Sexually transmitted diseases

Chlamydia trachomatis isolated from cervicovaginal samples in Sapporo, Japan, reveals the circulation of genetically diverse strains

This study was conducted to understand the molecular epidemiology of circulating Chlamydia trachomatis (Ct) strains in Sapporo, Japan.

Authors: Jeewan Thapa, Takanori Watanabe, Mana Isoba, Torahiko Okubo, Kiyotake Abe, Kunihiro Minami and Hiroyuki Yamaguchi

High prevalent human papillomavirus infections of the oral cavity of asymptomatic HIV-positive men

Incidence of anal and oral infections with Human Papillomavirus (HPV) is increasing, particularly among Human Immunodeficiency Virus-positive (HIV+) men. HPV type 16 has exhibited the highest incidence and onl...

Authors: Rocío Méndez-Martínez, Silvia Maldonado-Frías, Salvador Vázquez-Vega, Yanink Caro-Vega, José Guadalupe Rendón-Maldonado, Miriam Guido-Jiménez, Brenda Crabtree-Ramírez, Juan G. Sierra-Madero and Alejandro García-Carrancá

Where have all the susceptible gonococci gone? A historical review of changes in MIC distribution over the past 75 years

Does the emergence of antimicrobial resistance in Neisseria gonorrhoeae include the erasure of highly susceptible strains or does it merely involve a stretching of the MIC distribution? If it was the former this ...

Authors: Chris Kenyon, Jolein Laumen, Dorien Van Den Bossche and Christophe Van Dijck

Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China

Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study...

Authors: Ying Zhou, Yu-Mao Cai, Shi-Liang Li, Ning-Xiao Cao, Xiao-Feng Zhu, Feng Wang, Yan Han, Yue-Ping Yin and Xiang-Sheng Chen

The European gonococcal antimicrobial surveillance programme (Euro-GASP) appropriately reflects the antimicrobial resistance situation for Neisseria gonorrhoeae in the European Union/European Economic Area

European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) antimicrobial resistance (AMR) data are used to inform gonorrhoea treatment guidelines; therefore the data need to be robust and representat...

Authors: Michelle J. Cole, Chantal Quinten, Susanne Jacobsson, Michaela Day, Andrew J. Amato-Gauci, Neil Woodford, Gianfranco Spiteri and Magnus Unemo

Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study

Early diagnosis and treatment of neurosyphilis is of great significance for regression. There is no gold standard for the diagnosis of neurosyphilis. We did this study to explore the factors associated with th...

Authors: Yong Lu, Wujian Ke, Ligang Yang, Zhenyu Wang, Ping Lv, Jing Gu, Chun Hao, Jinghua Li, Yumao Cai, Mei Gu, Hongfang Liu, Wenjing Chen, Xiaohui Zhang, Liuyuan Wang, Yahui Liu, Bin Yang…

High prevalence of group B streptococcus ST17 hypervirulent clone among non-pregnant patients from a Hungarian venereology clinic

Although Streptococcus agalactiae is the leading causative agent of neonatal sepsis and meningitis, recently it is increasingly isolated from non-pregnant adults. The relation between its presence in the genitour...

Authors: Szilvia Kardos, Adrienn Tóthpál, Krisztina Laub, Katalin Kristóf, Eszter Ostorházi, Ferenc Rozgonyi and Orsolya Dobay

Men at risk of gonococcal urethritis: a case-control study in a Darwin sexual health clinic

Male urethritis is primary sexually transmitted. Northern Territory (NT) has the highest rates of gonococcal infection in Australia and local guidelines recommend empiric treatment with azithromycin and ceftri...

Authors: Winnie Chen, Suzanne Connor and Manoji Gunathilake

Prior cervical cytology and high-risk HPV testing results for 311 patients with invasive cervical adenocarcinoma: a multicenter retrospective study from China’s largest independent operator of pathology laboratories

High-risk human papillomavirus (HR-HPV) testing is more sensitive than cytology for the detection of cervical cancer and its precursors. However, limited and inconsistent data are available about the efficacy ...

Authors: Fengxiang Xie, Liran Zhang, Dongman Zhao, Xuefen Wu, Mingsong Wei, Xuelian Zhang, Xiaohui Wu, Hao Fang, Xue Xu, Meng Yang and Debo Qi

Contextualizing condoms: a cross-sectional study mapping intersections of locations of sexual contact, partner type, and substance use as contexts for sexual risk behavior among MSM in Peru

Condomless anal intercourse (CAI) appears to be increasing among men who have sex with men (MSM) globally, and is reported to be as high as 70% in recent studies in Peru. To improve understanding of the evolvi...

