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Sexually transmitted diseases

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV and HIV-associated infections are considered in a separate section.

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  1. The inflammasome responses in Treponema pallidum infection have been poorly understood to date. This study aimed to investigate the expression of the nucleotide-binding leucine-rich receptor protein 3 (NLRP3) inf...

    Authors: Li-Rong Lin, Yao Xiao, Wei Liu, Yu-Yan Chen, Xiao-Zhen Zhu, Zheng-Xiang Gao, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Wen-Dong Li, Xian-Ming Liang, Yong Lin, Li-Li Liu and Tian-Ci Yang

    Citation: BMC Infectious Diseases 2018 18:101

    Content type: Research article

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  2. We aimed to describe anatomic site-specific concordance of gonococcal infections in partnerships of men who have sex with men (MSM).

    Authors: Vincent J. Cornelisse, Lei Zhang, Matthew Law, Marcus Y. Chen, Catriona S. Bradshaw, Clare Bellhouse, Christopher K. Fairley and Eric P. F. Chow

    Citation: BMC Infectious Diseases 2018 18:95

    Content type: Research article

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  3. The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because...

    Authors: Susanne Buder, Sandra Dudareva, Klaus Jansen, Anna Loenenbach, Sergejs Nikisins, Andrea Sailer, Eva Guhl, Peter K. Kohl and Viviane Bremer

    Citation: BMC Infectious Diseases 2018 18:44

    Content type: Research article

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  4. Genital warts are one of the most common forms of sexually-transmitted disease, but their epidemiology has yet to be thoroughly elucidated. The present study was designed to shed light on the prevalence of cli...

    Authors: Silvia Cocchio, Chiara Bertoncello, Tatjana Baldovin, Alessandra Buja, Silvia Majori and Vincenzo Baldo

    Citation: BMC Infectious Diseases 2018 18:41

    Content type: Research article

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  5. HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of no...

    Authors: Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi and Adriana Ammassari

    Citation: BMC Infectious Diseases 2018 18:25

    Content type: Research article

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  6. Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women’s well-being. The a...

    Authors: Ettore Palma, Nadia Recine, Lavinia Domenici, Margherita Giorgini, Alessandra Pierangeli and Pierluigi Benedetti Panici

    Citation: BMC Infectious Diseases 2018 18:13

    Content type: Research article

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  7. Control of gonorrhea in resource-limited countries, such as Indonesia, is mostly unsuccessful. Examining Neisseria gonorrhoeae (Ng) transmission networks using strain typing might help prioritizing public health ...

    Authors: I Putu Yuda Hananta, Alje Pieter van Dam, Maarten Franciscus Schim van der Loeff, Mirjam Dierdorp, Carolien Marleen Wind, Hardyanto Soebono, Henry John Christiaan de Vries and Sylvia Maria Bruisten

    Citation: BMC Infectious Diseases 2018 18:7

    Content type: Research article

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  8. Chlamydia infections are common in both men and women, are often asymptomatic and can cause serious complications. Repeat testing in high-risk groups is therefore indicated. In the Netherlands, guidelines on r...

    Authors: Maartje Visser, Fleur van Aar, Femke D. H. Koedijk, Carolina J. G. Kampman and Janneke C. M. Heijne

    Citation: BMC Infectious Diseases 2017 17:782

    Content type: Research article

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  9. Some sexually transmitted infectious agents, such as Chlamydia trachomatis and Herpes simplex, cause local inflammation, and could contribute to Human Papillomavirus (HPV) and cervical lesion progression. Thus, t...

    Authors: Aline Teixeira Amorim, Lucas Miranda Marques, Guilherme Barreto Campos, Tássia Neves Lobão, Vanesca de Souza Lino, Ricardo Cesar Cintra, Maria Antonieta Andreoli, Luisa Lina Villa, Enrique Boccardo, Antonio Carlos Ricardo Braga Junior, Rossana Verónica Mendoza López, Djanilson Barbosa dos Santos, Gerson Maciel de Souza, Carla Cristina Romano and Jorge Timenetsky

    Citation: BMC Infectious Diseases 2017 17:769

    Content type: Research article

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  10. Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for m...

