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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Tuberculosis continues to be one of the leading causes of death worldwide and in the American region. Although multidrug-resistant tuberculosis (MDR-TB) remains a threat to TB control in Panama, few studies ha...

    Authors: Samantha Rosas, Jaime Bravo, Franklin Gonzalez, Nora de Moreno, Joel Sanchez, Ronnie G Gavilan and Amador Goodridge

    Citation: BMC Infectious Diseases 2013 13:442

    Content type: Research article

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  2. Lack of rapid and reliable susceptibility testing for second-line drugs used in the treatment of multidrug-resistant tuberculosis (MDR-TB) may limit treatment success.

    Authors: Stellah G Mpagama, Eric R Houpt, Suzanne Stroup, Happiness Kumburu, Jean Gratz, Gibson S Kibiki and Scott K Heysell

    Citation: BMC Infectious Diseases 2013 13:432

    Content type: Research article

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  3. Tuberculosis (TB) is a major cause of mortality and suffering worldwide, with over 95% of TB deaths occurring in low- and middle-income countries. In recent years, molecular typing methods have been widely use...

    Authors: Jean Paul Assam Assam, Véronique Penlap Beng, Fidelis Cho-Ngwa, Michel Toukam, Ane-Anyangwe Irene Ngoh, Mercy Kitavi, Inoster Nzuki, Juliette N Nyonka, Emilienne Tata, Jean Claude Tedom, Robert A Skilton, Roger Pelle and Vincent P K Titanji

    Citation: BMC Infectious Diseases 2013 13:431

    Content type: Research article

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  4. The 2007 World Health Organization (WHO) guideline to diagnose smear-negative tuberculosis (TB) in HIV-prevalent settings was mainly based on expert advice and therefore requires evaluation in real life situat...

    Authors: Gemeda Abebe, Amare Deribew, Ludwig Apers, Alemseged Abdissa, Yibeltal Kiflie, Olivier Koole and Robert Colebunders

    Citation: BMC Infectious Diseases 2013 13:427

    Content type: Research article

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  5. T cells are closely linked to the clinical manifestations of subjects with Mycobacterium tuberculosis (MTB) infection. T cell receptor beta variable (TCRBV) is a signal and indicative molecule on the membrane of ...

    Authors: Jiezuan Yang, Jianqin He, Haijun Huang, Zhongkang Ji, Li Wei, Ping Ye, Kaijin Xu and Lanjuan Li

    Citation: BMC Infectious Diseases 2013 13:423

    Content type: Research article

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  6. Paradoxical reactions from antibiotic treatment of Mycobacterium ulcerans have recently been recognized. Data is lacking regarding their incidence, clinical and diagnostic features, treatment, outcomes and risk f...

    Authors: Daniel P O’Brien, Mike Robson, N Deborah Friedman, Aaron Walton, Anthony McDonald, Peter Callan, Andrew Hughes, Richard Rahdon and Eugene Athan

    Citation: BMC Infectious Diseases 2013 13:416

    Content type: Research article

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  7. Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can b...

    Authors: Stephen D Lawn, Keertan Dheda, Andrew D Kerkhoff, Jonathan G Peter, Susan Dorman, Catharina C Boehme and Mark P Nicol

    Citation: BMC Infectious Diseases 2013 13:407

    Content type: Commentary

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  8. Flexible bronchoscopy with bronchial washing is a useful procedure for diagnosis of pulmonary tuberculosis (TB), when a patient cannot produce sputum spontaneously or when sputum smears are negative. However, ...

    Authors: Hongseok Yoo, Jae-Uk Song, Won-Jung Koh, Kyeongman Jeon, Sang-Won Um, Gee Young Suh, Man Pyo Chung, Hojoong Kim, O Jung Kwon, Nam Yong Lee, Sookyoung Woo and Hye Yun Park

    Citation: BMC Infectious Diseases 2013 13:404

    Content type: Research article

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  9. The aim of this study was to investigate the genetic diversity among Mycobacterium tuberculosis complex circulating in patients with no known risk factors for multi-drug resistant (MDR) tuberculosis (TB) living i...

    Authors: Francesca Barletta, Larissa Otero, Jimena Collantes, Belisa Asto, Bouke C de Jong, Carlos Seas and Leen Rigouts

    Citation: BMC Infectious Diseases 2013 13:397

    Content type: Research article

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  10. Young children exposed to Mycobacterium tuberculosis have a high risk of disease progression following infection. This study aimed to determine risk factors for M. tuberculosis infection and disease in children f...

