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Parasitological diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of parasitological diseases in humans, as well as related studies on molecular and cellular biology, pathophysiology, and epidemiology.

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  1. Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the fi...

    Authors: Katherine Plewes, Richard J. Maude, Aniruddha Ghose and Arjen M. Dondorp

    Citation: BMC Infectious Diseases 2015 15:555

    Content type: Case report

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  2. Toxoplasmosis is a zoonosis caused by Toxoplasma gondii, an intracellular protozoan parasite able to infect a wide range of hosts, including humans. Congenital infection can cause severe damage to the fetus. Thus...

    Authors: Ana Carolina de Morais Oliveira, Hellen Dayane Silva Borges, Fernando Reis Carvalho, Arlindo Gomes de Macêdo Jr., Caroline Martins Mota, Angela Maria de Morais Oliveira, Fernanda Maria Santiago, Cristina Guimarães Arantes Araújo, Deise Aparecida de Oliveira Silva, Tiago Wilson Patriarca Mineo, Vânia Olivetti Steffen Abdallah and José Roberto Mineo

    Citation: BMC Infectious Diseases 2015 15:519

    Content type: Research article

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  3. Lymphoedema and hydrocoele are the two most common clinical manifestations of lymphatic filariasis (LF). In order to effectively target morbidity management strategies, more information is rapidly needed on mo...

    Authors: Michelle C. Stanton, Square Z. Mkwanda, Alexander Y. Debrah, Linda Batsa, Nana-Kwadwo Biritwum, Achim Hoerauf, Matthew Cliffe, Abigail Best, Andrew Molineux and Louise A. Kelly-Hope

    Citation: BMC Infectious Diseases 2015 15:214

    Content type: Research article

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  4. Although malaria is preventable and treatable, it still claims 660,000 lives every year globally with children under five years of age having the highest burden. In Zambia, malaria rapid diagnostic tests (RDTs...

    Authors: Lungowe Sitali, James Chipeta, John M Miller, Hawela B Moonga, Nirbhay Kumar, William J Moss and Charles Michelo

    Citation: BMC Infectious Diseases 2015 15:204

    Content type: Research article

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  5. The 29 kDa Schistosoma haematobium species-specific antigen (ShSSA) is of remarkable interest in the diagnosis of urinary schistosomiasis although it had not been fully characterized.

    Authors: Uri S Markakpo, George E Armah, Julius N Fobil, Richard H Asmah, Isaac Anim-Baidoo, Alfred K Dodoo, Parnor Madjitey, Edward E Essuman, Somei Kojima and Kwabena M Bosompem

    Citation: BMC Infectious Diseases 2015 15:198

    Content type: Research article

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  6. Visceral leishmaniasis (VL), a potentially fatal disease, is most prevalent in the Indian subcontinent, East Africa and South America. Since the conventional antileishmanial drugs have many limitations we eval...

    Authors: Mohammad Asad, Pradyot Bhattacharya, Antara Banerjee and Nahid Ali

    Citation: BMC Infectious Diseases 2015 15:188

    Content type: Research article

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  7. Toxoplasma gondii infection has been associated with psychiatric diseases. However, there is no information about the link between this infection and patients with mental and behavioral disorders due to psychoact...

    Authors: Cosme Alvarado-Esquivel, David Carrillo-Oropeza, Sandy Janet Pacheco-Vega, Jesús Hernández-Tinoco, Misael Salcedo-Jaquez, Luis Francisco Sánchez-Anguiano, María Nalleli Ortiz-Jurado, Yesenia Alarcón-Alvarado, Oliver Liesenfeld and Isabel Beristain-García

    Citation: BMC Infectious Diseases 2015 15:172

    Content type: Research article

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  8. The objective of this study was to explore effects of khat (Catha edulis) on outcome of rodent malaria infection and its anti-plasmodial activities on Plasmodium berghei ANKA (PbA).

    Authors: Tsige Ketema, Moti Yohannes, Esayas Alemayehu and Argaw Ambelu

    Citation: BMC Infectious Diseases 2015 15:170

    Content type: Research article

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  9. Schistosoma mansoni infection represents a major cause of morbidity and mortality in many areas of the developing world. Effective vaccines against schistosomiasis are not available and disease management relies ...

