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Sexually transmitted diseases

Section edited by Stefan Baral & Joseph Tucker

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV and HIV-associated infections are considered in a separate section.

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  1. Sexually transmitted infections (STIs) cause a major public health problem that affect both men and women in developing and developed countries. The aim of the study was to estimate the prevalence of 11 STIs a...

    Authors: Jessica Hanna, Ruba Yassine, Rana El-Bikai, Martin D. Curran, Mathilde Azar, Joumana Yeretzian, Rana Skaf, Claude Afif, Toufic Saber, Saadeddine Itani, Manal Hubeish, Tamima El Jisr, Fadia Hamzeh and Mira El Chaar

    Citation: BMC Infectious Diseases 2020 20:375

    Content type: Research article

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  2. The prevalence of HIV/HCV/HBV/ Treponema pallidum is an essential health issue in China. However, there are few studies focused on foreigners living in China. This study aimed to assess the prevalence and socio-d...

    Authors: Benard Chimungu, Muqing Fu, Jian Wu, Jiali Wu, Liping Huang, Yingchun Dai, Shixing Tang, Jianming Zhang and Chengsong Wan

    Citation: BMC Infectious Diseases 2020 20:345

    Content type: Research article

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  3. Mycoplasma genitalium is an emerging sexually transmitted infection, with increasing rates of resistance to fluroquinolones and macrolides, the recommended treatments. Despite this, M. genitalium is not part of r...

    Authors: Tim Hart, Wen Ying Tang, Siti Aminah bte Mansoor, Martin T. W. Chio and Timothy Barkham

    Citation: BMC Infectious Diseases 2020 20:314

    Content type: Research article

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  4. Human papillomaviruses (HPVs) have been divided into mucosal and cutaneous types according to their primary epithelial tissue tropism. However, recent studies showed the presence of several cutaneous types in ...

    Authors: Elisa M. Bolatti, Lea Hošnjak, Diego Chouhy, Pablo E. Casal, María F. Re-Louhau, Hebe Bottai, Kristina Fujs Komloš, Mario Poljak and Adriana A. Giri

    Citation: BMC Infectious Diseases 2020 20:274

    Content type: Research article

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  5. Bolivia has the highest prevalence of cervical cancer in South America and the prevalence of viral sexually transmitted infections (STIs) among people in urban cities is increasing. Little is known about the p...

    Authors: Marianela Patzi-Churqui, Katty Terrazas-Aranda, Jan-Åke Liljeqvist, Magnus Lindh and Kristina Eriksson

    Citation: BMC Infectious Diseases 2020 20:204

    Content type: Research article

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  6. Treponema pallidum (T. pallidum) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have...

    Authors: Tao Huang, Jun Zhang, Wujian Ke, Xiaohui Zhang, Wentao Chen, Jieyi Yang, Yiwen Liao, Fangwen Liang, Shuqing Mei, Mingjiu Li, Zhenzhou Luo, Qiwei Zhang, Bin Yang and Heping Zheng

    Citation: BMC Infectious Diseases 2020 20:165

    Content type: Research article

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  7. Syphilis is a sexually transmitted infection (STI) transmitted from person to person mainly by sexual intercourse or through vertical transmission during pregnancy. Female sex workers (FSWs) are exposed especi...

    Authors: Ronaldo Lopes de Souza, Lucimar Di Paula dos Santos Madeira, Marcelo Victor Serejo Pereira, Rachel Macedo da Silva, João Bráullio de Luna Sales, Vania Nakauth Azevedo, Rosimar Neris Martins Feitosa, Jacqueline Cortinhas Monteiro, Marluisa de Oliveira Guimarães Ishak, Ricardo Ishak, Andre Luis Ribeiro Ribeiro, Aldemir B. Oliveira-Filho and Luiz Fernando Almeida Machado

    Citation: BMC Infectious Diseases 2020 20:129

    Content type: Research article

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  8. Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. Approval of HIV pre...

    Authors: Klaus Jansen, Gyde Steffen, Anja Potthoff, Ann-Kathrin Schuppe, Daniel Beer, Heiko Jessen, Stefan Scholten, Petra Spornraft-Ragaller, Viviane Bremer and Carsten Tiemann

    Citation: BMC Infectious Diseases 2020 20:110

    Content type: Research article

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  9. The rates of newly diagnosed cases of sexually transmitted diseases, including genital chlamydial infection and gonorrhea, are important for prevention and control of these diseases. However, nationwide rates ...