    Authors: James A Seddon, Anneke C Hesseling, Peter Godfrey-Faussett, Katherine Fielding and H Simon Schaaf

    Citation: BMC Infectious Diseases 2013 13:392

    Content type: Research article

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  11. The present study aimed to characterize Mycobacterium tuberculosis population structure and to identify transmission chains and risk factors by prospective molecular typing in conjunction with conventional epidem...

    Authors: Séverine Ferdinand, Julie Millet, Annick Accipe, Sylvie Cassadou, Pascal Chaud, Maryse Levy, Max Théodore and Nalin Rastogi

    Citation: BMC Infectious Diseases 2013 13:364

    Content type: Research article

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  12. Tuberculosis infection control (TBIC) is rarely implemented in the health facilities in resource limited settings. Understanding the reasons for low level of implementation is critical. The study aim was to as...

    Authors: Esther Buregyeya, Fred Nuwaha, Suzanne Verver, Bart Criel, Robert Colebunders, Rhoda Wanyenze, Joan N Kalyango, Achilles Katamba and Ellen MH Mitchell

    Citation: BMC Infectious Diseases 2013 13:360

    Content type: Research article

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  13. The World Health Organization has endorsed the use of molecular methods for the detection of TB and drug-resistant TB as a rapid alternative to culture-based systems. In South Africa, the Xpert MTB/Rif assay a...

    Authors: Maunank Shah, Violet Chihota, Gerrit Coetzee, Gavin Churchyard and Susan E Dorman

    Citation: BMC Infectious Diseases 2013 13:352

    Content type: Research article

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  14. To control tuberculosis (TB), it is critical to identify at risk populations. Schizophrenia is recognized as an important risk factor for TB. However, previous studies have been confounded by comorbidities, an...

    Authors: Shu-Chen Kuo, Yung-Tai Chen, Szu-Yuan Li, Yi-Tzu Lee, Albert C Yang, Te-Li Chen, Chia-Jen Liu, Tzeng-Ji Chen, Ih-Jen Su and Chang-Phone Fung

    Citation: BMC Infectious Diseases 2013 13:351

    Content type: Research article

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  15. The world health organization (WHO) declared tuberculosis (TB) a global emergency, mainly affecting people in sub-Saharan Africa. However there is little data about the burden of TB among adolescents. We estim...

    Authors: James Waako, Suzanne Verver, Anne Wajja, Willy Ssengooba, Moses L Joloba, Robert Colebunders, Philippa Musoke and Harriet Mayanja-Kizza

    Citation: BMC Infectious Diseases 2013 13:349

    Content type: Research article

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  16. There is a lack of information on the clinical characteristics of multidrug-resistant (MDR) tuberculosis (TB) and extensively drug-resistant (XDR) TB in the Jiangxi Province of China; furthermore, data have no...

    Authors: Xiaoliang Yuan, Tiantuo Zhang, Kazuyoshi Kawakami, Jiaxin Zhu, Wenzheng Zheng, Hongtao Li, Guofang Deng, Shaohua Tu and Weiyou Liu

    Citation: BMC Infectious Diseases 2013 13:315

    Content type: Research article

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  17. A positive tuberculin skin test (TST) is often defined by skin induration of ≥10 mm in people who are HIV-seronegative. However, to increase sensitivity for detection of Mycobacterium tuberculosis infection in th...

    Authors: Andrew D Kerkhoff, Ankur Gupta, Taraz Samandari and Stephen D Lawn

    Citation: BMC Infectious Diseases 2013 13:307

    Content type: Research article

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  18. Transmission of drug susceptible and drug resistant TB occurs in health care facilities, and community and households settings, particularly in highly prevalent TB and HIV areas. There is a paucity of data reg...

    Authors: Melissa Lygizos, Sheela V Shenoi, Ralph P Brooks, Ambika Bhushan, James CM Brust, Daniel Zelterman, Yanhong Deng, Veronika Northrup, Anthony P Moll and Gerald H Friedland

    Citation: BMC Infectious Diseases 2013 13:300

    Content type: Research article

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  19. Tuberculosis (TB) is the leading cause of mortality in high HIV-prevalence populations. HIV is driving the TB epidemic in many countries, especially those in sub-Saharan Africa. The aim of this study was to as...