Authors: R. Colby Passaro, Angelica Castañeda-Huaripata, Williams Gonzales-Saavedra, Susan Chavez-Gomez, Eddy R. Segura, Jordan E. Lake, Robinson Cabello and Jesse L. Clark

Co-occurrence of human papillomavirus (HPV) in newborns and their parents

The potential HPV transmission route includes horizontal transmission “in utero” and vertical transmission from parents. Less is known about the role of child’s father as a potential source of HPV infection an...

Authors: Mariusz Skoczyński, Anna Goździcka-Józefiak and Anna Kwaśniewska

Tolerability of IM penicillin G benzathine diluted or not with local anesthetics, or different gauge needles for syphilis treatment: a randomized clinical trial

Penicillin G Benzathine (PGB) is the cornerstone of syphilis treatment. However, its intramuscular (IM) administration is associated with pain at the site of injection. The dilution of PGB with local anestheti...

Authors: Vicente Estrada, Eva Santiago, Inmaculada Cabezas, Juan Luis Cotano, Juan Carlos Carrió, Manuel Fuentes-Ferrer, Mar Vera, Oskar Ayerdi, Carmen Rodríguez, Laura López, Noemí Cabello, María José Núñez, Teresa Puerta, Iñigo Sagastagoitia and Jorge Del Romero

Bacterial vaginosis, vulvovaginal candidiasis and trichomonal vaginitis among reproductive-aged women seeking primary healthcare in Sana’a city, Yemen

In Yemen, the underlying causes of infectious vaginitis have been neglected. Therefore, this study aimed to determine the prevalence and risk factors associated with bacterial vaginosis (BV), vulvovaginal cand...

Authors: Maha Abdul-Aziz, Mohammed A. K. Mahdy, Rashad Abdul-Ghani, Nuha A. Alhilali, Leena K. A. Al-Mujahed, Salma A. Alabsi, Fatima A. M. Al-Shawish, Noura J. M. Alsarari, Wala Bamashmos, Shahad J. H. Abdulwali, Mahdi Al Karawani and Abdullah A. Almikhlafy

Assessment of a new low-cost, PCR-based strategy for high-risk human papillomavirus DNA detection for cervical cancer prevention

HPV test implementation as a primary screening tool has the potential to decrease cervical cancer incidence as shown by several studies around the world. However, in many low-resource settings, the HPV test in...

Authors: Pedro Surriabre, Andrea Torrico, Tania Vargas, Fuantina Ugarte, Patricia Rodriguez and Véronique Fontaine

Four-color multiplex real-time PCR assay prototype targeting azithromycin resistance mutations in Mycoplasma genitalium

The worldwide expansion of macrolide-resistant Mycoplasma genitalium (MG) in cases of genital infections has led to an increased recurrence rate of these infections after first-line azithromycin treatment. By det...

Authors: Olivier Thellin, Benaïssa Elmoualij, Willy Zorzi, Jorgen S. Jensen, Renaud Close, Valerie Deregowski, Muriel Le Guern Fellous and Pascale Quatresooz

Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis

Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercour...

Authors: Patrizia Künzler-Heule, Sandra Engberg, Manuel Battegay, Axel J. Schmidt, Katharina Fierz, Huyen Nguyen, Agnes Kocher, Christiana Nöstlinger, Benjamin Hampel, Marcel Stöckle, Charles Béguelin, Julie Delaloye, Patrick Schmid, Markus Flepp, Mathieu Rougement, Dominique Laurent Braun…

High-volume workflow and performance comparisons for Chlamydia trachomatis and Neisseria gonorrhoeae testing using automated molecular platforms

The global burden of sexually transmitted infections (STIs) is high and there have been reports of increasing chlamydial and gonorrheal infections. High-volume screening programs for Chlamydia trachomatis (CT) an...

Authors: André Frontzek, Gudrun Aretzweiler, Daniela Winkens, Dana Duncan and Elizabeth M. Marlowe

Early syphilis: risk factors and clinical manifestations focusing on HIV-positive patients

Since 2000, substantial increases in syphilis in men who have sex with men (MSM) have been reported in many cities. Condomless anal sex (CAS) is one of the factors, along with drugs for sex and sex in group. T...

Authors: Maider Arando, Candela Fernandez-Naval, Miriam Mota-Foix, Desi Martinez, Pere Armengol, Maria Jesús Barberá, Juliana Esperalba and Martí Vall-Mayans

Are current guidelines adapted for patient eligibility to PrEP? A case report

Despite effective antiretroviral therapy developed over the last decade, HIV infection remains a major worldwide public health problem. Recently, a promising preventive treatment has been made available for HI...

