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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. High rates of Adverse Events (AEs) during treatment is one of the leading causes of unsuccessful treatment outcomes among patients with drug resistant tuberculosis (DR-TB). However, information related to AEs ...

    Authors: Arjunkumar Jakasania, Kalpita Shringarpure, Dixit Kapadia, Radhika Sharma, Kedar Mehta, Arpit Prajapati and Soundappan Kathirvel

    Citation: BMC Infectious Diseases 2020 20:918

    Content type: Research article

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  2. Tuberculosis (TB) is a major human threat, as evidenced by the large numbers of cases and deaths, particularly in developing countries with poor economic and educational statuses. Myanmar has one of the highes...

    Authors: Theint Theint Lwin, Tawatchai Apidechkul, Jongkon Saising, Panupong Upala, Ratipark Tamornpark, Chalitar Chomchoei, Fartima Yeemard, Wipob Suttana and Rachanee Sunsern

    Citation: BMC Infectious Diseases 2020 20:904

    Content type: Research article

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  3. South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying anti-rheumatic drugs are associated with an increased risk of tuberculosis. The objective of this study was to descr...

    Authors: Tessa du Toit, Tonya M. Esterhuizen, Nicki Tiffin, Ahmed A. Abulfathi, Helmuth Reuter and Eric H. Decloedt

    Citation: BMC Infectious Diseases 2020 20:900

    Content type: Research article

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  4. Tuberculosis (TB) though primarily affects the lungs it may also affect the other parts of the body and referred as extra pulmonary (EPTB). This study is focused on understanding the genetic diversity and mole...

    Authors: Shanmugam Sivakumar, Yuvaraj Chandramohan, Gokul Raj Kathamuthu, Gomathi Sekar, Devika Kandhasamy, Venkatesan Padmanaban, Syed Hissar, Srikanth P. Tripathy, Ramalingam Bethunaickan, Baskaran Dhanaraj, Subash Babu and Uma Devi Ranganathan

    Citation: BMC Infectious Diseases 2020 20:894

    Content type: Research article

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  5. Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is becoming a significant health burden. Recent advances in analysis techniques have allowed the accurate identification of previously unknown NTM speci...

    Authors: Tomoki Kuge, Kiyoharu Fukushima, Yuki Matsumoto, Yuko Abe, Eri Akiba, Kako Haduki, Haruko Saito, Tadayoshi Nitta, Akira Kawano, Takahiro Kawasaki, Takanori Matsuki, Hiroyuki Kagawa, Daisuke Motooka, Kazuyuki Tsujino, Mari Miki, Keisuke Miki…

    Citation: BMC Infectious Diseases 2020 20:888

    Content type: Case report

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  6. Following infection with Mycobacterium tuberculosis (M.tb), individuals may rapidly develop tuberculosis (TB) disease or enter a “latent” infection state with a low risk of progression to disease. Mathematical mo...

    Authors: Tom Sumner and Richard G. White

    Citation: BMC Infectious Diseases 2020 20:880

    Content type: Research article

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  7. To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, a...

    Authors: Warinyupa Pinitpuwadol, Nattaporn Tesavibul, Sutasinee Boonsopon, Darin Sakiyalak, Sucheera Sarunket and Pitipol Choopong

    Citation: BMC Infectious Diseases 2020 20:877

    Content type: Research article

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  8. Mycolicibacterium fortuitum is a species of the rapidly growing mycobacteria that can cause pulmonary infection. It is susceptible to multiple antibiotics both in vitro and in clinical practice, so that any combi...

    Authors: Kana Kurokawa, Norihiro Harada, Hitoshi Sasano, Haruhi Takagi, Satomi Takei, Ayako Nakamura, Keisuke Kamada, Atsushi Yoshida, Ken Kikuchi and Kazuhisa Takahashi

    Citation: BMC Infectious Diseases 2020 20:866

    Content type: Case report

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  9. Mycobacterium houstonense is rapidly growing mycobacteria (RGM) that belongs to M. fortuitum group. So far, there have been few associated reports of human diseases induced by M. houstonense worldwide.

    Authors: Xin Che, Qingjian Li, Luoziyi Wang, Jing Jiang, Xuzhong Shen, Yiwen Qian and Zhiliang Wang

    Citation: BMC Infectious Diseases 2020 20:849

    Content type: Case report

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  10. Etiological diagnosis of tuberculous pleuritis is challenging, owing to a paucity of Mycobacterium tuberculosis (MTB) in the affected region. Moreover, currently available methods, such as the detection of acid-f...