    Authors: Shereen F Mossallam, Eglal I Amer, Radwa E Ewaisha, Amal M Khalil, Hamida M Aboushleib and Mohammed Bahey-El-Din

    Citation: BMC Infectious Diseases 2015 15:147

    Content type: Research article

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  10. Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting. Modelling mass ...

    Authors: Jaline Gerardin, Philip Eckhoff and Edward A Wenger

    Citation: BMC Infectious Diseases 2015 15:144

    Content type: Research article

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  11. Some studies have suggested that helminth infections increase the risk of malaria infection and are associated with increased number of malaria attacks and anaemia. Thus interventions to control helminth infec...

    Authors: Safari M Kinung’hi, Pascal Magnussen, Coleman Kishamawe, Jim Todd and Birgitte J Vennervald

    Citation: BMC Infectious Diseases 2015 15:136

    Content type: Research article

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  12. Insulin resistance is a strong predictor of the development of type 2 diabetes mellitus. Chronic helminth infections might protect against insulin resistance via a caloric restriction state and indirectly via ...

    Authors: Dicky L Tahapary, Karin de Ruiter, Ivonne Martin, Lisette van Lieshout, Bruno Guigas, Pradana Soewondo, Yenny Djuardi, Aprilianto E Wiria, Oleg A Mayboroda, Jeanine J Houwing-Duistermaat, Hengki Tasman, Erliyani Sartono, Maria Yazdanbakhsh, Johannes W A Smit and Taniawati Supali

    Citation: BMC Infectious Diseases 2015 15:133

    Content type: Study protocol

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  13. Visceral leishmaniasis (VL) or kala-azar cases in seasonal labour migrants from highland areas are addressed to travel history to the Metema–Humera lowlands, northwestern Ethiopia. Factors that affect the inci...

    Authors: Wossenseged Lemma, Habte Tekie, Solomon Yared, Meshesha Balkew, Teshome Gebre-Michael, Alon Warburg and Asrat Hailu

    Citation: BMC Infectious Diseases 2015 15:99

    Content type: Research article

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  14. Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). In renal transplant recipients, visceral leishmaniasis causes severe damage to th...

    Authors: Avelar Alves de Silva, Álvaro Pacheco E Silva Filho, Ricardio de Castro Cinta Sesso, Ronaldo de Matos Esmeraldo, Cláudia Maria Costa de Oliveira, Paula Frassinetti Castelo Branco Camurca Fernandes, Rodrigo Alves de Oliveira, Leila Silveira Veira de Silva, Valencio Pereira de Carvalho, Carlos Henrique Nery Costa, Jesusmar Ximenes Andrade, Diana Marisa Barros da Silva and Roosevelt Valente Chaves

    Citation: BMC Infectious Diseases 2015 15:96

    Content type: Research article

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  15. During weeks 32–33, 2013, 24 cases of cryptosporidiosis were notified in the city of Halle (annual mean 2008–2012: 9 cases). We investigated the outbreak to identify the source and recommend control measures, ...

    Authors: Maximilian Gertler, Matthias Dürr, Peter Renner, Sven Poppert, Mona Askar, Janina Breidenbach, Christina Frank, Karina Preußel, Anika Schielke, Dirk Werber, Rachel Chalmers, Guy Robinson, Irmgard Feuerpfeil, Egbert Tannich, Christine Gröger, Klaus Stark…

    Citation: BMC Infectious Diseases 2015 15:88

    Content type: Research article

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  16. Leishmaniasis is an important parasitic disease affecting millions worldwide. Human cutaneous leishmaniasis (CL) is endemic in Rio de Janeiro, Brazil, where is caused by Leishmania braziliensis. The adaptive immu...

