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Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss and Eyal Oren 

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

Page 1 of 14

  1. In Vietnam, a country with a high tuberculosis (TB) burden, health professionals in both TB-specialized and non-TB-specialized general hospitals have a high risk of acquiring TB. The aims of the present study ...

    Authors: Chau Quy Ngo, Toshie Manabe, Giap Van Vu, Hanh Thi Chu, Trang Thi Thu Vu, Trang Thu Tran, Lan Thi Phuong Doan, Jin Takasaki and Koichiro Kudo

    Citation: BMC Infectious Diseases 2019 19:951

    Content type: Research article

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  2. Morbidity and mortality from Mycobacterium tuberculosis (Mtb) infection remain significant in cancer patients. We evaluated clinical characteristics, management, and outcomes in patients with active Mtb infection...

    Authors: Joumana Kmeid, Prathit A. Kulkarni, Marjorie V. Batista, Firas El Chaer, Amrita Prayag, Ella J. Ariza-Heredia, Victor E. Mulanovich and Roy F. Chemaly

    Citation: BMC Infectious Diseases 2019 19:934

    Content type: Research article

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  3. Pulmonary tuberculosis (PTB) is a major health and economic burden. Accurate PTB detection is an important step to eliminating TB globally. Interferon gamma-induced protein 10 (IP-10) has been reported as a po...

    Authors: Xia Qiu, Tao Xiong, Xiaojuan Su, Yi Qu, Long Ge, Yan Yue, Yan Zeng, Wenxing Li, Peng Hu and Dezhi Mu

    Citation: BMC Infectious Diseases 2019 19:924

    Content type: Research article

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  4. Pulmonary tuberculosis (TB) with detectable Mycobacterium tuberculosis in the sputum is a major source of transmission. In resource limited TB endemic settings, cure is declared through sputum smear examination f...

    Authors: Atiqa Ambreen, Muhammad Jamil, Mohammad Aqeel ur Rahman and Tehmina Mustafa

    Citation: BMC Infectious Diseases 2019 19:923

    Content type: Research article

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  5. A bi-directional interaction between diabetes mellitus and tuberculosis is well established and has been likened to that between HIV and TB. Whereas HIV screening is standard of care test in sub Saharan Africa...

    Authors: Patricia J. Munseri, Henrika Kimambo and Kisali Pallangyo

    Citation: BMC Infectious Diseases 2019 19:915

    Content type: Research article

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  6. Disseminated nontuberculous mycobacteria (NTM) infections occur mostly in immunocompromised patients. Therefore, it is difficult to diagnose disseminated NTM infections in patients without history of immunocom...

    Authors: Yun-Kai Yeh, Jing-Ya Ding, Cheng-Lung Ku and Wei-Chih Chen

    Citation: BMC Infectious Diseases 2019 19:909

    Content type: Case report

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  7. Drug-resistant tuberculosis (TB) is a major public health concern threathing the success of TB control efforts, and this is particularily problematic in Central Asia. Here, we present the first analysis of the...

    Authors: Anna Engström, Uladzimir Antonenka, Abdylat Kadyrov, Gulmira Kalmambetova, Katharina Kranzer, Matthias Merker, Olim Kabirov, Nargiza Parpieva, Asliddin Rajabov, Evgeni Sahalchyk, Zayniddin Sayfudtinov, Stefan Niemann and Harald Hoffmann

    Citation: BMC Infectious Diseases 2019 19:908

    Content type: Research article

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  8. The objectives of this study were to examine nutrient intakes of tuberculosis (TB) patients and to identify their associated factors.

    Authors: Zhewen Ren, Fei Zhao, Hui Chen, Dongmei Hu, Wentao Yu, Xiaoli Xu, Dingwen Lin, Fuyi Luo, Yueling Fan, Haijun Wang, Jun Cheng and Liyun Zhao

    Citation: BMC Infectious Diseases 2019 19:907

    Content type: Research article

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  9. Multidrug-resistant tuberculosis (MDR-TB) requires lengthy use of second-line drugs, burdened by many side effects. Hepatitis C virus (HCV) chronic infection increases risk of drug-induced liver injury (DILI) ...