    Authors: Chengjun Li, Chang Liu, Bingqi Sun, Wei Zhang, Yang Wang, Jiao Sun, Fang Ma and Yu Chen

    Citation: BMC Infectious Diseases 2020 20:840

    Content type: Research article

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  12. Severe and disseminated non-tuberculous mycobacterial (NTM) infections are frequently linked to a genetic predisposition but acquired defects of the interferon gamma (IFNγ) / interleukin 12 (IL-12) pathway nee...

    Authors: Malte Roerden, Rainer Döffinger, Gabriela Barcenas-Morales, Stephan Forchhammer, Stefanie Döbele and Christoph P. Berg

    Citation: BMC Infectious Diseases 2020 20:828

    Content type: Case report

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  13. Delay in the diagnosis of Tuberculosis (TB) remains a major challenge against achieving effective TB prevention and control. Though a number of studies with inconsistent findings were conducted in Ethiopia; un...

    Authors: Muluneh Alene, Moges Agazhe Assemie, Leltework Yismaw, Getnet Gedif, Daniel Bekele Ketema, Wodaje Gietaneh and Tadele Demilew Chekol

    Citation: BMC Infectious Diseases 2020 20:797

    Content type: Research article

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  14. Delay in diagnosis and treatment worsens the disease and clinical outcomes, which further enhances the transmission of tuberculosis (TB) in the community. Therefore, this study aims to assess treatment delay a...

    Authors: Huai-Zheng Gong, Chao Han, Feng-Lian Yang, Chun-Fang Wang, Jun-Li Wang and Mao-Shui Wang

    Citation: BMC Infectious Diseases 2020 20:793

    Content type: Research article

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  15. Tuberculosis (TB) remains a major public health concern in many low-income countries accounting for approximately two-thirds of deaths in people living with human immunodeficiency virus (HIV) infection. With p...

    Authors: Henry Dilonga Meriki, Ndze Henry Wung, Kukwah Anthony Tufon, Nyeke James Tony, Irene Ane-Anyangwe and Fidelis Cho-Ngwa

    Citation: BMC Infectious Diseases 2020 20:791

    Content type: Research article

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  16. People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target ...

    Authors: Patrick George Tobias Cudahy, Douglas Wilson and Ted Cohen

    Citation: BMC Infectious Diseases 2020 20:789

    Content type: Research article

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  17. Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The “Thwaites’ system” and “Lancet consensus scoring system” are utilized to differentiate TBM from bacterial meningiti...

    Authors: Tarek Sulaiman, Sai Medi, Hakan Erdem, Seniha Senbayrak, Derya Ozturk-Engin, Asuman Inan, Rok Civljak, Mihai Nechifor, Ayhan Akbulut, Alexandru Crisan, Muge Ozguler, Mustafa Namiduru, Branislava Savic, Olga Dulovic, Filiz Pehlivanoglu, Gonul Sengoz…

    Citation: BMC Infectious Diseases 2020 20:788

    Content type: Research article

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  18. Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013–2017.

    Authors: Teresa Domaszewska, Basel Karo, Ute Preuss, Christian Kollan, Annicka Reuss, Hans-Peter Blank, Bonita Brodhun, Barbara Hauer, Doris Altmann, Lena Fiebig, Walter Haas and Nita Perumal

    Citation: BMC Infectious Diseases 2020 20:766

    Content type: Research article

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  19. A more stringent QuantiFERON-TB Gold In-Tube (QFT) conversion (from negative to positive) definition has been proposed to allow more definite detection of recent tuberculosis (TB) infection. We explored altern...

    Authors: Rosa Sloot, Kwame Shanaube, Mareli Claassens, Lily Telisinghe, Ab Schaap, Peter Godfrey-Faussett, Helen Ayles and Sian Floyd

    Citation: BMC Infectious Diseases 2020 20:760

    Content type: Research article

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  20. Molecular epidemiological studies of Mycobacterium tuberculosis (MTB) are the core of current research to find out the association of the M. tuberculosis genotypes with its outbreak and transmission. The high pre...