    Authors: Raquel Ferraz, Clarissa F Cunha, Adriano Gomes-Silva, Armando O Schubach, Maria Inês F Pimentel, Marcelo Rosandiski Lyra, Sergio CF Mendonça, Cláudia M Valete-Rosalino, Alda Maria Da-Cruz and Álvaro Luiz Bertho

    Citation: BMC Infectious Diseases 2015 15:74

    Content type: Research article

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  17. Plasmodium knowlesi was identified as the fifth major malaria parasite in humans. It presents severe clinical symptoms and leads to mortality as a result of hyperparasitemia in a short period of time. This study ...

    Authors: Yeng Chen, Choon K Chan, Jesinda P Kerishnan, Yee L Lau, Yin-Ling Wong and Subash CB Gopinath

    Citation: BMC Infectious Diseases 2015 15:49

    Content type: Research article

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  18. To eliminate visceral leishmaniasis (VL) in India and Nepal, challenges of VL diagnosis, treatment and reporting need to be identified. Recent data indicate that VL is underreported and patients face delays wh...

    Authors: Jan P Boettcher, Yubaraj Siwakoti, Ana Milojkovic, Niyamat A Siddiqui, Chitra K Gurung, Suman Rijal, Pradeep Das, Axel Kroeger and Megha R Banjara

    Citation: BMC Infectious Diseases 2015 15:43

    Content type: Research article

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  19. For a long time, the role of CD8+ T cells in blood-stage malaria was not considered important because erythrocytes do not express major histocompatibility complex (MHC) class I proteins. While recent evidences su...

    Authors: Natália Satchiko Hojo-Souza, Dhelio Batista Pereira, Lívia Silva Araújo Passos, Pedro Henrique Gazzinelli-Guimarães, Mariana Santos Cardoso, Mauro Shugiro Tada, Graziela Maria Zanini, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno

    Citation: BMC Infectious Diseases 2015 15:35

    Content type: Research article

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  20. After the control of the main modes of Chagas disease (CD) transmission in most endemic countries, it is important to identify the participation of native sylvatic vectors in CD transmission. Although CD is no...

    Authors: Luiz Henrique Conde Sangenis, Roberto Magalhães Saraiva, Ingebourg Georg, Liane de Castro, Valdirene dos Santos Lima, André Luiz R Roque, Samanta Cristina das Chagas Xavier, Laura Cristina Santos, Fabiano A Fernandes, Otília Sarquis, Marli Maria Lima, Filipe Aníbal Carvalho-Costa and Márcio Neves Bóia

    Citation: BMC Infectious Diseases 2015 15:4

    Content type: Research article

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  21. The influence of environmental and climatic factors on malaria vector bionomics and transmission is an important topic in the context of climatic change particularly at macro-geographical level. Sahelian areas...

    Authors: El Hadji Malick Ngom, Ndèye Diango Faye, Cheikh Talla, El Hadji Ndiaye, Jacques-André Ndione, Ousmane Faye, Yamar Ba, Mawlouth Diallo and Ibrahima Dia

    Citation: BMC Infectious Diseases 2014 14:3838

    Content type: Research article

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  22. Visceral leishmaniasis (VL) is a severe disease caused by Leishmania infantum in the Mediterranean basin, and is associated with considerable morbidity and mortality. Infantile VL may begin suddenly, with high fe...

    Authors: Fraia Melchionda, Stefania Varani, Filomena Carfagnini, Tamara Belotti, Trentina Di Muccio, Roberto Tigani, Rosalba Bergamaschi and Andrea Pession

    Citation: BMC Infectious Diseases 2014 14:620

    Content type: Case report

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  23. Murray Valley encephalitis virus (MVEV) is a flavivirus that occurs in Australia and New Guinea. While clinical cases are uncommon, MVEV can cause severe encephalitis with high mortality. Sentinel chicken surv...

    Authors: Linda A Selvey, Cheryl A Johansen, Annette K Broom, Catarina Antão, Michael D Lindsay, John S Mackenzie and David W Smith

    Citation: BMC Infectious Diseases 2014 14:672

    Content type: Research article

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  24. There is a paucity of data pertaining to the epidemiology and public health impact of Enterobius vermicularis and Strongyloides stercoralis infections. We aimed to determine the extent of enterobiasis, strongyloi...