    Authors: Maria Musso, Silvia Mosti, Gina Gualano, Paola Mencarini, Rocco Urso, Piero Ghirga, Alessia Rianda, Franca Del Nonno, Delia Goletti and Fabrizio Palmieri

    Citation: BMC Infectious Diseases 2019 19:882

    Content type: Case report

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  10. On 7th June, 2018, a primary school in Beijing, China notified Shunyi CDC of an outbreak of acute respiratory disease characterized by fever and cough among students and resulting in nine hospitalization cases...

    Authors: Wen-Zeng Zhang, Song-Jian Zhang, Quan-Yi Wang, Yin-Dong Li, Hong-Bo Jing, Guang-Yi Hu and Dan Wu

    Citation: BMC Infectious Diseases 2019 19:871

    Content type: Research article

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  11. The therapeutic response of cervical tuberculous lymphadenitis (CTBL) may be delayed or paradoxical, with the frequent development of residual lymph nodes (LNs) during and after antituberculous treatment. We i...

    Authors: Hyeri Seok, Ji Hoon Jeon, Kyung Ho Oh, Hee Kyoung Choi, Won Suk Choi, Young Hen Lee, Hyung Suk Seo, Soon You Kwon and Dae Won Park

    Citation: BMC Infectious Diseases 2019 19:867

    Content type: Research article

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  12. Tuberculosis is an important health concern in Iraq, but limited research has examined the quality of tuberculosis care and the survival of the patients. This study aimed to assess the 12-month survival of tub...

    Authors: Salah Tofik Jalal Balaky, Ahang Hasan Mawlood and Nazar P. Shabila

    Citation: BMC Infectious Diseases 2019 19:865

    Content type: Research article

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  13. Tuberculosis (TB) remains one of the infectious diseases with a leading cause of death among adults worldwide. Metformin, a first-line medication for the treatment of type 2 diabetes, may have potential for tr...

    Authors: Xinyu Yu, Ling Li, Liangtao Xia, Xin Feng, Fan Chen, Shiyi Cao and Xiang Wei

    Citation: BMC Infectious Diseases 2019 19:859

    Content type: Research article

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  14. The dual challenge of low diagnostic sensitivity of microscopy test and technical challenge of performing a TB culture test poses a problem for case detection and initiation of Tuberculosis (TB) second-line tr...

    Authors: S. A. Aricha, L. Kingwara, N. W. Mwirigi, L. Chaba, T. Kiptai, J. Wahogo, J. S. Otwabe, P. O. Onyango, M. Karanja, C. Ayieko and S. W. Matu

    Citation: BMC Infectious Diseases 2019 19:852

    Content type: Research article

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  15. In Lao People’s Democratic Republic (PDR), tuberculosis (TB) prevalence was estimated at 540/100,000 in 2011. Nevertheless, little is known about the genetic characteristics and anti-TB drug resistance of the Myc...

    Authors: Silaphet Somphavong, Jean-Luc Berland, Marie Gauthier, Thi Thuong Vu, Quang Huy Nguyen, Vibol Iem, Phouvang Vongvichit, Donekham Inthavong, Vanthala Akkhavong, Phetsavanh Chanthavilay, Sengaloun Soundala, Inthalaphone Keovichit, Glaucia Paranhos-Baccalà, Phimpha Paboriboune, Thi Van Anh Nguyen and Anne-Laure Bañuls

    Citation: BMC Infectious Diseases 2019 19:851

    Content type: Research article

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  16. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) shows great potential for diagnosis and assessing therapeutic response of tuberculous spondylitis. Tuberculous spondylitis required long-term ant....

