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Sexually transmitted diseases

Section edited by Stefan Baral & Joseph Tucker

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV and HIV-associated infections are considered in a separate section.

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  1. Content type: Research article

    Nucleic acid amplification tests (NAAT) are well-accepted in diagnosis and surveillance of sexually infectious pathogens worldwide. However, performance differences between a RNA-based NAAT and DNA-based NAAT ...

    Authors: Yuying Liang, Xin Jin, Fang Yuan, Zhanjia Li and Shuiping Chen

    Citation: BMC Infectious Diseases 2018 18:651

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  2. Content type: Research article

    In the Netherlands, there are strong disparities in Chlamydia trachomatis (CT) prevalence between ethnic groups. The current study aims to identify whether socioeconomic status, sexual risk behavior and sexual he...

    Authors: Sebastiaan H. Hulstein, Amy Matser, Catharina J. Alberts, Marieke B. Snijder, Martina Willhauck-Fleckenstein, Katrin Hufnagel, Maria Prins, Henry J. C. de Vries, Maarten F. Schim van der Loeff and Tim Waterboer

    Citation: BMC Infectious Diseases 2018 18:612

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  3. Content type: Research article

    The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the Europea...

    Authors: Michaela J. Day, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Andrew J. Amato-Gauci, Michelle J. Cole and Magnus Unemo

    Citation: BMC Infectious Diseases 2018 18:609

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  4. Content type: Research article

    The increasing prevalence of macrolide resistant Mycoplasma genitalium is a major concern worldwide. In Cuba, several cases of clinical treatment failure with 1 g single dose and extended azithromycin regimen hav...

    Authors: Brian Arturo Mondeja, Javier Couri, Nadia Maria Rodríguez, Orestes Blanco, Carmen Fernández and Jørgen Skov Jensen

    Citation: BMC Infectious Diseases 2018 18:601

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  5. Content type: Research article

    Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa. There is nil systematic review and meta-analysis on Chlamydia trachomatis infect...

    Authors: Siraj Hussen, Demelash Wachamo, Zemenu Yohannes and Endale Tadesse

    Citation: BMC Infectious Diseases 2018 18:596

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  6. Content type: Research article

    HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological and inflammatory disease, associated with HTLV-1 infection. HAM/TSP neurological disease is a consequence of an...

    Authors: Doris Schor, Luís Cristóvão Porto, Eric Henrique Roma, Marcel de Souza Borges Quintana, Gustavo Milson Fabricio-Silva, Maria Gloria Bonecini-Almeida, Abelardo Queiroz-Campos Araújo and Maria Jose Andrada-Serpa

    Citation: BMC Infectious Diseases 2018 18:593

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  7. Content type: Study protocol

    Cervical cancer (CC) is caused by a persistent infection of high-risk human papillomavirus (HR-HPV). While most HPV infections are transient, persistent HPV infections are a significant health problem in Mexic...

    Authors: K. Torres-Poveda, M. Bahena-Román, K. Delgado-Romero and V. Madrid-Marina

    Citation: BMC Infectious Diseases 2018 18:582

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  8. Content type: Study protocol

    Chlamydia trachomatis (chlamydia), the most commonly reported sexually transmitted infection (STI) in the Netherlands, can lead to severe reproductive complications. Reasons for the sustained chlamydia prevalence...

    Authors: Daphne A. van Wees, Janneke C. M. Heijne, Titia Heijman, Karlijn C. J. G. Kampman, Karin Westra, Anne de Vries, Mirjam E. E. Kretzschmar and Chantal den Daas

    Citation: BMC Infectious Diseases 2018 18:559

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  9. Content type: Research article

    Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with simila...

    Authors: Simon C. Masha, Piet Cools, Patrick Descheemaeker, Marijke Reynders, Eduard J. Sanders and Mario Vaneechoutte

    Citation: BMC Infectious Diseases 2018 18:549

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  10. Content type: Research article

    In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiolog...