    Authors: Zhangyan Lyu, Xiaoshuang Feng, Ni Li, Wei Zhao, Luopei Wei, Yuheng Chen, Wenjing Yang, Hongxia Ma, Bing Yao, Kai Zhang, Zhibin Hu, Hongbing Shen, Dong Hang and Min Dai

    Citation: BMC Infectious Diseases 2017 17:714

    Content type: Research article

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  11. If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this wou...

    Authors: Chris Kenyon

    Citation: BMC Infectious Diseases 2017 17:682

    Content type: Research article

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  12. Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality ...

    Authors: Evalyne Wambui Kanyina, Lucy Kamau and Margaret Muturi

    Citation: BMC Infectious Diseases 2017 17:647

    Content type: Research article

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  13. Maternal syphilis is a health threat to both the pregnant women and the children. This study aimed to delineate the longitudinal trend of maternal syphilis and burden of associated adverse pregnant outcomes (A...

    Authors: Yang Li, Liping Zhu, Li Du, Lingxiao Qu, Weili Jiang and Biao Xu

    Citation: BMC Infectious Diseases 2017 17:626

    Content type: Research article

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  14. The treatment failure and reinfection rates among syphilis patients are high, and relevant studies in China are limited. The aim of this study was to detect the rates of treatment failure and reinfection after...

    Authors: Zhenzhou Luo, Lin Zhu, Yi Ding, Jun Yuan, Wu Li, Qiuhong Wu, Lishan Tian, Li Zhang, Guomao Zhou, Tao Zhang, Jianping Ma, Zhongwei Chen, Tubao Yang, Tiejian Feng and Min Zhang

    Citation: BMC Infectious Diseases 2017 17:620

    Content type: Research article

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  15. Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to info...

    Authors: Michelle J. Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J. Amato-Gauci and Magnus Unemo

    Citation: BMC Infectious Diseases 2017 17:617

    Content type: Research article

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  16. Despite the guidelines for managing sexual assault being in place, victims of sexual assault attended to at Kadoma General Hospital consistently raised complaints related to the quality of care offered. Medico...

    Authors: Stanley Tapesana, Daniel Chirundu, Gerald Shambira, Notion Tafara Gombe, Tsitsi Patience Juru and Tshimanga Mufuta

    Citation: BMC Infectious Diseases 2017 17:602

    Content type: Research article

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  17. Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may inc...

    Authors: Jean Wysler Domercant, Frantz Jean Louis, Erin Hulland, Mark Griswold, Jocelyne Andre-Alboth, Tun Ye and Barbara J. Marston

    Citation: BMC Infectious Diseases 2017 17:577

    Content type: Research article

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  18. Testing for reinfection at 3 to 6 months following treatment for Chlamydia Trachomatis or Neisseria gonorrhoea is recommended in best practice sexual health management guidelines. This study aimed to describe rat...

    Authors: Sally B. Rose, Susan M. Garrett, James Stanley and Susan R. H. Pullon

    Citation: BMC Infectious Diseases 2017 17:526

    Content type: Research article

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  19. Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquir...

    Authors: Maaike Spaltenstein, Françoise Humbert, Diem-Lan Vu, Ilker Uçkay and Gregor John

    Citation: BMC Infectious Diseases 2017 17:520

    Content type: Case report

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  20. The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination ...

    Authors: Yang Bai, Feng Niu, Lidi Liu, Hui Sha, Yimei Wang and Song Zhao

    Citation: BMC Infectious Diseases 2017 17:513

    Content type: Case report

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  21. Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are sc...

    Authors: Gerit Korr, Michael Thamm, Irina Czogiel, Christina Poethko-Mueller, Viviane Bremer and Klaus Jansen

    Citation: BMC Infectious Diseases 2017 17:471

    Content type: Research article

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  22. Gonorrhoea is one of the most common sexually transmissible infections in men who have sex with men (MSM). Gonorrhoea rates have increased substantially in recent years. There is concern that increasing gonorr...