    Authors: Ikchan Jeon, Eunjung Kong and Sang Woo Kim

    Citation: BMC Infectious Diseases 2019 19:845

    Content type: Case report

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  17. In settings such as China, where universal implementation of directly observed therapy (DOT) is not feasible, innovative approaches are needed to support patient adherence to TB treatment. The electronic medic...

    Authors: Ni Wang, Hui Zhang, Yang Zhou, Hui Jiang, Bing Dai, Miaomiao Sun, Ying Li, Amelia Kinter and Fei Huang

    Citation: BMC Infectious Diseases 2019 19:844

    Content type: Research article

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  18. Household contact tracing of index TB cases has been advocated as a key part of TB control for many years, but has not been widely implemented in many low-resource setting because of the current dearth of high...

    Authors: Peter MacPherson, Emily L. Webb, Ebrahim Variava, Sanjay G. Lala, Minja Milovanovic, Andrew Ratsela, Limakatso Lebina, Anthony Kinghorn and Neil A. Martinson

    Citation: BMC Infectious Diseases 2019 19:839

    Content type: Study protocol

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  19. Tuberculosis (TB) is a major public health problem in developing countries like Bangladesh. Female sex workers (FSWs) and their clients are active sources for spreading TB. The purpose of this study was to ass...

    Authors: Md. Masud Rana, Md. Rafiqul Islam, Sheikh MoinUddin, Md. Abdul Wadood and Md. Golam Hossain

    Citation: BMC Infectious Diseases 2019 19:837

    Content type: Research article

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  20. Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling. However, as yet, there are no su...

    Authors: Reem Gharbi, Besma Mhenni, Saloua Ben Fraj and Helmi Mardassi

    Citation: BMC Infectious Diseases 2019 19:819

    Content type: Research article

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  21. Multi-drug resistant Tuberculosis (MDR-TB) is a strain of Mycobacterium tuberculosis that is resistant to at least Rifampicin and Isoniazid drugs. The treatment success rate for MDR-TB cases is lower than for dru...

    Authors: Teklu Molie, Zelalem Teklemariam, Eveline Klinkenberg, Yadeta Dessie, Andargachew Kumsa, Hussen Mohammed, Adisalem Debebe, Dawit Assefa, Abebe Habte, Ahmed Bedru, Daniel Fiseha and Berhanu Seyoum

    Citation: BMC Infectious Diseases 2019 19:818

    Content type: Research article

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  22. The emergence of Drug-Resistance Tuberculosis (DR-TB) is an increasing global public health problem. Lost to Follow-up (LTFU) from DR-TB treatment remains a major barrier to tuberculosis epidemic control and b...

    Authors: Getahun Molla Kassa, Alemayehu Shimeka Teferra, Haileab Fekadu Wolde, Atalay Goshu Muluneh and Mehari Woldemariam Merid

    Citation: BMC Infectious Diseases 2019 19:817

    Content type: Research article

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  23. The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalenc...

    Authors: Roger I. Calderon, Maria B. Arriaga, Kattya Lopez, Nadia N. Barreda, Oswaldo M. Sanabria, José F. Fróes Neto, Davi Neri Araújo, Leonid Lecca and Bruno B. Andrade

    Citation: BMC Infectious Diseases 2019 19:799

    Content type: Research article

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  24. Regimens that could treat both rifampin-resistant (RR) and rifampin-susceptible tuberculosis (TB) while shortening the treatment duration have reached late-stage clinical trials. Decisions about whether and ho...

    Authors: Emily A. Kendall, Shelly Malhotra, Sarah Cook-Scalise, Claudia M. Denkinger and David W. Dowdy

    Citation: BMC Infectious Diseases 2019 19:794

    Content type: Research article

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  25. To investigate the prevalence and factors associated with the prevalence of multidrug/rifampicin-resistant tuberculosis among suspected drug resistant tuberculosis patients in Botswana.