    Authors: Balewgizie Sileshi, Negussie Deyessa, Belaineh Girma, Muluken Melese and Pedro Suarez

    Citation: BMC Infectious Diseases 2013 13:297

    Content type: Research article

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  20. Nucleic acid amplification assays allow for the rapid and accurate detection of Mycobacterium tuberculosis (MTB) directly in clinical specimens thereby facilitating diagnosis of tuberculosis (TB). With the fully ...

    Authors: Uladzimir Antonenka, Sabine Hofmann-Thiel, Laziz Turaev, Ainura Esenalieva, Mokhonim Abdulloeva, Evgeni Sahalchyk, Tarig Alnour and Harald Hoffmann

    Citation: BMC Infectious Diseases 2013 13:280

    Content type: Research article

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  21. Leprosy is a contagious and chronic systemic granulomatous disease caused by Mycobacterium leprae. In the pathogenesis of leprosy, granulomas play a key role, however, the mechanisms of the formation and maintena...

    Authors: Hongsheng Wang, Yumi Maeda, Yasuo Fukutomi and Masahiko Makino

    Citation: BMC Infectious Diseases 2013 13:279

    Content type: Research article

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  22. The role of the surface capsular polysaccharides (CPs) of Mycobacterium tuberculosis (Mtb) in the pathogenesis of infection and disease, as well their potential for use as diagnostic reagents and vaccine antigens...

    Authors: Wendy A Keitel, ZhongDong Dai, Robert W Awe, Robert L Atmar, Sheldon Morris, Rachel Schneerson and John B Robbins

    Citation: BMC Infectious Diseases 2013 13:276

    Content type: Research article

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  23. It is estimated that Lao People’s Democratic Republic (Lao PDR) ranks fifth among the seven countries most affected by TB in the WHO Western Pacific Region. However, because of late implementation of mycobacte...

    Authors: Vibol Iem, Silaphet Somphavong, Yves Buisson, Nicolas Steenkeste, Franck Breysse, Monique Chomarat, Phannasinh Sylavanh, Phouratsamy Nanthavong, Alain Rajoharison, Jean-Luc Berland and Phimpha Paboriboune

    Citation: BMC Infectious Diseases 2013 13:275

    Content type: Research article

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  24. Abdominal tuberculosis continues to be a major public health problem worldwide and poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries. This study was condu...

    Authors: Phillipo L Chalya, Mabula D Mchembe, Stephen E Mshana, Peter F Rambau, Hyasinta Jaka and Joseph B Mabula

    Citation: BMC Infectious Diseases 2013 13:270

    Content type: Research article

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  25. M. tuberculosis remains one of the world’s deadliest pathogens in part because of its ability to establish persistent, latent infections, which can later reactivate to cause disease. In regions of the globe wher...

    Authors: Liya Wassie, Abraham Aseffa, Markos Abebe, Michael Z Gebeyehu, Martha Zewdie, Adane Mihret, Girum Erenso, Menberwork Chanyalew, Hiwot Tilahun, Lawrence K Yamuah, Peter Andersen and Mark T Doherty

    Citation: BMC Infectious Diseases 2013 13:265

    Content type: Research article

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  26. Mycobacterium abscessus is a rapidly growing mycobacterium responsible for progressive pulmonary disease, soft tissue and wound infections. The incidence of disease due to M. abscessus has been increasing in Que...

    Authors: Rachel Thomson, Carla Tolson, Hanna Sidjabat, Flavia Huygens and Megan Hargreaves

    Citation: BMC Infectious Diseases 2013 13:241

    Content type: Research article

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  27. The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current mo...

    Authors: Danila V Zimenkov, Olga V Antonova, Alexey V Kuz’min, Yulia D Isaeva, Ludmila Y Krylova, Sergey A Popov, Alexander S Zasedatelev, Vladimir M Mikhailovich and Dmitry A Gryadunov

    Citation: BMC Infectious Diseases 2013 13:240

    Content type: Research article

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  28. Representative population-based data on the epidemiology of pulmonary non-tuberculous mycobacterial (PNTM) infections in Europe are limited. However, these data are needed in order to optimise patient care and...

    Authors: Felix C Ringshausen, Rosa-Marie Apel, Franz-Christoph Bange, Andrés de Roux, Mathias W Pletz, Jessica Rademacher, Hendrik Suhling, Dirk Wagner and Tobias Welte

    Citation: BMC Infectious Diseases 2013 13:231

    Content type: Research article

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  29. Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). The annotation of functional genome and signaling network in M. tuberculosis are still not systematic. Essential ...

