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Sexually transmitted diseases

Section edited by Stefan Baral & Joseph Tucker

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV and HIV-associated infections are considered in a separate section.

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  1. Repressive legal environments and widespread human rights violations act as structural impediments to efforts to engage key populations at risk of HIV infection in HIV prevention, care, and treatment efforts. ...

    Authors: Anne L. Stangl, Devaki Singh, Michael Windle, Kirsty Sievwright, Katherine Footer, Alexandrina Iovita, Stella Mukasa and Stefan Baral

    Citation: BMC Infectious Diseases 2019 19:209

    Content type: Research article

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  2. Stigma is a multifaceted concept that potentiates Human Immunodeficiency Virus and sexually transmitted infection acquisition and transmission risks among key populations, including men who have sex with men (...

    Authors: Ashley L. Grosso, Sosthenes C. Ketende, Shauna Stahlman, Odette Ky-Zerbo, Henri Gautier Ouedraogo, Seni Kouanda, Cesaire Samadoulougou, Marcel Lougue, Jules Tchalla, Simplice Anato, Sodji Dometo, Felicity D. Nadedjo, Vincent Pitche and Stefan D. Baral

    Citation: BMC Infectious Diseases 2019 19:208

    Content type: Research article

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  3. Chlamydia trachomatis infections in women continue to be a major public health concern due to their high prevalence and consequent reproductive morbidities. While antibiotics are usually efficient to clear the Ch...

    Authors: Noa Ziklo, Wilhelmina M. Huston, Kuong Taing and Peter Timms

    Citation: BMC Infectious Diseases 2019 19:218

    Content type: Research article

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  4. Human Papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. The present systematic review summarizes data regarding the prevalence of HPV and the distribution of sub...

    Authors: Anargyros Skoulakis, Serafim Fountas, Myrto Mantzana-Peteinelli, Kleoniki Pantelidi and Efthymia Petinaki

    Citation: BMC Infectious Diseases 2019 19:192

    Content type: Research article

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  5. Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determin...

    Authors: Etienne E. Muller, Mahlape P. Mahlangu, David A. Lewis and Ranmini S. Kularatne

    Citation: BMC Infectious Diseases 2019 19:148

    Content type: Research article

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  6. Syphilis screening can be successfully integrated into antenatal clinics, and potentially avert significant morbidity and mortality to unborn infants. A minority of male partners report for testing and treatme...

    Authors: Edith Nakku-Joloba, Juliet Kiguli, Christine Nalwadda Kayemba, Adeline Twimukye, Joshua Kimeze Mbazira, Rosalind Parkes-Ratanshi, Monica Birungi, Joshua Kyenkya, Josaphat Byamugisha, Charlotte Gaydos and Yukari C. Manabe

    Citation: BMC Infectious Diseases 2019 19:124

    Content type: Research article

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  7. Human papillomavirus (HPV) contributes to the development of cervical and oropharyngeal tumors. The increased incidence of HPV associated oropharyngeal tumors is lately being observed also in Polish population...

    Authors: Katarzyna Kiwerska, Agata Jozefiak, Janina Markowska, Witold Kedzia, Joanna Jackowska and Malgorzata Wierzbicka

    Citation: BMC Infectious Diseases 2019 19:122

    Content type: Research article

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  8. Crowdsourcing method is an excellent tool for developing tailored interventions to improve sexual health. We evaluated the implementation of an innovation contest for sexual health promotion in China.

    Authors: Ye Zhang, Songyuan Tang, Katherine Li, Lai Sze Tso, Barry L. Bayus, David Glidden, Bin Yang, Heping Zheng, Chongyi Wei, Joseph Tucker and Weiming Tang

    Citation: BMC Infectious Diseases 2019 19:112

    Content type: Research article

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  9. To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated the distribution characteristics and genotypes of human papillomavirus (HPV) and the prevalence of multip...

    Authors: Xiao-wen Yuan, Yi-Jian Li, Quan Qiu, Zi-yuan Luo and Xue-feng Zhao

    Citation: BMC Infectious Diseases 2019 19:71

    Content type: Research article

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  10. Chlamydia trachomatis and Neisseria gonorrhoeae are the most common pathogens causing genital tract infections. Female commercial sex workers (FCSWs) are the key population to be affected by sexually transmitted ...