Authors: Elise K. Van Obberghen, Delphine Viard, Alain Lafeuillade, Alexandre Civiletti, Fanny Rocher and Milou-Daniel Drici

A lung abscess caused by secondary syphilis – the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report

In Japan and other countries, the number of patients with syphilis is increasing year by year. Recently, the cases of the pulmonary involvement in patients with secondary syphilis have been reported. However, ...

Authors: Shinji Futami, Takayuki Takimoto, Futoshi Nakagami, Shingo Satoh, Masanari Hamaguchi, Muneyoshi Kuroyama, Kotaro Miyake, Shohei Koyama, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida and Atsushi Kumanogoh

Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam

Human papillomavirus (HPV) causes cancers in men, including penile, anal, and oropharyngeal cancers. This cross-sectional study aimed to investigate the prevalence, the genotypes, and the risk factors of HPV i...

Authors: Hai Ha Long Le, Xiuqiong Bi, Azumi Ishizaki, Hung Van Le, Trung Vu Nguyen and Hiroshi Ichimura

Estimate of male urethritis incidences in France between 2007 and 2017 with a specific focus on Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis infections

In a context of increasing use of Nucleic Acid Amplification Test, diagnoses of Neisseria gonorrhoeae and Chlamydia trachomatis infections among men increased in Europe and USA since 2007. We aimed to describe tr...

Authors: Louise Rossignol, Laurianne Feuillepain, Ndeindo Ndeikoundam Ngangro, Cécile Souty, Nelly Fournet, Yann Le Strat, Noémie Baroux, Thomas Hanslik, Florence Lot and Thierry Blanchon

Assessing the cost-effectiveness of HPV vaccination strategies for adolescent girls and boys in the UK

Human papillomavirus (HPV) is the most widespread sexually transmitted infection worldwide. It causes several health consequences, in particular accounting for the majority of cervical cancer cases in women. I...

Authors: Samik Datta, Joshua Pink, Graham F. Medley, Stavros Petrou, Sophie Staniszewska, Martin Underwood, Pam Sonnenberg and Matt J. Keeling

Demographic characteristics of transfusion-transmitted infections among blood donors in China

Demographic characteristic surveillance of transfusion-transmitted infections (TTIs) among blood donors is crucial to formulating control strategies and preventing TTIs. This study aimed to investigate the dem...

Authors: Le Chang, Junpeng Zhao, Fei Guo, Huimin Ji, Lu Zhang, Xinyi Jiang and Lunan Wang

Seroprevalence and risk factors on Syphilis among blood donors in Chengdu, China,from 2005 to 2017

High-risk population of blood donation increases the prevalence of transmit blood-borne diseases and harm the blood safety. Syphilis accounts for approximately 10% of commonly sexually transmitted diseases. Th...

Authors: Shuangli Liu, Liping Luo, Guangxiang Xi, Like Wan, Li Zhong, Xue Chen, Tianxiang Gong, Shuping Li, Yi He and Na Li

Risk factors associated with gonorrhea and chlamydia transmission in selected health facilities in Ghana

Understanding the underlying epidemiology that shapes Neisseria gonorrhoeae (GC), and Chlamydia trachomatis (CT) infections can contribute to data driven policies directed towards curbing the proliferation of the...

Authors: Helena Dela, Naiki Attram, Eric Behene, Selassie Kumordjie, Kwasi Kennedy Addo, Edward Owusu Nyarko, Nicholas N. A. Kyei, John Nii Ayite Carroll, Cynthia Kwakye, Christopher Anthony Duplessis, Nehkonti Adams, Eric Garges and Andrew Gordon Letizia

Distribution of high-risk HPV types among women in Sichuan province, China: a cross-sectional study

Persistent infection with high-risk human papillomavirus (HR-HPV) is a major cause of cervical intraepithelial neoplasia and invasive cervical cancer. We investigated the prevalence of HR-HPV infection and dis...

Authors: Lixia He and Junyong He

Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Herpes simplex virus type-2 (HSV-2) infection is the main cause of genital ulcer disease and increases the risk of HIV acquisition. Little information is available regards the epidemiological characteristics o...

Authors: Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi’an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu…

Factors associated with syphilis infection: a cross-sectional survey among outpatients in Asikuma Odoben Brakwa District, Ghana

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. The disease affects all ages and both sexes but more prevalent among the sexually active age group of 15–49 years. The purp...