    Authors: Blackson Pitolo Tembo and Ntambwe Gustav Malangu

    Citation: BMC Infectious Diseases 2019 19:779

    Content type: Research article

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  26. Environmental bacteria, nontuberculous mycobacteria (NTM), are recognized as one of the major human infection pathogens. NTM are prone to be mistaken as multidrug-resistant Mycobacterium tuberculosis and challeng...

    Authors: Chunmei Hu, Lili Huang, Min Cai, Weixiao Wang, Xudong Shi and Wei Chen

    Citation: BMC Infectious Diseases 2019 19:764

    Content type: Research article

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  27. Leprosy continues to be a health problem in endemic areas. More than 200,000 new cases of leprosy per year suggest that transmission of the disease is still ongoing, presumably as airborne infection through na...

    Authors: Marcus Beissner, Anna Woestemeier, Malkin Saar, Kossi Badziklou, Issaka Maman, Charlotte Amedifou, Magdalena Wagner, Franz X. Wiedemann, Komi Amekuse, Basile Kobara, Karl-Heinz Herbinger, Abiba Banla Kere, Thomas Löscher and Gisela Bretzel

    Citation: BMC Infectious Diseases 2019 19:753

    Content type: Technical advance

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  28. Although the incidence of tuberculosis (TB) has decreased in South Korea, the mortality rate remains high. TB mortality is a key indicator for TB control interventions. The purpose of this study was to assess ...

    Authors: Jinsoo Min, Ju Sang Kim, Hyung Woo Kim, Ah Young Shin, Hyeon-Kyoung Koo, Sung-Soon Lee, Yang-Ki Kim, Kyeong-Cheol Shin, Jung Hyun Chang, Gayoung Chun, Joosun Lee, Mi Sun Park and Jae Seuk Park

    Citation: BMC Infectious Diseases 2019 19:735

    Content type: Research article

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  29. At a time when programs were struggling to design effective regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB), the marketing authorization of bedaquiline and delamanid was a critical deve...

    Authors: Uzma Khan, Helena Huerga, Aamir J. Khan, Carole D. Mitnick, Catherine Hewison, Francis Varaine, Mathieu Bastard, Michael Rich, Molly F. Franke, Sidney Atwood, Palwasha Y. Khan and Kwonjune J. Seung

    Citation: BMC Infectious Diseases 2019 19:733

    Content type: Study protocol

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  30. Isoniazid resistant tuberculosis is the most prevalent type of resistance in Swaziland and over two-thirds of the isoniazid resistant tuberculosis patients are tuberculosis and human immunodeficiency virus co-...

    Authors: Nonhlanhla Christinah Dlamini, Dar-Der Ji and Li-Yin Chien

    Citation: BMC Infectious Diseases 2019 19:731

    Content type: Research article

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  31. Nucleic acid amplification tests (NAAT) have been used as a diagnostic tool for pulmonary tuberculosis (PTB) in Taiwan for many years. In accordance with Taiwanese legislation, health care personnel are requir...

    Authors: Chih-Wei Wu, Yao-Kuang Wu, Chou-Chin Lan, Mei-Chen Yang, Ting-Qian Dong, I-Shiang Tzeng and Shu-Shien Hsiao

    Citation: BMC Infectious Diseases 2019 19:726

    Content type: Research article

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  32. Non-tuberculous mycobacteria cause chronic pulmonary infection, but pleuritis and pleural effusion are rarely associated with infection with non-tuberculous mycobacteria, especially rapid-growing mycobacteria.

    Authors: Ryosuke Hirabayashi, Atsushi Nakagawa, Hiroshi Takegawa and Keisuke Tomii

    Citation: BMC Infectious Diseases 2019 19:720

    Content type: Case report

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  33. Despite rapid scale up of antiretroviral therapy (ART), Tuberculosis (TB) remains the commonest opportunistic infection and cause of death among HIV infected individuals in resource limited settings like India...