    Authors: Guangyu Xu, Bin Liu, Fang Wang, Chengguo Wei, Ying Zhang, Jiyao Sheng, Guoqing Wang and Fan Li

    Citation: BMC Infectious Diseases 2013 13:227

    Content type: Correspondence

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  30. The prevalence and the patterns of ocular inflammatory disease and ocular tuberculosis (TB) are largely undocumented among Multidrug Resistant TB (MDR-TB) patients co-infected with Human Immunodeficiency Virus...

    Authors: Salil Mehta, Homa Mansoor, Samsuddin Khan, Peter Saranchuk and Petros Isaakidis

    Citation: BMC Infectious Diseases 2013 13:225

    Content type: Research article

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  31. Diagnosis of pulmonary tuberculosis (PTB) is difficult in infants and young children. For microbiological confirmation of PTB children, sequential gastric lavage (GL) is recommended. Induced sputum (IS) may be...

    Authors: Marta Ruiz Jiménez, Sara Guillén Martín, Luis M Prieto Tato, Juana B Cacho Calvo, Ana Álvarez García, Beatriz Soto Sánchez and Jose T Ramos Amador

    Citation: BMC Infectious Diseases 2013 13:222

    Content type: Research article

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  32. An association between chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) has been described, mainly due to smoking and corticosteroid use. Whether inhaled corticosteroid (ICS) therapy is assoc...

    Authors: Chih-Hsin Lee, Ming-Chia Lee, Chin-Chung Shu, Chor-Shen Lim, Jann-Yuan Wang, Li-Na Lee and Kun-Mao Chao

    Citation: BMC Infectious Diseases 2013 13:194

    Content type: Research article

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  33. Tuberculosis (TB) is still a great challenge to public health in sub-Saharan Africa. Most transmissions occur between the onset of coughing and initiation of treatment. Delay in diagnosis is significant to dis...

    Authors: Luigi Segagni Lusignani, Gianluca Quaglio, Andrea Atzori, Joseph Nsuka, Ross Grainger, Maria Da Conceiçao Palma, Giovanni Putoto and Fabio Manenti

    Citation: BMC Infectious Diseases 2013 13:168

    Content type: Research article

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  34. Multidrug resistant (MDR) and extensively-drug resistant (XDR) tuberculosis (TB) are a serious threat to the national TB control programs of developing countries, and the situation is further worsened by the h...

    Authors: Sunil Sethi, Abhishek Mewara, Sunil Kumar Dhatwalia, Harpal Singh, Rakesh Yadav, Khushwinder Singh, Dheeraj Gupta, Ajay Wanchu and Meera Sharma

    Citation: BMC Infectious Diseases 2013 13:137

    Content type: Research article

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  35. The diagnosis of childhood tuberculosis remains a challenge worldwide. The Xpert MTB/RIF test, a rapid mycobacteria tuberculosis diagnostic tool, was recommended for use in children based on data from adult st...

    Authors: Moorine Penninah Sekadde, Eric Wobudeya, Moses L Joloba, Willy Ssengooba, Harriet Kisembo, Sabrina Bakeera-Kitaka and Philippa Musoke

    Citation: BMC Infectious Diseases 2013 13:133

    Content type: Research article

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  36. Although Ethiopia ranks seventh among the world’s 22 high-burden tuberculosis (TB) countries, little is known about strain diversity and transmission. In this study, we present the first in-depth analysis of t...

    Authors: Belay Tessema, Joerg Beer, Matthias Merker, Frank Emmrich, Ulrich Sack, Arne C Rodloff and Stefan Niemann

    Citation: BMC Infectious Diseases 2013 13:131

    Content type: Research article

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  37. A better understanding of the quality of cellular immune responses directed against molecularly defined targets will guide the development of TB diagnostics and identification of molecularly defined, clinicall...

    Authors: Nancy Alvarez-Corrales, Raija K Ahmed, Carol A Rodriguez, Kithiganahalli N Balaji, Rebeca Rivera, Ramakrishna Sompallae, Nalini K Vudattu, Sven E Hoffner, Alimuddin Zumla, Lelany Pineda-Garcia and Markus Maeurer

    Citation: BMC Infectious Diseases 2013 13:125

    Content type: Research article

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  38. There is a documented increase of diabetes mellitus in Sub Saharan Africa, a region where tuberculosis is highly endemic. Currently, diabetes mellitus is one of the recognised risk factors of tuberculosis. No ...

