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HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Content type: Research article

    Anemia is common among people living with HIV infection and is frequently associated with poor quality of life and poor prognosis. It has been well described in antiretroviral naïve individuals and those on no...

    Authors: McNeil Ngongondo, Nora E. Rosenberg, Christopher C. Stanley, Robertino Lim, Dennis Ongubo, Richard Broadhurst, Colin Speight, Robert Flick, Petros Tembo and Mina C. Hosseinpour

    Citation: BMC Infectious Diseases 2018 18:39

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  2. Content type: Research article

    Combined antiretroviral therapy (cART) in HIV-infected patients has been associated with lipodystrophy, metabolic abnormalities, and an increased risk of cardiovascular disease. Ultrasound measures of carotid ...

    Authors: Maria Teresa Beires, André Silva-Pinto, Ana Cristina Santos, António José Madureira, Jorge Pereira, Davide Carvalho, António Sarmento and Paula Freitas

    Citation: BMC Infectious Diseases 2018 18:32

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  3. Content type: Research article

    A new model of care is required to meet the changing needs of people living with HIV (PLWH), particularly in low and middle-income countries, where prevalence is highest. We evaluated a palliative care interve...

    Authors: Keira Lowther, Richard Harding, Victoria Simms, Aabid Ahmed, Zipporah Ali, Nancy Gikaara, Lorraine Sherr, Hellen Kariuki, Irene J. Higginson and Lucy Ellen Selman

    Citation: BMC Infectious Diseases 2018 18:27

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  4. Content type: Research article

    Metabolic and cardiovascular diseases (CVD) represent a major problem in HIV infection. The aim of this study was to evaluate the relationship of HIV infection and antiretroviral therapy (ART) with circulating...

    Authors: Mario Luca Morieri, Viola Guardigni, Juana Maria Sanz, Edoardo Dalla Nora, Cecilia Soavi, Giovanni Zuliani, Laura Sighinolfi and Angelina Passaro

    Citation: BMC Infectious Diseases 2018 18:10

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  5. Content type: Case report

    Individuals lacking immune recovery during suppressive cART will still represent a clinical issue in the years to come, given the high proportion of HIV-infected subjects introducing therapy late in the course...

    Authors: Camilla Tincati, Esther Merlini, Antonella d’Arminio Monforte and Giulia Marchetti

    Citation: BMC Infectious Diseases 2018 18:8

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  6. Content type: Research article

    Newly diagnosed HIV-positive men who have sex with men (MSM) are an important subgroup in HIV intervention. How newly diagnosed HIV-positive MSM look at HIV/AIDS is consequential and is potentially associated ...

    Authors: Xiaobing Wu, Joseph T. F. Lau, Winnie W. S. Mak, Jing Gu, Phoenix K. H. Mo and Xiaodong Wang

    Citation: BMC Infectious Diseases 2018 18:2

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  7. Content type: Research article

    The HIV-1 DNA reservoir is an important marker that reflects viro-immunological status and can be affected by multiple viral or cellular factors. Determining the potential factors associated with the size of t...

    Authors: Yongsong Yue, Nidan Wang, Yang Han, Ting Zhu, Jing Xie, Zhifeng Qiu, Xiaojing Song, Yanling Li, Jean-Pierre Routy, Jianhua Wang and Taisheng Li

    Citation: BMC Infectious Diseases 2017 17:771

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  8. Content type: Research article

    The outbreak of the Ebola virus disease (EVD) in 2014 led to massive dropouts in HIV care in Guinea. Meanwhile, Médecins Sans Frontières (MSF) was implementing a six-monthly appointment spacing approach adapte...

    Authors: Cavin Epie Bekolo, Abdourahimi Diallo, Mit Philips, Joseph-Desire Yuma, Letizia Di Stefano, Stéphanie Drèze, Jerome Mouton, Youssouf Koita and Ousseni W. Tiomtore

    Citation: BMC Infectious Diseases 2017 17:766

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  9. Content type: Research article

    According to World Health Organization (WHO) guidelines, which have also been adopted by the National AIDS Control Organization (NACO), India, Efavirenz-based Anti-Retroviral Therapy (ART) is better in Human-I...

    Authors: Sanjeev Sinha, Kartik Gupta, Srikanth Tripathy, Sahajal Dhooria, Sanjay Ranjan and R. M. Pandey

    Citation: BMC Infectious Diseases 2017 17:761

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  10. Content type: Research article

    There is today no gold standard method to accurately define the time passed since infection at HIV diagnosis. Infection timing and incidence measurement is however essential to better monitor the dynamics of l...

