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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Current understanding of tuberculosis (TB) genotype clustering in the US is based on individual risk factors. This study sought to identify whether area-based socioeconomic status (SES) was associated with gen...

    Authors: Eyal Oren, Masahiro Narita, Charles Nolan and Jonathan Mayer

    Citation: BMC Infectious Diseases 2014 14:227

    Content type: Research article

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  2. Tuberculosis (TB) transmission rates are exceptionally high in endemic TB settings. Adolescence represents a period of increasing TB infection and disease but little is known as to where adolescents acquire TB...

    Authors: Keren Middelkoop, Linda-Gail Bekker, Carl Morrow, Namee Lee and Robin Wood

    Citation: BMC Infectious Diseases 2014 14:221

    Content type: Research article

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  3. Mycobacterium ulcerans (M. ulcerans) causes a devastating necrotising infection of skin tissue leading to progressive ulceration. M. ulcerans is the only human pathogen that secretes mycolactone, a polyketide mo...

    Authors: Fred S Sarfo, Richard O Phillips, Jihui Zhang, Mohammed K Abass, Justice Abotsi, Yaw A Amoako, Yaw Adu-Sarkodie, Clive Robinson and Mark H Wansbrough-Jones

    Citation: BMC Infectious Diseases 2014 14:202

    Content type: Research article

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  4. Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. Early diagnosis of MDR-TB patients is essential for minimizing the risk of Mycobacterium tuberculosis (MTB) transmission. The convention...

    Authors: Ruijuan Zheng, Changtai Zhu, Qi Guo, Lianhua Qin, Jie Wang, Junmei Lu, Haiyan Cui, Zhenling Cui, Baoxue Ge, Jinming Liu and Zhongyi Hu

    Citation: BMC Infectious Diseases 2014 14:200

    Content type: Research article

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  5. Mycobacterium bovis bacillus Calmette-Guérin (BCG) is known to be only partially effective in inhibiting M. tuberculosis (MTB) multiplication in human. A new recombinant (r) urease-deficient BCG (BCG-dHCM) that ...

    Authors: Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai and Masahiko Makino

    Citation: BMC Infectious Diseases 2014 14:179

    Content type: Research article

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  6. We investigated the determinants of sputum culture non-conversion following intensive phase of treatment, and assessed the effects on the outcome among patients treated for a first episode of smear positive tu...

    Authors: Eric Walter Pefura-Yone, André Pascal Kengne and Christopher Kuaban

    Citation: BMC Infectious Diseases 2014 14:138

    Content type: Research article

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  7. Tuberculosis (TB) control remains a challenge in Malawi despite the National TB Control Program since 1984. This study aimed at measuring patient and health system delays and identifying factors associated wit...

    Authors: Lumbani Makwakwa, Mei-ling Sheu, Chen-Yuan Chiang, Shoei-Loong Lin and Peter W Chang

    Citation: BMC Infectious Diseases 2014 14:132

    Content type: Research article

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  8. Tuberculosis is classified as either pulmonary or extra-pulmonary (EPTB). While much focus has been paid to pulmonary tuberculosis, EPTB has received scant attention. Moreover, EPTB is viewed as one wastebaske...

    Authors: Tobias Pusch, Jotam G Pasipanodya, Ronald G Hall II and Tawanda Gumbo

    Citation: BMC Infectious Diseases 2014 14:115

    Content type: Research article

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  9. Biological agents such as tumor necrosis factor-α inhibitors are known to cause mycobacterium infections. Here, we report a disseminated non-tuberculosis case caused by TNF-α inhibitor therapy and a probable p...

    Authors: Takahiro Takazono, Shigeki Nakamura, Yoshifumi Imamura, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Kakeya, Katsunori Yanagihara and Shigeru Kohno

    Citation: BMC Infectious Diseases 2014 14:114

    Content type: Case report

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  10. A rapid diagnostic test for active tuberculosis (TB) at the clinical point-of-care could expedite case detection and accelerate TB treatment initiation. We assessed the diagnostic accuracy of a rapid urine lip...

    Authors: Paul K Drain, Elena Losina, Sharon M Coleman, Janet Giddy, Douglas Ross, Jeffrey N Katz, Rochelle P Walensky, Kenneth A Freedberg and Ingrid V Bassett

    Citation: BMC Infectious Diseases 2014 14:110

    Content type: Research article

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  11. HIV infection reduces the likelihood that individuals with pulmonary tuberculosis are smear positive and that they have cavitatory disease. Antiretroviral therapy (ART) may shift the pattern of disease to be m...

