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Sexually transmitted diseases

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV and HIV-associated infections are considered in a separate section.

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  1. Reinfections of Chlamydia trachomatis (Ct) are common. In a two-armed intervention study at an urban STI clinic in the Netherlands, heterosexual Ct-positive visitors received an invitation for retesting after 4–5...

    Authors: Hannelore M Götz, Mireille EG Wolfers, Ad Luijendijk and Ingrid VF van den Broek

    Citation: BMC Infectious Diseases 2013 13:239

    Content type: Research article

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  2. Data on risk factors of recurrent bacterial vaginosis (RBV) are still scarce. We used data from female sex workers (FSW) participating in a randomized controlled microbicide trial to examine predictors of BV r...

    Authors: Fernand A Guédou, Lut Van Damme, Jennifer Deese, Tania Crucitti, Marissa Becker, Florence Mirembe, Suniti Solomon and Michel Alary

    Citation: BMC Infectious Diseases 2013 13:208

    Content type: Research article

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  3. Cervicitis is a syndrome of cervical inflammation and a common condition in female sex workers (FSW), a subpopulation vulnerable to sexually transmitted infections. Local data is essential for guiding syndromi...

    Authors: Simon Pollett, Martha Calderon, Kristen Heitzinger, Vicky Solari, Silvia M Montano and Joseph Zunt

    Citation: BMC Infectious Diseases 2013 13:195

    Content type: Research article

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  4. For almost two decades, chlamydia and gonorrhoea diagnosis rates in remote Indigenous communities have been up to 30 times higher than for non-Indigenous Australians. The high levels of population movement kno...

    Authors: Ben B Hui, Richard T Gray, David P Wilson, James S Ward, Anthony M A Smith, David J Philip, Matthew G Law, Jane S Hocking and David G Regan

    Citation: BMC Infectious Diseases 2013 13:188

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2014 14:86

  5. There has been a rapid decline in the number of young heterosexuals diagnosed with genital warts at outpatient sexual health services since the national human papillomavirus (HPV) vaccination program started i...

    Authors: Hammad Ali, Rebecca J Guy, Handan Wand, Tim RH Read, David G Regan, Andrew E Grulich, Christopher K Fairley and Basil Donovan

    Citation: BMC Infectious Diseases 2013 13:140

    Content type: Research article

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  6. High-risk human papilloma virus (HR-HPV) infection is associated with the development of cervical cancer. HPV vaccination reduces the risk of developing malignant lesions and is expected to change the dynamics...

    Authors: Karl Ulrich Petry, Alexander Luyten, Annika Justus, Angelika Iftner, Sarah Strehlke, Axel Reinecke-Lüthge, Elisabeth Grunwald, Renate Schulze-Rath and Thomas Iftner

    Citation: BMC Infectious Diseases 2013 13:135

    Content type: Research article

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  7. The national Human Papillomavirus (HPV) Immunisation Programme in New Zealand was introduced in 2008, and involves routine vaccination of girls 12–13 years with a catch-up for females aged up to 19 years. The ...

    Authors: Leonardo M Simonella, Hazel Lewis, Megan Smith, Harold Neal, Collette Bromhead and Karen Canfell

    Citation: BMC Infectious Diseases 2013 13:114

    Content type: Research article

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  8. Syphilis causes up to 1,500,000 congenital syphilis cases annually. These could be prevented if all pregnant women were screened, and those with syphilis treated with a single dose of penicillin before 28 week...

    Authors: Pieter W Smit, Thomas van der Vlis, David Mabey, John Changalucha, Julius Mngara, Benjamin D Clark, Aura Andreasen, Jim Todd, Mark Urassa, Basia Zaba and Rosanna W Peeling

    Citation: BMC Infectious Diseases 2013 13:102

    Content type: Technical advance

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  9. Seroreactivity, processes of seroconversion and seroreversion, in the context of HPV infection has been investigated in numerous studies. However, the data resulting from these studies are usually not accounte...

    Authors: Igor A Korostil, Suzanne M Garland, Matthew G Law and David G Regan

    Citation: BMC Infectious Diseases 2013 13:83

    Content type: Research article

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  10. Pre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention. Data on HPV prevalence i...

    Authors: Cristina Giambi, Serena Donati, Francesca Carozzi, Stefania Salmaso, Silvia Declich, Marta L Ciofi degli Atti, Guglielmo Ronco, Maria P Alibrandi, Silvia Brezzi, Natalina Collina, Daniela Franchi, Amedeo Lattanzi, Maria C Minna, Roberto Nannini, Elena Barretta, Elena Burroni…

    Citation: BMC Infectious Diseases 2013 13:74

    Content type: Research article

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  11. A cross sectional study to investigate HPV prevalence according to age and cytology.