    Authors: Déborah Ferreira Noronha de Castro Rocha, Luana Rocha da Cunha Rosa, Carla de Almeida Silva, Brunna Rodrigues de Oliveira, Thaynara Lorrane Silva Martins, Regina Maria Bringel Martins, Marcos André de Matos, Megmar Aparecida dos Santos Carneiro, Juliana Pontes Soares, Ana Cristina de Oliveira e Silva, Márcia Maria de Souza, Robert L. Cook, Karlla Antonieta Amorim Caetano and Sheila Araujo Teles

    Citation: BMC Infectious Diseases 2018 18:546

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  11. Content type: Research article

    Incarcerated people carry a high burden of infection, including blood-borne diseases (BBDs). It is also known that one million people contract a sexually transmitted infection (STI) every day worldwide, which ...

    Authors: Komal Chacowry Pala, Stéphanie Baggio, Nguyen Toan Tran, François Girardin, Hans Wolff and Laurent Gétaz

    Citation: BMC Infectious Diseases 2018 18:539

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  12. Content type: Research article

    A population-based study of Chlamydia trachomatis (CT) infections is essential in designing a specific control program; however, no large investigation of CT infections among the general population in mainland Ch...

    Authors: Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi’an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu…

    Citation: BMC Infectious Diseases 2018 18:534

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  13. Content type: Research article

    Human papillomavirus (HPV), Epstein-Barr virus (EBV) and herpes simplex virus (HSV) cause sexually transmitted diseases (STDs) that are frequently found in men who have sex with men (MSM) with human immunodeficie...

    Authors: Jureeporn Chuerduangphui, Kanisara Proyrungroj, Chamsai Pientong, Saowarop Hinkan, Jiratha Budkaew, Charinya Pimson, Bandit Chumworathayi, Ploenpit Hanond and Tipaya Ekalaksananan

    Citation: BMC Infectious Diseases 2018 18:509

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  14. Content type: Research article

    Ascertaining if the clinical and immunological response to repeat syphilis differs from that in initial syphilis may assist in designing optimal syphilis screening strategies and vaccine design.

    Authors: Chris Kenyon, Kara Krista Osbak, Tania Crucitti and Luc Kestens

    Citation: BMC Infectious Diseases 2018 18:479

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  15. Content type: Research article

    Chlamydia trachomatis and Neisseria gonorrhoeae are the two common transmissible pathogens from pregnant women to their neonates. Given the lack of routine screening and treatment of pregnant women in some areas,...

    Authors: Bahman Pourabbas, Zahra Rezaei, Jalal Mardaneh, Mozhgan Shahian and Abdolvahab Alborzi

    Citation: BMC Infectious Diseases 2018 18:477

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  16. Content type: Research article

    Infection with Chlamydia trachomatis (Ct) is the most commonly reported sexually transmitted infection in Europe. In Germany, Ct screening is offered free of charge to pregnant women since 1995 and to women < 25 ...

    Authors: Alexandra Sarah Lang, Matthias an der Heiden, Klaus Jansen, Andrea Sailer, Viviane Bremer and Sandra Dudareva

    Citation: BMC Infectious Diseases 2018 18:424

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  17. Content type: Research article

    Herpes simplex virus infection is a global health concern with disproportionately high burden in low and middle-income countries. There is a paucity of data on the prevalence of HSV infection in Ghana, which n...

    Authors: Oksana Debrah, Francis Agyemang-Yeboah, Richard Harry Asmah, Emmanuel Timmy-Donkoh, Mohammed Mustapha Seini, Linda Ahenkorah Fondjo, Nilok Sight and Ellis Owusu-Dabo

    Citation: BMC Infectious Diseases 2018 18:378

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  18. Content type: Research article

    Studies comparing self-samples and clinician-collected samples for high-risk human papillomavirus (HPV) detection using clinically validated PCR-based HPV DNA assays are limited. We measured the concordance of...

    Authors: Mette Tranberg, Jørgen Skov Jensen, Bodil Hammer Bech, Jan Blaakær, Hans Svanholm and Berit Andersen

    Citation: BMC Infectious Diseases 2018 18:348

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  19. Content type: Research article

    Blood transfusion is associated with several risks particularly exposure to blood transfusion-transmissible infections (TTI), including: Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency...