    Authors: Chris Verhofstede, Katrien Fransen, Annelies Van Den Heuvel, Kristel Van Laethem, Jean Ruelle, Ellen Vancutsem, Karolien Stoffels, Sigi Van den Wijngaert, Marie-Luce Delforge, Dolores Vaira, Laura Hebberecht, Marlies Schauvliege, Virginie Mortier, Kenny Dauwe and Steven Callens

    Citation: BMC Infectious Diseases 2017 17:738

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  11. Content type: Research article

    Before Pre-Exposure Prophylaxis (PrEP) was officially recommended and made available, a few surveys among gay and bisexual men, and persons living with HIV/AIDS (PLWHA), identified an informal use of antiretro...

    Authors: Antonio Palummieri, Gabriella De Carli, Éric Rosenthal, Patrice Cacoub, Cristina Mussini and Vincenzo Puro

    Citation: BMC Infectious Diseases 2017 17:734

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  12. Content type: Research article

    Knowledge of HIV status can be important in reducing the risk of HIV exposure. In a European sample of men-who-have-sex-with-men (MSM), we aimed to identify factors associated with HIV serostatus disclosure to...

    Authors: Ulrich Marcus, Susanne Barbara Schink, Nigel Sherriff, Anna-Marie Jones, Lorenzo Gios, Cinta Folch, Torsten Berglund, Christiana Nöstlinger, Marta Niedźwiedzka-Stadnik, Sonia F. Dias, Ana F. Gama, Emilia Naseva, Ivailo Alexiev, Danica Staneková, Igor Toskin, Daniela Pitigoi…

    Citation: BMC Infectious Diseases 2017 17:730

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  13. Content type: Research article

    Switch strategies based on rilpivirine/tenofovir/emtricitabine or on an integrase inhibitor (InSTI) plus tenofovir/emtricitabine have never been compared in randomized clinical trials. The main aim of the stud...

    Authors: Nicola Gianotti, Andrea Poli, Silvia Nozza, Laura Galli, Nadia Galizzi, Marco Ripa, Marco Merli, Alessia Carbone, Vincenzo Spagnuolo, Adriano Lazzarin and Antonella Castagna

    Citation: BMC Infectious Diseases 2017 17:723

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  14. Content type: Research article

    There is ongoing controversy regarding abacavir use in the treatment of HIV infection and the risk of subsequent development of cardiovascular disease. It is unclear how the risk varies as exposure accumulates.

    Authors: Kunchok Dorjee, Sanjiv M. Baxi, Arthur L. Reingold and Alan Hubbard

    Citation: BMC Infectious Diseases 2017 17:708

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  15. Content type: Research article

    Early HIV diagnosis and initiation onto antiretroviral therapy may prevent ongoing spread of HIV. Risk Tracing Snowball Approach (RTSA) has been shown to be effective in detecting new HIV cases in other settin...

    Authors: Srean Chhim, John Macom, Chettana Pav, Nirada Nim, Phearun Yun, Sopheap Seng, Kolab Chhim, Sovannary Tuot and Siyan Yi

    Citation: BMC Infectious Diseases 2017 17:689

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  16. Content type: Research article

    Enterocytozoon bieneusi has been increasingly reported to infect humans and various mammals. Microsporidia cause diarrhea in HIV-infected patients worldwide. PCR amplification and sequ...

    Authors: Hua Liu, Zhihua Jiang, Zhongying Yuan, Jianhai Yin, Zunfu Wang, Bingxue Yu, Dongsheng Zhou, Yujuan Shen and Jianping Cao

    Citation: BMC Infectious Diseases 2017 17:684

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  17. Content type: Research article

    Despite young people being a key population for HIV prevention, the HIV epidemic amongst young Brazilians is perceived to be growing. We therefore reviewed all published literature on HIV prevalence and risk f...

    Authors: Igor Pedrosa Saffier, Hélia Kawa and Guy Harling

    Citation: BMC Infectious Diseases 2017 17:675

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  18. Content type: Research article

    There is limited information on patterns of treatment change among new initiators of highly active antiretroviral therapy (HAART) in the regions most affected by HIV/AIDS. This makes it difficult to identify t...

    Authors: Daniel N. A. Ankrah, Margaret Lartey, Aukje K. Mantel-Teeuwisse and Hubert G. M. Leufkens

    Citation: BMC Infectious Diseases 2017 17:664

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  19. Content type: Research article

    Dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy.