    Authors: Eric P. F. Chow, Sandra Walker, Jane S. Hocking, Catriona S. Bradshaw, Marcus Y. Chen, Sepehr N. Tabrizi, Benjamin P. Howden, Matthew G. Law, Kate Maddaford, Tim R. H. Read, David A. Lewis, David M. Whiley, Lei Zhang, Andrew E. Grulich, John M. Kaldor, Vincent J. Cornelisse…

    Citation: BMC Infectious Diseases 2017 17:456

    Content type: Study protocol

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  23. Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans ...

    Authors: Sari L. Reisner, Madeline B. Deutsch, Sarah M. Peitzmeier, Jaclyn M. White Hughto, Timothy Cavanaugh, Dana J. Pardee, Sarah McLean, Elliot J. Marrow, Matthew J. Mimiaga, Lori Panther, Marcy Gelman, Jamison Green and Jennifer Potter

    Citation: BMC Infectious Diseases 2017 17:444

    Content type: Study protocol

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  24. Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) populati...

    Authors: Nan-Yu Chen, Zhuo-Hao Liu, Shian-Sen Shie, Tsung-Hsing Chen and Ting-Shu Wu

    Citation: BMC Infectious Diseases 2017 17:441

    Content type: Research article

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  25. Men who have sex with men (MSM) constitute a risk group for sexual transmitted infections (STIs), including HIV. Despite counselling interventions, risk behaviour remains high. Syndemic theory holds that psych...

    Authors: Roel C. A. Achterbergh, Jannie J. van der Helm, Wim van den Brink and Henry J. C. de Vries

    Citation: BMC Infectious Diseases 2017 17:398

    Content type: Study protocol

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  26. Bacterial vaginosis (BV) is one of the leading causes of vaginal complaints among women of childbearing age. The role of Gardnerella vaginalis remains controversial due to its presence in healthy and BV-type vagi...

    Authors: Migle Janulaitiene, Virginija Paliulyte, Svitrigaile Grinceviciene, Jolita Zakareviciene, Alma Vladisauskiene, Agne Marcinkute and Milda Pleckaityte

    Citation: BMC Infectious Diseases 2017 17:394

    Content type: Research article

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  27. HPV infection is the major pathogenic factor underlying cervical cancer and precancerous lesions. The cervical HPV infection rates in gynaecological outpatients from Hangzhou, China, were studied in the period...

    Authors: Lili Qian, Yu Zhang, Dawei Cui, Bin Lou, Yimin Chen, Ying Yu, Yonglin Liu and Yu Chen

    Citation: BMC Infectious Diseases 2017 17:393

    Content type: Research article

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  28. Although the correlation of HPV genotype with cervical precursor lesions and invasive cancer has been confirmed, the role of HPV genotype in cervical cancer prognosis is less conclusive. This study aims to sys...

    Authors: Dong Hang, Meiqun Jia, Hongxia Ma, Jing Zhou, Xiaoshuang Feng, Zhangyan Lyu, Jian Yin, Hong Cui, Yin Yin, Guangfu Jin, Zhibin Hu, Hongbing Shen, Kai Zhang, Ni Li and Min Dai

    Citation: BMC Infectious Diseases 2017 17:391

    Content type: Research article

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  29. Antimicrobial resistance (AMR) and genetic determinants of resistance of N. gonorrhoeae isolates from Hefei, China, were characterized adding a breadth of information to the molecular epidemiology of gonococcal r...

    Authors: Fa-Xing Jiang, Qian Lan, Wen-Jing Le and Xiao-Hong Su

    Citation: BMC Infectious Diseases 2017 17:366

    Content type: Research article

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  30. Human papillomavirus (HPV) is the most common sexually transmitted agent, and it can cause cervical lesions and cancer in females. Currently, information regarding the prevalence of HPV in Cyprus is lacking. T...

    Authors: George Krashias, Dana Koptides and Christina Christodoulou

    Citation: BMC Infectious Diseases 2017 17:346

    Content type: Research article

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  31. Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteri...

    Authors: Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu and Tian-Ci Yang

    Citation: BMC Infectious Diseases 2017 17:310

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:357

  32. Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of NG test prac...