    Authors: Nejat Siraj, Oliver Okoth Achila, John Issac, Efrem Menghisteab, Maedn Hailemariam, Semere Hagos, Yosan Gebremeskel and Daniel Tesfamichael

    Citation: BMC Infectious Diseases 2018 18:264

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  20. Content type: Research article

    Chlamydia prevalence in the Netherlands remains high despite targeted efforts. Effective Partner Notification (PN) and Partner Treatment (PT) can interrupt transmission and prevent re-infections. Patient Initi...

    Authors: Anita C. Nanhoe, Maartje Visser, Jurriaan J. Omlo, Anita J. C. M. Watzeels, Ingrid V. van den Broek and Hannelore M. Götz

    Citation: BMC Infectious Diseases 2018 18:243

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  21. Content type: Research article

    Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence rega...

    Authors: Ramadhani Abdul, Annette A. M. Gerritsen, Mary Mwangome and Eveline Geubbels

    Citation: BMC Infectious Diseases 2018 18:229

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  22. Content type: Research article

    Many young men who have sex with men (YMSM) are reluctant to seek health services and trust local physicians. Online information seeking may encourage YMSM to identify and see trustworthy physicians, obtain se...

    Authors: Bolin Cao, Peipei Zhao, Cedric Bien, Stephen Pan, Weiming Tang, Julia Watson, Guodong Mi, Yi Ding, Zhenzhou Luo and Joseph D. Tucker

    Citation: BMC Infectious Diseases 2018 18:228

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  23. Content type: Research article

    Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are availab...

    Authors: Wei-Wei Cao, Rong-Rong Zhou, Xinghua Ou, Ling-Xi Shi, Chao-Qi Xiao, Ting-Yin Chen, Hua Tan, Xue-Gong Fan, Bi-Juan Li and Ning Li

    Citation: BMC Infectious Diseases 2018 18:145

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  24. Content type: Research article

    Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it is unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate for determ...

    Authors: Ying Jiang, Ruihui Weng, Yuefeng Zhang, Rong Fan, Yulun Liu, Zhigang Chen, Fuhua Peng, Yong Chen and Xiaohong Chen

    Citation: BMC Infectious Diseases 2018 18:144

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  25. Content type: Research article

    Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aim...

    Authors: Paula Tiittala, Matti Ristola, Kirsi Liitsola, Jukka Ollgren, Päivikki Koponen, Heljä-Marja Surcel, Eija Hiltunen-Back, Irja Davidkin and Pia Kivelä

    Citation: BMC Infectious Diseases 2018 18:137

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  26. Content type: Research article

    Despite availability of effective treatment and the implementation of focused antenatal care (ANC), still the prevalence of syphilis persists in Ethiopia. Yet, data is not found in southern Ethiopia. Therefore...

    Authors: Anteneh Amsalu, Getachew Ferede and Demissie Assegu

    Citation: BMC Infectious Diseases 2018 18:109

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  27. Content type: Research article

    The inflammasome responses in Treponema pallidum infection have been poorly understood to date. This study aimed to investigate the expression of the nucleotide-binding leucine-rich receptor protein 3 (NLRP3) inf...

    Authors: Li-Rong Lin, Yao Xiao, Wei Liu, Yu-Yan Chen, Xiao-Zhen Zhu, Zheng-Xiang Gao, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Wen-Dong Li, Xian-Ming Liang, Yong Lin, Li-Li Liu and Tian-Ci Yang

    Citation: BMC Infectious Diseases 2018 18:101

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  28. Content type: Research article

    We aimed to describe anatomic site-specific concordance of gonococcal infections in partnerships of men who have sex with men (MSM).

    Authors: Vincent J. Cornelisse, Lei Zhang, Matthew Law, Marcus Y. Chen, Catriona S. Bradshaw, Clare Bellhouse, Christopher K. Fairley and Eric P. F. Chow

    Citation: BMC Infectious Diseases 2018 18:95

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  29. Content type: Research article

    The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because...