    Authors: Amedeo F. Capetti, Maria Vittoria Cossu, Giancarlo Orofino, Gaetana Sterrantino, Giovanni Cenderello, Giuseppe V. De Socio, Anna Maria Cattelan, Alessandro Soria, Stefano Rusconi, Niccolò Riccardi, Gian Maria Baldin, Fosca P. Niero, Giorgio Barbarini and Giuliano Rizzardini

    Citation: BMC Infectious Diseases 2017 17:658

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  20. Content type: Research article

    Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed. ART is also included in recent infection test...

    Authors: Helena Huerga, Fisseha Shiferie, Eduard Grebe, Ruggero Giuliani, Jihane Ben Farhat, Gilles Van-Cutsem and Karen Cohen

    Citation: BMC Infectious Diseases 2017 17:653

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  21. Content type: Case report

    Hemophagocytic lymphohistiocytosis (HLH) is an uncommon systemic inflammatory condition that can result from infections, autoimmune diseases and malignancies. It is a rarely reported life threatening complicat...

    Authors: Farheen Manji, Evan Wilson, Etienne Mahe, John Gill and John Conly

    Citation: BMC Infectious Diseases 2017 17:633

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  22. Content type: Research article

    Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28...

    Authors: Hiroki Yagura, Dai Watanabe, Hiroyuki Kushida, Kosuke Tomishima, Hiroaki Togami, Atsushi Hirano, Masaaki Takahashi, Kazuyuki Hirota, Motoko Ikuma, Daisuke Kasai, Yasuharu Nishida, Munehiro Yoshino, Kunio Yamazaki, Tomoko Uehira and Takuma Shirasaka

    Citation: BMC Infectious Diseases 2017 17:622

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  23. Content type: Research article

    The clinical care of people living with HIV changed fundamentally as a result of the development of effective antiretroviral therapy (ART). HIV infection is now a long-term treatable condition. We report a nat...

    Authors: A. Molloy, H. Curtis, F. Burns and A. Freedman

    Citation: BMC Infectious Diseases 2017 17:619

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  24. Content type: Study protocol

    With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the in...

    Authors: Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Guy Baril, Sylvie Trottier, Benoit Trottier, Marianne Harris, Sharon Walmsley, Brian Conway, Alexander Wong, Jean-Pierre Routy, Colin Kovacs, Paul A. MacPherson, Kenneth Marc Monteith, Samer Mansour, George Thanassoulis, Michal Abrahamowicz…

    Citation: BMC Infectious Diseases 2017 17:611

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  25. Content type: Research article

    Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we e...

    Authors: Tatiana Pereira da Silva, Carmem Beatriz Wagner Giacoia-Gripp, Carolina A. Schmaltz, Flavia Marinho Sant’Anna, Maria Helena Saad, Juliana Arruda de Matos, Julio Castro Alves de Lima e Silva, Valeria Cavalcanti Rolla and Mariza Gonçalves Morgado

    Citation: BMC Infectious Diseases 2017 17:606

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  26. Content type: Research article

    We describe the accumulation of HIV-1 drug resistance and its effect on the activity of next-line components in patients with virological failure (HIV-1 RNA >1000 copies/mL) after 1 year (t1) of first-line ant...

    Authors: Andrea De Luca, Zita Jorge Sidumo, Giacomo Zanelli, Noorjehan Abdul Magid, Richard Luhanga, Davide Brambilla, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi, Leonardo Palombi and Susanna Ceffa

    Citation: BMC Infectious Diseases 2017 17:605

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  27. Content type: Review

    Current antiretroviral therapy (ART) used to treat human immunodeficiency virus (HIV) patients is life-long because it only suppresses de novo infections. Recent efforts to eliminate HIV have tested the abilit...

    Authors: Kristian Thorlund, Marc S. Horwitz, Brian T. Fife, Richard Lester and D. William Cameron

    Citation: BMC Infectious Diseases 2017 17:595

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  28. Content type: Research article

    Switch from first to second-line ART is recommended by WHO for patients with virologic failure. Delays in switching may contribute to accumulated drug resistance, advanced immunosuppression, increased morbidit...

    Authors: Victor Ssempijja, Gertrude Nakigozi, Larry Chang, Ron Gray, Maria Wawer, Anthony Ndyanabo, Jingo Kasule, David Serwadda, Barbara Castelnuovo, Anja van’t Hoog and Steven James Reynolds

    Citation: BMC Infectious Diseases 2017 17:582

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  29. Content type: Research article

    Persistent residual viremia (RV) and low grade inflammation and immune activation have been associated with non-AIDS defining events. The impact of persistent RV and HIV-DNA load on immune activation/inflammat...