    Authors: Casper D. J. den Heijer, Christian J. P. A. Hoebe, Geneviève A. F. S. van Liere, Jan E. A. M. van Bergen, Jochen W. L. Cals, Frans S. Stals and Nicole H. T. M. Dukers-Muijrers

    Citation: BMC Infectious Diseases 2017 17:290

    Content type: Research article

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  33. Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI) among young women, can result in serious sequelae. Although the course of infection is often ...

    Authors: B. M. Hoenderboom, A. A. M. van Oeffelen, B. H. B. van Benthem, J. E. A. M. van Bergen, N. H. T. M. Dukers-Muijrers, H. M. Götz, C. J. P. A. Hoebe, A. A. Hogewoning, F. R. M. van der Klis, D. van Baarle, J. A. Land, M. A. B. van der Sande, M. G. van Veen, F. de Vries, S. A. Morré and I. V. F. van den Broek

    Citation: BMC Infectious Diseases 2017 17:264

    Content type: Study protocol

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  34. Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru.

    Authors: Noah Kojima, Hayoung Park, Kelika A. Konda, Dvora L. Joseph Davey, Claire C. Bristow, Brandon Brown, Segundo R. Leon, Silver K. Vargas, Gino M. Calvo, Carlos F. Caceres and Jeffrey D. Klausner

    Citation: BMC Infectious Diseases 2017 17:255

    Content type: Research article

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  35. Human papillomavirus (HPV) is one of the most common sexually transmitted pathogens. This observational study was conducted to estimate the trend of hospitalization for genital warts (GWs) in the Veneto region...

    Authors: Silvia Cocchio, Tatjana Baldovin, Chiara Bertoncello, Alessandra Buja, Patrizia Furlan, Mario Saia and Vincenzo Baldo

    Citation: BMC Infectious Diseases 2017 17:249

    Content type: Research article

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  36. There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and gen...

    Authors: Jing-fen Lu, Guo-rong Shen, Qiong Li, Xu Chen, Chun-fang Ma and Tong-hua Zhu

    Citation: BMC Infectious Diseases 2017 17:226

    Content type: Research article

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  37. Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in the United States (U.S.) [1] and remains a major public health problem. We determined the cos...

    Authors: Jared Ditkowsky, Khushal H. Shah, Margaret R. Hammerschlag, Stephan Kohlhoff and Tamar A. Smith-Norowitz

    Citation: BMC Infectious Diseases 2017 17:155

    Content type: Research article

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  38. HIV-related stigma always is major obstacles to an effective HIV response worldwide. The effect of HIV-related stigma on HIV prevention and treatment is particularly serious in China. This study was to examine...

    Authors: Xin Li, Lili Yuan, Xiaoxia Li, Jingli Shi, Liying Jiang, Chundi Zhang, Xiujing Yang, Yeli Zhang, Donghui Zhao and Yashuang Zhao

    Citation: BMC Infectious Diseases 2017 17:154

    Content type: Research article

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  39. Chlamydia, gonorrhoea and syphilis are readily treatable sexually transmitted infections (STIs) which continue to occur at high rates in Australia, particularly among Aboriginal Australians. This study aimed t...

    Authors: Barbara Nattabi, Veronica Matthews, Jodie Bailie, Alice Rumbold, David Scrimgeour, Gill Schierhout, James Ward, Rebecca Guy, John Kaldor, Sandra C. Thompson and Ross Bailie

    Citation: BMC Infectious Diseases 2017 17:148

    Content type: Research article

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  40. The Human papillomavirus is the most common sexually transmitted virus worldwide. The objective of this study was to estimate: 1) the prevalence and the incidence of external genital warts (eGW) in a sample of...

    Authors: Barbara Suligoi, Giorgio Vittori, Maria Cristina Salfa, Laura Timelli, Dario Corsini, Giovanni Fattorini and Luciano Mariani

    Citation: BMC Infectious Diseases 2017 17:126

    Content type: Research article

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  41. The purpose of this study was to describe what is known about HIV infection and other sexually transmitted diseases, infection transmission routes, care, and sources of information, from the viewpoint of men h...

