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BMC Infectious Diseases

HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Content type: Research article

    Dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy.

    Authors: Amedeo F. Capetti, Maria Vittoria Cossu, Giancarlo Orofino, Gaetana Sterrantino, Giovanni Cenderello, Giuseppe V. De Socio, Anna Maria Cattelan, Alessandro Soria, Stefano Rusconi, Niccolò Riccardi, Gian Maria Baldin, Fosca P. Niero, Giorgio Barbarini and Giuliano Rizzardini

    Citation: BMC Infectious Diseases 2017 17:658

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  2. Content type: Research article

    Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed. ART is also included in recent infection test...

    Authors: Helena Huerga, Fisseha Shiferie, Eduard Grebe, Ruggero Giuliani, Jihane Ben Farhat, Gilles Van-Cutsem and Karen Cohen

    Citation: BMC Infectious Diseases 2017 17:653

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  3. Content type: Case report

    Hemophagocytic lymphohistiocytosis (HLH) is an uncommon systemic inflammatory condition that can result from infections, autoimmune diseases and malignancies. It is a rarely reported life threatening complicat...

    Authors: Farheen Manji, Evan Wilson, Etienne Mahe, John Gill and John Conly

    Citation: BMC Infectious Diseases 2017 17:633

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  4. Content type: Research article

    Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28...

    Authors: Hiroki Yagura, Dai Watanabe, Hiroyuki Kushida, Kosuke Tomishima, Hiroaki Togami, Atsushi Hirano, Masaaki Takahashi, Kazuyuki Hirota, Motoko Ikuma, Daisuke Kasai, Yasuharu Nishida, Munehiro Yoshino, Kunio Yamazaki, Tomoko Uehira and Takuma Shirasaka

    Citation: BMC Infectious Diseases 2017 17:622

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  5. Content type: Research article

    The clinical care of people living with HIV changed fundamentally as a result of the development of effective antiretroviral therapy (ART). HIV infection is now a long-term treatable condition. We report a nat...

    Authors: A. Molloy, H. Curtis, F. Burns and A. Freedman

    Citation: BMC Infectious Diseases 2017 17:619

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  6. Content type: Study protocol

    With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the in...

    Authors: Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Guy Baril, Sylvie Trottier, Benoit Trottier, Marianne Harris, Sharon Walmsley, Brian Conway, Alexander Wong, Jean-Pierre Routy, Colin Kovacs, Paul A. MacPherson, Kenneth Marc Monteith, Samer Mansour, George Thanassoulis, Michal Abrahamowicz…

    Citation: BMC Infectious Diseases 2017 17:611

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  7. Content type: Research article

    Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we e...

    Authors: Tatiana Pereira da Silva, Carmem Beatriz Wagner Giacoia-Gripp, Carolina A. Schmaltz, Flavia Marinho Sant’Anna, Maria Helena Saad, Juliana Arruda de Matos, Julio Castro Alves de Lima e Silva, Valeria Cavalcanti Rolla and Mariza Gonçalves Morgado

    Citation: BMC Infectious Diseases 2017 17:606

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  8. Content type: Research article

    We describe the accumulation of HIV-1 drug resistance and its effect on the activity of next-line components in patients with virological failure (HIV-1 RNA >1000 copies/mL) after 1 year (t1) of first-line ant...

    Authors: Andrea De Luca, Zita Jorge Sidumo, Giacomo Zanelli, Noorjehan Abdul Magid, Richard Luhanga, Davide Brambilla, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi, Leonardo Palombi and Susanna Ceffa

    Citation: BMC Infectious Diseases 2017 17:605

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  9. Content type: Review

    Current antiretroviral therapy (ART) used to treat human immunodeficiency virus (HIV) patients is life-long because it only suppresses de novo infections. Recent efforts to eliminate HIV have tested the abilit...

    Authors: Kristian Thorlund, Marc S. Horwitz, Brian T. Fife, Richard Lester and D. William Cameron

    Citation: BMC Infectious Diseases 2017 17:595

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  10. Content type: Research article

    Switch from first to second-line ART is recommended by WHO for patients with virologic failure. Delays in switching may contribute to accumulated drug resistance, advanced immunosuppression, increased morbidit...