    Authors: Francesca Falasca, Daniele Di Carlo, Corrado De Vito, Isabella Bon, Gabriella d’Ettorre, Alessandra Fantauzzi, Ivano Mezzaroma, Caterina Fimiani, Maria Carla Re, Vincenzo Vullo, Guido Antonelli and Ombretta Turriziani

    Citation: BMC Infectious Diseases 2017 17:581

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  30. Content type: Review

    Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or...

    Authors: Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D’Abbraccio, Gabriella d’Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo and Nicola Squillace

    Citation: BMC Infectious Diseases 2017 17:551

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  31. Content type: Research article

    UNAIDS calls for fewer than 500,000 new HIV infections/year by 2020, with treatment-as-prevention being a key part of their strategy for achieving the target. A better understanding of the contribution to tran...

    Authors: Nicky McCreesh, Ioannis Andrianakis, Rebecca N. Nsubuga, Mark Strong, Ian Vernon, Trevelyan J. McKinley, Jeremy E. Oakley, Michael Goldstein, Richard Hayes and Richard G. White

    Citation: BMC Infectious Diseases 2017 17:557

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  32. Content type: Research article

    Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.

    Authors: Stefan Schlabe, Martin Vogel, Christoph Boesecke, Carolynne Schwarze-Zander, Jürgen K. Rockstroh, Christian Körner, Klara Brixius and Jan-Christian Wasmuth

    Citation: BMC Infectious Diseases 2017 17:550

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  33. Content type: Research article

    Evaluation of the HIV Testing Week (HTW) 2015 in Amsterdam: the number of (positive) tested persons, characteristics and testing history of the tested population, the differences in attendance per location and...

    Authors: M. Bartelsman, I. K. Joore, J. E. van Bergen, A. A. Hogewoning, F. R. Zuure and M. G. van Veen

    Citation: BMC Infectious Diseases 2017 17:529

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  34. Content type: Research article

    Human Immunodeficiency Virus (HIV), syphilis, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are sexually transmitted infections (STIs) and share modes of transmission. These infections are generally more...

    Authors: Mwumvaneza Mutagoma, Laetitia Nyirazinyoye, Dieudonné Sebuhoro, David J. Riedel and Joseph Ntaganira

    Citation: BMC Infectious Diseases 2017 17:525

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  35. Content type: Research article

    Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential short-term impact of c...

    Authors: Stéphanie Blaizot, Helena Huerga, Benjamin Riche, Tom Ellman, Amir Shroufi, Jean-François Etard and René Ecochard

    Citation: BMC Infectious Diseases 2017 17:522

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  36. Content type: Research article

    The impact of HIV on TB, and the implications for TB control, has been acknowledged as a public health challenge. It is imperative therefore to assess the burden of HIV on TB patients as an indicator for monit...

    Authors: Eric Osei, Joyce Der, Richard Owusu, Philip Kofie and Wisdom Kudzo Axame

    Citation: BMC Infectious Diseases 2017 17:504

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  37. Content type: Study protocol

    Tenofovir disoproxil fumarate (TDF) is key component of pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV, but existing tools to monitor drug adherence are often inaccurate. Detection of...

    Authors: Tim R. Cressey, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Rachel W. Kubiak, Pra-ornsuda Sukrakanchana, Kanchana Than-in-at, Jared Baeten, Wasna Sirirungsi, Ratchada Cressey and Paul K. Drain

    Citation: BMC Infectious Diseases 2017 17:496

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  38. Content type: Research article

    Observed adverse effects of antiretroviral therapy (ART) on the lipid profile could be of significance in pregnancy. This systematic review aims to summarize studies that investigated the association between H...

    Authors: Marissa J. Harmsen, Joyce L. Browne, Francois Venter, Kerstin Klipstein-Grobusch and Marcus J. Rijken

    Citation: BMC Infectious Diseases 2017 17:489

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  39. Content type: Research article

    The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely ...

    Authors: Alexandra Hofmann, Andrea Hauser, Ruth Zimmermann, Claudia Santos-Hövener, Jörg Bätzing-Feigenbaum, Stephan Wildner, Claudia Kücherer, Norbert Bannert, Osamah Hamouda, Viviane Bremer and Barbara Bartmeyer

    Citation: BMC Infectious Diseases 2017 17:484

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  40. Content type: Research article

    Rilpivirine is safe and effective in HIV-naïve patients with low baseline HIV-RNA or in switch strategy. It offers the advantages of few drug-drug interactions and a favourable toxicity profile. We aimed to de...