    Authors: Davis Kibirige, Richard Ssekitoleko, Edrisa Mutebi and William Worodria

    Citation: BMC Infectious Diseases 2013 13:122

    Content type: Research article

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  39. The purpose of this study was to evaluate the differences in clinical characteristics and treatment outcomes between older and younger tuberculosis (TB) patients in Korea.

    Authors: Yong Soo Kwon, Su Young Chi, In Jae Oh, Kyu Sik Kim, Yu Il Kim, Sung Chul Lim and Young Chul Kim

    Citation: BMC Infectious Diseases 2013 13:121

    Content type: Research article

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  40. Mycobacterium tuberculosis is characterised by limited genomic diversity, which makes the application of whole genome sequencing particularly attractive for clinical and epidemiological investigation. However, i...

    Authors: Josephine M Bryant, Anita C Schürch, Henk van Deutekom, Simon R Harris, Jessica L de Beer, Victor de Jager, Kristin Kremer, Sacha A F T van Hijum, Roland J Siezen, Martien Borgdorff, Stephen D Bentley, Julian Parkhill and Dick van Soolingen

    Citation: BMC Infectious Diseases 2013 13:110

    Content type: Research article

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  41. The association between pulmonary tuberculosis (PTB) and diabetes mellitus (DM) has been previously attracted much attention. Diabetes alters immunity to tuberculosis, leading to more frequent treatment failur...

    Authors: Qiuzhen Wang, Aiguo Ma, Ib Christian Bygbjerg, Xiuxia Han, Yufeng Liu, Shanliang Zhao and Jing Cai

    Citation: BMC Infectious Diseases 2013 13:104

    Content type: Study protocol

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  42. Public hospitals in China play an important role in tuberculosis (TB) control. Three models of hospital and TB control exist in China. The dispensary model is the most common one in which a TB dispensary provi...

    Authors: Xiaolin Wei, Guanyang Zou, Jia Yin, John Walley and Qiang Sun

    Citation: BMC Infectious Diseases 2013 13:93

    Content type: Research article

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  43. Smear microscopy, a mainstay of tuberculosis (TB) diagnosis in developing countries, cannot differentiate M. tuberculosis complex from NTM infection, while pulmonary TB shares clinical signs with NTM disease, cau...

    Authors: Benon B Asiimwe, Godwins B Bagyenzi, Willy Ssengooba, Francis Mumbowa, Gerald Mboowa, Anne Wajja, Harriet Mayanja-Kiiza, Philippa M Musoke, Eric Wobudeya, Gunilla Kallenius and Moses L Joloba

    Citation: BMC Infectious Diseases 2013 13:88

    Content type: Research article

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  44. In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format. Therefore,...

    Authors: Mai NT Huyen, Kristin Kremer, Nguyen TN Lan, Tran N Buu, Frank GJ Cobelens, Edine W Tiemersma, Petra de Haas and Dick van Soolingen

    Citation: BMC Infectious Diseases 2013 13:63

    Content type: Research article

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  45. Identifying people at higher risk of developing tuberculosis with human immunodeficiency virus (HIV) infection may improve clinical management of co-infections. Iron influences tuberculosis (TB) pathogenesis, ...

    Authors: Joann M McDermid, Branwen J Hennig, Marianne van der Sande, Adrian VS Hill, Hilton C Whittle, Assan Jaye and Andrew M Prentice

    Citation: BMC Infectious Diseases 2013 13:48

    Content type: Research article

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  46. Apoptosis-associated biomarkers are rarely studied, especially their role in predicting the development of tuberculosis (TB) from latent TB infection and in prognostication.

    Authors: Chin-Chung Shu, Ming-Fang Wu, Chia-Lin Hsu, Chun-Ta Huang, Jann-Yuan Wang, Shie-Liang Hsieh, Chong-Jen Yu, Li-Na Lee and Pan-Chyr Yang

    Citation: BMC Infectious Diseases 2013 13:45

    Content type: Research article

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  47. Phage lysin, extracted from three bacteriophages was used in place of antibiotics to control the overgrowth of normal flora in processed sputum samples leading to the sensitive detection of Mycobacterium tubercul...

    Authors: Balaji Subramanyam, Gomathi Sivaramakrishnan, Azger Dusthackeer and Vanaja Kumar

    Citation: BMC Infectious Diseases 2013 13:44

    Content type: Research article

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