    Authors: Miyuki Kawado, Shuji Hashimoto, Akiko Ohta, Mari S. Oba, Ritei Uehara, Kiyosu Taniguchi, Tomimasa Sunagawa, Masaki Nagai and Yoshitaka Murakami

    Citation: BMC Infectious Diseases 2020 20:77

    Content type: Research article

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  10. This study was conducted to understand the molecular epidemiology of circulating Chlamydia trachomatis (Ct) strains in Sapporo, Japan.

    Authors: Jeewan Thapa, Takanori Watanabe, Mana Isoba, Torahiko Okubo, Kiyotake Abe, Kunihiro Minami and Hiroyuki Yamaguchi

    Citation: BMC Infectious Diseases 2020 20:53

    Content type: Research article

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  11. Incidence of anal and oral infections with Human Papillomavirus (HPV) is increasing, particularly among Human Immunodeficiency Virus-positive (HIV+) men. HPV type 16 has exhibited the highest incidence and onl...

    Authors: Rocío Méndez-Martínez, Silvia Maldonado-Frías, Salvador Vázquez-Vega, Yanink Caro-Vega, José Guadalupe Rendón-Maldonado, Miriam Guido-Jiménez, Brenda Crabtree-Ramírez, Juan G. Sierra-Madero and Alejandro García-Carrancá

    Citation: BMC Infectious Diseases 2020 20:27

    Content type: Research article

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  12. Does the emergence of antimicrobial resistance in Neisseria gonorrhoeae include the erasure of highly susceptible strains or does it merely involve a stretching of the MIC distribution? If it was the former this ...

    Authors: Chris Kenyon, Jolein Laumen, Dorien Van Den Bossche and Christophe Van Dijck

    Citation: BMC Infectious Diseases 2019 19:1085

    Content type: Research article

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  13. Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study...

    Authors: Ying Zhou, Yu-Mao Cai, Shi-Liang Li, Ning-Xiao Cao, Xiao-Feng Zhu, Feng Wang, Yan Han, Yue-Ping Yin and Xiang-Sheng Chen

    Citation: BMC Infectious Diseases 2019 19:1041

    Content type: Research article

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  14. European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) antimicrobial resistance (AMR) data are used to inform gonorrhoea treatment guidelines; therefore the data need to be robust and representat...

    Authors: Michelle J. Cole, Chantal Quinten, Susanne Jacobsson, Michaela Day, Andrew J. Amato-Gauci, Neil Woodford, Gianfranco Spiteri and Magnus Unemo

    Citation: BMC Infectious Diseases 2019 19:1040

    Content type: Research article

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  15. Early diagnosis and treatment of neurosyphilis is of great significance for regression. There is no gold standard for the diagnosis of neurosyphilis. We did this study to explore the factors associated with th...

    Authors: Yong Lu, Wujian Ke, Ligang Yang, Zhenyu Wang, Ping Lv, Jing Gu, Chun Hao, Jinghua Li, Yumao Cai, Mei Gu, Hongfang Liu, Wenjing Chen, Xiaohui Zhang, Liuyuan Wang, Yahui Liu, Bin Yang…

    Citation: BMC Infectious Diseases 2019 19:1017

    Content type: Research article

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  16. Although Streptococcus agalactiae is the leading causative agent of neonatal sepsis and meningitis, recently it is increasingly isolated from non-pregnant adults. The relation between its presence in the genitour...

    Authors: Szilvia Kardos, Adrienn Tóthpál, Krisztina Laub, Katalin Kristóf, Eszter Ostorházi, Ferenc Rozgonyi and Orsolya Dobay

    Citation: BMC Infectious Diseases 2019 19:1009

    Content type: Research article

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  17. High-risk human papillomavirus (HR-HPV) testing is more sensitive than cytology for the detection of cervical cancer and its precursors. However, limited and inconsistent data are available about the efficacy ...

    Authors: Fengxiang Xie, Liran Zhang, Dongman Zhao, Xuefen Wu, Mingsong Wei, Xuelian Zhang, Xiaohui Wu, Hao Fang, Xue Xu, Meng Yang and Debo Qi

    Citation: BMC Infectious Diseases 2019 19:962

    Content type: Research article

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  18. Condomless anal intercourse (CAI) appears to be increasing among men who have sex with men (MSM) globally, and is reported to be as high as 70% in recent studies in Peru. To improve understanding of the evolvi...

    Authors: R. Colby Passaro, Angelica Castañeda-Huaripata, Williams Gonzales-Saavedra, Susan Chavez-Gomez, Eddy R. Segura, Jordan E. Lake, Robinson Cabello and Jesse L. Clark

    Citation: BMC Infectious Diseases 2019 19:958

    Content type: Research article

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  19. The potential HPV transmission route includes horizontal transmission “in utero” and vertical transmission from parents. Less is known about the role of child’s father as a potential source of HPV infection an...

