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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. The global population is ageing quickly and our understanding of age-related changes in the immune system suggest that the elderly will have less immunological protection from active tuberculosis (TB).

    Authors: Rachel Byng-Maddick and Mahdad Noursadeghi

    Citation: BMC Infectious Diseases 2016 16:119

    Content type: Review

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  2. Tuberculosis is one of the leading causes of morbidity and mortality in developing countries. Analysis of the host immune response may help with generating point-of-care tests for personalised monitoring. Thus...

    Authors: Joseph Mendy, Toyin Togun, Olumuyiwa Owolabi, Simon Donkor, Martin O. C. Ota and Jayne S. Sutherland

    Citation: BMC Infectious Diseases 2016 16:115

    Content type: Research article

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  3. Although there is a large increase in investment for tuberculosis control in Myanmar, there are few operational analyses to inform policies. Only 34 % of nationally reported cases are from women. In this study...

    Authors: MS. Khan, TM. Khine, C. Hutchison, RJ. Coker, KM. Hane, AL. Innes and S. Aung

    Citation: BMC Infectious Diseases 2016 16:110

    Content type: Research article

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  4. Tuberculosis remains a major public health problem in China. The Hebei province is located in the Beijing-Tianjin-Hebei integration region; however little information about the genetic diversity of Mycobacterium ...

    Authors: Yanan Li, Xinrui Cao, Shiming Li, Hao Wang, Jianlin Wei, Peng Liu, Jing Wang, Zhi Zhang, Huixia Gao, Machao Li, Kanglin Wan and Erhei Dai

    Citation: BMC Infectious Diseases 2016 16:107

    Content type: Research article

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  5. Long-term outcomes in non-HIV immunocompromised patients with disseminated Mycobacterium avium complex (dMAC) infections are unknown and the need for post-treatment secondary prophylaxis against MAC is uncertain ...

    Authors: Siddharth Sridhar, Kitty S. C. Fung, Jasper F. W. Chan, Jimmy Y. W. Lam, Eric K. T. Yip, Ivan F.N. Hung, Alan K. L. Wu, Tak-Lun Que, Susanna K. P. Lau and Patrick C. Y. Woo

    Citation: BMC Infectious Diseases 2016 16:74

    Content type: Research article

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  6. In high incidence settings, the majority of Mycobacterium tuberculosis (M.tb) transmission occurs outside the household. Little is known about where people’s indoor contacts occur outside the household, and how t...

    Authors: Nicky McCreesh, Clare Looker, Peter J. Dodd, Ian D. Plumb, Kwame Shanaube, Monde Muyoyeta, Peter Godfrey-Faussett, Elizabeth L. Corbett, Helen Ayles and Richard G. White

    Citation: BMC Infectious Diseases 2016 16:71

    Content type: Research article

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  7. Abdominal tuberculosis (TB) is an uncommon affliction in adolescence. It is usually associated with pulmonary tuberculosis. The disease is caused by lymphohaematogenous spread after primary infection in the lu...

    Authors: Sze Li Siow, Hon Leong Sha and Chee Ming Wong

    Citation: BMC Infectious Diseases 2016 16:68

    Content type: Case report

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  8. The risk of anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic viral hepatitis (CVH) is not clear. The aim of this study was to investigate incidence and risk factors associated w...

    Authors: Wan Soo Kim, Sang Soo Lee, Chang Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Jeong Woo Hong, Hyun Seon You and Hyun Chin Cho

    Citation: BMC Infectious Diseases 2016 16:50

    Content type: Research article

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  9. Human immunodeficiency virus (HIV)-associated tuberculosis deaths have decreased worldwide over the past decade. We sought to evaluate the effect of HIV status on tuberculosis mortality among patients undergoi...