    Authors: Ameet Dravid, Kartik Natarajan, Mahenderkumar Medisetty, Raviraj Gawali, Uma Mahajan, Milind Kulkarni, Chinmay Saraf, Charuta Ghanekar, Sachin Kore, Niranjan Rathod and Mrudula Dravid

    Citation: BMC Infectious Diseases 2019 19:714

    Content type: Research article

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  34. In recent years, studies on the diagnostic accuracy of in-house real-time PCR (hRT-PCR) assay for the detection of Mycobacterium tuberculosis (Mtb) have been reported with unignorable discrepancies. To assess the...

    Authors: Zhenhong Wei, Xiaoping Zhang, Chaojun Wei, Liang Yao, Yonghong Li, Xiaojing Zhang, Hui Xu, Yanjuan Jia, Rui Guo, Yu Wu, Kehu Yang and Xiaoling Gao

    Citation: BMC Infectious Diseases 2019 19:701

    Content type: Research article

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  35. Extra-pulmonary tuberculosis (EPTB) represents about 14% of all cases of tuberculosis (TB) in Malaysia. The aims of the study include evaluation of socio-demographic factors, clinical manifestations, co-morbid...

    Authors: Amer Hayat Khan, Syed Azhar Syed Sulaiman, Madeeha Laghari, Mohamed Azmi Hassali, Abdul Razak Muttalif, Zohra Bhatti, Long Chiau Ming and Bandeh Ali Talpur

    Citation: BMC Infectious Diseases 2019 19:691

    Content type: Research article

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  36. Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown to be the major causes for INH resistance...

    Authors: Fengmin Huo, Jie Lu, Zhaojing Zong, Wei Jing, Jin Shi, Yifeng Ma, Lingling Dong, Liping Zhao, Yufeng Wang, Hairong Huang and Yu Pang

    Citation: BMC Infectious Diseases 2019 19:689

    Content type: Research article

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  37. Adolescents are a prime target group for tuberculosis (TB) vaccine trials that include prevention of infection (POI). The BCG vaccine is given at birth and does not prevent TB infection. TB infection, a critic...

    Authors: Videlis Nduba, Anna H. van’t Hoog, Annefleur de Bruijn, Ellen M. H. Mitchell, Kayla Laserson and Martien Borgdorff

    Citation: BMC Infectious Diseases 2019 19:682

    Content type: Research article

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  38. Previous qualitative studies suggested that the false negative rate of the T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients. However, more prec...

    Authors: Kui Li, Caiyong Yang, Zicheng Jiang, Shengxi Liu, Jun Liu, Chuanqi Fan, Tao Li and Xuemin Dong

    Citation: BMC Infectious Diseases 2019 19:673

    Content type: Research article

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  39. The neutrophil to lymphocyte ratio (NL ratio) has been reported to be a predictive biomarker of tuberculosis (TB). We assessed the association between the NL ratio and the incidence of active TB cases within 1...

    Authors: Reiko Miyahara, Surachai Piyaworawong, Vivek Naranbhai, Prarit Prachamat, Prapimporn Kriengwatanapong, Naho Tsuchiya, Jiraporn Wongyai, Surasit Bupachat, Norio Yamada, Surin Summanapan, Surakameth Mahasirimongkol and Hideki Yanai

    Citation: BMC Infectious Diseases 2019 19:667

    Content type: Research article

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  40. The diagnoses of active smear negative PTB, remains difficult. As a result, treatment is often carried out empirically relaying on clinical criteria. The distribution and magnitude of smear negative PTB, smear...

