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Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss and Eyal Oren 

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

Page 1 of 11

  1. Content type: Research article

    Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of ...

    Authors: Youn Jeong Kim, Ji Young Kang, Sang Il Kim, Mee Soo Chang, Yang Ree Kim and Yeon Joon Park

    Citation: BMC Infectious Diseases 2018 18:457

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  2. Content type: Research article

    It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of periphera...

    Authors: Liping Yan, Hongbo Shen and Heping Xiao

    Citation: BMC Infectious Diseases 2018 18:453

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  3. Content type: Research article

    Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycob...

    Authors: Jie Shi, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li and Jin Xing

    Citation: BMC Infectious Diseases 2018 18:447

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  4. Content type: Research article

    Multidrug resistant-tuberculosis (MDR-TB) is a major global health concern. Its treatment requires toxic medications, is longer and costlier than drug-susceptible TB, and often results in productivity losses a...

    Authors: Lisa Kawatsu, Kazuhiro Uchimura, Kiyohiko Izumi, Akihiro Ohkado and Takashi Yoshiyama

    Citation: BMC Infectious Diseases 2018 18:445

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  5. Content type: Research article

    Tuberculosis (TB), especially extrapulmonary tuberculosis (EPTB), is an important cause of fever of unknown origin (FUO) in TB-burdened areas. Little information is known about patients with EPTB with clinical...

    Authors: Jeong-Han Kim, Eu Suk Kim, Kang-Il Jun, Hyun gul Jung, Ji Hwan Bang, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh and Sang-Won Park

    Citation: BMC Infectious Diseases 2018 18:426

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  6. Content type: Research article

    The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions ha...

    Authors: Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci and Milton Ozório Moraes

    Citation: BMC Infectious Diseases 2018 18:422

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  7. Content type: Research article

    Diabetes is associated with increased risk of tuberculosis (TB) treatment failure, death, and relapse compared to patients without diabetes. Current TB regimens are available as fixed dose combination (FDC) an...

    Authors: Mohammad H. Al-Shaer, Hazem Elewa, Yosra Alkabab, Lama H. Nazer and Scott K. Heysell

    Citation: BMC Infectious Diseases 2018 18:384

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  8. Content type: Research article

    In Cape Town, the roll-out of antiretroviral therapy (ART) has increased over the last decade with an estimated coverage of 63% of HIV- positive patients in 2013. The influence of ART on the characteristics of...

    Authors: Richard Kaplan, Sabine Hermans, Judy Caldwell, Karen Jennings, Linda-Gail Bekker and Robin Wood

    Citation: BMC Infectious Diseases 2018 18:356

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  9. Content type: Research article

    Matrix metalloproteinases (MMPs) are considered to be key mediators of tuberculosis (TB) pathology but their role in tuberculosis – diabetes comorbidity (TB-DM) is not well understood.

    Authors: Nathella P. Kumar, Kadar Moideen, Vijay Viswanathan, Basavaradhya S. Shruthi, Shanmugam Sivakumar, Pradeep A. Menon, Hardy Kornfeld and Subash Babu

    Citation: BMC Infectious Diseases 2018 18:345

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  10. Content type: Research article

    Increasing case notifications is one of the top programmatic priorities of National TB Control Programmes (NTPs). To find more cases, NTPs often need to consider expanding TB case-detection activities to popul...

    Authors: Marek Lalli, Matthew Hamilton, Carel Pretorius, Debora Pedrazzoli, Richard G. White and Rein M. G. J. Houben

    Citation: BMC Infectious Diseases 2018 18:340

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  11. Content type: Research article

    Globally, 40% of all tuberculosis (TB) cases, 65% paediatric cases and 75% multi-drug resistant TB (MDR-TB) cases are missed due to underreporting and/or under diagnosis. A recent Kenyan TB prevalence survey f...

    Authors: J. N. Oliwa, J. Maina, P. Ayieko, D. Gathara, I. A. Kathure, E. Masini, A. H. van’t Hoog, M. B. van Hensbroek and M. English

    Citation: BMC Infectious Diseases 2018 18:328

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  12. Content type: Research article

    The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the sta...

    Authors: Conor D. Tweed, Angela M. Crook, Evans I. Amukoye, Rodney Dawson, Andreas H. Diacon, Madeline Hanekom, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Michael E. Murphy, Saraswathi E. Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Genevieve H. Wills…

    Citation: BMC Infectious Diseases 2018 18:317

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  13. Content type: Research article

    Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. ‘Blanket approach’ is an operational strategy for leprosy po...