    Authors: Lumbani Munthali, Palwasha Y Khan, Nimrod J Mwaungulu, Femia Chilongo, Sian Floyd, Michael Kayange, Judith R Glynn, Neil French and Amelia C Crampin

    Citation: BMC Infectious Diseases 2014 14:107

    Content type: Research article

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  12. The incidence and characteristics of tuberculosis (TB) in remote areas of Papua New Guinea (PNG) are largely unknown. The purpose of our study was to determine the incidence of TB in the Gulf Province of PNG a...

    Authors: Gail B Cross, Katie Coles, Mandana Nikpour, Owen A Moore, Justin Denholm, Emma S McBryde, Damon P Eisen, Beverlyn Warigi, Robyn Carter, Sushil Pandey, Paul Harino, Peter Siba, Christopher Coulter, Ivo Mueller, Suparat Phuanukoonnon and Marc Pellegrini

    Citation: BMC Infectious Diseases 2014 14:93

    Content type: Research article

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  13. Children are highly susceptible to tuberculosis; thus, there is need for safe and effective preventive interventions. Our objective was to evaluate the efficacy of isoniazid in prevention of tuberculosis morbi...

    Authors: James Ayieko, Lisa Abuogi, Brett Simchowitz, Elizabeth A Bukusi, Allan H Smith and Arthur Reingold

    Citation: BMC Infectious Diseases 2014 14:91

    Content type: Research article

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  14. Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care [uncon...

    Authors: Elizabeth A Reddy, Boniface N Njau, Susan C Morpeth, Kathryn E Lancaster, Alison C Tribble, Venance P Maro, Levina J Msuya, Anne B Morrissey, Gibson S Kibiki, Nathan M Thielman, Coleen K Cunningham, Werner Schimana, John F Shao, Shein-Chung Chow, Jason E Stout, John A Crump…

    Citation: BMC Infectious Diseases 2014 14:89

    Content type: Research article

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  15. In the context of decreasing tuberculosis prevalence in China, we examined the effectiveness of screening household contacts of tuberculosis patients.

    Authors: Zhongwei Jia, Shiming Cheng, Yan Ma, Tianhao Zhang, Liqiong Bai, Weiguo Xu, Xiaoxin He, Peiru Zhang, Jinkou Zhao and David C Christiani

    Citation: BMC Infectious Diseases 2014 14:64

    Content type: Research article

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  16. Since non-tuberculous mycobacteria (NTM) disease is not notifiable in most European Union (EU) and European Economic Area (EEA) countries, the epidemiological situation of the >150 NTM species is largely unkno...

    Authors: Marieke J van der Werf, Csaba Ködmön, Vera Katalinić-Janković, Tiina Kummik, Hanna Soini, Elvira Richter, Dimitrios Papaventsis, Enrico Tortoli, Monique Perrin, Dick van Soolingen, Manca Žolnir-Dovč and Vibeke Østergaard Thomsen

    Citation: BMC Infectious Diseases 2014 14:62

    Content type: Research article

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  17. With Fluorotype MTB (FT MTB, HAIN Lifesciences, Germany) a new semi-automated assay for detection of M. tuberculosis complex (MTBC) in clinical specimens has been introduced. In a prospective study, we evaluated ...

    Authors: Sabine Hofmann-Thiel and Harald Hoffmann

    Citation: BMC Infectious Diseases 2014 14:59

    Content type: Research article

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  18. The rapid identification of acid-fast bacilli recovered from patient specimens as Mycobacterium tuberculosis complex (MTC) is critically important for accurate diagnosis and treatment. A thin-layer immunochromato...

    Authors: Kinuyo Chikamatsu, Akio Aono, Hiroyuki Yamada, Tetsuhiro Sugamoto, Tomoko Kato, Yuko Kazumi, Kiyoko Tamai, Hideji Yanagisawa and Satoshi Mitarai

    Citation: BMC Infectious Diseases 2014 14:54

    Content type: Research article

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  19. The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacteri...

    Authors: Sebabrata Mahapatra, Ann M Hess, John L Johnson, Kathleen D Eisenach, Mary A DeGroote, Phineas Gitta, Moses L Joloba, Gilla Kaplan, Gerhard Walzl, W Henry Boom and John T Belisle

    Citation: BMC Infectious Diseases 2014 14:53

    Content type: Research article

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  20. Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation.