    Authors: Waganeh Sinshaw, Abebaw Kebede, Adane Bitew, Ephrem Tesfaye, Mengistu Tadesse, Zemedu Mehamed, Bazezew Yenew, Misikir Amare, Biniyam Dagne, Getu Diriba, Ayinalem Alemu, Muluwork Getahun, Dinka Fikadu, Kassu Desta and Habteyes Hailu Tola

    Citation: BMC Infectious Diseases 2019 19:641

    Content type: Research article

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  41. Tuberculosis (TB) is the infectious disease that kills the most people worldwide. The use of geoepidemiological techniques to demonstrate the dynamics of the disease in vulnerable communities is essential for ...

    Authors: Luana Seles Alves, Danielle Talita dos Santos, Marcos Augusto Moraes Arcoverde, Thais Zamboni Berra, Luiz Henrique Arroyo, Antônio Carlos Vieira Ramos, Ivaneliza Simionato de Assis, Ana Angélica Rêgo de Queiroz, Jonas Boldini Alonso, Josilene Dália Alves, Marcela Paschoal Popolin, Mellina Yamamura, Juliane de Almeida Crispim, Elma Mathias Dessunti, Pedro Fredemir Palha, Francisco Chiaraval-Neto…

    Citation: BMC Infectious Diseases 2019 19:628

    Content type: Research article

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  42. Malnutrition and diabetes are risk factors for active tuberculosis (TB), possible risk factors for latent TB infection (LTBI), and may interact to alter their effect on these outcomes. Studies to date have not...

    Authors: Rachel W. Kubiak, Sonali Sarkar, C. Robert Horsburgh, Gautam Roy, Mario Kratz, Ayiraveetil Reshma, Selby Knudsen, Padmini Salgame, Jerrold J. Ellner, Paul K. Drain and Natasha S. Hochberg

    Citation: BMC Infectious Diseases 2019 19:627

    Content type: Research article

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  43. About 10% latent tuberculosis infections (LTBI) would progress to active tuberculosis (TB), if left prophylactic therapy. Tuberculin skin test (TST) is the most widely used method for LTBI screening in the sch...

    Authors: Demin Cao, Zhiguo Zhang, Zhen Yang, Shubo Ma, Zhaogang Sun, Huijuan Duan, Baoli Zhu and Fei Zhao

    Citation: BMC Infectious Diseases 2019 19:619

    Content type: Research article

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  44. The increased transmission of multidrug-resistant (MDR) tuberculosis (TB) poses a challenge to tuberculosis prevention and control in Sri Lanka. Isoniazid (INH) is a key element of the first line anti tubercul...

    Authors: Roshanthi Eranga Karunaratne, Lahiru A. Wijenayaka, Sandya Sulochana Wijesundera, K. M. Nalin De Silva, Chamila Priyangani Adikaram and Jennifer Perera

    Citation: BMC Infectious Diseases 2019 19:618

    Content type: Research article

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  45. China contributed 8.9% of all incident cases of tuberculosis globally in 2017, and understanding the spatiotemporal distribution of pulmonary tuberculosis (PTB) in major transmission foci in the country is cri...

    Authors: Ting Li, Qu Cheng, Charles Li, Everleigh Stokes, Philip Collender, Alison Ohringer, Xintong Li, Jing Li, Jonathan L. Zelner, Song Liang, Changhong Yang, Justin V. Remais and Jin’ge He

    Citation: BMC Infectious Diseases 2019 19:615

    Content type: Research article

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  46. Early diagnosis of gastric tuberculosis is often challenging because the disease is very rare and its clinical manifestation is nonspecific and misleading. To raise the awareness and emphasize early diagnosis ...

    Authors: Jun Ma, Hongyun Yin and Huikang Xie

    Citation: BMC Infectious Diseases 2019 19:589

    Content type: Case report

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  47. With the aim of preparing a more effective, safe and economical vaccine for tuberculosis, inhalable live mycobacterium formulations were evaluated.

    Authors: Puja S. Nagpal, Ashwani Kesarwani, Parul Sahu and Pramod Upadhyay

    Citation: BMC Infectious Diseases 2019 19:568

    Content type: Research article

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