    Authors: Anuj Tiwari, Steaven Dandel, Rita Djupuri, Liesbeth Mieras and Jan Hendrik Richardus

    Citation: BMC Infectious Diseases 2018 18:324

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  14. Content type: Research article

    Nontuberculous mycobacteria (NTM) infections in patients with cystic fibrosis (CF) is increasing globally. However, the related epidemiology, comorbidities, and clinical impact of NTM infection remains unclear...

    Authors: Maxine S. Eikani, Melodee Nugent, Arash Poursina, Pippa Simpson and Hara Levy

    Citation: BMC Infectious Diseases 2018 18:311

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  15. Content type: Case report

    Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of treatment are extremely rar...

    Authors: Akira Machida, Tasuku Ishihara, Eiichiro Amano and Shinichi Otsu

    Citation: BMC Infectious Diseases 2018 18:313

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  16. Content type: Research article

    Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitu...

    Authors: Sileshi Abdissa, Tamrat Abebe, Gobena Ameni, Sisay Teklu, Yonas Bekuretsion, Markos Abebe and Adane Mihret

    Citation: BMC Infectious Diseases 2018 18:304

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  17. Content type: Research article

    We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum cultu...

    Authors: Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S. M. Mostafa Kamal, Annemarie van Schadewijk, Pieter S. Hiemstra, Gudmundur H. Gudmundsson, Birgitta Agerberth and Rubhana Raqib

    Citation: BMC Infectious Diseases 2018 18:303

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  18. Content type: Research article

    Efficient and effective strategies for identifying cases of active tuberculosis (TB) in rural sub-Saharan Africa are lacking. Household contact tracing offers a potential approach to diagnose more TB cases, an...

    Authors: Kristen M. Little, Reginah Msandiwa, Neil Martinson, Jonathan Golub, Richard Chaisson and David Dowdy

    Citation: BMC Infectious Diseases 2018 18:299

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  19. Content type: Case report

    Tuberculous (TB) pneumonia can induce acute respiratory distress syndrome (ARDS). Although TB pneumonia is one of the causes of disease and death among children worldwide, the literature on TB pneumonia-induce...

    Authors: Dong Tien Ngo, Phuc Huu Phan, Shoji Kawachi, Noriko Nakajima, Naoyuki Hirata, Akira Ainai, Thuy Thi Bich Phung, Dien Minh Tran and Hai Thanh Le

    Citation: BMC Infectious Diseases 2018 18:294

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  20. Content type: Case report

    Although intravesical bacille Calmette-Guérin (BCG) therapy is accepted as an effective treatment for bladder cancer, serious complications may occur in rare cases. To date, only 4 cases have been reported in ...

    Authors: Takuya Kusakabe, Kenji Endo, Itaru Nakamura, Hidekazu Suzuki, Hirosuke Nishimura, Shinji Fukushima and Kengo Yamamoto

    Citation: BMC Infectious Diseases 2018 18:290

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  21. Content type: Research article

    Tuberculosis (TB) case finding is an important component of TB control because it can reduce transmission of Mycobacterium tuberculosis (MTB) through prompt detection and treatment of infectious patients.

    Authors: Godfrey Bigogo, Kevin Cain, Diana Nyole, Geoffrey Masyongo, Joshua Auko Auko, Newton Wamola, Albert Okumu, Janet Agaya, Joel Montgomery, Martien Borgdorff and Deron Burton

    Citation: BMC Infectious Diseases 2018 18:262

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  22. Content type: Research article

    Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely under...

    Authors: Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang and Jing Zhou

    Citation: BMC Infectious Diseases 2018 18:261

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  23. Content type: Research article

    The recurrence of tuberculosis (TB) disease in treated patients can serve as a marker of the efficacy of TB control programs. Recurrent disease represents either endogenous reactivation with the same strain of My...

    Authors: Laila Parvaresh, Taryn Crighton, Elena Martinez, Andrea Bustamante, Sharon Chen and Vitali Sintchenko

    Citation: BMC Infectious Diseases 2018 18:265

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  24. Content type: Research article

    Tuberculosis is among the top ten cause of death (9th) from a single infectious agent worldwide. It even ranks above HIV/AIDS. It is among the top 10 causes of death among children. Globally there are estimate...

    Authors: Bereket Gebremichael, Tsega-Ab Abebaw, Tsedey Moges, Admas Abera Abaerei and Nadia Worede

    Citation: BMC Infectious Diseases 2018 18:252

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  25. Content type: Research article

    Ethiopia is one of the world health organization defined higher tuberculosis (TB) burden countries where the disease remains a massive public health threat. This study aimed to identify the prevalence and asso...