    Authors: Gustavo E. Velásquez, J. Peter Cegielski, Megan B. Murray, Martin J. A. Yagui, Luis L. Asencios, Jaime N. Bayona, César A. Bonilla, Hector O. Jave, Gloria Yale, Carmen Z. Suárez, Eduardo Sanchez, Christian Rojas, Sidney S. Atwood, Carmen C. Contreras, Janeth Santa Cruz and Sonya S. Shin

    Citation: BMC Infectious Diseases 2016 16:45

    Content type: Research article

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  10. The occurrence of non-contiguous, multiple, and remote involvement tuberculous spondylitis is rare. The clinical presentation in patients with multifocal musculoskeletal tuberculosis may closely mimic that in ...

    Authors: Meiping Ye, Jinwei Huang, Jie Wang, Jianmin Ren, Jianfei Tu, Weibo You and Taohui Zhu

    Citation: BMC Infectious Diseases 2016 16:34

    Content type: Case report

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  11. Although the isolation of clarithromycin (CAM)-resistant Mycobacterium avium complex (MAC) indicates a poor treatment outcome and increased mortality, there have been only a few reports on drug treatment for C...

    Authors: Tsukasa Kadota, Hirotoshi Matsui, Takashi Hirose, Junko Suzuki, Minako Saito, Tomohiro Akaba, Kouichi Kobayashi, Shunsuke Akashi, Masahiro Kawashima, Atsuhisa Tamura, Hideaki Nagai, Shinobu Akagawa, Nobuyuki Kobayashi and Ken Ohta

    Citation: BMC Infectious Diseases 2016 16:31

    Content type: Research article

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  12. Mycobacterium tuberculosis (Mtb) is reported to infect about a third of the world’s population but only 10 % are thought to develop active tuberculosis (TB) disease. Host immunity regulated by human leukocyte ant...

    Authors: Dan Wamala, Helen Koyokoyo Buteme, Samuel Kirimunda, Gunilla Kallenius and Moses Joloba

    Citation: BMC Infectious Diseases 2016 16:23

    Content type: Research article

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  13. Leprosy remains an important public health problem in some specific high-burden pockets areas, including the Brazilian Amazon region, where it is hyperendemic among children.

    Authors: Josafá Gonçalves Barreto, Donal Bisanzio, Marco Andrey Cipriani Frade, Tania Mara Pires Moraes, Angélica Rita Gobbo, Layana de Souza Guimarães, Moisés Batista da Silva, Gonzalo M. Vazquez-Prokopec, John Stewart Spencer, Uriel Kitron and Claudio Guedes Salgado

    Citation: BMC Infectious Diseases 2015 15:527

    Content type: Research article

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  14. Bangladesh is one of the 27 high burden countries for multidrug resistant tuberculosis listed by the World Health Organization. Delay in multidrug resistant tuberculosis treatment may allow progression of the ...

    Authors: Mahfuza Rifat, John Hall, Christopher Oldmeadow, Ashaque Husain and Abul Hasnat Milton

    Citation: BMC Infectious Diseases 2015 15:526

    Content type: Research article

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  15. Intraocular tuberculosis is uncommon and has various clinical presentations. Lack of specific clinical clues can make the diagnosis challenging. The purpose of this study is to report a clinical presentation o...

    Authors: Sunee Chansangpetch, Anita Manassakorn, Prasart Laksanaphuk and Usanee Reinprayoon

    Citation: BMC Infectious Diseases 2015 15:476

    Content type: Case report

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  16. The diagnosis of leprosy is based on clinical symptoms of the disease, which may not be sufficient to ensure early diagnosis. The development of effective tools for the early detection of infection, such as ra...

    Authors: Ana Paula Mendes Carvalho, Angélica da Conceição Oliveira Coelho Fabri, Rodrigo Corrêa Oliveira and Francisco Carlos Félix Lana

    Citation: BMC Infectious Diseases 2015 15:219

    Content type: Research article

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  17. Serological tests can be important tools to assist in the diagnosis of leprosy and can contribute to an earlier diagnosis. The aim of this study was to evaluate the antibody responses against phenolic glycolip...