    Authors: Mariusz Skoczyński, Anna Goździcka-Józefiak and Anna Kwaśniewska

    Citation: BMC Infectious Diseases 2019 19:930

    Content type: Research article

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  20. Penicillin G Benzathine (PGB) is the cornerstone of syphilis treatment. However, its intramuscular (IM) administration is associated with pain at the site of injection. The dilution of PGB with local anestheti...

    Authors: Vicente Estrada, Eva Santiago, Inmaculada Cabezas, Juan Luis Cotano, Juan Carlos Carrió, Manuel Fuentes-Ferrer, Mar Vera, Oskar Ayerdi, Carmen Rodríguez, Laura López, Noemí Cabello, María José Núñez, Teresa Puerta, Iñigo Sagastagoitia and Jorge Del Romero

    Citation: BMC Infectious Diseases 2019 19:883

    Content type: Research article

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  21. In Yemen, the underlying causes of infectious vaginitis have been neglected. Therefore, this study aimed to determine the prevalence and risk factors associated with bacterial vaginosis (BV), vulvovaginal cand...

    Authors: Maha Abdul-Aziz, Mohammed A. K. Mahdy, Rashad Abdul-Ghani, Nuha A. Alhilali, Leena K. A. Al-Mujahed, Salma A. Alabsi, Fatima A. M. Al-Shawish, Noura J. M. Alsarari, Wala Bamashmos, Shahad J. H. Abdulwali, Mahdi Al Karawani and Abdullah A. Almikhlafy

    Citation: BMC Infectious Diseases 2019 19:879

    Content type: Research article

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  22. HPV test implementation as a primary screening tool has the potential to decrease cervical cancer incidence as shown by several studies around the world. However, in many low-resource settings, the HPV test in...

    Authors: Pedro Surriabre, Andrea Torrico, Tania Vargas, Fuantina Ugarte, Patricia Rodriguez and Véronique Fontaine

    Citation: BMC Infectious Diseases 2019 19:842

    Content type: Research article

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  23. The worldwide expansion of macrolide-resistant Mycoplasma genitalium (MG) in cases of genital infections has led to an increased recurrence rate of these infections after first-line azithromycin treatment. By det...

    Authors: Olivier Thellin, Benaïssa Elmoualij, Willy Zorzi, Jorgen S. Jensen, Renaud Close, Valerie Deregowski, Muriel Le Guern Fellous and Pascale Quatresooz

    Citation: BMC Infectious Diseases 2019 19:827

    Content type: Research article

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  24. Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercour...

    Authors: Patrizia Künzler-Heule, Sandra Engberg, Manuel Battegay, Axel J. Schmidt, Katharina Fierz, Huyen Nguyen, Agnes Kocher, Christiana Nöstlinger, Benjamin Hampel, Marcel Stöckle, Charles Béguelin, Julie Delaloye, Patrick Schmid, Markus Flepp, Mathieu Rougement, Dominique Laurent Braun…

    Citation: BMC Infectious Diseases 2019 19:821

    Content type: Research article

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  25. The global burden of sexually transmitted infections (STIs) is high and there have been reports of increasing chlamydial and gonorrheal infections. High-volume screening programs for Chlamydia trachomatis (CT) an...

    Authors: André Frontzek, Gudrun Aretzweiler, Daniela Winkens, Dana Duncan and Elizabeth M. Marlowe

    Citation: BMC Infectious Diseases 2019 19:797

    Content type: Research article

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  26. Since 2000, substantial increases in syphilis in men who have sex with men (MSM) have been reported in many cities. Condomless anal sex (CAS) is one of the factors, along with drugs for sex and sex in group. T...

    Authors: Maider Arando, Candela Fernandez-Naval, Miriam Mota-Foix, Desi Martinez, Pere Armengol, Maria Jesús Barberá, Juliana Esperalba and Martí Vall-Mayans

    Citation: BMC Infectious Diseases 2019 19:727

    Content type: Research article

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  27. Despite effective antiretroviral therapy developed over the last decade, HIV infection remains a major worldwide public health problem. Recently, a promising preventive treatment has been made available for HI...

    Authors: Elise K. Van Obberghen, Delphine Viard, Alain Lafeuillade, Alexandre Civiletti, Fanny Rocher and Milou-Daniel Drici

    Citation: BMC Infectious Diseases 2019 19:601

    Content type: Case report

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  28. In Japan and other countries, the number of patients with syphilis is increasing year by year. Recently, the cases of the pulmonary involvement in patients with secondary syphilis have been reported. However, ...