Authors: Martin Banong-le, Samuel Kwabena Ofosu and Francis Anto

A cross-sectional analysis of factors associated with detection of oncogenic human papillomavirus in human immunodeficiency virus-infected and uninfected Kenyan women

Cervical cancer is caused by oncogenic human papillomaviruses (HPV) and is one of the most common malignancies in women living in sub-Saharan Africa. Women infected with the human immunodeficiency virus (HIV) ...

Authors: A. Ermel, P. Tonui, M. Titus, Y. Tong, N. Wong, J. Ong’echa, K. Muthoka, S. Kiptoo, A. Moormann, J. Hogan, A. Mwangi, S. Cu-Uvin, P. J. Loehrer, O. Orang’o and D. Brown

Predictors of virological treatment failure among adult HIV patients on first-line antiretroviral therapy in Woldia and Dessie hospitals, Northeast Ethiopia: a case-control study

Virological treatment failure is a problem that a Human Immune Virus patient faces after starting treatment due to different factors. However, there were few studies done on the predictors of virological treat...

Authors: Mohammed Ahmed, Hailu Merga and Habtemu Jarso

Syphilis-attributable adverse pregnancy outcomes in China: a retrospective cohort analysis of 1187 pregnant women with different syphilis treatment

Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose of this study was to compare the frequency of adverse pregnancy outcomes among syphilis-seropositive w...

Authors: Huihui Liu, Niannian Chen, Jia Yu, Weiming Tang, Jianrong He, Huiyun Xiao, Suifang Lin, Fang Hu, Qiong Feng, Joseph D. Tucker, Huimin Xia and Xiu Qiu

Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data

Confidence in any diagnostic and antimicrobial susceptibility testing data is provided by appropriate and regular quality assurance (QA) procedures. In Europe, the European Gonococcal Antimicrobial Susceptibil...

Authors: Michelle J. Cole, Nerteley Quaye, Susanne Jacobsson, Michaela Day, Elizabeth Fagan, Catherine Ison, Rachel Pitt, Shila Seaton, Neil Woodford, Angelika Stary, Sonja Pleininger, Tania Crucitti, Blaženka Hunjak, Panayiota Maikanti, Steen Hoffmann, Jelena Viktorova…

Sexual health and human rights: protecting rights to promote health

Authors: Joseph D. Tucker, Benjamin M. Meier, Cecilia Devoto, Eva Szunyogova and Stefan Baral

Preventing sexually transmitted and blood borne infections (STBBIs) among sex workers: a critical review of the evidence on determinants and interventions in high-income countries

Across diverse regions globally, sex workers continue to face a disproportionate burden of HIV and other sexually transmitted and blood borne infections (STBBIs). Evidence suggests that behavioural and biomedi...

Authors: Elena Argento, Shira Goldenberg and Kate Shannon

A systematic review of selected human rights programs to improve HIV-related outcomes from 2003 to 2015: what do we know?

Repressive legal environments and widespread human rights violations act as structural impediments to efforts to engage key populations at risk of HIV infection in HIV prevention, care, and treatment efforts. ...

Authors: Anne L. Stangl, Devaki Singh, Michael Windle, Kirsty Sievwright, Katherine Footer, Alexandrina Iovita, Stella Mukasa and Stefan Baral

Development and reliability of metrics to characterize types and sources of stigma among men who have sex with men and female sex workers in Togo and Burkina Faso

Stigma is a multifaceted concept that potentiates Human Immunodeficiency Virus and sexually transmitted infection acquisition and transmission risks among key populations, including men who have sex with men (...

Authors: Ashley L. Grosso, Sosthenes C. Ketende, Shauna Stahlman, Odette Ky-Zerbo, Henri Gautier Ouedraogo, Seni Kouanda, Cesaire Samadoulougou, Marcel Lougue, Jules Tchalla, Simplice Anato, Sodji Dometo, Felicity D. Nadedjo, Vincent Pitche and Stefan D. Baral

High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response

Chlamydia trachomatis infections in women continue to be a major public health concern due to their high prevalence and consequent reproductive morbidities. While antibiotics are usually efficient to clear the Ch...

Authors: Noa Ziklo, Wilhelmina M. Huston, Kuong Taing and Peter Timms

Prevalence of human papillomavirus and subtype distribution in male partners of women with cervical intraepithelial neoplasia (CIN): a systematic review

Human Papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. The present systematic review summarizes data regarding the prevalence of HPV and the distribution of sub...

Authors: Anargyros Skoulakis, Serafim Fountas, Myrto Mantzana-Peteinelli, Kleoniki Pantelidi and Efthymia Petinaki

Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Johannesburg, South Africa, 2007–2014

Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determin...