    Authors: Angélica da Conceição Oliveira Coelho Fabri, Ana Paula Mendes Carvalho, Sergio Araujo, Luiz Ricardo Goulart, Ana Márcia Menezes de Mattos, Henrique Couto Teixeira, Isabela Maria Bernardes Goulart, Malcolm S. Duthie, Rodrigo Correa-Oliveira and Francisco Carlos Félix Lana

    Citation: BMC Infectious Diseases 2015 15:218

    Content type: Research article

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  18. Authors: Nicola M Zetola, Nenad Macesic, Sanghyuk S Shin, Alexandra Peloso, Ronald Ncube, Jeffrey D Klausner, Chawangwa Modongo and Ronald G Collman

    Citation: BMC Infectious Diseases 2015 15:211

    Content type: Erratum

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    The original article was published in BMC Infectious Diseases 2014 14:409

  19. Directly observed therapy (DOT), as recommended by the World Health Organization, is used in many countries to deliver tuberculosis (TB) treatment. The effectiveness of community-based (CB DOT) versus clinic D...

    Authors: Cameron M Wright, Lenna Westerkamp, Sarah Korver and Claudia C Dobler

    Citation: BMC Infectious Diseases 2015 15:210

    Content type: Research article

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  20. The leprosy transmission chain is very complex and, in order to intervene in this transmission, more must be known about the factors linked to falling ill. There are doubts as to the influence of population si...

    Authors: Mônica Duarte-Cunha, Geraldo Marcelo da Cunha and Reinaldo Souza-Santos

    Citation: BMC Infectious Diseases 2015 15:196

    Content type: Research article

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  21. The incidence of M. tuberculosis (MTB) and non tuberculous Mycobacterium species (NTMs) like M. avium and M. kansasii has increased due to Human Immunodeficiency Virus (HIV) epidemic. Therefore accurate, rapid an...

    Authors: Arnold Bainomugisa, Eddie Wampande, Chris Muchwa, Joseph Akol, Paul Mubiri, Henry Ssenyungule, Enock Matovu, Sam Ogwang and Moses Joloba

    Citation: BMC Infectious Diseases 2015 15:181

    Content type: Research article

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  22. Nearly one third of the world is infected with latent tuberculosis infection (LTBI) and a vast pool of individuals with LTBI persists in developing countries, posing a major barrier to global TB control. The a...

    Authors: Florence N Kizza, Justin List, Allan K Nkwata, Alphonse Okwera, Amara E Ezeamama, Christopher C Whalen and Juliet N Sekandi

    Citation: BMC Infectious Diseases 2015 15:165

    Content type: Research article

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  23. Tetrandrine is a natural chemical product purified from fourstamen stephania root which recently has been shown to act similarly as synthesized drug efflux pump inhibitor verapamil. The aim of the study is to exa...

    Authors: Zhe Zhang, Jie Yan, Kaijin Xu, Zhongkang Ji and Lanjuan Li

    Citation: BMC Infectious Diseases 2015 15:153

    Content type: Research article

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  24. Mannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. Polymorphism of MBL and MASP-2 genes may affect the serum concentrati...

    Authors: Mengshi Chen, Ying Liang, Wufei Li, Mian Wang, Li Hu, Benjamin Kwaku Abuaku, Xin Huang, Hongzhuan Tan and Shi Wu Wen

    Citation: BMC Infectious Diseases 2015 15:151

    Content type: Research article

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  25. In limited resource settings, sputum smear conversion at the end of the intensive phase of tuberculosis treatment is an indicator not only of patients’ response to treatment, but also of anti-tuberculosis prog...

    Authors: Fabrice Nembot Djouma, Michel Noubom, Jérôme Ateudjieu and Hubert Donfack

    Citation: BMC Infectious Diseases 2015 15:139

    Content type: Research article

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  26. The available pharmacokinetic data on anti-tubercular drugs in children raises the concern of suboptimal plasma concentrations attained when doses extrapolated from adult studies are used. Also, there is lack ...