    Authors: Shinji Futami, Takayuki Takimoto, Futoshi Nakagami, Shingo Satoh, Masanari Hamaguchi, Muneyoshi Kuroyama, Kotaro Miyake, Shohei Koyama, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida and Atsushi Kumanogoh

    Citation: BMC Infectious Diseases 2019 19:598

    Content type: Case report

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  29. Human papillomavirus (HPV) causes cancers in men, including penile, anal, and oropharyngeal cancers. This cross-sectional study aimed to investigate the prevalence, the genotypes, and the risk factors of HPV i...

    Authors: Hai Ha Long Le, Xiuqiong Bi, Azumi Ishizaki, Hung Van Le, Trung Vu Nguyen and Hiroshi Ichimura

    Citation: BMC Infectious Diseases 2019 19:578

    Content type: Research article

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  30. In a context of increasing use of Nucleic Acid Amplification Test, diagnoses of Neisseria gonorrhoeae and Chlamydia trachomatis infections among men increased in Europe and USA since 2007. We aimed to describe tr...

    Authors: Louise Rossignol, Laurianne Feuillepain, Ndeindo Ndeikoundam Ngangro, Cécile Souty, Nelly Fournet, Yann Le Strat, Noémie Baroux, Thomas Hanslik, Florence Lot and Thierry Blanchon

    Citation: BMC Infectious Diseases 2019 19:561

    Content type: Research article

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  31. Human papillomavirus (HPV) is the most widespread sexually transmitted infection worldwide. It causes several health consequences, in particular accounting for the majority of cervical cancer cases in women. I...

    Authors: Samik Datta, Joshua Pink, Graham F. Medley, Stavros Petrou, Sophie Staniszewska, Martin Underwood, Pam Sonnenberg and Matt J. Keeling

    Citation: BMC Infectious Diseases 2019 19:552

    Content type: Research article

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  32. Demographic characteristic surveillance of transfusion-transmitted infections (TTIs) among blood donors is crucial to formulating control strategies and preventing TTIs. This study aimed to investigate the dem...

    Authors: Le Chang, Junpeng Zhao, Fei Guo, Huimin Ji, Lu Zhang, Xinyi Jiang and Lunan Wang

    Citation: BMC Infectious Diseases 2019 19:514

    Content type: Research article

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  33. High-risk population of blood donation increases the prevalence of transmit blood-borne diseases and harm the blood safety. Syphilis accounts for approximately 10% of commonly sexually transmitted diseases. Th...

    Authors: Shuangli Liu, Liping Luo, Guangxiang Xi, Like Wan, Li Zhong, Xue Chen, Tianxiang Gong, Shuping Li, Yi He and Na Li

    Citation: BMC Infectious Diseases 2019 19:509

    Content type: Research article

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  34. Understanding the underlying epidemiology that shapes Neisseria gonorrhoeae (GC), and Chlamydia trachomatis (CT) infections can contribute to data driven policies directed towards curbing the proliferation of the...

    Authors: Helena Dela, Naiki Attram, Eric Behene, Selassie Kumordjie, Kwasi Kennedy Addo, Edward Owusu Nyarko, Nicholas N. A. Kyei, John Nii Ayite Carroll, Cynthia Kwakye, Christopher Anthony Duplessis, Nehkonti Adams, Eric Garges and Andrew Gordon Letizia

    Citation: BMC Infectious Diseases 2019 19:425

    Content type: Research article

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  35. Herpes simplex virus type-2 (HSV-2) infection is the main cause of genital ulcer disease and increases the risk of HIV acquisition. Little information is available regards the epidemiological characteristics o...

    Authors: Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi’an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu…

    Citation: BMC Infectious Diseases 2019 19:382

    Content type: Research article

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  36. Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. The disease affects all ages and both sexes but more prevalent among the sexually active age group of 15–49 years. The purp...

    Authors: Martin Banong-le, Samuel Kwabena Ofosu and Francis Anto

    Citation: BMC Infectious Diseases 2019 19:360

    Content type: Research article

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  37. Cervical cancer is caused by oncogenic human papillomaviruses (HPV) and is one of the most common malignancies in women living in sub-Saharan Africa. Women infected with the human immunodeficiency virus (HIV) ...

    Authors: A. Ermel, P. Tonui, M. Titus, Y. Tong, N. Wong, J. Ong’echa, K. Muthoka, S. Kiptoo, A. Moormann, J. Hogan, A. Mwangi, S. Cu-Uvin, P. J. Loehrer, O. Orang’o and D. Brown

    Citation: BMC Infectious Diseases 2019 19:352

    Content type: Research article

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  38. Virological treatment failure is a problem that a Human Immune Virus patient faces after starting treatment due to different factors. However, there were few studies done on the predictors of virological treat...

