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Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss and Eyal Oren 

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

Page 1 of 12

  1. Content type: Research article

    This study investigated the treatment outcomes, and factors affecting the outcomes, of new tuberculosis (TB) patients in Busan, South Korea.

    Authors: Jeongha Mok, Daeseong An, Seoungjin Kim, Miyoung Lee, Changhoon Kim and Hyunjin Son

    Citation: BMC Infectious Diseases 2018 18:655

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  2. Content type: Research article

    Tuberculosis (TB) caused an estimated 1.4 million deaths and 10.4 million new cases globally in 2015. TB rates in the United States continue to steadily decline, yet rates in the State of Hawaii are perenniall...

    Authors: Kent J. Koster, Angela Largen, Jeffrey T. Foster, Kevin P. Drees, Lishi Qian, Ed Desmond, Xuehua Wan, Shaobin Hou and James T. Douglas

    Citation: BMC Infectious Diseases 2018 18:608

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  3. Content type: Research article

    Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of ...

    Authors: N. B. Hoa, P. D. Phuc, N. T. Hien, V. Q. Hoa, P. H. Thuong, P. T. Anh and N. V. Nhung

    Citation: BMC Infectious Diseases 2018 18:603

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  4. Content type: Research article

    In developing countries, tuberculosis (TB) is a major public health problem and the leading cause of death among patients with HIV (Human Immunodeficiency Virus). Until 2001, the tuberculin skin test (TST) was...

    Authors: Giselle Burlamaqui Klautau, Nadijane Valéria Ferreira da Mota, Mauro José Costa Salles, Marcelo Nascimento Burattini and Denise Silva Rodrigues

    Citation: BMC Infectious Diseases 2018 18:585

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  5. Content type: Research article

    Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of non-c...

    Authors: Yvette Louise Schein, Tesfaye Madebo, Hilde Elise Andersen, Trude Margrete Arnesen, Anne Ma Dyrhol-Riise, Hallgeir Tveiten, Richard A. White and Brita Askeland Winje

    Citation: BMC Infectious Diseases 2018 18:587

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  6. Content type: Research article

    Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages...

    Authors: Jorge Rodrigues de Sousa, Francisco Dias Lucena Neto, Mirian Nacagami Sotto and Juarez Antonio Simões Quaresma

    Citation: BMC Infectious Diseases 2018 18:576

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  7. Content type: Research article

    The enteric string test can be used to obtain a specimen for microbiological confirmation of tuberculosis in children, but it is not widely used for this. The aim of this analysis to evaluate this approach in ...

    Authors: Karla T. Tafur, Julia Coit, Segundo R. Leon, Cynthia Pinedo, Silvia S. Chiang, Carmen Contreras, Roger Calderon, Milagros J. Mendoza, Leonid Lecca and Molly F. Franke

    Citation: BMC Infectious Diseases 2018 18:574

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  8. Content type: Research article

    By 2014 although tuberculosis (TB) incidence had fallen by an average of 1.5% per year since 2000 and was 18% lower than the level of in 2000, 1.5 million people died for TB in that year. One of reason was tha...

    Authors: Tao Shi, Tongxin Li, Jungang Li, Jing Wang and Zehua Zhang

    Citation: BMC Infectious Diseases 2018 18:565

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  9. Content type: Research article

    Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine w...

    Authors: Ming-Gui Wang, Miao-Miao Zhang, Yu Wang, Shou-Quan Wu, Meng Zhang and Jian-Qing He

    Citation: BMC Infectious Diseases 2018 18:561

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  10. Content type: Research article

    Globally recommended measures for comprehensive tuberculosis (TB) infection control (IC) are inadequately practiced in most health care facilities in Ethiopia. The aim of this study was to assess the extent of...

    Authors: Asfaw Ayalew, Zewdu Gashu, Tadesse Anteneh, Nebiyu Hiruy, Dereje Habte, Degu Jerene, Genetu Alem, Ilili Jemal, Muluken Melese and Pedro G. Suarez

    Citation: BMC Infectious Diseases 2018 18:557

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  11. Content type: Research article

    China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review ...

    Authors: Yun Qian, Qixin Han, Wenjun Liu, Wei-En Yuan and Cunyi Fan

    Citation: BMC Infectious Diseases 2018 18:543

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  12. Content type: Research article

    The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains un...

