Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss, Eyal Oren & Anna Vassall

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Research article

    G allele at −924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis

    Forkhead box protein 3 (FoxP3) is an important factor for development and function of Regulatory T cells (Treg). Studies have found an association between common gene polymorphisms in FoxP3 and some infectious di...

    Elham Beiranvand, Saeid Abediankenari, Soghra Khani, Hamideh Mahmoodzadeh Hosseini, Sirous Zeinali, Behnoush Beiranvand, Mehdi Goudarzi and Sima Sadat Seyedjavadi

    BMC Infectious Diseases 2017 17:673

    Published on: 11 October 2017

  2. Commentary

    Rational use of Xpert testing in patients with presumptive TB: clinicians should be encouraged to use the test-treat threshold

    A recently published Ugandan study on tuberculosis (TB) diagnosis in HIV-positive patients with presumptive smear-negative TB, which showed that out of 90 patients who started TB treatment, 20% (18/90) had a p...

    Tom Decroo, Aquiles R. Henríquez-Trujillo, Anja De Weggheleire and Lutgarde Lynen

    BMC Infectious Diseases 2017 17:674

    Published on: 11 October 2017

  3. Technical advance

    Evaluation of Mycobacterium tuberculosis viability in OMNIgene-SPUTUM reagent upon multi-day transport at ambient temperature

    Maintaining the quality of clinical specimens for tuberculosis (TB) testing is a major challenge in many high TB burden-limited resources countries. Sample referral systems in low and middle income countries a...

    Elisa Tagliani, Riccardo Alagna, Silva Tafaj, Hasan Hafizi and Daniela Maria Cirillo

    BMC Infectious Diseases 2017 17:663

    Published on: 2 October 2017

  4. Research article

    Predictors of unsuccessful interim treatment outcomes of multidrug resistant tuberculosis patients

    Interim treatment outcomes at 6-months for multidrug-resistant tuberculosis (MDR-TB) treatment are among the most basic performance monitoring and key evaluation indicators in the Stop and End TB strategy of t...

    Muhammad Atif, Arslan Bashir, Nafees Ahmad, Razia Kaneez Fatima, Sehar Saba and Shane Scahill

    BMC Infectious Diseases 2017 17:655

    Published on: 29 September 2017

  5. Research article

    Rifampicin resistance in mycobacterium tuberculosis patients using GeneXpert at Livingstone Central Hospital for the year 2015: a cross sectional explorative study

    Since the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literatu...

    Sepiso K. Masenga, Harrison Mubila and Benson M. Hamooya

    BMC Infectious Diseases 2017 17:640

    Published on: 22 September 2017

  6. Research article

    Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

    Sub-Saharan Africa continues to document high pediatric tuberculosis (TB) burden, especially among the urban poor. One recommended preventive strategy involves tracking and isoniazid preventive therapy (IPT) f...

    Florence Nafula Okwara, John Paul Oyore, Fred Nabwire Were and Samson Gwer

    BMC Infectious Diseases 2017 17:623

    Published on: 16 September 2017

  7. Research article

    Light-emitting diode fluorescent microscopy and Xpert MTB/RIF® assay for diagnosis of pulmonary tuberculosis among patients attending Ambo hospital, west-central Ethiopia

    The relatively simple and cheaper light-emitting diode fluorescent microscopy (LED-FM) was recommended by the World Health Organization (WHO) to replace the conventional tuberculosis (TB) microscopy in both hi...

    Alemu Gadissa Gelalcha, Abebaw Kebede and Hassen Mamo

    BMC Infectious Diseases 2017 17:613

    Published on: 11 September 2017

  8. Research article

    Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity

    Concurrent diabetes mellitus and tuberculosis represent a significant health problem worldwide. Patients with diabetes mellitus have a high risk of tuberculosis, which may be mediated by an abnormal innate imm...

    María Teresa Herrera, Yolanda Gonzalez, Fernando Hernández-Sánchez, Guadalupe Fabián-San Miguel and Martha Torres

    BMC Infectious Diseases 2017 17:610

    Published on: 7 September 2017

  9. Research article

    Treatment outcomes for isoniazid-resistant tuberculosis under program conditions in British Columbia, Canada

    Every year, over 1 million people develop isoniazid (INH) resistant tuberculosis (TB). Yet, the optimal treatment regimen remains unclear. Given increasing prevalence, the clinical efficacy of regimens used by...