    Authors: Alelign Tadele, Siraj Hussen and Techalew Shimelis

    Citation: BMC Infectious Diseases 2019 19:61

    Content type: Research article

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  11. The incidence of Chlamydia trachomatis (Ct) urethritis has been increasing for the past 10 years. There is little data regarding the screening of Ct infection in asymptomatic men in France, despite the national r...

    Authors: Paul Rondeau, Nadia Valin, Dominique Decré, Pierre-Marie Girard, Karine Lacombe and Laure Surgers

    Citation: BMC Infectious Diseases 2019 19:31

    Content type: Research article

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  12. Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.

    Authors: Eileen O. Dareng, Sally N. Adebamowo, Ayotunde Famooto, Oluwatoyosi Olawande, Michael K. Odutola, Yinka Olaniyan, Richard A. Offiong, Paul P. Pharoah and Clement A. Adebamowo

    Citation: BMC Infectious Diseases 2019 19:27

    Content type: Research article

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  13. Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are mostly asymptomatic, and important reservoir sites of infection as they often go undetected and may be more difficult to eradicate with...

    Authors: Johanna M. E. Venter, Precious M. Mahlangu, Etienne E. Müller, David A. Lewis, Kevin Rebe, Helen Struthers, James McIntyre and Ranmini S. Kularatne

    Citation: BMC Infectious Diseases 2019 19:6

    Content type: Research article

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  14. Oncogenic Human papillomavirus (HPV) infections are closely associated with anal cancer which is high among human immunodeficiency virus (HIV) infected males. There are no data regarding anal HPV infection and...

    Authors: Abhilasha Gautam, Jaya Chakravarty, Vijay Kumar Singh, Amrita Ghosh, Shashi Bhushan Chauhan, Madhukar Rai and Shyam Sundar

    Citation: BMC Infectious Diseases 2018 18:692

    Content type: Research article

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  15. The number of cases of Lymphogranuloma venereum (LGV) is increasing in Europe. The described epidemic is mostly confined to HIV positive men who have sex with men (MSM). However, dissemination of LGV from HIV ...

    Authors: Irith De Baetselier, Achilleas Tsoumanis, Ruth Verbrugge, Bénédicte De Deken, Hilde Smet, Saïd Abdellati, Vicky Cuylaerts, Ludwig Apers and Tania Crucitti

    Citation: BMC Infectious Diseases 2018 18:689

    Content type: Research article

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  16. A high rectal and oropharyngeal sexually transmitted infection (STI) burden has been reported among men who have sex with men (MSM) in many regions, but little data exists on rectal and oropharyngeal STIs amon...

    Authors: Li-Gang Yang, Xiao-Hui Zhang, Pei-Zhen Zhao, Zheng-Yu Chen, Wu-Jian Ke, Xu-Qi Ren, Liu-Yuan Wang, Wei-Ying Chen and Joseph D. Tucker

    Citation: BMC Infectious Diseases 2018 18:675

    Content type: Research article

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  17. Nucleic acid amplification tests (NAAT) are well-accepted in diagnosis and surveillance of sexually infectious pathogens worldwide. However, performance differences between a RNA-based NAAT and DNA-based NAAT ...

    Authors: Yuying Liang, Xin Jin, Fang Yuan, Zhanjia Li and Shuiping Chen

    Citation: BMC Infectious Diseases 2018 18:651

    Content type: Research article

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  18. In the Netherlands, there are strong disparities in Chlamydia trachomatis (CT) prevalence between ethnic groups. The current study aims to identify whether socioeconomic status, sexual risk behavior and sexual he...

    Authors: Sebastiaan H. Hulstein, Amy Matser, Catharina J. Alberts, Marieke B. Snijder, Martina Willhauck-Fleckenstein, Katrin Hufnagel, Maria Prins, Henry J. C. de Vries, Maarten F. Schim van der Loeff and Tim Waterboer

    Citation: BMC Infectious Diseases 2018 18:612

    Content type: Research article

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  19. The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the Europea...

    Authors: Michaela J. Day, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Andrew J. Amato-Gauci, Michelle J. Cole and Magnus Unemo

    Citation: BMC Infectious Diseases 2018 18:609

    Content type: Research article

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  20. The increasing prevalence of macrolide resistant Mycoplasma genitalium is a major concern worldwide. In Cuba, several cases of clinical treatment failure with 1 g single dose and extended azithromycin regimen hav...