    Authors: Che-Liang Chung, Yen-Fu Chen, Yen-Ting Lin, Jann-Yuan Wang, Shuenn-Wen Kuo and Jin-Shing Chen

    Citation: BMC Infectious Diseases 2018 18:530

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  13. Content type: Research article

    The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve ...

    Authors: Alireza Neshani, Reza Kamali Kakhki, Mojtaba Sankian, Hosna Zare, Amin Hooshyar Chichaklu, Mahsa Sayyadi and Kiarash Ghazvini

    Citation: BMC Infectious Diseases 2018 18:517

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  14. Content type: Research article

    Early diagnosis of tuberculosis (TB) and involvement of the public-private partnership are critical to eradicate TB. Patients need to receive proper treatment through the National Tuberculosis Control Programm...

    Authors: K. A. T. M. Ehsanul Huq, Michiko Moriyama, Khalequ Zaman, Mohammod Jobayer Chisti, Julie Long, Akramul Islam, Shahed Hossain, Habiba Shirin, Mohammad Jyoti Raihan, Sajeda Chowdhury and Md Moshiur Rahman

    Citation: BMC Infectious Diseases 2018 18:515

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  15. Content type: Debate

    The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-expo...

    Authors: Liesbeth F Mieras, Anna T Taal, Wim H van Brakel, Emmanuelle Cambau, Paul R Saunderson, W Cairns S Smith, Cita Rosita S Prakoeswa, Linda Astari, David M Scollard, Dejair Caitano do Nascimento, Jacques Grosset, Hemanta K Kar, Shinzo Izumi, Laura Gillini, Marcos C L Virmond and Marieke G G Sturkenboom

    Citation: BMC Infectious Diseases 2018 18:506

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  16. Content type: Research article

    The depletion of CD4 cell is the underlying reason for TB hyper-susceptibility among people with HIV. Consequently, the trend of TB dynamics is usually hidden by the HIV outbreak.

    Authors: Dao Nguyen Vinh, Dang Thi Minh Ha, Nguyen Thi Hanh, Guy Thwaites, Maciej F. Boni, Hannah E. Clapham and Nguyen Thuy Thuong Thuong

    Citation: BMC Infectious Diseases 2018 18:494

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  17. Content type: Study protocol

    An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not cle...

    Authors: Bronwyn Myers, Tara C Bouton, Elizabeth J Ragan, Laura F White, Helen McIlleron, Danie Theron, Charles D H Parry, C Robert Horsburgh, Robin M Warren and Karen R Jacobson

    Citation: BMC Infectious Diseases 2018 18:488

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  18. Content type: Research article

    The programmatic management of Multidrug-resistant tuberculosis (MDR-TB) is entirely based on a WHO recommended long-term, 18–24 month lasting treatment regimen. However, growing evidence shows that low treatm...

    Authors: Setegn Eshetie, Animut Alebel, Fasil Wagnew, Demeke Geremew, Alebachew Fasil and Ulrich Sack

    Citation: BMC Infectious Diseases 2018 18:486

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  19. Content type: Research article

    HIV is a major driver of the tuberculosis epidemic in sub-Saharan Africa. The population-level impact of antiretroviral therapy (ART) scale-up on tuberculosis rates in this region has not been well studied. We...

    Authors: Diya Surie, Martien W. Borgdorff, Kevin P. Cain, Eleanor S. Click, Kevin M. DeCock and Courtney M. Yuen

    Citation: BMC Infectious Diseases 2018 18:481

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  20. Content type: Research article

    Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of ...

    Authors: Youn Jeong Kim, Ji Young Kang, Sang Il Kim, Mee Soo Chang, Yang Ree Kim and Yeon Joon Park

    Citation: BMC Infectious Diseases 2018 18:457

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  21. Content type: Research article

    It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of periphera...

    Authors: Liping Yan, Hongbo Shen and Heping Xiao

    Citation: BMC Infectious Diseases 2018 18:453

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  22. Content type: Research article

    Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycob...

    Authors: Jie Shi, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li and Jin Xing

    Citation: BMC Infectious Diseases 2018 18:447

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  23. Content type: Research article

    Multidrug resistant-tuberculosis (MDR-TB) is a major global health concern. Its treatment requires toxic medications, is longer and costlier than drug-susceptible TB, and often results in productivity losses a...