    Authors: Biresaw Demile, Amare Zenebu, Haile Shewaye, Siqing Xia and Awoke Guadie

    Citation: BMC Infectious Diseases 2018 18:249

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  26. Content type: Research article

    Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) i...

    Authors: Song Yee Kim, Jungho Kim, Deok Ryun Kim, Young Ae Kang, Sungyoung Bong, Jonghee Lee, Suyeon Kim, Nam Suk Lee, Bora Sim, Sang-Nae Cho, Young Sam Kim and Hyejon Lee

    Citation: BMC Infectious Diseases 2018 18:240

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  27. Content type: Research article

    With the widespread use of rifampicin and isoniazid, bacterial resistance has become a growing problem. Additionally, the lack of relevant baseline information for the frequency of drug-resistant tuberculosis ...

    Authors: Ming-Jin Zhang, Wen-Zhi Ren, Xue-Juan Sun, Yang Liu, Ke-Wei Liu, Zhong-Hao Ji, Wei Gao and Bao Yuan

    Citation: BMC Infectious Diseases 2018 18:234

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  28. Content type: Case report

    Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral...

    Authors: Megan E. Gray, Peter W. Liu and Brian Wispelwey

    Citation: BMC Infectious Diseases 2018 18:235

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  29. Content type: Research article

    Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Severa...

    Authors: Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J. Ellner, Yukari C. Manabe and Padmini Salgame

    Citation: BMC Infectious Diseases 2018 18:220

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  30. Content type: Case report

    Mycobacterium arupense, first identified in 2006, is a slow-growing nontuberculous mycobacterium (NTM) and an emerging cause of tenosynovitis, potentially associated with immunosuppression. However, unlike the di...

    Authors: Xian Zhou, Qiaoling Ruan, Weimin Jiang, Xinyu Wang, Yuan Jiang, Shenglei Yu, Yu Xu, Jing Li, Yangyi Zhang, Wenhong Zhang and Yuekai Hu

    Citation: BMC Infectious Diseases 2018 18:221

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  31. Content type: Research article

    TB outbreaking in schools is extremely complex, and presents a major challenge for public health. Understanding the knowledge, attitudes and practices among student TB patients in such settings is fundamental ...

    Authors: Yahui Fan, Shaoru Zhang, Yan Li, Yuelu Li, Tianhua Zhang, Weiping Liu and Hualin Jiang

    Citation: BMC Infectious Diseases 2018 18:213

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  32. Content type: Research article

    India plans to eliminate tuberculosis (TB) by 2025, and has identified screening and prevention as key activities. Household contacts (HHCs) of index TB cases are a high-risk population that would benefit from...

    Authors: Andrea DeLuca, Gauri Dhumal, Mandar Paradkar, Nishi Suryavanshi, Vidya Mave, Rewa Kohli, Shri Vijay Bala Yogendra Shivakumar, Vidula Hulyolkar, Archana Gaikwad, Ashwini Nangude, Geeta Pardeshi, Dileep Kadam and Amita Gupta

    Citation: BMC Infectious Diseases 2018 18:202

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  33. Content type: Research article

    The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to preve...

    Authors: N. Bionghi, A. Daftary, B. Maharaj, Z. Msibi, K. R. Amico, G. Friedland, C. Orrell, N. Padayatchi and M. R. O’Donnell

    Citation: BMC Infectious Diseases 2018 18:171

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  34. Content type: Research article

    Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical eff...

    Authors: Rafael Silva Gama, Thalisson Artur Ribeiro Gomides, Chaiana Fróes Magalhães Gama, Suelen Justo Maria Moreira, Fernanda Saloum de Neves Manta, Lorena Bruna P. de Oliveira, Pedro Henrique Ferreira Marçal, Euzenir Nunes Sarno, Milton Ozório Moraes, Raúl Marcel González Garcia and Lucia Alves de Oliveira Fraga

    Citation: BMC Infectious Diseases 2018 18:153

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  35. Content type: Research article

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequen...

    Authors: Audrey Forson, Awewura Kwara, Samuel Kudzawu, Michael Omari, Jacob Otu, Florian Gehre, Bouke de Jong and Martin Antonio

    Citation: BMC Infectious Diseases 2018 18:149

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  36. Content type: Research article

    Pretreatment loss to follow-up (PTLFU) is a barrier to tuberculosis (TB) control in India’s Revised National TB Control Programme (RNTCP). PTLFU studies have not been conducted in India’s mega-cities, where pa...