    Authors: Susanne Buder, Sandra Dudareva, Klaus Jansen, Anna Loenenbach, Sergejs Nikisins, Andrea Sailer, Eva Guhl, Peter K. Kohl and Viviane Bremer

    Citation: BMC Infectious Diseases 2018 18:44

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  30. Content type: Research article

    Genital warts are one of the most common forms of sexually-transmitted disease, but their epidemiology has yet to be thoroughly elucidated. The present study was designed to shed light on the prevalence of cli...

    Authors: Silvia Cocchio, Chiara Bertoncello, Tatjana Baldovin, Alessandra Buja, Silvia Majori and Vincenzo Baldo

    Citation: BMC Infectious Diseases 2018 18:41

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  31. Content type: Research article

    HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of no...

    Authors: Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi and Adriana Ammassari

    Citation: BMC Infectious Diseases 2018 18:25

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  32. Content type: Research article

    Control of gonorrhea in resource-limited countries, such as Indonesia, is mostly unsuccessful. Examining Neisseria gonorrhoeae (Ng) transmission networks using strain typing might help prioritizing public health ...

    Authors: I Putu Yuda Hananta, Alje Pieter van Dam, Maarten Franciscus Schim van der Loeff, Mirjam Dierdorp, Carolien Marleen Wind, Hardyanto Soebono, Henry John Christiaan de Vries and Sylvia Maria Bruisten

    Citation: BMC Infectious Diseases 2018 18:7

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  33. Content type: Research article

    Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women’s well-being. The a...

    Authors: Ettore Palma, Nadia Recine, Lavinia Domenici, Margherita Giorgini, Alessandra Pierangeli and Pierluigi Benedetti Panici

    Citation: BMC Infectious Diseases 2018 18:13

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  34. Content type: Research article

    Chlamydia infections are common in both men and women, are often asymptomatic and can cause serious complications. Repeat testing in high-risk groups is therefore indicated. In the Netherlands, guidelines on r...

    Authors: Maartje Visser, Fleur van Aar, Femke D. H. Koedijk, Carolina J. G. Kampman and Janneke C. M. Heijne

    Citation: BMC Infectious Diseases 2017 17:782

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  35. Content type: Research article

    Some sexually transmitted infectious agents, such as Chlamydia trachomatis and Herpes simplex, cause local inflammation, and could contribute to Human Papillomavirus (HPV) and cervical lesion progression. Thus, t...

    Authors: Aline Teixeira Amorim, Lucas Miranda Marques, Guilherme Barreto Campos, Tássia Neves Lobão, Vanesca de Souza Lino, Ricardo Cesar Cintra, Maria Antonieta Andreoli, Luisa Lina Villa, Enrique Boccardo, Antonio Carlos Ricardo Braga Junior, Rossana Verónica Mendoza López, Djanilson Barbosa dos Santos, Gerson Maciel de Souza, Carla Cristina Romano and Jorge Timenetsky

    Citation: BMC Infectious Diseases 2017 17:769

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  36. Content type: Research article

    Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for m...

    Authors: Zhangyan Lyu, Xiaoshuang Feng, Ni Li, Wei Zhao, Luopei Wei, Yuheng Chen, Wenjing Yang, Hongxia Ma, Bing Yao, Kai Zhang, Zhibin Hu, Hongbing Shen, Dong Hang and Min Dai

    Citation: BMC Infectious Diseases 2017 17:714

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  37. Content type: Research article

    If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this wou...

    Authors: Chris Kenyon

    Citation: BMC Infectious Diseases 2017 17:682

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  38. Content type: Research article

    Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality ...

    Authors: Evalyne Wambui Kanyina, Lucy Kamau and Margaret Muturi

    Citation: BMC Infectious Diseases 2017 17:647

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  39. Content type: Research article

    Maternal syphilis is a health threat to both the pregnant women and the children. This study aimed to delineate the longitudinal trend of maternal syphilis and burden of associated adverse pregnant outcomes (A...