    Authors: Nahya Salim, Tobias Schindler, Ummi Abdul, Julian Rothen, Blaise Genton, Omar Lweno, Alisa S Mohammed, John Masimba, Denis Kwaba, Salim Abdulla, Marcel Tanner, Claudia Daubenberger and Stefanie Knopp

    Citation: BMC Infectious Diseases 2014 14:644

    Content type: Research article

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  25. Little is known about the parasite/host factors that lead to Post Kala-azar Dermal Leishmaniasis (PKDL) in some visceral leishmaniasis (VL) patients after drug-cure. Studies in Sudan provide evidence for assoc...

    Authors: Mohamed A M Salih, Michaela Fakiola, Mohamed H Abdelraheem, Brima M Younis, Ahmed M Musa, Ahmed M ElHassan, Jenefer M Blackwell, Muntaser E Ibrahim and Hiba S Mohamed

    Citation: BMC Infectious Diseases 2014 14:662

    Content type: Research article

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  26. Majority of individuals with history of visceral leishmaniasis (VL) exhibit strong immunity to re-infection, however, the mechanism of resistance is poorly understood. It is unclear whether CD8+ T cells contribut...

    Authors: Himanshu Kaushal, Rachel Bras-Gonçalves, Narender Singh Negi, Jean-Loup Lemesre, Gérard Papierok and Poonam Salotra

    Citation: BMC Infectious Diseases 2014 14:653

    Content type: Research article

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  27. Leishmania infantum is a flagellated protozoan parasite that is able to parasitize blood and tissue. Leishmania species cause a spectrum of clinical disease with cutaneous, visceral or mucosal involvement. L. in...

    Authors: Amy Crowe, John Slavin, Damien Stark and Craig Aboltins

    Citation: BMC Infectious Diseases 2014 14:597

    Content type: Case report

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  28. The protozoan parasite Entamoeba histolytica (E. histolytica) usually asymptomatically colonizes the human intestine. In the minority of the cases, the parasite evades from the gut and can induce severe symptoms ...

    Authors: Hannah Bernin, Claudia Marggraff, Thomas Jacobs, Norbert Brattig, Le Van An, Jörg Blessmann and Hannelore Lotter

    Citation: BMC Infectious Diseases 2014 14:621

    Content type: Research article

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  29. A previously published proof of principle phase IIa trial with 113 patients from Kabul showed that bipolar high-frequency (HF) electro-cauterization (EC) of cutaneous leishmaniasis (CL) ulcers and subsequent m...

    Authors: Hans-Christian Stahl, Faridullah Ahmadi, Ulrike Schleicher, Rainer Sauerborn, Justo Lorenzo Bermejo, Mohammed Latif Amirih, Ibrahim Sakhayee, Christian Bogdan and Kurt-Wilhelm Stahl

    Citation: BMC Infectious Diseases 2014 14:619

    Content type: Research article

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  30. Malaria during pregnancy remains a serious public health problem. The aim of this study was to determine the prevalence and possible risk factors for malaria in pregnant women attending antenatal clinic at two...

    Authors: Mamoudou Cisse, Ibrahim Sangare, Guekoun Lougue, Sanata Bamba, Dramane Bayane and Robert Tinga Guiguemde

    Citation: BMC Infectious Diseases 2014 14:631

    Content type: Research article

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  31. Refining the spatial and temporal data on malaria transmissions at a defined ecological setting has practical implications for targeted malaria control and enhancing efficient allocation of resources. Spatial ...

    Authors: Lelisa Sena, Wakgari Deressa and Ahmed Ali

    Citation: BMC Infectious Diseases 2014 14:625

    Content type: Research article

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  32. Authors: Syazwan Saidin, Muhammad Hafiznur Yunus, Nor Dyana Zakaria, Khairunisak Abdul Razak, Lim Boon Huat, Nurulhasanah Othman and Rahmah Noordin

    Citation: BMC Infectious Diseases 2014 14:533

    Content type: Erratum

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    The original article was published in BMC Infectious Diseases 2014 14:182

  33. Cryptosporidium hominis and C. parvum are usually considered to be the major pathogens responsible for human cryptosporidiosis. However, there have been few studies regarding the molecular epidemiology of Crypto...