    Authors: Elena Argyri, Stefanos Papaspyridakos, Elpida Tsimplaki, Lina Michala, Evangelia Myriokefalitaki, Issidora Papassideri, Dimitra Daskalopoulou, Ioanna Tsiaoussi, George Magiakos and Efstathia Panotopoulou

    Citation: BMC Infectious Diseases 2013 13:53

    Content type: Research article

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  12. Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health concern worldwide. In Vietnam, knowledge regarding N. gonorrhoeae prevalence and AMR is limited, and data concerning genetic charac...

    Authors: Birgitta Olsen, Pham Thi Lan, Daniel Golparian, Emma Johansson, Tran Hau Khang and Magnus Unemo

    Citation: BMC Infectious Diseases 2013 13:40

    Content type: Research article

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  13. Anogenital warts (AGWs) are a common, highly infectious disease caused by the human papillomavirus (HPV), whose high recurrence rates contribute to direct medical costs, productivity loss and increased psychos...

    Authors: Harshila Patel, Monika Wagner, Puneet Singhal and Smita Kothari

    Citation: BMC Infectious Diseases 2013 13:39

    Content type: Research article

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  14. Chlamydia trachomatis may cause multiple different urogenital tract disorders, but current non-culture assays for rapid screening of C. trachomatis typically use immunochromatography-based methods. We establishe...

    Authors: Ze-yu Wang, Guang-yu Fu, Shan-mei Wang, Dong-chun Qin, Zhong-quan Wang and Jing Cui

    Citation: BMC Infectious Diseases 2013 13:36

    Content type: Research article

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  15. Knowledge on antimicrobial drug resistance and genetic characteristics of Neisseria gonorrhoeae isolates circulating in India, Pakistan, and Bhutan is sorely lacking. In this paper, we describe the prevalence of ...

    Authors: Sunil Sethi, Daniel Golparian, Manju Bala, Dorji Dorji, Muhammad Ibrahim, Kausar Jabeen and Magnus Unemo

    Citation: BMC Infectious Diseases 2013 13:35

    Content type: Research article

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  16. As most genital Chlamydia trachomatis infections are asymptomatic, many patients do not seek health care for testing. Infections remain undiagnosed and untreated. We studied whether screening with information and...

    Authors: Hilde Kløvstad, Olav Natås, Aage Tverdal and Preben Aavitsland

    Citation: BMC Infectious Diseases 2013 13:30

    Content type: Research article

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  17. Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The pu...

    Authors: Ginesa Albero, Luisa L Villa, Eduardo Lazcano-Ponce, William Fulp, Mary R Papenfuss, Alan G Nyitray, Beibei Lu, Xavier Castellsagué, Martha Abrahamsen, Danélle Smith, F Xavier Bosch, Jorge Salmerón, Manuel Quiterio and Anna R Giuliano

    Citation: BMC Infectious Diseases 2013 13:18

    Content type: Research article

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  18. There are no data available on human papillomavirus (HPV) infections in women living in the Mississippi Delta, where cervical cancer incidence and mortality among African American women is among the highest in...

    Authors: Philip E Castle, Julia C Gage, Edward E Partridge, Alfio Rausa, Patti E Gravitt and Isabel C Scarinci

    Citation: BMC Infectious Diseases 2013 13:5

    Content type: Research article

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  19. Wolfsburg HPV Epidemiological Study (WOLVES) is a population-based cohort study on HPV infections and associated diseases in the pre-vaccination era in young women in Wolfsburg, Germany.

    Authors: Karl Ulrich Petry, Alexander Luyten, Annika Justus, Angelika Iftner, Sarah Strehlke, Renate Schulze-Rath and Thomas Iftner

    Citation: BMC Infectious Diseases 2012 12:367

    Content type: Research article

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  20. Syphilis is a growing public health problem among men who have sex with men (MSM) globally. Rapid and accurate detection of syphilis is vital to ensure patients and their contacts receive timely treatment and ...

    Authors: Matt Shields, Rebecca J Guy, Neisha J Jeoffreys, Robert J Finlayson and Basil Donovan

    Citation: BMC Infectious Diseases 2012 12:353

    Content type: Research article

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  21. Genital Human papilloma virus (HPV) is one of the most commonly diagnosed Sexually Transmitted Infection (STIs) in men and women. Knowledge about HPV infection among men is limited. This study aims to determin...

    Authors: Vivian Colón-López, Ana P Ortiz, Lizbeth M Del Toro-Mejías, Hermes García, Michael C Clatts and Joel Palefsky

    Citation: BMC Infectious Diseases 2012 12:346

    Content type: Research article

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  22. Men who have sex with men (MSM) especially those who are HIV positive are at risk for HPV-associated anal cancer. We systematically reviewed studies with data on the prevalence of vaccine preventable anal HPV ...

