Luu T Lien, Pham H Thuong, Pham TN Bich, Naoto Keicho and Nobuyuki Kobayashi

    Citation: BMC Infectious Diseases 2012 12:31

    Content type: Research article

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  31. Confirming tuberculosis (TB) disease in suspects in resource limited settings is challenging and calls for the development of more suitable diagnostic tools. Different Mycobacterium tuberculosis (M.tb) infection ...

    Authors: Novel N Chegou, Gillian F Black, Andre G Loxton, Kim Stanley, Paulin N Essone, Michel R Klein, Shreemanta K Parida, Stefan HE Kaufmann, T Mark Doherty, Annemieke H Friggen, Kees L Franken, Tom H Ottenhoff and Gerhard Walzl

    Citation: BMC Infectious Diseases 2012 12:10

    Content type: Research article

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  32. Only 5% of the estimated global multidrug resistant TB (MDRTB) load is currently detected. Endemic Mumbai with increasing MDR would benefit from the introduction of molecular methods to detect resistance.

    Authors: Monica Prem Tolani, Desiree Therese Blossom D'souza and Nerges Furdoon Mistry

    Citation: BMC Infectious Diseases 2012 12:9

    Content type: Research article

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  33. Cardiac tuberculosis is rare and usually manifests as tuberculous pericarditis. Involvement of other part of the heart is unusual and descriptions in the pediatric literature are confined to few case reports r...

    Authors: Cantinotti M, De Gaudio M, de Martino M, Assanta N, Moschetti R, Veneruso G, Crocetti M, Murzi B, Chiappini E and Galli L

    Citation: BMC Infectious Diseases 2011 11:359

    Content type: Case report

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  34. A new DNA line probe assay (Speed-oligo Mycobacteria, Vircell) has been launched for rapid differentiation of Mycobacterium spp. from cultures. Compared to other line-probe assays, Speed-oligo Mycobacteria covers...

    Authors: Sabine Hofmann-Thiel, Laziz Turaev, Tarig Alnour, Lore Drath, Maria Müllerova and Harald Hoffmann

    Citation: BMC Infectious Diseases 2011 11:353

    Content type: Research article

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  35. Concomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series of challenges for treatment compliance for both providers and patients. We carried out this study t...

    Authors: Magda Maruza, Maria FP Militão Albuquerque, Isabella Coimbra, Líbia V Moura, Ulisses R Montarroyos, Demócrito B Miranda Filho, Heloísa R Lacerda, Laura C Rodrigues and Ricardo AA Ximenes

    Citation: BMC Infectious Diseases 2011 11:351

    Content type: Research article

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  36. Deficient serum vitamin D levels have been associated with incidence of tuberculosis (TB), and latent tuberculosis infection (LTBI). However, to our knowledge, no studies on vitamin D status and tuberculin ski...

    Authors: Alberto Arnedo-Pena, José Vicente Juan-Cerdán, Angeles Romeu-Garcia, Daniel Garcia-Ferrer, Rita Holguín-Gómez, Jesús Iborra-Millet, Concepción Herrero-Carot, María Jesús Sanchis Piñana, Juan Bellido-Blasco, José Antonio Ferrero-Vega, Lourdes Safont Adsuara, Esther Silvestre Silvestre, Noemi Meseguer Ferrer and Vicenta Rodrigo Bartual

    Citation: BMC Infectious Diseases 2011 11:349

    Content type: Research article

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  37. Caused by Mycobacterium leprae (ML), leprosy presents a strong immune-inflammatory component, whose status dictates both the clinical form of the disease and the occurrence of reactional episodes. Evidence has sh...

    Authors: Luciana Silva Rodrigues, Mariana Andrea Hacker, Ximena Illarramendi, Maria Fernanda Miguens Castelar Pinheiro, José Augusto da Costa Nery, Euzenir Nunes Sarno and Maria Cristina Vidal Pessolani

    Citation: BMC Infectious Diseases 2011 11:339

    Content type: Research article

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  38. Diseases caused by Mycobacterium tuberculosis (TB) among adult patients with hematological malignancies have rarely been investigated.

    Authors: Chien-Yuan Chen, Wang-Huei Sheng, Aristine Cheng, Woei Tsay, Shang-Yi Huang, Jih-Luh Tang, Yee-Chun Chen, Jaun-Yuan Wang, Hwei-Fang Tien and Shan-Chwen Chang

    Citation: BMC Infectious Diseases 2011 11:324

    Content type: Research article

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  39. Interferon-gamma release assays (IGRA) are more specific than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis infection. Data on sensitivity are controversial in HIV infection.

    Authors: Luigia Elzi, Ingrid Steffen, Hansjakob Furrer, Jan Fehr, Matthias Cavassini, Bernard Hirschel, Matthias Hoffmann, Enos Bernasconi, Stefano Bassetti and Manuel Battegay

    Citation: BMC Infectious Diseases 2011 11:319

    Content type: Research article

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  40. Bovine tuberculosis (BTB) is endemic in Ethiopian cattle. The aim of this study was to assess BTB prevalence at an intensive contact interface in Meskan Woreda (district) in cattle, small ruminants and suspected ...