    Authors: Yanyan Jiang, Jinhua Ren, Zhongying Yuan, Aiqin Liu, Hong Zhao, Hua Liu, Lei Chu, Wei Pan, Jianping Cao, Yijin Lin and Yujuan Shen

    Citation: BMC Infectious Diseases 2014 14:555

    Content type: Research article

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  34. Schistosomiasis constitutes a major public health problem, and 200 million people are estimated to be infected with schistosomiasis worldwide. In Brazil, schistosomiasis has been reported in 19 states, showing...

    Authors: Maria Cristina Carvalho Espírito-Santo, Mónica Viviana Alvarado-Mora, Emmanuel Dias-Neto, Lívia Souza Botelho-Lima, João Paulo Moreira, Maria Amorim, Pedro Luiz Silva Pinto, Ashley R Heath, Vera Lúcia Pagliusi Castilho, Elenice Messias do Nascimento Gonçalves, Expedito José de Albuquerque Luna, Flair José Carrilho, João Renato Rebello Pinho and Ronaldo Cesar Borges Gryschek

    Citation: BMC Infectious Diseases 2014 14:558

    Content type: Research article

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  35. The distributions of incubation and relapse periods are key components of infectious disease models for the malaria parasite Plasmodium vivax; however, detailed distributions based upon experimental data are lack...

    Authors: Andrew A Lover, Xiahong Zhao, Zheng Gao, Richard J Coker and Alex R Cook

    Citation: BMC Infectious Diseases 2014 14:539

    Content type: Research article

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  36. In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail and their clinical and pathological significance are unknown. A prospective observational study was undert...

    Authors: Richard James Maude, BUM Wahid Ahmed, Abu Hayat Md Waliur Rahman, Ridwanur Rahman, Mohammed Ishaque Majumder, Darryl Braganza Menezes, Abdullah Abu Sayeed, Laura Hughes, Thomas J MacGillivray, Shyamanga Borooah, Baljean Dhillon, Arjen M Dondorp and Mohammad Abul Faiz

    Citation: BMC Infectious Diseases 2014 14:527

    Content type: Research article

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  37. Toxoplasma gondii is an obligate intracellular parasite which can infect almost all mammalian animals, leading to toxoplasmosis. T. gondii rhoptry protein 38 (TgROP38) is an active rhoptry protein kinase which i...

    Authors: Ying Xu, Nian-Zhang Zhang, Qi-Dong Tan, Jia Chen, Jing Lu, Qian-Ming Xu and Xing-Quan Zhu

    Citation: BMC Infectious Diseases 2014 14:525

    Content type: Research article

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  38. Host genotype accounts for a component of the variability in susceptibility to childhood Plasmodium falciparum malaria. However, despite numerous examples of host polymorphisms associated with tolerance or resist...

    Authors: George M Warimwe, Gregory Fegan, Esther W Kiragu, Jennifer N Musyoki, Alexander W Macharia, Kevin Marsh, Thomas N Williams and Peter C Bull

    Citation: BMC Infectious Diseases 2014 14:524

    Content type: Research article

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  39. Trichuriasis is a parasitic disease caused by the human whipworm, Trichuris trichiura. It affects millions worldwide, particularly in the tropics. This nematode parasite burrows into the colonic epithelium result...

    Authors: Rebecca JM Hurst, Thomas Hopwood, Amanda L Gallagher, Frederick A Partridge, Timothy Burgis, David B Sattelle and Kathryn J Else

    Citation: BMC Infectious Diseases 2014 14:520

    Content type: Research article

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  40. Pathological changes due to infection with Schistosoma haematobium include cytokine-mediated urinary tract inflammation. The involved cytokines may be excreted in urine and their presence in urine may therefore r...

    Authors: Kariuki H Njaanake, Paul E Simonsen, Birgitte J Vennervald, Dunstan A Mukoko, Claus M Reimert, Kimani Gachuhi, Walter G Jaoko and Benson B Estambale

    Citation: BMC Infectious Diseases 2014 14:501

    Content type: Research article

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  41. Available treatments for uncomplicated hepatic cystic echinococcosis (CE) include surgery, medical therapy with albendazole (ABZ), percutaneous interventions and the watch-and-wait (WW) approach. Current guide...