Authors: Etienne E. Muller, Mahlape P. Mahlangu, David A. Lewis and Ranmini S. Kularatne

Perspectives on male partner notification and treatment for syphilis among antenatal women and their partners in Kampala and Wakiso districts, Uganda

Syphilis screening can be successfully integrated into antenatal clinics, and potentially avert significant morbidity and mortality to unborn infants. A minority of male partners report for testing and treatme...

Authors: Edith Nakku-Joloba, Juliet Kiguli, Christine Nalwadda Kayemba, Adeline Twimukye, Joshua Kimeze Mbazira, Rosalind Parkes-Ratanshi, Monica Birungi, Joshua Kyenkya, Josaphat Byamugisha, Charlotte Gaydos and Yukari C. Manabe

Oral-genital human papillomavirus infection in Polish couples: frequent detection of HPV 42

Human papillomavirus (HPV) contributes to the development of cervical and oropharyngeal tumors. The increased incidence of HPV associated oropharyngeal tumors is lately being observed also in Polish population...

Authors: Katarzyna Kiwerska, Agata Jozefiak, Janina Markowska, Witold Kedzia, Joanna Jackowska and Malgorzata Wierzbicka

Quantitative evaluation of an innovation contest to enhance a sexual health campaign in China

Crowdsourcing method is an excellent tool for developing tailored interventions to improve sexual health. We evaluated the implementation of an innovation contest for sexual health promotion in China.

Authors: Ye Zhang, Songyuan Tang, Katherine Li, Lai Sze Tso, Barry L. Bayus, David Glidden, Bin Yang, Heping Zheng, Chongyi Wei, Joseph Tucker and Weiming Tang

Prevalence and genotype distribution of human papillomavirus among 9945 women from the Nanhai area of Foshan

To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated the distribution characteristics and genotypes of human papillomavirus (HPV) and the prevalence of multip...

Authors: Xiao-wen Yuan, Yi-Jian Li, Quan Qiu, Zi-yuan Luo and Xue-feng Zhao

Prevalence and associated factors of Chlamydia trachomatis and Neisseria gonorrhoeae among female commercial sex workers in Hawassa City, Southern Ethiopia

Chlamydia trachomatis and Neisseria gonorrhoeae are the most common pathogens causing genital tract infections. Female commercial sex workers (FCSWs) are the key population to be affected by sexually transmitted ...

Authors: Alelign Tadele, Siraj Hussen and Techalew Shimelis

Chlamydia trachomatis screening in urine among asymptomatic men attending an STI clinic in Paris: a cross-sectional study

The incidence of Chlamydia trachomatis (Ct) urethritis has been increasing for the past 10 years. There is little data regarding the screening of Ct infection in asymptomatic men in France, despite the national r...

Authors: Paul Rondeau, Nadia Valin, Dominique Decré, Pierre-Marie Girard, Karine Lacombe and Laure Surgers

Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women

Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.

Authors: Eileen O. Dareng, Sally N. Adebamowo, Ayotunde Famooto, Oluwatoyosi Olawande, Michael K. Odutola, Yinka Olaniyan, Richard A. Offiong, Paul P. Pharoah and Clement A. Adebamowo

Comparison of an in-house real-time duplex PCR assay with commercial HOLOGIC® APTIMA assays for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis in urine and extra-genital specimens

Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are mostly asymptomatic, and important reservoir sites of infection as they often go undetected and may be more difficult to eradicate with...

Authors: Johanna M. E. Venter, Precious M. Mahlangu, Etienne E. Müller, David A. Lewis, Kevin Rebe, Helen Struthers, James McIntyre and Ranmini S. Kularatne

Human papillomavirus infection & anal cytological abnormalities in HIV-positive men in eastern India

Oncogenic Human papillomavirus (HPV) infections are closely associated with anal cancer which is high among human immunodeficiency virus (HIV) infected males. There are no data regarding anal HPV infection and...

Authors: Abhilasha Gautam, Jaya Chakravarty, Vijay Kumar Singh, Amrita Ghosh, Shashi Bhushan Chauhan, Madhukar Rai and Shyam Sundar

Lymphogranuloma venereum is on the rise in Belgium among HIV negative men who have sex with men: surveillance data from 2011 until the end of June 2017

The number of cases of Lymphogranuloma venereum (LGV) is increasing in Europe. The described epidemic is mostly confined to HIV positive men who have sex with men (MSM). However, dissemination of LGV from HIV ...

Authors: Irith De Baetselier, Achilleas Tsoumanis, Ruth Verbrugge, Bénédicte De Deken, Hilde Smet, Saïd Abdellati, Vicky Cuylaerts, Ludwig Apers and Tania Crucitti