    Authors: Lisa Kawatsu, Kazuhiro Uchimura, Kiyohiko Izumi, Akihiro Ohkado and Takashi Yoshiyama

    Citation: BMC Infectious Diseases 2018 18:445

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  24. Content type: Research article

    Tuberculosis (TB), especially extrapulmonary tuberculosis (EPTB), is an important cause of fever of unknown origin (FUO) in TB-burdened areas. Little information is known about patients with EPTB with clinical...

    Authors: Jeong-Han Kim, Eu Suk Kim, Kang-Il Jun, Hyun gul Jung, Ji Hwan Bang, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh and Sang-Won Park

    Citation: BMC Infectious Diseases 2018 18:426

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  25. Content type: Research article

    The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions ha...

    Authors: Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci and Milton Ozório Moraes

    Citation: BMC Infectious Diseases 2018 18:422

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  26. Content type: Research article

    Diabetes is associated with increased risk of tuberculosis (TB) treatment failure, death, and relapse compared to patients without diabetes. Current TB regimens are available as fixed dose combination (FDC) an...

    Authors: Mohammad H. Al-Shaer, Hazem Elewa, Yosra Alkabab, Lama H. Nazer and Scott K. Heysell

    Citation: BMC Infectious Diseases 2018 18:384

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  27. Content type: Research article

    In Cape Town, the roll-out of antiretroviral therapy (ART) has increased over the last decade with an estimated coverage of 63% of HIV- positive patients in 2013. The influence of ART on the characteristics of...

    Authors: Richard Kaplan, Sabine Hermans, Judy Caldwell, Karen Jennings, Linda-Gail Bekker and Robin Wood

    Citation: BMC Infectious Diseases 2018 18:356

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  28. Content type: Research article

    Matrix metalloproteinases (MMPs) are considered to be key mediators of tuberculosis (TB) pathology but their role in tuberculosis – diabetes comorbidity (TB-DM) is not well understood.

    Authors: Nathella P. Kumar, Kadar Moideen, Vijay Viswanathan, Basavaradhya S. Shruthi, Shanmugam Sivakumar, Pradeep A. Menon, Hardy Kornfeld and Subash Babu

    Citation: BMC Infectious Diseases 2018 18:345

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  29. Content type: Research article

    Increasing case notifications is one of the top programmatic priorities of National TB Control Programmes (NTPs). To find more cases, NTPs often need to consider expanding TB case-detection activities to popul...

    Authors: Marek Lalli, Matthew Hamilton, Carel Pretorius, Debora Pedrazzoli, Richard G. White and Rein M. G. J. Houben

    Citation: BMC Infectious Diseases 2018 18:340

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  30. Content type: Research article

    Globally, 40% of all tuberculosis (TB) cases, 65% paediatric cases and 75% multi-drug resistant TB (MDR-TB) cases are missed due to underreporting and/or under diagnosis. A recent Kenyan TB prevalence survey f...

    Authors: J. N. Oliwa, J. Maina, P. Ayieko, D. Gathara, I. A. Kathure, E. Masini, A. H. van’t Hoog, M. B. van Hensbroek and M. English

    Citation: BMC Infectious Diseases 2018 18:328

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  31. Content type: Research article

    The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the sta...

    Authors: Conor D. Tweed, Angela M. Crook, Evans I. Amukoye, Rodney Dawson, Andreas H. Diacon, Madeline Hanekom, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Michael E. Murphy, Saraswathi E. Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Genevieve H. Wills…

    Citation: BMC Infectious Diseases 2018 18:317

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  32. Content type: Research article

    Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. ‘Blanket approach’ is an operational strategy for leprosy po...

    Authors: Anuj Tiwari, Steaven Dandel, Rita Djupuri, Liesbeth Mieras and Jan Hendrik Richardus

    Citation: BMC Infectious Diseases 2018 18:324

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  33. Content type: Research article

    Nontuberculous mycobacteria (NTM) infections in patients with cystic fibrosis (CF) is increasing globally. However, the related epidemiology, comorbidities, and clinical impact of NTM infection remains unclear...

    Authors: Maxine S. Eikani, Melodee Nugent, Arash Poursina, Pippa Simpson and Hara Levy

    Citation: BMC Infectious Diseases 2018 18:311

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  34. Content type: Case report

    Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of treatment are extremely rar...

    Authors: Akira Machida, Tasuku Ishihara, Eiichiro Amano and Shinichi Otsu

    Citation: BMC Infectious Diseases 2018 18:313

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  35. Content type: Research article

    Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitu...