    Authors: Chong Wang, Yan-Yuan Li, Xiang Li, Li-Liang Wei, Xiu-Yun Yang, Dan-Dan Xu, Ting-Ting Jiang, Zhong-Jie Li, Zhong-Liang Chen, Xing Zhang, Ji-Yan Liu, Ze-Peng Ping and Ji-Cheng Li

    Citation: BMC Infectious Diseases 2014 14:52

    Content type: Research article

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  21. Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelec...

    Authors: Ezekiel Mupere, LaShaunda Malone, Sarah Zalwango, Alphonse Okwera, Mary Nsereko, Daniel J Tisch, Isabel M Parraga, Catherine M Stein, Roy Mugerwa, W Henry Boom, Harriet K Mayanja and Christopher C Whalen

    Citation: BMC Infectious Diseases 2014 14:24

    Content type: Research article

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  22. Patients on anti-tuberculosis treatment may develop acute kidney injury (AKI), but little is known about the renal outcome and prognostic factors, especially in an aging population. This study aimed to calcula...

    Authors: Chia-Hao Chang, Yen-Fu Chen, Vin-Cent Wu, Chin-Chung Shu, Chih-Hsin Lee, Jann-Yuan Wang, Li-Na Lee and Chong-Jen Yu

    Citation: BMC Infectious Diseases 2014 14:23

    Content type: Research article

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  23. This paper reports findings from the prevalence survey conducted in Shandong China in 2010, a province with a population of 94 million. This study aimed to estimate TB prevalence of the province in 2010 in com...

    Authors: Xiaolin Wei, Xiulei Zhang, Jia Yin, John Walley, Rachel Beanland, Guanyang Zou, Hongmei Zhang, Fang Li, Zhimin Liu, Benny CY Zee and Sian M Griffiths

    Citation: BMC Infectious Diseases 2014 14:21

    Content type: Research article

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  24. Early detection and treatment of TB is essential for the success of TB control program performance. The aim of this study was to determine the length and analyze predictors of patients’, health systems’ and to...

    Authors: Solomon A Yimer, Gunnar A Bjune and Carol Holm-Hansen

    Citation: BMC Infectious Diseases 2014 14:19

    Content type: Research article

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  25. Rifampicin resistance is a risk factor for poor outcome in tuberculosis. Therefore, we sought to describe the characteristics and management of Rifampicin monoresistant (RMR) tuberculosis (TB) in France.

    Authors: Vanina Meyssonnier, Thuy Van Bui, Nicolas Veziris, Vincent Jarlier and Jérôme Robert

    Citation: BMC Infectious Diseases 2014 14:18

    Content type: Research article

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  26. In drug-resistant TB settings, specimen collection is critical for drug-susceptibility testing (DST). This observational study included multiple specimen types collected from pediatric TB suspects with the aim...

    Authors: Tania A Thomas, Scott K Heysell, Prashini Moodley, Romualde Montreuil, Xia Ha, Gerald Friedland, Sheila A Bamber, Anthony P Moll, Neel Gandhi, William E Brant, Willem Sturm and Sarita Shah

    Citation: BMC Infectious Diseases 2014 14:11

    Content type: Research article

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  27. Although extrapulmonary tuberculosis (EPTB) is less frequent than Pulmonary Tuberculosis (PTB) and is a secondary target for national TB control programs, its significance has increased worldwide during the HI...

    Authors: Teresa Gomes, Bárbara Reis-Santos, Adelmo Bertolde, John L Johnson, Lee W Riley and Ethel Leonor Maciel

    Citation: BMC Infectious Diseases 2014 14:9

    Content type: Research article

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  28. In the antibiotic era, tuberculosis (TB) still causes a substantial number of mortalities. We aimed to identify the causes and risks of death among TB patients.

    Authors: Chou-Han Lin, Chou-Jui Lin, Yao-Wen Kuo, Jann-Yuan Wang, Chia-Lin Hsu, Jong-Min Chen, Wern-Cherng Cheng and Li-Na Lee

    Citation: BMC Infectious Diseases 2014 14:5

    Content type: Research article

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  29. The Xpert MTB/RIF assay has garnered significant interest as a sensitive and rapid diagnostic tool to improve detection of sensitive and drug resistant tuberculosis. However, most existing literature has descr...

    Authors: Jacob Creswell, Andrew J Codlin, Emmanuel Andre, Mark A Micek, Ahmed Bedru, E Jane Carter, Rajendra-Prasad Yadav, Andrei Mosneaga, Bishwa Rai, Sayera Banu, Miranda Brouwer, Lucie Blok, Suvanand Sahu and Lucica Ditiu

    Citation: BMC Infectious Diseases 2014 14:2

    Content type: Research article

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  30. Data exploring the potential use of effector molecules produced by cytotoxic T lymphocytes (CTLs) in the immunodiagnostics of tuberculosis (TB) are scarce. The present study focused a) to gain an insight into the...