    Authors: Huachun Zou, Christopher K Fairley, Jane S Hocking, Suzanne M Garland, Andrew E Grulich and Marcus Y Chen

    Citation: BMC Infectious Diseases 2012 12:341

    Content type: Correspondence

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  23. The incidence of syphilis is increasing in many parts of the world. Clinicians may have limited experience in the diagnosis when the clinical appearance is unusual. If early diagnosis is not made and prompt tr...

    Authors: Kejian Zhu, Qiang Zhou, Rui Han and Hao Cheng

    Citation: BMC Infectious Diseases 2012 12:338

    Content type: Case report

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  24. This epidemiological study was carried out in Sfax (south of Tunisia) and focused on genital Chlamydia trachomatis (C. trachomatis) genovar distribution.

    Authors: Houda Gharsallah, Olfa Frikha-Gargouri, Hanen Sellami, Fatma Besbes, Abir Znazen and Adnene Hammami

    Citation: BMC Infectious Diseases 2012 12:333

    Content type: Research article

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  25. Early sexual behaviour has been shown to differ significantly between genders, but few studies have addressed this topic to explain the commonly observed differences in chlamydia rates between adolescent girls...

    Authors: Kirsten Gravningen, Anne-Sofie Furberg, Gunnar Skov Simonsen and Tom Wilsgaard

    Citation: BMC Infectious Diseases 2012 12:319

    Content type: Research article

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  26. Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous women living in remote co...

    Authors: Alice R Rumbold, Sarah E Tan, John R Condon, Debbie Taylor-Thomson, Maria Nickels, Sepehr N Tabrizi, Margaret LJ Davy, Margaret M O’Brien, Christine M Connors, Ibrahim Zardawi, Jim Stankovich and Suzanne M Garland

    Citation: BMC Infectious Diseases 2012 12:243

    Content type: Research article

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  27. Few data are available in Afghanistan to shape national military force health practices, particularly with regard to sexually-transmitted infections (STIs). We measured prevalence and correlates of HIV, syphil...

    Authors: Catherine S Todd, Abdul Nasir, G Farooq Mansoor, Sayed M Sahibzada, Linda L Jagodzinski, Farzana Salimi, M Naim Khateri, Braden R Hale, R Vincent Barthel and Paul T Scott

    Citation: BMC Infectious Diseases 2012 12:196

    Content type: Research article

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  28. The presence of hydrogen peroxide (H2O2) producing Lactobacillus in the vagina may play a role in controlling genital HIV-1 shedding. Sensitive molecular methods improve our ability to characterize the vaginal mi...

    Authors: Jennifer E Balkus, Caroline Mitchell, Kathy Agnew, Congzhou Liu, Tina Fiedler, Susan E Cohn, Amneris Luque, Robert Coombs, David N Fredricks and Jane Hitti

    Citation: BMC Infectious Diseases 2012 12:188

    Content type: Research article

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  29. Pelvic inflammatory disease (PID) results from the ascending spread of microorganisms from the vagina and endocervix to the upper genital tract. PID can lead to infertility, ectopic pregnancy and chronic pelvi...

    Authors: Sereina A Herzog, Christian L Althaus, Janneke CM Heijne, Pippa Oakeshott, Sally Kerry, Phillip Hay and Nicola Low

    Citation: BMC Infectious Diseases 2012 12:187

    Content type: Research article

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  30. The development of safe topical microbicides that can preserve the integrity of cervicovaginal tract epithelial barrier is of great interest as this may minimize the potential for increased susceptibility to S...

    Authors: Gracie Vargas, Igor Patrikeev, Jingna Wei, Brent Bell, Kathleen Vincent, Nigel Bourne and Massoud Motamedi

    Citation: BMC Infectious Diseases 2012 12:48

    Content type: Research article

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  31. Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate the relationship between va...

    Authors: Megan A Clarke, Ana Cecilia Rodriguez, Julia C Gage, Rolando Herrero, Allan Hildesheim, Sholom Wacholder, Robert Burk and Mark Schiffman

    Citation: BMC Infectious Diseases 2012 12:33

    Content type: Research article

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  32. A protocol for cervical cancer screening among sexually active women 25 to 65 years of age was introduced in 2006 in Catalonia, Spain to increase coverage and to recommend a 3-year-interval between screening c...

    Authors: Raquel Ibáñez, Judit Moreno-Crespi, Montserrat Sardà, Josefina Autonell, Montserrat Fibla, Cristina Gutiérrez, Belen Lloveras, María Alejo, Isabel Català, Francesc Alameda, Miquel Casas, F Xavier Bosch and Silvia de Sanjosé

    Citation: BMC Infectious Diseases 2012 12:25

    Content type: Research article

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  33. Men who have sex with men (MSM) are a known group at risk for hepatitis A and outbreaks among this group are frequent. In Barcelona, vaccination for MSM has been recommended since 1994. In 1998 a vaccination c...