    Authors: Beena E. Thomas, Ramnath Subbaraman, Senthil Sellappan, Chandra Suresh, J. Lavanya, Savari Lincy, Agnes Lawrence Raja, B. Javeed, S. Kokila, S. Arumugam, Soumya Swaminathan and Kenneth H. Mayer

    Citation: BMC Infectious Diseases 2018 18:142

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  37. Content type: Research article

    Since 2006, the Peruvian National TB program (NTP) recommends voluntary counseling and testing (VCT) for all tuberculosis (TB) patients. Responding to the differential burden of both diseases in Peru, TB is ma...

    Authors: Suzanne Ramírez, Fernando Mejía, Marlene Rojas, Carlos Seas, Patrick Van der Stuyft, Eduardo Gotuzzo and Larissa Otero

    Citation: BMC Infectious Diseases 2018 18:136

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  38. Content type: Research article

    Precise designation of high risk forms of latent Mycobacterium tuberculosis-M.tb infections (LTBI) is impossible. Delineation of high-risk LTBI can, however, allow for chemoprophylaxis and curtail majority cases ...

    Authors: Misaki Wayengera, David P. Kateete, Benon Asiimwe and Moses L. Joloba

    Citation: BMC Infectious Diseases 2018 18:133

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  39. Content type: Research article

    Drug resistant tuberculosis (TB) is increasing in prevalence worldwide. Treatment failure and relapse is known to be high for patients with isoniazid resistant TB treated with standard first line regimens. How...

    Authors: Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thi Hanh, Jeremy Day, Sarah Dunstan, Nguyen Thi Quynh Nhu, Vo Sy Kiet, Nguyen Huu Lan, Nguyen Huy Dung, Nguyen Thi Ngoc Lan, Nguyen Thuong Thuong, Nguyen Ngoc Lan, Phạm Thị Thúy Liễu, Nguyễn Thị Hồng, Đào Công Điệp, Nguyễn Thị Kim Thanh…

    Citation: BMC Infectious Diseases 2018 18:112

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  40. Content type: Research article

    Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there is una...

    Authors: Medard Beyanga, Benson R. Kidenya, Lisa Gerwing-Adima, Eleanor Ochodo, Stephen E. Mshana and Christa Kasang

    Citation: BMC Infectious Diseases 2018 18:110

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  41. Content type: Research article

    Few prospective cohort studies, none in China, have investigated the relationship between treatment outcomes of multidrug-resistant tuberculosis (MDR-TB) patients and sputum culture conversion. Factors affecti...

    Authors: Qiao Liu, Peng Lu, Leonardo Martinez, Haitao Yang, Wei Lu, Xiaoyan Ding and Limei Zhu

    Citation: BMC Infectious Diseases 2018 18:114

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  42. Content type: Research article

    Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program...

    Authors: Yufeng Wen, Zhiping Zhang, Xianxiang Li, Dan Xia, Jun Ma, Yuanyuan Dong and Xinwei Zhang

    Citation: BMC Infectious Diseases 2018 18:104

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  43. Content type: Research article

    In 2012, the World Health Organization launched guidelines for systematically investigating contacts of persons with infectious tuberculosis (TB) in low- and middle-income countries. As such, it is necessary t...

    Authors: Gladys Kigozi, Michelle Engelbrecht, Christo Heunis and André Janse van Rensburg

    Citation: BMC Infectious Diseases 2018 18:106

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  44. Content type: Case report

    Mycobacterium tuberculosis (M. tuberculosis) disease is a generally well-known problem among immunocompromised adults and children. In pediatric oncology, only few cases of M. tuberculosis disease are reported so...

    Authors: Karoline van de Loo, Stefan Balzer, Colin R. MacKenzie, Thomas M. Boemers, Monika Ortmann, Jörg Schaper, Arndt Borkhardt, Hans-Jürgen Laws and Michaela Kuhlen

    Citation: BMC Infectious Diseases 2018 18:105

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  45. Content type: Research article

    Growth-based drug susceptibility testing (DST) is the reference standard for diagnosing drug-resistant tuberculosis (TB), but standard time to result (TTR) is typically ≥ 3 weeks. Rapid tests can reduce that T...

    Authors: Erik J. Groessl, Theodore G. Ganiats, Naomi Hillery, Andre Trollip, Roberta L. Jackson, Donald G. Catanzaro, Timothy C. Rodwell, Richard S. Garfein, Camilla Rodrigues, Valeriu Crudu, Thomas C. Victor and Antonino Catanzaro

    Citation: BMC Infectious Diseases 2018 18:102

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