    Authors: Brian Arturo Mondeja, Javier Couri, Nadia Maria Rodríguez, Orestes Blanco, Carmen Fernández and Jørgen Skov Jensen

    Citation: BMC Infectious Diseases 2018 18:601

    Content type: Research article

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  21. Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa. There is nil systematic review and meta-analysis on Chlamydia trachomatis infect...

    Authors: Siraj Hussen, Demelash Wachamo, Zemenu Yohannes and Endale Tadesse

    Citation: BMC Infectious Diseases 2018 18:596

    Content type: Research article

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  22. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological and inflammatory disease, associated with HTLV-1 infection. HAM/TSP neurological disease is a consequence of an...

    Authors: Doris Schor, Luís Cristóvão Porto, Eric Henrique Roma, Marcel de Souza Borges Quintana, Gustavo Milson Fabricio-Silva, Maria Gloria Bonecini-Almeida, Abelardo Queiroz-Campos Araújo and Maria Jose Andrada-Serpa

    Citation: BMC Infectious Diseases 2018 18:593

    Content type: Research article

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  23. Cervical cancer (CC) is caused by a persistent infection of high-risk human papillomavirus (HR-HPV). While most HPV infections are transient, persistent HPV infections are a significant health problem in Mexic...

    Authors: K. Torres-Poveda, M. Bahena-Román, K. Delgado-Romero and V. Madrid-Marina

    Citation: BMC Infectious Diseases 2018 18:582

    Content type: Study protocol

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  24. Chlamydia trachomatis (chlamydia), the most commonly reported sexually transmitted infection (STI) in the Netherlands, can lead to severe reproductive complications. Reasons for the sustained chlamydia prevalence...

    Authors: Daphne A. van Wees, Janneke C. M. Heijne, Titia Heijman, Karlijn C. J. G. Kampman, Karin Westra, Anne de Vries, Mirjam E. E. Kretzschmar and Chantal den Daas

    Citation: BMC Infectious Diseases 2018 18:559

    Content type: Study protocol

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  25. Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with simila...

    Authors: Simon C. Masha, Piet Cools, Patrick Descheemaeker, Marijke Reynders, Eduard J. Sanders and Mario Vaneechoutte

    Citation: BMC Infectious Diseases 2018 18:549

    Content type: Research article

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  26. In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiolog...

    Authors: Déborah Ferreira Noronha de Castro Rocha, Luana Rocha da Cunha Rosa, Carla de Almeida Silva, Brunna Rodrigues de Oliveira, Thaynara Lorrane Silva Martins, Regina Maria Bringel Martins, Marcos André de Matos, Megmar Aparecida dos Santos Carneiro, Juliana Pontes Soares, Ana Cristina de Oliveira e Silva, Márcia Maria de Souza, Robert L. Cook, Karlla Antonieta Amorim Caetano and Sheila Araujo Teles

    Citation: BMC Infectious Diseases 2018 18:546

    Content type: Research article

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  27. Incarcerated people carry a high burden of infection, including blood-borne diseases (BBDs). It is also known that one million people contract a sexually transmitted infection (STI) every day worldwide, which ...

    Authors: Komal Chacowry Pala, Stéphanie Baggio, Nguyen Toan Tran, François Girardin, Hans Wolff and Laurent Gétaz

    Citation: BMC Infectious Diseases 2018 18:539

    Content type: Research article

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  28. A population-based study of Chlamydia trachomatis (CT) infections is essential in designing a specific control program; however, no large investigation of CT infections among the general population in mainland Ch...

    Authors: Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi’an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu…

    Citation: BMC Infectious Diseases 2018 18:534

    Content type: Research article

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  29. Human papillomavirus (HPV), Epstein-Barr virus (EBV) and herpes simplex virus (HSV) cause sexually transmitted diseases (STDs) that are frequently found in men who have sex with men (MSM) with human immunodeficie...

    Authors: Jureeporn Chuerduangphui, Kanisara Proyrungroj, Chamsai Pientong, Saowarop Hinkan, Jiratha Budkaew, Charinya Pimson, Bandit Chumworathayi, Ploenpit Hanond and Tipaya Ekalaksananan

    Citation: BMC Infectious Diseases 2018 18:509

    Content type: Research article

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  30. Ascertaining if the clinical and immunological response to repeat syphilis differs from that in initial syphilis may assist in designing optimal syphilis screening strategies and vaccine design.