    Authors: Aparna Mukherjee, Thirumurthy Velpandian, Mohit Singla, Kunwar Kanhiya, Sushil K Kabra and Rakesh Lodha

    Citation: BMC Infectious Diseases 2015 15:126

    Content type: Research article

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  27. Tuberculosis (TB) is a global public health concern. It is even more so as its incidence seems to be increasing in South Africa. The aim of this study was to describe and compare the tuberculosis infection con...

    Authors: Ntambwe Malangu and Michah Mngomezulu

    Citation: BMC Infectious Diseases 2015 15:117

    Content type: Research article

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  28. Ethiopia, a high tuberculosis (TB) burden country, reports one of the highest incidence rates of extra-pulmonary TB dominated by cervical lymphadenitis (TBLN). Infection with Mycobacterium bovis has previously be...

    Authors: Stefan Berg, Esther Schelling, Elena Hailu, Rebuma Firdessa, Balako Gumi, Girume Erenso, Endalamaw Gadisa, Araya Mengistu, Meseret Habtamu, Jemal Hussein, Teklu Kiros, Shiferaw Bekele, Wondale Mekonnen, Yohannes Derese, Jakob Zinsstag, Gobena Ameni…

    Citation: BMC Infectious Diseases 2015 15:112

    Content type: Research article

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  29. Close contacts of patients with tuberculosis (TB) have a substantial risk of developing the disease, particularly during the first year after exposure. Household contact investigation has recently been recomme...

    Authors: Gregory James Fox, Le Phuong Loan, Nguyen Viet Nhung, Nguyen Thi Loi, Dinh Ngoc Sy, Warwick John Britton and Guy Barrington Marks

    Citation: BMC Infectious Diseases 2015 15:103

    Content type: Research article

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  30. Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Toll-like-receptors (TLRs) are important for the recognition of the causative agent Mycobacterium tuberculosis. Negative regulation of...

    Authors: Dana C Blok, Liesbeth M Kager, Arie J Hoogendijk, Ivar O Lede, Wahid Rahman, Rumana Afroz, Paul Bresser, Jaring S van der Zee, Aniruddha Ghose, Caroline E Visser, Menno D de Jong, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan…

    Citation: BMC Infectious Diseases 2015 15:98

    Content type: Research article

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  31. In 2009, Brazil was the sole high-burden country to use three drugs [rifampin (R), isoniazid (H) and pyrazinamide (Z)] as the standard treatment for sensitive tuberculosis, with RH in fixed-dose combination (F...

    Authors: José Ueleres Braga and Anete Trajman

    Citation: BMC Infectious Diseases 2015 15:81

    Content type: Research article

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  32. Outcomes of antibiotic treatment for lung disease caused by nontuberculous mycobacteria (NTM) are unsatisfactory. The role of adjunctive surgery in the treatment of NTM lung disease is still unclear.

    Authors: Hyung Koo Kang, Hye Yun Park, Dohun Kim, Byeong-Ho Jeong, Kyeongman Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim and Won-Jung Koh

    Citation: BMC Infectious Diseases 2015 15:76

    Content type: Research article

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  33. The GeneXpertMTB/RIF (Xpert) assay is now recommended by WHO for diagnosis of tuberculosis (TB) in children but evaluation data is limited.

    Authors: Do Chau Giang, Tran Ngoc Duong, Dang Thi Minh Ha, Ho Thi Nhan, Marcel Wolbers, Nguyen Thi Quynh Nhu, Dorothee Heemskerk, Nguyen Dang Quang, Doan Thanh Phuong, Pham Thu Hang, Tran Huu Loc, Nguyen Thi Ngoc Lan, Nguyen Huy Dung, Jeremy Farrar and Maxine Caws

    Citation: BMC Infectious Diseases 2015 15:70

    Content type: Research article

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  34. The appearance of smear-positivity but culture-negativity (SPCN) for acid-fast bacilli among sputum specimen is frequently found in pulmonary tuberculosis (TB) patients during treatment. This study aimed to in...