    Authors: Cecilia Tortajada, Patricia G de Olalla, Elia Diez, Rosa M Pinto, Albert Bosch, Unai Perez, Milagros Sanz and Joan A Caylà

    Citation: BMC Infectious Diseases 2012 12:11

    Content type: Research article

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  34. Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their roles in chlamydial infection have not been evaluated.

    Authors: Bo Peng, Chunxue Lu, Lingli Tang, I-Tien Yeh, Zhimin He, Yimou Wu and Guangming Zhong

    Citation: BMC Infectious Diseases 2011 11:347

    Content type: Research article

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  35. Herpes simplex virus type-2 (HSV-2) is one of the most common sexually transmitted infections that facilitate human immunodeficiency virus (HIV) acquisition by over two fold or more. The development of HSV-2 c...

    Authors: Dipankar Biswas, Biswajyoti Borkakoty, Jagadish Mahanta, Kamini Walia, Lahari Saikia, Brogen S Akoijam, Lobsang Jampa, Alia Kharkongar and Eric Zomawia

    Citation: BMC Infectious Diseases 2011 11:325

    Content type: Research article

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  36. Cervical cancer is the second most common cancer in women worldwide. Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor associated with cervical cancer. This study an...

    Authors: Paloma Martín, Linah Kilany, Diego García, Ana M López-García, Mª José Martín-Azaña, Victor Abraira and Carmen Bellas

    Citation: BMC Infectious Diseases 2011 11:316

    Content type: Research article

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  37. Sexually transmitted infections (STIs) are among the frequent risks encountered by travelers. Efficient interventions are needed to improve the understanding of the risks of STIs. We investigated the potential...

    Authors: Nicolas Senn, Serge de Valliere, Didier Berdoz and Blaise Genton

    Citation: BMC Infectious Diseases 2011 11:300

    Content type: Research article

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  38. Young people are disproportionately affected by sexually transmissible infections in Australia but face barriers to accessing sexual health services, including concerns over confidentiality and, for some, geog...

    Authors: Cameryn C Garrett, Jane Hocking, Marcus Y Chen, Christopher K Fairley and Maggie Kirkman

    Citation: BMC Infectious Diseases 2011 11:285

    Content type: Research article

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  39. High-risk strains of human papillomavirus (HPV) cause cervical cancer. American Indian (AI) women in the Northern Plains of the U.S. have significantly higher incidence and mortality rates for cervical cancer ...

    Authors: Delf C Schmidt-Grimminger, Maria C Bell, Clemma J Muller, Diane M Maher, Subhash C Chauhan and Dedra S Buchwald

    Citation: BMC Infectious Diseases 2011 11:252

    Content type: Research article

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  40. Oncogenic human papillomavirus (HPV) infection prevalence is required to determine optimal vaccination strategies. We systematically reviewed the prevalence of oncogenic cervical HPV infection among Canadian f...

    Authors: Andrea C Tricco, Carmen H Ng, Vladimir Gilca, Andrea Anonychuk, Ba' Pham and Shirra Berliner

    Citation: BMC Infectious Diseases 2011 11:235

    Content type: Research article

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  41. As most genital chlamydia infections are asymptomatic, screening is the main way to detect and cases for treatment. We undertook a systematic review of studies assessing the efficacy of interventions for incre...

    Authors: Rebecca J Guy, Hammad Ali, Bette Liu, Simone Poznanski, James Ward, Basil Donovan, John Kaldor and Jane Hocking

    Citation: BMC Infectious Diseases 2011 11:211

    Content type: Research article

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  42. Sexually transmitted infection (STI) screening programmes are implemented in many countries to decrease burden of STI and to improve sexual health. Screening for Chlamydia trachomatis and Neisseria gonorrhoeae ha...

    Authors: Remco PH Peters, Stephan P Verweij, Noëmi Nijsten, Sander Ouburg, Johan Mutsaers, Casper L Jansen, A Petra van Leeuwen and Servaas A Morré

    Citation: BMC Infectious Diseases 2011 11:203

    Content type: Research article

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  43. Herpes Simplex Virus type 2 (HSV-2) has public health importance as a leading cause of genital ulcers, a co-factor in HIV-1 acquisition and transmission and as a cause of neonatal herpes infections. Little is ...

    Authors: Joyce U Nyiro, Eduard J Sanders, Caroline Ngetsa, Steve Wale, Ken Awuondo, Elizabeth Bukusi, Matthew A Price, Pauli N Amornkul and D James Nokes

    Citation: BMC Infectious Diseases 2011 11:155

    Content type: Research article

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