    Kamila Romanowski, Leslie Y. Chiang, David Z. Roth, Mel Krajden, Patrick Tang, Victoria J. Cook and James C. Johnston

    BMC Infectious Diseases 2017 17:604

    Published on: 4 September 2017

  10. Research article

    Suitability of saliva for Tuberculosis diagnosis: comparing with serum

    In the search for fast, simple and better ways for diagnosis of tuberculosis (TB), there is need to discover and evaluate new biomarkers that are found in samples other than sputum to determine their effective...

    Anna Ritah Namuganga, Novel N. Chegou, Paul Mubiri, Gerhard Walzl and Harriet Mayanja-Kizza

    BMC Infectious Diseases 2017 17:600

    Published on: 31 August 2017

  11. Research article

    The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study

    The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child household contacts...

    Vera Golla, Kathryn Snow, Anna M. Mandalakas, Simon H. Schaaf, Karen Du Preez, Anneke C. Hesseling and James A. Seddon

    BMC Infectious Diseases 2017 17:593

    Published on: 29 August 2017

  12. Research article

    Tuberculosis active case finding in Cambodia: a pragmatic, cost-effectiveness comparison of three implementation models

    Globally, almost 40% of tuberculosis (TB) patients remain undiagnosed, and those that are diagnosed often experience prolonged delays before initiating correct treatment, leading to ongoing transmission. While...

    Richard James, Keovathanak Khim, Lydia Boudarene, Joanne Yoong, Chea Phalla, Saly Saint, Pichenda Koeut, Tan Eang Mao, Richard Coker and Mishal Sameer Khan

    BMC Infectious Diseases 2017 17:580

    Published on: 22 August 2017

  13. Research article

    Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad

    Emergence of Multidrug-resistant (MDR) strains constitutes a significant public health problem worldwide. Prevalence of MDR tuberculosis from Chad is unavailable to date.

    Awa Ba Diallo, Gedeon W. Ossoga, Geraldine Daneau, Seynabou Lo, Richard Ngandolo, Colette Diguimbaye Djaibé, Barou Djouater, Souleymane Mboup, Bouke C. de Jong, Aissatou G. Diallo and Florian Gehre

    BMC Infectious Diseases 2017 17:579

    Published on: 22 August 2017

  14. Research article

    Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil

    In household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversio...

    Edward C. Jones-López, Carlos Acuña-Villaorduña, Geisa Fregona, Patricia Marques-Rodrigues, Laura F. White, David Jamil Hadad, Lucilia Pereira Dutra-Molina, Solange Vinhas, Avery I. McIntosh, Mary Gaeddert, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J. Ellner and Reynaldo Dietze

    BMC Infectious Diseases 2017 17:576

    Published on: 18 August 2017

  15. Research article

    Treatment outcomes of patients with multidrug-resistant and extensively drug resistant tuberculosis in Hunan Province, China

    The worldwide emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has posed additional challenges for global tuberculosis (TB) control efforts, as limite...

    Kefyalew Addis Alene, Hengzhong Yi, Kerri Viney, Emma S. McBryde, Kunyun Yang, Liqiong Bai, Darren J. Gray, Archie C. A. Clements and Zuhui Xu

    BMC Infectious Diseases 2017 17:573

    Published on: 16 August 2017

  16. Research article

    Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil

    The implementation of rapid drug susceptibility testing (DST) is a current global priority for TB control. However, data are scarce on patient-relevant outcomes for presumptive diagnosis of drug-resistant tube...

    D. M. P. Ramalho, P. F. C. Miranda, M. K. Andrade, T. Brígido, M. P. Dalcolmo, E. Mesquita, C. F. Dias, A. N. Gambirasio, J. Ueleres Braga, A. Detjen, P. P. J. Phillips, I. Langley, P. I. Fujiwara, S. B. Squire, M. M. Oliveira and A. L. Kritski

    BMC Infectious Diseases 2017 17:571

    Published on: 15 August 2017

  17. Research article

    Predictors of delayed care seeking for tuberculosis in southern India: an observational study

    Reducing delay to accessing care is necessary to reduce the Tuberculosis (TB) burden in high incidence countries such as India. This study aimed to identify factors associated with delays in seeking care for T...

    Sarah E. Van Ness, Ankit Chandra, Sonali Sarkar, Jane Pleskunas, Jerrold J. Ellner, Gautam Roy, Subitha Lakshminarayanan, Swaroop Sahu, C. Robert Horsburgh Jr, Helen E. Jenkins and Natasha S. Hochberg

    BMC Infectious Diseases 2017 17:567

    Published on: 15 August 2017

  18. Research article

    The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study

    The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk...

    Lauren Philips, Janicke Visser, Daan Nel and Renée Blaauw

    BMC Infectious Diseases 2017 17:570

    Published on: 15 August 2017

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