    Authors: Wen-Cheng Chao, Yi-Wen Huang, Ming-Chih Yu, Wen-Ta Yang, Chou-Jui Lin, Jen-Jyh Lee, Ruay-Ming Huang, Chi-Chang Shieh, Shun-Tien Chien and Jung-Yien Chien

    Citation: BMC Infectious Diseases 2015 15:67

    Content type: Research article

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  35. Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be mi...

    Authors: Lydia Nakiyingi, Willy Ssengooba, Damalie Nakanjako, Derek Armstrong, Molly Holshouser, Bruce J Kirenga, Maunank Shah, Harriet Mayanja-Kizza, Moses L Joloba, Jerrold J Ellner, Susan E Dorman and Yukari C Manabe

    Citation: BMC Infectious Diseases 2015 15:62

    Content type: Research article

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  36. The screening and treatment of latent tuberculosis (TB) infection reduces the risk of progression to active disease and is currently recommended for HIV-infected patients. The aim of this study is to evaluate,...

    Authors: Chloé Wyndham-Thomas, Violette Dirix, Kinda Schepers, Charlotte Martin, Marc Hildebrand, Jean-Christophe Goffard, Fanny Domont, Myriam Libin, Marc Loyens, Camille Locht, Jean-Paul Van Vooren and Françoise Mascart

    Citation: BMC Infectious Diseases 2015 15:59

    Content type: Research article

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  37. Blood stream tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) is common among HIV-positive patients, turning rapidly fatal unless detected and treated promptly. Blood culture is currently the standar...

    Authors: Freddie Bwanga, Claudia Disqué, Michael G Lorenz, Vera Allerheiligen, William Worodria, Allan Luyombya, Irene Najjingo and Michael Weizenegger

    Citation: BMC Infectious Diseases 2015 15:48

    Content type: Research article

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  38. Single nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB). This study aimed to investigate ...

    Authors: Xing Zhang, Yanyuan Li, Xiang Li, Wanjiang Zhang, Zhifen Pan, Fang Wu, Chong Wang, Zhongliang Chen, Tingting Jiang, Dandan Xu, Zepeng Ping, Jiyan Liu, Changming Liu, Zhongjie Li and Ji-Cheng Li

    Citation: BMC Infectious Diseases 2015 15:41

    Content type: Research article

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  39. Tuberculosis (TB) is generally well controlled in Malaysia, but remains an important problem in the nation’s eastern states. In order to better understand factors contributing to high TB rates in the eastern s...

    Authors: Timothy William, Uma Parameswaran, Wai Khew Lee, Tsin Wen Yeo, Nicholas M Anstey and Anna P Ralph

    Citation: BMC Infectious Diseases 2015 15:32

    Content type: Research article

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  40. Data on the association between influenza and tuberculosis are limited. We describe the characteristics of patients with laboratory-confirmed tuberculosis, laboratory-confirmed influenza and tuberculosis-influ...

    Authors: Sibongile Walaza, Stefano Tempia, Halima Dawood, Ebrahim Variava, Jocelyn Moyes, Adam L Cohen, Nicole Wolter, Michelle Groome, Claire von Mollendorf, Kathleen Kahn, Marthi Pretorius, Marietjie Venter, Shabir A Madhi and Cheryl Cohen

    Citation: BMC Infectious Diseases 2015 15:26

    Content type: Research article

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  41. Tuberculosis (TB) rates among prisoners are more than 20 times that of the general population in Brazil, yet there are limited data available to facilitate the development of effective interventions in this hi...