    Authors: Sileshi Abdissa, Tamrat Abebe, Gobena Ameni, Sisay Teklu, Yonas Bekuretsion, Markos Abebe and Adane Mihret

    Citation: BMC Infectious Diseases 2018 18:304

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  36. Content type: Research article

    We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum cultu...

    Authors: Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S. M. Mostafa Kamal, Annemarie van Schadewijk, Pieter S. Hiemstra, Gudmundur H. Gudmundsson, Birgitta Agerberth and Rubhana Raqib

    Citation: BMC Infectious Diseases 2018 18:303

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  37. Content type: Research article

    Efficient and effective strategies for identifying cases of active tuberculosis (TB) in rural sub-Saharan Africa are lacking. Household contact tracing offers a potential approach to diagnose more TB cases, an...

    Authors: Kristen M. Little, Reginah Msandiwa, Neil Martinson, Jonathan Golub, Richard Chaisson and David Dowdy

    Citation: BMC Infectious Diseases 2018 18:299

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  38. Content type: Case report

    Tuberculous (TB) pneumonia can induce acute respiratory distress syndrome (ARDS). Although TB pneumonia is one of the causes of disease and death among children worldwide, the literature on TB pneumonia-induce...

    Authors: Dong Tien Ngo, Phuc Huu Phan, Shoji Kawachi, Noriko Nakajima, Naoyuki Hirata, Akira Ainai, Thuy Thi Bich Phung, Dien Minh Tran and Hai Thanh Le

    Citation: BMC Infectious Diseases 2018 18:294

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  39. Content type: Case report

    Although intravesical bacille Calmette-Guérin (BCG) therapy is accepted as an effective treatment for bladder cancer, serious complications may occur in rare cases. To date, only 4 cases have been reported in ...

    Authors: Takuya Kusakabe, Kenji Endo, Itaru Nakamura, Hidekazu Suzuki, Hirosuke Nishimura, Shinji Fukushima and Kengo Yamamoto

    Citation: BMC Infectious Diseases 2018 18:290

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  40. Content type: Research article

    Tuberculosis (TB) case finding is an important component of TB control because it can reduce transmission of Mycobacterium tuberculosis (MTB) through prompt detection and treatment of infectious patients.

    Authors: Godfrey Bigogo, Kevin Cain, Diana Nyole, Geoffrey Masyongo, Joshua Auko Auko, Newton Wamola, Albert Okumu, Janet Agaya, Joel Montgomery, Martien Borgdorff and Deron Burton

    Citation: BMC Infectious Diseases 2018 18:262

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  41. Content type: Research article

    Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely under...

    Authors: Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang and Jing Zhou

    Citation: BMC Infectious Diseases 2018 18:261

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  42. Content type: Research article

    The recurrence of tuberculosis (TB) disease in treated patients can serve as a marker of the efficacy of TB control programs. Recurrent disease represents either endogenous reactivation with the same strain of My...

    Authors: Laila Parvaresh, Taryn Crighton, Elena Martinez, Andrea Bustamante, Sharon Chen and Vitali Sintchenko

    Citation: BMC Infectious Diseases 2018 18:265

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  43. Content type: Research article

    Tuberculosis is among the top ten cause of death (9th) from a single infectious agent worldwide. It even ranks above HIV/AIDS. It is among the top 10 causes of death among children. Globally there are estimate...

    Authors: Bereket Gebremichael, Tsega-Ab Abebaw, Tsedey Moges, Admas Abera Abaerei and Nadia Worede

    Citation: BMC Infectious Diseases 2018 18:252

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  44. Content type: Research article

    Ethiopia is one of the world health organization defined higher tuberculosis (TB) burden countries where the disease remains a massive public health threat. This study aimed to identify the prevalence and asso...

    Authors: Biresaw Demile, Amare Zenebu, Haile Shewaye, Siqing Xia and Awoke Guadie

    Citation: BMC Infectious Diseases 2018 18:249

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  45. Content type: Research article

    Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) i...

    Authors: Song Yee Kim, Jungho Kim, Deok Ryun Kim, Young Ae Kang, Sungyoung Bong, Jonghee Lee, Suyeon Kim, Nam Suk Lee, Bora Sim, Sang-Nae Cho, Young Sam Kim and Hyejon Lee

    Citation: BMC Infectious Diseases 2018 18:240

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  46. Content type: Case report

    Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral...

    Authors: Megan E. Gray, Peter W. Liu and Brian Wispelwey

    Citation: BMC Infectious Diseases 2018 18:235

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