    Authors: Mohammed Ahmed, Hailu Merga and Habtemu Jarso

    Citation: BMC Infectious Diseases 2019 19:305

    Content type: Research article

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  39. Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose of this study was to compare the frequency of adverse pregnancy outcomes among syphilis-seropositive w...

    Authors: Huihui Liu, Niannian Chen, Jia Yu, Weiming Tang, Jianrong He, Huiyun Xiao, Suifang Lin, Fang Hu, Qiong Feng, Joseph D. Tucker, Huimin Xia and Xiu Qiu

    Citation: BMC Infectious Diseases 2019 19:292

    Content type: Research article

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  40. Confidence in any diagnostic and antimicrobial susceptibility testing data is provided by appropriate and regular quality assurance (QA) procedures. In Europe, the European Gonococcal Antimicrobial Susceptibil...

    Authors: Michelle J. Cole, Nerteley Quaye, Susanne Jacobsson, Michaela Day, Elizabeth Fagan, Catherine Ison, Rachel Pitt, Shila Seaton, Neil Woodford, Angelika Stary, Sonja Pleininger, Tania Crucitti, Blaženka Hunjak, Panayiota Maikanti, Steen Hoffmann, Jelena Viktorova…

    Citation: BMC Infectious Diseases 2019 19:281

    Content type: Research article

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  41. Across diverse regions globally, sex workers continue to face a disproportionate burden of HIV and other sexually transmitted and blood borne infections (STBBIs). Evidence suggests that behavioural and biomedi...

    Authors: Elena Argento, Shira Goldenberg and Kate Shannon

    Citation: BMC Infectious Diseases 2019 19:212

    Content type: Research article

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  42. Repressive legal environments and widespread human rights violations act as structural impediments to efforts to engage key populations at risk of HIV infection in HIV prevention, care, and treatment efforts. ...

    Authors: Anne L. Stangl, Devaki Singh, Michael Windle, Kirsty Sievwright, Katherine Footer, Alexandrina Iovita, Stella Mukasa and Stefan Baral

    Citation: BMC Infectious Diseases 2019 19:209

    Content type: Research article

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  43. Stigma is a multifaceted concept that potentiates Human Immunodeficiency Virus and sexually transmitted infection acquisition and transmission risks among key populations, including men who have sex with men (...

    Authors: Ashley L. Grosso, Sosthenes C. Ketende, Shauna Stahlman, Odette Ky-Zerbo, Henri Gautier Ouedraogo, Seni Kouanda, Cesaire Samadoulougou, Marcel Lougue, Jules Tchalla, Simplice Anato, Sodji Dometo, Felicity D. Nadedjo, Vincent Pitche and Stefan D. Baral

    Citation: BMC Infectious Diseases 2019 19:208

    Content type: Research article

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  44. Chlamydia trachomatis infections in women continue to be a major public health concern due to their high prevalence and consequent reproductive morbidities. While antibiotics are usually efficient to clear the Ch...

    Authors: Noa Ziklo, Wilhelmina M. Huston, Kuong Taing and Peter Timms

    Citation: BMC Infectious Diseases 2019 19:218

    Content type: Research article

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  45. Human Papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. The present systematic review summarizes data regarding the prevalence of HPV and the distribution of sub...

    Authors: Anargyros Skoulakis, Serafim Fountas, Myrto Mantzana-Peteinelli, Kleoniki Pantelidi and Efthymia Petinaki

    Citation: BMC Infectious Diseases 2019 19:192

    Content type: Research article

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  46. Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determin...

    Authors: Etienne E. Muller, Mahlape P. Mahlangu, David A. Lewis and Ranmini S. Kularatne

    Citation: BMC Infectious Diseases 2019 19:148

    Content type: Research article

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  47. Syphilis screening can be successfully integrated into antenatal clinics, and potentially avert significant morbidity and mortality to unborn infants. A minority of male partners report for testing and treatme...

    Authors: Edith Nakku-Joloba, Juliet Kiguli, Christine Nalwadda Kayemba, Adeline Twimukye, Joshua Kimeze Mbazira, Rosalind Parkes-Ratanshi, Monica Birungi, Joshua Kyenkya, Josaphat Byamugisha, Charlotte Gaydos and Yukari C. Manabe

    Citation: BMC Infectious Diseases 2019 19:124

    Content type: Research article

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