    Authors: Andrea da Silva Santos Carbone, Dayse Sanchez Guimarães Paião, Renata Viebrantz Enne Sgarbi, Everton Ferreira Lemos, Renato Fernando Cazanti, Marcos Massaki Ota, Alexandre Laranjeira Junior, José Victor Bortolotto Bampi, Vanessa Perreira Fayad Elias, Simone Simionatto, Ana Rita Coimbra Motta-Castro, Maurício Antonio Pompílio, Sandra Maria do Valle de Oliveira, Albert I Ko, Jason R Andrews and Julio Croda

    Citation: BMC Infectious Diseases 2015 15:24

    Content type: Research article

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  42. Evidence suggests that human leukocyte antigen (HLA) alleles influence the host immune response against Mycobacterium leprae. However, the association between HLA alleles and borderline (B) leprosy has not been s...

    Authors: Fabiana Covolo de Souza-Santana, Elaine Valim Camarinha Marcos, Maria Esther Salles Nogueira, Somei Ura and Jane Tomimori

    Citation: BMC Infectious Diseases 2015 15:22

    Content type: Research article

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  43. We evaluated predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial compari...

    Authors: John A Crump, Xingye Wu, Michelle A Kendall, Prudence D Ive, Johnstone J Kumwenda, Beatriz Grinsztejn, Ute Jentsch and Susan Swindells

    Citation: BMC Infectious Diseases 2015 15:12

    Content type: Research article

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  44. To date, more than 125 species of nontuberculous mycobacteria (NTM) have been identified. In this study, we investigated the frequency and clinical implication of the rarely isolated NTM from respiratory speci...

    Authors: Junghyun Kim, Moon-Woo Seong, Eui-Chong Kim, Sung Koo Han and Jae-Joon Yim

    Citation: BMC Infectious Diseases 2015 15:9

    Content type: Research article

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  45. The diagnostic accuracy of fine-needle aspiration (FNA) cytology for the diagnosis of tuberculous lymphadenitis (TBLN) is confounded by mimicking cytomorphologic disorders. The objective of this study was to d...

    Authors: Ketema Abdissa, Mulualem Tadesse, Mesele Bezabih, Alemayehu Bekele, Ludwig Apers, Leen Rigouts and Gemeda Abebe

    Citation: BMC Infectious Diseases 2014 14:720

    Content type: Research article

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  46. Although the evidence base regarding the use of the Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis (TB) when testing respiratory samples is well established, the evidence base for its diagnostic a...

    Authors: Laura Maynard-Smith, Natasha Larke, Jurgens A Peters and Stephen D Lawn

    Citation: BMC Infectious Diseases 2014 14:709

    Content type: Research article

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  47. Tuberculosis (TB) mortality remains high across sub-Saharan Africa despite integration of TB and HIV/ART programmes. To inform programme design and service delivery, we estimated mortality by time from startin...

    Authors: Nigel Field, Megan SC Lim, Jill Murray, Robert J Dowdeswell, Judith R Glynn and Pam Sonnenberg

    Citation: BMC Infectious Diseases 2014 14:3858

    Content type: Research article

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  48. It is debated whether interferon-based therapy (IBT) would affect the incidence of active tuberculosis (TB) among hepatitis C virus (HCV) infected patients. Although some case reports have demonstrated a possi...

    Authors: Shang-Yi Lin, Tun-Chieh Chen, Po-Liang Lu, Chun-Yu Lin, Wei-Ru Lin, Yi-Hsin Yang and Yen-Hsu Chen

    Citation: BMC Infectious Diseases 2014 14:705

    Content type: Research article

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  49. The global increase in the burden of multidrug-resistant tuberculosis (MDR-TB) underscores an urgent need for data on factors involved in generation and spread of TB drug resistance. We performed molecular ana...

    Authors: Nicholas Ezati, Deus Lukoye, Eddie M Wampande, Kenneth Musisi, George W Kasule, Frank GJ Cobelens, David P Kateete and Moses L Joloba

    Citation: BMC Infectious Diseases 2014 14:703

    Content type: Research article

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.