    Authors: Yang Li, Liping Zhu, Li Du, Lingxiao Qu, Weili Jiang and Biao Xu

    Citation: BMC Infectious Diseases 2017 17:626

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  40. Content type: Research article

    The treatment failure and reinfection rates among syphilis patients are high, and relevant studies in China are limited. The aim of this study was to detect the rates of treatment failure and reinfection after...

    Authors: Zhenzhou Luo, Lin Zhu, Yi Ding, Jun Yuan, Wu Li, Qiuhong Wu, Lishan Tian, Li Zhang, Guomao Zhou, Tao Zhang, Jianping Ma, Zhongwei Chen, Tubao Yang, Tiejian Feng and Min Zhang

    Citation: BMC Infectious Diseases 2017 17:620

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  41. Content type: Research article

    Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to info...

    Authors: Michelle J. Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J. Amato-Gauci and Magnus Unemo

    Citation: BMC Infectious Diseases 2017 17:617

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  42. Content type: Research article

    Despite the guidelines for managing sexual assault being in place, victims of sexual assault attended to at Kadoma General Hospital consistently raised complaints related to the quality of care offered. Medico...

    Authors: Stanley Tapesana, Daniel Chirundu, Gerald Shambira, Notion Tafara Gombe, Tsitsi Patience Juru and Tshimanga Mufuta

    Citation: BMC Infectious Diseases 2017 17:602

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  43. Content type: Research article

    Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may inc...

    Authors: Jean Wysler Domercant, Frantz Jean Louis, Erin Hulland, Mark Griswold, Jocelyne Andre-Alboth, Tun Ye and Barbara J. Marston

    Citation: BMC Infectious Diseases 2017 17:577

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  44. Content type: Research article

    Testing for reinfection at 3 to 6 months following treatment for Chlamydia Trachomatis or Neisseria gonorrhoea is recommended in best practice sexual health management guidelines. This study aimed to describe rat...

    Authors: Sally B. Rose, Susan M. Garrett, James Stanley and Susan R. H. Pullon

    Citation: BMC Infectious Diseases 2017 17:526

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  45. Content type: Case report

    Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquir...

    Authors: Maaike Spaltenstein, Françoise Humbert, Diem-Lan Vu, Ilker Uçkay and Gregor John

    Citation: BMC Infectious Diseases 2017 17:520

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  46. Content type: Case report

    The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination ...

    Authors: Yang Bai, Feng Niu, Lidi Liu, Hui Sha, Yimei Wang and Song Zhao

    Citation: BMC Infectious Diseases 2017 17:513

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  47. Content type: Research article

    Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are sc...

    Authors: Gerit Korr, Michael Thamm, Irina Czogiel, Christina Poethko-Mueller, Viviane Bremer and Klaus Jansen

    Citation: BMC Infectious Diseases 2017 17:471

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  48. Content type: Study protocol

    Gonorrhoea is one of the most common sexually transmissible infections in men who have sex with men (MSM). Gonorrhoea rates have increased substantially in recent years. There is concern that increasing gonorr...

    Authors: Eric P. F. Chow, Sandra Walker, Jane S. Hocking, Catriona S. Bradshaw, Marcus Y. Chen, Sepehr N. Tabrizi, Benjamin P. Howden, Matthew G. Law, Kate Maddaford, Tim R. H. Read, David A. Lewis, David M. Whiley, Lei Zhang, Andrew E. Grulich, John M. Kaldor, Vincent J. Cornelisse…

    Citation: BMC Infectious Diseases 2017 17:456

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  49. Content type: Study protocol

    Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans ...

    Authors: Sari L. Reisner, Madeline B. Deutsch, Sarah M. Peitzmeier, Jaclyn M. White Hughto, Timothy Cavanaugh, Dana J. Pardee, Sarah McLean, Elliot J. Marrow, Matthew J. Mimiaga, Lori Panther, Marcy Gelman, Jamison Green and Jennifer Potter

    Citation: BMC Infectious Diseases 2017 17:444

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  50. Content type: Research article

    Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) populati...

    Authors: Nan-Yu Chen, Zhuo-Hao Liu, Shian-Sen Shie, Tsung-Hsing Chen and Ting-Shu Wu

    Citation: BMC Infectious Diseases 2017 17:441

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