    Authors: Rea Tschopp, Kidist Bobosha, Abraham Aseffa, Esther Schelling, Meseret Habtamu, Rahel Iwnetu, Elena Hailu, Rebuma Firdessa, Jemal Hussein, Douglas Young and Jakob Zinsstag

    Citation: BMC Infectious Diseases 2011 11:318

    Content type: Research article

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  41. Mycobacterium genavense is a rare nontuberculous mycobacteria (NTM). Human infections are mostly disseminated in the setting of the AIDS epidemic or the use of aggressive immunosuppressive treatments. M. genaven...

    Authors: Blandine Rammaert, Louis-Jean Couderc, Elisabeth Rivaud, Patrick Honderlick, David Zucman, Marie-France Mamzer, Pierre Cahen, Emmanuel Bille, Marc Lecuit, Olivier Lortholary and Emilie Catherinot

    Citation: BMC Infectious Diseases 2011 11:311

    Content type: Case report

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  42. Community-based screening for TB, combined with HIV and syphilis testing, faces a number of barriers. One significant barrier is the value that target communities place on such screening.

    Authors: Neela D Goswami, Emily Hecker, David P Holland, Susanna Naggie, Gary M Cox, Ann Mosher, Debbie Turner, Yvonne Torres, Carter Vickery, Marshall A Ahearn, Michela LM Blain, Petra Rasmussen and Jason E Stout

    Citation: BMC Infectious Diseases 2011 11:305

    Content type: Research article

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  43. Globally, China is the second place with high burden of tuberculosis (TB). To explore the characteristics of the pathogens of Mycobacterium tuberculosis (MTB) circulating in this area is helpful for understanding...

    Authors: Qiao Liu, Dandan Yang, Weiguo Xu, Jianming Wang, Bing LV, Yan Shao, Honghuan Song, Guoli Li, Haiyan Dong, Kanglin Wan and Hua Wang

    Citation: BMC Infectious Diseases 2011 11:288

    Content type: Research article

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  44. Recently, one genome-wide association study identified a susceptibility locus of rs4331426 on chromosome 18q11.2 for tuberculosis in the African population. To validate the significance of this susceptibility ...

    Authors: Yaoyao Dai, Xia Zhang, Hongqiu Pan, Shaowen Tang, Hongbing Shen and Jianming Wang

    Citation: BMC Infectious Diseases 2011 11:282

    Content type: Research article

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  45. Tuberculosis remains a serious public health threat and economic burden in Russia with escalating rates of drug resistance against a background of growing HIV-epidemic. Samara Oblast is one of the regions of t...

    Authors: Yanina Balabanova, Vladimir Tchernyshev, Igor Tsigankov, Svetlana Maximova, Natalya Mikheeva, Ljudmila Fedyukovitch, Sergey Kuznetsov, Ivan Fedorin and Francis Drobniewski

    Citation: BMC Infectious Diseases 2011 11:276

    Content type: Research article

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  46. There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-g Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).

    Authors: Naasha J Talati, Esteban Gonzalez-Diaz, Charles Mutemba, Joyanna Wendt, William Kilembe, Lawrence Mwananyanda, Elwyn Chomba, Susan Allen, Carlos del Rio and Henry M Blumberg

    Citation: BMC Infectious Diseases 2011 11:264

    Content type: Research article

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  47. Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the treatment of choice for superficial bladder carcinoma. Complications of BCG therapy include local infections and disseminated BCG infection wi...

    Authors: Cindy Q Gao, Rozina Mithani, Jack Leya, Lesley Dawravoo, Arvin Bhatia, John Antoine, Felipe De Alba, Peter A Russo and Claus J Fimmel

    Citation: BMC Infectious Diseases 2011 11:260

    Content type: Case report

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  48. Drug susceptibility testing (DST) remains an important concern for implementing treatment of MDR tuberculosis patients. Implementation of molecular tests for drug resistance identification would facilitate DST...

    Authors: Corinne Surcouf, Seiha Heng, Catherine Pierre-Audigier, Véronique Cadet-Daniel, Amine Namouchi, Alan Murray, Brigitte Gicquel and Bertrand Guillard

    Citation: BMC Infectious Diseases 2011 11:255

    Content type: Research article

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  49. Interferon-gamma release assays (IGRA) are used for tuberculosis (TB) screening in healthcare workers (HCWs). However, data on specificity of IGRA in serial testing of HCWs is sparse. Therefore the specificity...

    Authors: Anja Schablon, Roland Diel, Genia Diner, Ute Anske, Wulf Pankow, Felix C Ringshausen and Albert Nienhaus

    Citation: BMC Infectious Diseases 2011 11:245

    Content type: Research article

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  50. Pyrazinamide (PZA) is an important first-line drug in multidrug-resistant tuberculosis (MDRTB) treatment. However, the unreliable results obtained from traditional susceptibility testing limits its usefulness ...

    Authors: Yu-Chi Chiu, Shiang-Fen Huang, Kwok-Woon Yu, Yu-Chin Lee, Jia-Yih Feng and Wei-Juin Su

    Citation: BMC Infectious Diseases 2011 11:240

    Content type: Research article

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