    Authors: Delphine Sculier, Angèle Gayet-Ageron, Manuel Battegay, Matthias Cavassini, Jan Fehr, Cedric Hirzel, Patrick Schmid, Enos Bernasconi and Alexandra Calmy

    Citation: BMC Infectious Diseases 2017 17:476

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  41. Content type: Research article

    In 2014, there were 170,000 new HIV-infected children globally. The rate of HIV transmission from mother to child in Ethiopia was 18%. Though there are a number of HIV-related studies conducted in Ethiopia, th...

    Authors: Nurilign Abebe Moges, Getachew Mullu Kassa and Dube Jara Boneya

    Citation: BMC Infectious Diseases 2017 17:475

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  42. Content type: Research article

    In Brazil, due to the rapid increase in programmes for the prevention of mother-to-child transmission (PMTCT), routine programme data are widely available. The objective of this study was to assess the utility...

    Authors: Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso and Adele Schwartz Benzaken

    Citation: BMC Infectious Diseases 2017 17:469

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  43. Content type: Research article

    In West Africa where HIV-1 and HIV-2 co-circulate, the co-infection with hepatitis B virus (HBV) and hepatitis Delta virus (HDV) is not well described. This study aimed at estimating the prevalence of HBV and ...

    Authors: Patrick A. Coffie, Boris K. Tchounga, Guillaume Bado, Mathieu Kabran, Daouda K. Minta, Gilles Wandeler, Geoffrey S. Gottlieb, François Dabis, Serge P. Eholie and Didier K. Ekouevi

    Citation: BMC Infectious Diseases 2017 17:466

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  44. Content type: Research article

    Malawi’s national antiretroviral therapy program provides atazanavir/ritonavir–based second line regimens which cause concentration-dependent rise in indirect bilirubin. We sought to determine if elevated bili...

    Authors: Dennis Miyoge Ongubo, Robertino Lim, Hannock Tweya, Christopher Chikhosi Stanley, Petros Tembo, Richard Broadhurst, Salem Gugsa, McNeil Ngongondo, Colin Speight, Tom Heller, Sam Phiri and Mina C. Hosseinipour

    Citation: BMC Infectious Diseases 2017 17:461

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  45. Content type: Study protocol

    Though home-based human immunodeficiency virus (HIV) counseling and testing (HBHCT) is implemented in many sub-Saharan African countries as part of their HIV programs, linkage to HIV care remains a challenge. ...

    Authors: Susan M. Kiene, Seth C. Kalichman, Katelyn M. Sileo, Nicolas A. Menzies, Rose Naigino, Chii-Dean Lin, Moses H. Bateganya, Haruna Lule and Rhoda K. Wanyenze

    Citation: BMC Infectious Diseases 2017 17:460

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  46. Content type: Research article

    HIV infection is associated with increased risk of cardiovascular disease beyond that explained by traditional risk factors. Altered gut microbiota, microbial translocation, and immune activation have been pro...

    Authors: Judith M. Haissman, Anna K. Haugaard, Sisse R. Ostrowski, Rolf K. Berge, Johannes R. Hov, Marius Trøseid and Susanne D. Nielsen

    Citation: BMC Infectious Diseases 2017 17:445

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  47. Content type: Research article

    Viral suppression is a critical indicator of HIV treatment success. In the era of test-and-start, little is known about treatment outcomes and time to undetectable viral loads. This study compares treatment ou...

    Authors: Rogers Ssebunya, Rhoda K. Wanyenze, Heather Lukolyo, Milton Mutto, Grace Kisitu, Pauline Amuge, Albert Maganda and Adeodata Kekitiinwa

    Citation: BMC Infectious Diseases 2017 17:439

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  48. Content type: Research article

    Scaling up HIV testing is the first step in the HIV treatment continuum which is important for controlling the HIV epidemic among men who have sex with men (MSM). Following an online HIV testing intervention a...

    Authors: Ngai Sze Wong, Weiming Tang, Larry Han, John Best, Ye Zhang, Shujie Huang, Heping Zheng, Bin Yang, Chongyi Wei, Stephen W. Pan and Joseph D. Tucker

    Citation: BMC Infectious Diseases 2017 17:437

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  49. Content type: Research article

    The Xpert® MTB/RIF (XP) has a higher sensitivity than sputum smear microscopy (70% versus 35%) for TB diagnosis and has been endorsed by the WHO for TB high burden countries to increase case finding among HIV ...

    Authors: Sabine M. Hermans, Juliet A. Babirye, Olive Mbabazi, Francis Kakooza, Robert Colebunders, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, Rosalind Parkes-Ratanshi and Yukari C. Manabe

    Citation: BMC Infectious Diseases 2017 17:433

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