    Authors: Anamika Gupta, Pallavi Sinha, Vijay Nema, Pramod K. Gupta, Pampi Chakraborty, Savita Kulkarni, Nalin Rastogi and Shampa Anupurba

    Citation: BMC Infectious Diseases 2020 20:752

    Content type: Research article

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  21. Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC). Mapping the genetic diversity of MTBC in high TB burden country like Ethiopia is important to understand principles of the disease transmi...

    Authors: Biniam Wondale, Kwon Keehwan, Girmay Medhin, Takele Teklu, Temesgen Mohammed, Samuel Tolosa, Aboma Zewude, Friehiwot Amsalu, Rembert Pieper and Gobena Ameni

    Citation: BMC Infectious Diseases 2020 20:750

    Content type: Research article

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  22. Effective active case finding (ACF) activities are essential for early identification of new cases of active tuberculosis (TB) and latent TB infection (LTBI). Accurate diagnostics as well as the ability to ide...

    Authors: Caroline Corbett, Aizat Kulzhabaeva, Tatjana Toichkina, Gulmira Kalmambetova, Sevim Ahmedov, Uladzimir Antonenka, Altyn Iskakova, Dilorom Kosimova, Dasha Migunov, Bakyt Myrzaliev, Evgeni Sahalchyk, Nagira Umetalieva, Monica Vogel, Abdylat Kadyrov and Harald Hoffmann

    Citation: BMC Infectious Diseases 2020 20:746

    Content type: Research article

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  23. Children living with sputum smear-positive adult tuberculosis (TB) patients are vulnerable to acquire tubercular infection. Contact tracing is an important strategy to control tubercular infection in the commu...

    Authors: Geetika Srivastava, M. M. A. Faridi and Shiv Sagar Gupta

    Citation: BMC Infectious Diseases 2020 20:720

    Content type: Research article

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  24. Mycobacterium bovis could infect patients with immunodeficiency or immunosuppressive conditions via Bacillus Calmette-Guérin (BCG) vaccination. Tuberculosis-related hemophagocytic syndrome (HPS) is reported, but ...

    Authors: Buyun Shi, Ming Chen, Zhi Xia, Shuna Xiao, Wen Tang, Chenguang Qin, Ying Cheng, Tao Huang, Chengjiao Huang, Yong Li and Hui Xu

    Citation: BMC Infectious Diseases 2020 20:711

    Content type: Case report

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  25. Intravesical administration of Bacillus Calmette–Guérin (BCG) has proven useful for treatment and prevention of recurrence of superficial bladder cancer and in situ carcinoma. However, fatal side effects such ...

    Authors: Gen Shimizu, Ryota Amano, Itaru Nakamura, Akane Wada, Masanobu Kitagawa and Shuta Toru

    Citation: BMC Infectious Diseases 2020 20:708

    Content type: Case report

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  26. To investigate the incidence of active tuberculosis (TB) among COPD patients using fluticasone/salmeterol or budesonide/formoterol, and to identify any differences between these two groups of patients.

    Authors: Tsan-Ming Huang, Kuan-Chih Kuo, Ya-Hui Wang, Cheng-Yi Wang, Chih-Cheng Lai, Hao-Chien Wang, Likwang Chen and Chong-Jen Yu

    Citation: BMC Infectious Diseases 2020 20:706

    Content type: Research article

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  27. There is limited research to guide TB treatment specifically in pregnant women and few studies have described the presentation of TB in pregnant women. We aimed to understand TB presentation and treatment outc...

    Authors: Brittney J. van de Water, Meredith B. Brooks, Chuan-Chin Huang, Letizia Trevisi, Leonid Lecca, Carmen Contreras, Jerome Galea, Roger Calderon, Rosa Yataco, Megan Murray and Mercedes C. Becerra

    Citation: BMC Infectious Diseases 2020 20:686

    Content type: Research article

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  28. Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB is being threatened by the increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series of sev...

    Authors: Oana Joean, Thea Thiele, Katharina Schütz, Nicolaus Schwerk, Ludwig Sedlacek, Barbara Kalsdorf, Ulrich Baumann and Matthias Stoll

    Citation: BMC Infectious Diseases 2020 20:678

    Content type: Research article

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  29. Person-centred care, an internationally recognised priority, describes the involvement of people in their care and treatment decisions, and the consideration of their needs and priorities within service delive...