    Authors: Tarja Suominen, Teppo Heikkinen, Marja Pakarinen, Anne-Mari Sepponen and Jari Kylmä

    Citation: BMC Infectious Diseases 2017 17:121

    Content type: Research article

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  42. Cervical cancer and its precursor, high-grade cervical intraepithelial neoplasia (CIN2/3), are associated with persistent high-risk human papillomavirus (HPV) infection. HPV genotype prevalence varies with sev...

    Authors: Lei Zhang, Qingqing Bi, Hua Deng, Jing Xu, Juan Chen, Meilian Zhang and Xiaofeng Mu

    Citation: BMC Infectious Diseases 2017 17:107

    Content type: Research article

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  43. Cervical cancer is the leading cause of cancer morbidity and mortality among women in Nepal and Bhutan. Data on high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities among Nepali and Bhu...

    Authors: Madhav P. Bhatta, Derek C. Johnson, Mingma Lama, Shilu Aryal, Pema Lhaki and Sadeep Shrestha

    Citation: BMC Infectious Diseases 2017 17:73

    Content type: Research article

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  44. Previous studies have discussed the overlapping and reinforcing effects (defined as a syndemic) of psychosocial problems on high-risk sexual behaviors among men who have sex with men (MSM). The present study a...

    Authors: Ying Wang, Zezhou Wang, Mengmeng Jia, Ajuan Liang, Dong Yuan, Zhe Sun, Feng Gan, Yichen Wang, Yong Cai and Zhiruo Zhang

    Citation: BMC Infectious Diseases 2017 17:46

    Content type: Research article

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  45. Rectal infection with Chlamydia trachomatis is one of the most common bacterial sexually transmissible infections among men who have sex with men (MSM) with diagnosis rates continuing to rise. Current treatment g...

    Authors: Andrew Lau, Fabian Kong, Christopher K. Fairley, Basil Donovan, Marcus Chen, Catriona Bradshaw, Mark Boyd, Janaki Amin, Peter Timms, Sepehr Tabrizi, David G. Regan, David A. Lewis, Anna McNulty and Jane S. Hocking

    Citation: BMC Infectious Diseases 2017 17:35

    Content type: Study protocol

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  46. Our study aimed to describe the concordance of chlamydia infections of the rectum and urethra in men who have sex with men (MSM) and their male partners.

    Authors: Vincent J. Cornelisse, Christopher J. Sherman, Jane S Hocking, Henrietta Williams, Lei Zhang, Marcus Y. Chen, Catriona S. Bradshaw, Clare Bellhouse, Christopher K Fairley and Eric P. F. Chow

    Citation: BMC Infectious Diseases 2017 17:22

    Content type: Research article

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  47. Men who have sex with men (MSM) are at high risk of HIV and sexually transmitted infections (STIs) in China and globally. Engaging in commercial sex put them at even greater risk. This study estimated the prev...

    Authors: Cunge Zheng, Jun-jie Xu, Qing-hai Hu, Yan-qiu Yu, Zhen-xing Chu, Jing Zhang, Xiao-xu Han, Lin Lu, Zhe Wang, Ji-hua Fu, Xi Chen, Hong-jing Yan, Yong-jun Jiang, Wen-qing Geng, Sten H. Vermund, Han-Zhu Qian…

    Citation: BMC Infectious Diseases 2016 16:765

    Content type: Research article

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  48. Late presentation of human immunodeficiency virus (HIV) is associated with heterosexual transmission, particularly among heterosexual men in Asia. Although data on HIV/sexually transmitted infection (STI) test...

    Authors: Raymond Boon Tar Lim, Dede Kam Tyng Tham, Olive N. Y. Cheung, Bee Choo Tai, Roy Chan and Mee Lian Wong

    Citation: BMC Infectious Diseases 2016 16:763

    Content type: Research article

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  49. Use of treponemal tests to screen for syphilis (caused by Treponema pallidum pallidum) poses challenges with infection status classification, especially in settings where other treponemal infections are endemic. ...

    Authors: Edward Tieru Dassah, Yaw Adu-Sarkodie and Philippe Mayaud

    Citation: BMC Infectious Diseases 2016 16:745

    Content type: Research article

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