    Authors: Chris Kenyon, Kara Krista Osbak, Tania Crucitti and Luc Kestens

    Citation: BMC Infectious Diseases 2018 18:479

    Content type: Research article

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  31. Chlamydia trachomatis and Neisseria gonorrhoeae are the two common transmissible pathogens from pregnant women to their neonates. Given the lack of routine screening and treatment of pregnant women in some areas,...

    Authors: Bahman Pourabbas, Zahra Rezaei, Jalal Mardaneh, Mozhgan Shahian and Abdolvahab Alborzi

    Citation: BMC Infectious Diseases 2018 18:477

    Content type: Research article

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  32. Infection with Chlamydia trachomatis (Ct) is the most commonly reported sexually transmitted infection in Europe. In Germany, Ct screening is offered free of charge to pregnant women since 1995 and to women < 25 ...

    Authors: Alexandra Sarah Lang, Matthias an der Heiden, Klaus Jansen, Andrea Sailer, Viviane Bremer and Sandra Dudareva

    Citation: BMC Infectious Diseases 2018 18:424

    Content type: Research article

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  33. Herpes simplex virus infection is a global health concern with disproportionately high burden in low and middle-income countries. There is a paucity of data on the prevalence of HSV infection in Ghana, which n...

    Authors: Oksana Debrah, Francis Agyemang-Yeboah, Richard Harry Asmah, Emmanuel Timmy-Donkoh, Mohammed Mustapha Seini, Linda Ahenkorah Fondjo, Nilok Sight and Ellis Owusu-Dabo

    Citation: BMC Infectious Diseases 2018 18:378

    Content type: Research article

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  34. Studies comparing self-samples and clinician-collected samples for high-risk human papillomavirus (HPV) detection using clinically validated PCR-based HPV DNA assays are limited. We measured the concordance of...

    Authors: Mette Tranberg, Jørgen Skov Jensen, Bodil Hammer Bech, Jan Blaakær, Hans Svanholm and Berit Andersen

    Citation: BMC Infectious Diseases 2018 18:348

    Content type: Research article

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  35. Blood transfusion is associated with several risks particularly exposure to blood transfusion-transmissible infections (TTI), including: Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency...

    Authors: Nejat Siraj, Oliver Okoth Achila, John Issac, Efrem Menghisteab, Maedn Hailemariam, Semere Hagos, Yosan Gebremeskel and Daniel Tesfamichael

    Citation: BMC Infectious Diseases 2018 18:264

    Content type: Research article

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  36. Chlamydia prevalence in the Netherlands remains high despite targeted efforts. Effective Partner Notification (PN) and Partner Treatment (PT) can interrupt transmission and prevent re-infections. Patient Initi...

    Authors: Anita C. Nanhoe, Maartje Visser, Jurriaan J. Omlo, Anita J. C. M. Watzeels, Ingrid V. van den Broek and Hannelore M. Götz

    Citation: BMC Infectious Diseases 2018 18:243

    Content type: Research article

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  37. Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence rega...

    Authors: Ramadhani Abdul, Annette A. M. Gerritsen, Mary Mwangome and Eveline Geubbels

    Citation: BMC Infectious Diseases 2018 18:229

    Content type: Research article

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  38. Many young men who have sex with men (YMSM) are reluctant to seek health services and trust local physicians. Online information seeking may encourage YMSM to identify and see trustworthy physicians, obtain se...

    Authors: Bolin Cao, Peipei Zhao, Cedric Bien, Stephen Pan, Weiming Tang, Julia Watson, Guodong Mi, Yi Ding, Zhenzhou Luo and Joseph D. Tucker

    Citation: BMC Infectious Diseases 2018 18:228

    Content type: Research article

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  39. Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are availab...

    Authors: Wei-Wei Cao, Rong-Rong Zhou, Xinghua Ou, Ling-Xi Shi, Chao-Qi Xiao, Ting-Yin Chen, Hua Tan, Xue-Gong Fan, Bi-Juan Li and Ning Li

    Citation: BMC Infectious Diseases 2018 18:145

    Content type: Research article

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  40. Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it is unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate for determ...