    Authors: Shona Horter, Beverley Stringer, Nell Gray, Nargiza Parpieva, Khasan Safaev, Zinaida Tigay, Jatinder Singh and Jay Achar

    Citation: BMC Infectious Diseases 2020 20:675

    Content type: Research article

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  30. Mycobacterium jacuzzii (M. jacuzzii) was first isolated in 2003 by insertion of breast implants in Tel Aviv, Israel. In this case report, we describe our experience in detection of M. jacuzzii using phenotypic an...

    Authors: Fatemeh Sakhaee, Morteza Masoumi, Farzam Vaziri, Seyed Davar Siadat and Abolfazl Fateh

    Citation: BMC Infectious Diseases 2020 20:672

    Content type: Case report

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  31. Tuberculosis is still a significant diagnostic and therapeutic challenge with high proportion of smear- and culture- negative incidences worldwide. The conventional diagnostic tests are time-consuming and have...

    Authors: Lingna Lyu, Zihui Li, Liping Pan, Hongyan Jia, Qi Sun, Qiuyue Liu and Zongde Zhang

    Citation: BMC Infectious Diseases 2020 20:657

    Content type: Research article

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  32. Tuberculosis (TB) is transmitted in bioaerosols containing Mycobacterium tuberculosis (Mtb). Despite being central to ongoing TB transmission, no routine diagnostic assay exists to measure Mtb in bioaerosols. Fur...

    Authors: Benjamin Patterson, Anastasia Koch, Sophia Gessner, Ryan Dinkele, Melitta Gqada, Wayne Bryden, Frank Cobelens, Francesca Little, Digby F. Warner and Robin Wood

    Citation: BMC Infectious Diseases 2020 20:587

    Content type: Study protocol

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    The Correction to this article has been published in BMC Infectious Diseases 2020 20:624

  33. Non-adherence to tuberculosis (TB) treatment is the most important cause of poor TB outcomes, and improving support for TB patients is a primary priority for governments, but there has been little research on ...

    Authors: Xu Chen, Liang Du, Ruiheng Wu, Jia Xu, Haoqiang Ji, Yu Zhang, Xuexue Zhu and Ling Zhou

    Citation: BMC Infectious Diseases 2020 20:623

    Content type: Research article

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  34. To improve treatment outcomes for tuberculosis (TB), efforts to reduce treatment failure are necessary. The aim of our study was to describe the characteristics of subjects who had failed treatment of tubercul...

    Authors: Hyeon-Kyoung Koo, Jinsoo Min, Hyung Woo Kim, Joosun Lee, Ju Sang Kim, Jae Seuk Park and Sung-Soon Lee

    Citation: BMC Infectious Diseases 2020 20:622

    Content type: Research article

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  36. Ratios of different immune cell populations (i.e., monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte ratios) have been studied as a means of predicting future tuberculosis (TB) disease ...

    Authors: Christiaan A. Rees, Dwan B. Pineros, Maryam Amour, Patricia Munseri, Jamila Said, Albert Magohe, Mecky Matee, Kisali Pallangyo and C. Fordham von Reyn

    Citation: BMC Infectious Diseases 2020 20:609

    Content type: Research article

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  37. Implementation of an effective Tuberculosis Routine Surveillance System in low-income countries like Tanzania is problematic, despite being an essential tool for the detection and effective monitoring of drug ...

    Authors: Basra Esmail Doulla, Stephen Bertel Squire, Eleanor MacPherson, Esther Stanslaus Ngadaya, Beatrice Kemilembe Mutayoba and Ivor Langley

    Citation: BMC Infectious Diseases 2020 20:594

    Content type: Research article

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  38. Treatment of tuberculosis infection (TBI) in individuals at high risk for tuberculosis (TB) disease is a priority for TB elimination in the US. Newly arrived refugees in Middle Tennessee are screened for TBI, ...

    Authors: Adoma Manful, Leslie Waller, Ben Katz, Jason Cummins, Jon Warkentin, Billy Reagon, Joanna Shaw-Kaikai, Yuwei Zhu and Yuri F. van der Heijden

    Citation: BMC Infectious Diseases 2020 20:592

    Content type: Research article

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  39. In sub-Saharan Africa (SSA), most prisons are overcrowded with poor ventilation and put prisoners disproportionally at risk of exposure to Mycobacterium tuberculosis (TB) and developing TB infection but are mostl...

    Authors: Desmond Kuupiel, Portia Vezi, Vitalis Bawontuo, Ernest Osei and Tivani P. Mashamba-Thompson

    Citation: BMC Infectious Diseases 2020 20:570

    Content type: Research article

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  40. Globally, tuberculosis (TB) is the 10th leading cause of death. Despite no country achieved its target, the world health organization (WHO) proposed a 90–90-90 approach to fastening the end TB strategy. Improv...