    Authors: Victor Ssempijja, Gertrude Nakigozi, Larry Chang, Ron Gray, Maria Wawer, Anthony Ndyanabo, Jingo Kasule, David Serwadda, Barbara Castelnuovo, Anja van’t Hoog and Steven James Reynolds

    Citation: BMC Infectious Diseases 2017 17:582

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  11. Content type: Research article

    Persistent residual viremia (RV) and low grade inflammation and immune activation have been associated with non-AIDS defining events. The impact of persistent RV and HIV-DNA load on immune activation/inflammat...

    Authors: Francesca Falasca, Daniele Di Carlo, Corrado De Vito, Isabella Bon, Gabriella d’Ettorre, Alessandra Fantauzzi, Ivano Mezzaroma, Caterina Fimiani, Maria Carla Re, Vincenzo Vullo, Guido Antonelli and Ombretta Turriziani

    Citation: BMC Infectious Diseases 2017 17:581

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  12. Content type: Review

    Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or...

    Authors: Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D’Abbraccio, Gabriella d’Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo and Nicola Squillace

    Citation: BMC Infectious Diseases 2017 17:551

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  13. Content type: Research article

    UNAIDS calls for fewer than 500,000 new HIV infections/year by 2020, with treatment-as-prevention being a key part of their strategy for achieving the target. A better understanding of the contribution to tran...

    Authors: Nicky McCreesh, Ioannis Andrianakis, Rebecca N. Nsubuga, Mark Strong, Ian Vernon, Trevelyan J. McKinley, Jeremy E. Oakley, Michael Goldstein, Richard Hayes and Richard G. White

    Citation: BMC Infectious Diseases 2017 17:557

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  14. Content type: Research article

    Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.

    Authors: Stefan Schlabe, Martin Vogel, Christoph Boesecke, Carolynne Schwarze-Zander, Jürgen K. Rockstroh, Christian Körner, Klara Brixius and Jan-Christian Wasmuth

    Citation: BMC Infectious Diseases 2017 17:550

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  15. Content type: Research article

    Evaluation of the HIV Testing Week (HTW) 2015 in Amsterdam: the number of (positive) tested persons, characteristics and testing history of the tested population, the differences in attendance per location and...

    Authors: M. Bartelsman, I. K. Joore, J. E. van Bergen, A. A. Hogewoning, F. R. Zuure and M. G. van Veen

    Citation: BMC Infectious Diseases 2017 17:529

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  16. Content type: Research article

    Human Immunodeficiency Virus (HIV), syphilis, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are sexually transmitted infections (STIs) and share modes of transmission. These infections are generally more...

    Authors: Mwumvaneza Mutagoma, Laetitia Nyirazinyoye, Dieudonné Sebuhoro, David J. Riedel and Joseph Ntaganira

    Citation: BMC Infectious Diseases 2017 17:525

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  17. Content type: Research article

    Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential short-term impact of c...

    Authors: Stéphanie Blaizot, Helena Huerga, Benjamin Riche, Tom Ellman, Amir Shroufi, Jean-François Etard and René Ecochard

    Citation: BMC Infectious Diseases 2017 17:522

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  18. Content type: Research article

    The impact of HIV on TB, and the implications for TB control, has been acknowledged as a public health challenge. It is imperative therefore to assess the burden of HIV on TB patients as an indicator for monit...

    Authors: Eric Osei, Joyce Der, Richard Owusu, Philip Kofie and Wisdom Kudzo Axame

    Citation: BMC Infectious Diseases 2017 17:504

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  19. Content type: Study protocol

    Tenofovir disoproxil fumarate (TDF) is key component of pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV, but existing tools to monitor drug adherence are often inaccurate. Detection of...

    Authors: Tim R. Cressey, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Rachel W. Kubiak, Pra-ornsuda Sukrakanchana, Kanchana Than-in-at, Jared Baeten, Wasna Sirirungsi, Ratchada Cressey and Paul K. Drain

    Citation: BMC Infectious Diseases 2017 17:496

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  20. Content type: Research article

    The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely ...

    Authors: Alexandra Hofmann, Andrea Hauser, Ruth Zimmermann, Claudia Santos-Hövener, Jörg Bätzing-Feigenbaum, Stephan Wildner, Claudia Kücherer, Norbert Bannert, Osamah Hamouda, Viviane Bremer and Barbara Bartmeyer

    Citation: BMC Infectious Diseases 2017 17:484

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