    Authors: Laura E Savolainen, Pekka Koskivirta, Anu Kantele, Heikki Valleala, Liana Pusa, Riitta Tuompo, Benita Westerlund-Wikström and Tamara Tuuminen

    Citation: BMC Infectious Diseases 2013 13:573

    Content type: Research article

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  31. The Philippines has an extremely high rate of tuberculosis but little is known about M. tuberculosis genotypes and transmission dynamics in this country. The aim of this study was to determine the proportion of h...

    Authors: Irene G Sia, Seanne P Buckwalter, Kelly A Doerr, Sonia Lugos, Rebecca Kramer, Ruth Orillaza-Chi, Maria Imelda Quelapio, Thelma E Tupasi and Nancy L Wengenack

    Citation: BMC Infectious Diseases 2013 13:571

    Content type: Research article

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  32. Mobile phone text messaging (SMS) has the potential to promote adherence to tuberculosis treatment. This systematic review aims to synthesize current evidence on the effectiveness of SMS interventions in impro...

    Authors: Mweete D Nglazi, Linda-Gail Bekker, Robin Wood, Gregory D Hussey and Charles S Wiysonge

    Citation: BMC Infectious Diseases 2013 13:566

    Content type: Research article

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  33. This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE)...

    Authors: Ae-Ra Lee, Jinwoo Lee, Sun-Mi Choi, Moon-Woo Seong, Sung A Kim, Myoungsil Kim, Kyung Ok Chae, Ji Sun Lee and Jae-Joon Yim

    Citation: BMC Infectious Diseases 2013 13:558

    Content type: Research article

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  34. Adenosine deaminase (ADA) is useful in the diagnosis of tuberculous pleural effusion (TPE). This study aims to determine the factors affecting pleural fluid ADA levels and to establish the optimal ADA levels f...

    Authors: Tunn Ren Tay and Augustine Tee

    Citation: BMC Infectious Diseases 2013 13:546

    Content type: Research article

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  35. Control of tuberculosis (TB) depends on early diagnosis and treatment at the primary health care level. However, many patients are still diagnosed late with TB at hospitals. The present study aimed to investig...

    Authors: Gracieli Nadalon Deponti, Denise Rossato Silva, Ana Cláudia Coelho, Alice Mânica Muller and Paulo de Tarso Roth Dalcin

    Citation: BMC Infectious Diseases 2013 13:538

    Content type: Research article

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  36. Association studies have been employed to investigate the relationships between host single nucleotide polymorphisms (SNPs) and susceptibility to pulmonary Tuberculosis (PTB). However, such candidate genetic m...

    Authors: Yu Yang, Xiangwei Li, Wei Cui, Ling Guan, Fei Shen, Jinsheng Xu, Feng Zhou, Mufei Li, Cong Gao, Qi Jin, Jianmin Liu and Lei Gao

    Citation: BMC Infectious Diseases 2013 13:511

    Content type: Research article

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  37. Smear-negative pulmonary tuberculosis (SN-PTB), which is common in HIV-infected patients, is difficult to diagnose using smear microscopy alone. In 2007, the WHO developed an algorithm to improve the diagnosis...

    Authors: Simon Walusimbi, Freddie Bwanga, Ayesha De Costa, Melles Haile, Moses Joloba and Sven Hoffner

    Citation: BMC Infectious Diseases 2013 13:507

    Content type: Research article

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  38. Noninvasive and convenient biomarkers for early diagnosis of tuberculosis (TB) remain an urgent need. The aim of this study was to discover and identify potential biomarkers specific for TB.

    Authors: Jiyan Liu, Tingting Jiang, Liliang Wei, Xiuyun Yang, Chong Wang, Xing Zhang, Dandan Xu, Zhongliang Chen, Fuquan Yang and Ji-Cheng Li

    Citation: BMC Infectious Diseases 2013 13:506

    Content type: Research article

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  39. Despite efforts to eliminate leprosy as public health problem, delayed diagnosis and disabilities still occur in many countries. Leprosy diagnosis remains based on clinical manifestations and the number of cli...