    Authors: Kassahun Alemu Gelaye, Getu Debalkie, Tadesse Awoke Ayele, Sintayehu Daba Wami, Malede Mequanent Sisay, Destaw Fetene, Haileab Fekadu Wolde and Temesgen Yihunie Akalu

    Citation: BMC Infectious Diseases 2020 20:579

    Content type: Research article

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  41. China ranks second in the world in terms of numbers of tuberculosis (TB) cases and is one of the top three countries with the largest number of multidrug-resistant and rifampicin-resistant TB (MDR/RR-TB). It a...

    Authors: Liwen Zhang, Wei Xing, Jiani Zhou, Rui Zhang, Yong Cheng, Jin Li, Geng Wang, Shili Liu and Ying Li

    Citation: BMC Infectious Diseases 2020 20:576

    Content type: Research article

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  42. There is a general dearth of information on extrapulmonary tuberculosis (EPTB). Here, we investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tsh...

    Authors: Doctor B. Sibandze, Beki T. Magazi, Lesibana A. Malinga, Nontuthuko E. Maningi, Bong-Akee Shey, Jotam G. Pasipanodya and Nontombi N. Mbelle

    Citation: BMC Infectious Diseases 2020 20:556

    Content type: Research article

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  43. Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM an...

    Authors: Andrew D. Kerkhoff, Nicky Longley, Nicola Kelly, Anna Cross, Monica Vogt, Robin Wood, Sabine Hermans, Stephen D. Lawn and Thomas S. Harrison

    Citation: BMC Infectious Diseases 2020 20:555

    Content type: Research article

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  44. We examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates of tuberculosis.

    Authors: Mary R. Reichler, Christina Hirsch, Yan Yuan, Awal Khan, Susan E. Dorman, Neil Schluger and Timothy R. Sterling

    Citation: BMC Infectious Diseases 2020 20:553

    Content type: Research article

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  45. Bacteriological confirmation (BC) proportion among notified pulmonary TB patients in China is among the lowest in the world. This study was to understand the yield of BC using different testing strategies and ...

    Authors: Guoqin Zhang, Yuhua Zhang, Mingting Chen and Fan Zhang

    Citation: BMC Infectious Diseases 2020 20:548

    Content type: Research article

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  46. The main advantage of GeneXpert MTB/RIF® (Xpert) molecular diagnostic technology is the rapid detection of M.tuberculosis DNA and mutations associated with rifampicin (RIF) resistance for timely initiation of app...

    Authors: Julia V. Ershova, Grigory V. Volchenkov, Tatiana R. Somova, Tatiana A. Kuznetsova, Natalia V. Kaunetis, Dorothy Kaminski, Olga V. Demikhova, Larisa N. Chernousova, Irina A. Vasilyeva, Eleanor M. Kerr, J. Peter Cegielski and Ekaterina V. Kurbatova

    Citation: BMC Infectious Diseases 2020 20:543

    Content type: Research article

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  47. China is a country with a high burden of pulmonary tuberculosis (PTB). Chongqing is in the southwest of China, where the notification rate of PTB ranks tenth in China. This study analyzed the temporal and spat...

    Authors: Ya Yu, Bo Wu, Chengguo Wu, Qingya Wang, Daiyu Hu and Wei Chen

    Citation: BMC Infectious Diseases 2020 20:531

    Content type: Research article

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  48. Tuberculosis and intestinal parasites are mostly affecting poor people. They are in a vicious since one is the risk factor for the other. However, the comprehensive report on the burden and co-incidence of int...

    Authors: Ayinalem Alemu, Zebenay Workneh Bitew and Teshager Worku

    Citation: BMC Infectious Diseases 2020 20:510

    Content type: Research article

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  50. Tuberculosis is a disease that may affect any organ of the body. Multifocal tuberculosis involving multiple systems with associated symptoms are rare, which makes the diagnosis challenging. Distinguishing mult...

    Authors: Congxiao Wang, Ying Luan, Shifeng Liu, Mingwei Zhao, Hao Zhang, Wei Li, Zixiang Li, Xiaokun Hu and Lijing Peng

    Citation: BMC Infectious Diseases 2020 20:495

    Content type: Case report

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