    Authors: Ying Jiang, Ruihui Weng, Yuefeng Zhang, Rong Fan, Yulun Liu, Zhigang Chen, Fuhua Peng, Yong Chen and Xiaohong Chen

    Citation: BMC Infectious Diseases 2018 18:144

    Content type: Research article

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  41. Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aim...

    Authors: Paula Tiittala, Matti Ristola, Kirsi Liitsola, Jukka Ollgren, Päivikki Koponen, Heljä-Marja Surcel, Eija Hiltunen-Back, Irja Davidkin and Pia Kivelä

    Citation: BMC Infectious Diseases 2018 18:137

    Content type: Research article

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  42. Despite availability of effective treatment and the implementation of focused antenatal care (ANC), still the prevalence of syphilis persists in Ethiopia. Yet, data is not found in southern Ethiopia. Therefore...

    Authors: Anteneh Amsalu, Getachew Ferede and Demissie Assegu

    Citation: BMC Infectious Diseases 2018 18:109

    Content type: Research article

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  43. The inflammasome responses in Treponema pallidum infection have been poorly understood to date. This study aimed to investigate the expression of the nucleotide-binding leucine-rich receptor protein 3 (NLRP3) inf...

    Authors: Li-Rong Lin, Yao Xiao, Wei Liu, Yu-Yan Chen, Xiao-Zhen Zhu, Zheng-Xiang Gao, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Wen-Dong Li, Xian-Ming Liang, Yong Lin, Li-Li Liu and Tian-Ci Yang

    Citation: BMC Infectious Diseases 2018 18:101

    Content type: Research article

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  44. We aimed to describe anatomic site-specific concordance of gonococcal infections in partnerships of men who have sex with men (MSM).

    Authors: Vincent J. Cornelisse, Lei Zhang, Matthew Law, Marcus Y. Chen, Catriona S. Bradshaw, Clare Bellhouse, Christopher K. Fairley and Eric P. F. Chow

    Citation: BMC Infectious Diseases 2018 18:95

    Content type: Research article

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  45. The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because...

    Authors: Susanne Buder, Sandra Dudareva, Klaus Jansen, Anna Loenenbach, Sergejs Nikisins, Andrea Sailer, Eva Guhl, Peter K. Kohl and Viviane Bremer

    Citation: BMC Infectious Diseases 2018 18:44

    Content type: Research article

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  46. Genital warts are one of the most common forms of sexually-transmitted disease, but their epidemiology has yet to be thoroughly elucidated. The present study was designed to shed light on the prevalence of cli...

    Authors: Silvia Cocchio, Chiara Bertoncello, Tatjana Baldovin, Alessandra Buja, Silvia Majori and Vincenzo Baldo

    Citation: BMC Infectious Diseases 2018 18:41

    Content type: Research article

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  47. HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of no...

    Authors: Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi and Adriana Ammassari

    Citation: BMC Infectious Diseases 2018 18:25

    Content type: Research article

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  48. Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women’s well-being. The a...

    Authors: Ettore Palma, Nadia Recine, Lavinia Domenici, Margherita Giorgini, Alessandra Pierangeli and Pierluigi Benedetti Panici

    Citation: BMC Infectious Diseases 2018 18:13

    Content type: Research article

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  49. Control of gonorrhea in resource-limited countries, such as Indonesia, is mostly unsuccessful. Examining Neisseria gonorrhoeae (Ng) transmission networks using strain typing might help prioritizing public health ...

    Authors: I Putu Yuda Hananta, Alje Pieter van Dam, Maarten Franciscus Schim van der Loeff, Mirjam Dierdorp, Carolien Marleen Wind, Hardyanto Soebono, Henry John Christiaan de Vries and Sylvia Maria Bruisten

    Citation: BMC Infectious Diseases 2018 18:7

    Content type: Research article

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  50. Chlamydia infections are common in both men and women, are often asymptomatic and can cause serious complications. Repeat testing in high-risk groups is therefore indicated. In the Netherlands, guidelines on r...

    Authors: Maartje Visser, Fleur van Aar, Femke D. H. Koedijk, Carolina J. G. Kampman and Janneke C. M. Heijne

    Citation: BMC Infectious Diseases 2017 17:782

    Content type: Research article

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