    Authors: Francesca Rinaldi, Annalisa De Silvestri, Francesca Tamarozzi, Federico Cattaneo, Raffaella Lissandrin and Enrico Brunetti

    Citation: BMC Infectious Diseases 2014 14:492

    Content type: Research article

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  42. In this paper we study the distribution of leukocyte populations and of cytokine-producing cells in the spleen of a patient with visceral leishmaniasis resistant to clinical treatment. It is the first attempt ...

    Authors: Washington LC dos-Santos, Carla Pagliari, Lina G Santos, Valter A Almeida, Thiago LV e Silva, João de J Coutinho Jr., Tulio Souza, Maria IS Duarte, Luiz AR de Freitas and Carlos HN Costa

    Citation: BMC Infectious Diseases 2014 14:491

    Content type: Case report

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  43. Over 650 million people globally are at risk of schistosomiasis infection, while more than 200 million people are infected of which the higher disease rates occur in children. Eighty three students between 6-2...

    Authors: Nagla Gasmelseed, Nhashal E Karamino, Mohammed O Abdelwahed, Anas O Hamdoun and Ahmed E Elmadani

    Citation: BMC Infectious Diseases 2014 14:469

    Content type: Research article

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  44. In vitro studies show that Leishmania infection decreases the adhesion of inflammatory phagocytes to connective tissue by a mechanism dependent on the modulation of integrin function. However, we know little abo...

    Authors: Micely DR Hermida, Priscila G Doria, Angela MP Taguchi, José O Mengel and Washington LC dos-Santos

    Citation: BMC Infectious Diseases 2014 14:450

    Content type: Research article

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  45. Malaria burden is high in Nigeria, yet information on the major mosquito vectors is lacking especially in the Sudan savannah region of the country. In order to facilitate the design of future insecticide-based...

    Authors: Sulaiman S Ibrahim, Yayo A Manu, Zainab Tukur, Helen Irving and Charles S Wondji

    Citation: BMC Infectious Diseases 2014 14:441

    Content type: Research article

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  46. Vaccines are the most effective agents to control infections. However, recombinant vaccines often do not elicit strong immune responses. Protein antigens combined with proper adjuvants have been widely used to...

    Authors: Xiaojing Sun, Mei Mei, Xu Zhang, Fusong Han, Boyin Jia, Xiaoyan Wei, Zhiguang Chang, Huijun Lu, Jigang Yin, Qijun Chen and Ning Jiang

    Citation: BMC Infectious Diseases 2014 14:429

    Content type: Research article

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  47. Visceral Leishmaniasis is endemic to Brazil, where it is caused by Leishmania infantum (syn. Leishmania chagasi). Following parasite inoculation, individuals may experience asymptomatic infection, raising the pos...

    Authors: Kiyoshi F Fukutani, Virgínia Figueiredo, Fabiana S Celes, Juqueline R Cristal, Aldina Barral, Manoel Barral-Netto and Camila I de Oliveira

    Citation: BMC Infectious Diseases 2014 14:422

    Content type: Research article

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  48. Malaria and helminth infections are thought to negatively affect children’s nutritional status and to impair their physical and cognitive development. Yet, the current evidence-base is weak. The purpose of thi...

    Authors: Eveline Hürlimann, Clarisse A Houngbedji, Prisca B N’Dri, Dominique Bänninger, Jean T Coulibaly, Peiling Yap, Kigbafori D Silué, Eliézer K N’Goran, Giovanna Raso and Jürg Utzinger

    Citation: BMC Infectious Diseases 2014 14:411

    Content type: Research article

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  49. Katayama fever is an acute clinical condition characterised by high fever, dry cough and general malaise occurring during early Schistosoma spp. infection. It is predominantly reported in travellers from non-ende...

    Authors: Heimo Lagler, Cihan Ay, Fredrik Waneck, Rainer Gattringer, Wolfgang Graninger and Michael Ramharter

    Citation: BMC Infectious Diseases 2014 14:357

    Content type: Research article

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.