    Authors: Ludimila Paula Vaz Cardoso, Ronaldo Ferreira Dias, Aline Araújo Freitas, Emerith Mayra Hungria, Regiane Morillas Oliveira, Marco Collovati, Steven G Reed, Malcolm S Duthie and Mariane Martins Araújo Stefani

    Citation: BMC Infectious Diseases 2013 13:497

    Content type: Research article

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  40. Non-tuberculous mycobacteria (NTM) are opportunistic pathogens in immuno-compromised patients. They are also increasingly recognized as pathogens in immuno-competent individuals. Globally, an increase in NTM i...

    Authors: Imran Ahmed, Kauser Jabeen and Rumina Hasan

    Citation: BMC Infectious Diseases 2013 13:493

    Content type: Research article

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  41. Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population...

    Authors: Eddie M Wampande, Ezekiel Mupere, Sara M Debanne, Benon B Asiimwe, Mary Nsereko, Harriet Mayanja, Kathleen Eisenach, Gilla Kaplan, Henry W Boom, Sebastien Gagneux and Moses L Joloba

    Citation: BMC Infectious Diseases 2013 13:484

    Content type: Research article

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  42. Mycobacteirum wolinskyi is a member of the Mycobacterium smegmatis group, which is less frequently found in clinical settings than other nontuberculous mycobacterium (NTM) species. However, its clinical signific...

    Authors: Seung Jin Yoo, Keun Hwa Lee, Sung-No Jung and Sang Taek Heo

    Citation: BMC Infectious Diseases 2013 13:479

    Content type: Case report

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  43. Drug-resistant tuberculosis (TB), including resistance to both rifampicin (RIF) and isoniazid (INH) referred to as multidrug-resistant tuberculosis (MDR-TB), has become an increasing global threat in recent ye...

    Authors: Eunjin Cho, Isdore Chola Shamputa, Hyun-Kyung Kwak, Jiim Lee, Myungsun Lee, Soohee Hwang, Doosoo Jeon, Cheon Tae Kim, Sangnae Cho, Laura E Via, Clifton E Barry 3rd and Jong Seok Lee

    Citation: BMC Infectious Diseases 2013 13:478

    Content type: Research article

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  44. Despite the latest World Health Organization guidelines advocating daily therapy in HIV-TB co-infected individuals, there are few recent studies comparing outcomes of thrice-weekly anti-tuberculosis treatment ...

    Authors: Richa Vashishtha, Krishna Mohan, Bhagteshwar Singh, Satish K Devarapu, Vishnubhatla Sreenivas, Sanjay Ranjan, Deepak Gupta, Sanjeev Sinha and Surendra K Sharma

    Citation: BMC Infectious Diseases 2013 13:468

    Content type: Research article

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  45. Children make up a significant proportion of the global tuberculosis (TB) caseload, and experience considerable TB-related morbidity and mortality. Unfortunately, it is not easy to diagnose TB in the first yea...

    Authors: Susanna Esposito, Alberto Giannini, Pietro Biondetti, Nicola Bonelli, Mario Nosotti, Samantha Bosis, Edoardo Calderini and Nicola Principi

    Citation: BMC Infectious Diseases 2013 13:461

    Content type: Case report

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  46. The tuberculin skin test (TST) is used to test for latent tuberculosis (TB) infection and support the diagnosis of active TB. However, little is known about the relationship between the TST result and the clin...

    Authors: Sara C Auld, Eleanor S Click, Charles M Heilig, Roque Miramontes, Kevin P Cain, Gregory P Bisson and William R Mac Kenzie

    Citation: BMC Infectious Diseases 2013 13:460

    Content type: Research article

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  47. Population based prevalence survey is an important epidemiological index to measure the burden of tuberculosis (TB) disease and monitor progress towards TB control in high burden countries like Ethiopia. This ...

    Authors: Gebretsadik Berhe, Fikre Enqueselassie, Elena Hailu, Wondale Mekonnen, Tsigemariam Teklu, Ataklti Gebretsadik, Rezene Berhe, Tewodros Haile and Abraham Aseffa

    Citation: BMC Infectious Diseases 2013 13:448

    Content type: Research article

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  48. The screening of both healthcare workers and students attending teaching hospitals for latent tuberculosis infection (LTBI) is recommended in hospitals of many countries with a low-incidence of TB, including I...

    Authors: Paolo Durando, Giovanni Sotgiu, Fabio Spigno, Mauro Piccinini, Giovanni Mazzarello, Claudio Viscoli, Francesco Copello, Alessandro Poli, Filippo Ansaldi and Giancarlo Icardi

    Citation: BMC Infectious Diseases 2013 13:443

    Content type: Research article

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