HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Research article

    Syphilis and HIV prevalence and associated factors to their co-infection, hepatitis B and hepatitis C viruses prevalence among female sex workers in Rwanda

    Human Immunodeficiency Virus (HIV), syphilis, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are sexually transmitted infections (STIs) and share modes of transmission. These infections are generally more...

    Mwumvaneza Mutagoma, Laetitia Nyirazinyoye, Dieudonné Sebuhoro, David J. Riedel and Joseph Ntaganira

    BMC Infectious Diseases 2017 17:525

    Published on: 28 July 2017

  2. Research article

    Combined interventions to reduce HIV incidence in KwaZulu-Natal: a modelling study

    Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential short-term impact of c...

    Stéphanie Blaizot, Helena Huerga, Benjamin Riche, Tom Ellman, Amir Shroufi, Jean-François Etard and René Ecochard

    BMC Infectious Diseases 2017 17:522

    Published on: 26 July 2017

  3. Research article

    The burden of HIV on Tuberculosis patients in the Volta region of Ghana from 2012 to 2015: implication for Tuberculosis control

    The impact of HIV on TB, and the implications for TB control, has been acknowledged as a public health challenge. It is imperative therefore to assess the burden of HIV on TB patients as an indicator for monit...

    Eric Osei, Joyce Der, Richard Owusu, Philip Kofie and Wisdom Kudzo Axame

    BMC Infectious Diseases 2017 17:504

    Published on: 19 July 2017

  4. Study protocol

    A randomized clinical pharmacokinetic trial of Tenofovir in blood, plasma and urine in adults with perfect, moderate and low PrEP adherence: the TARGET study

    Tenofovir disoproxil fumarate (TDF) is key component of pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV, but existing tools to monitor drug adherence are often inaccurate. Detection of...

    Tim R. Cressey, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Rachel W. Kubiak, Pra-ornsuda Sukrakanchana, Kanchana Than-in-at, Jared Baeten, Wasna Sirirungsi, Ratchada Cressey and Paul K. Drain

    BMC Infectious Diseases 2017 17:496

    Published on: 14 July 2017

  5. Research article

    Surveillance of recent HIV infections among newly diagnosed HIV cases in Germany between 2008 and 2014

    The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely ...

    Alexandra Hofmann, Andrea Hauser, Ruth Zimmermann, Claudia Santos-Hövener, Jörg Bätzing-Feigenbaum, Stephan Wildner, Claudia Kücherer, Norbert Bannert, Osamah Hamouda, Viviane Bremer and Barbara Bartmeyer

    BMC Infectious Diseases 2017 17:484

    Published on: 11 July 2017

  6. Research article

    The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

    Observed adverse effects of antiretroviral therapy (ART) on the lipid profile could be of significance in pregnancy. This systematic review aims to summarize studies that investigated the association between H...

    Marissa J. Harmsen, Joyce L. Browne, Francois Venter, Kerstin Klipstein-Grobusch and Marcus J. Rijken

    BMC Infectious Diseases 2017 17:489

    Published on: 11 July 2017

  7. Research article

    Rate of HIV transmission and associated factors among HIV-exposed infants in selected health facilities of East and West Gojjam Zones, Northwest Ethiopia; retrospective cohort study

    In 2014, there were 170,000 new HIV-infected children globally. The rate of HIV transmission from mother to child in Ethiopia was 18%. Though there are a number of HIV-related studies conducted in Ethiopia, th...

    Nurilign Abebe Moges, Getachew Mullu Kassa and Dube Jara Boneya

    BMC Infectious Diseases 2017 17:475

    Published on: 6 July 2017

  8. Research article

    Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study

    Rilpivirine is safe and effective in HIV-naïve patients with low baseline HIV-RNA or in switch strategy. It offers the advantages of few drug-drug interactions and a favourable toxicity profile. We aimed to de...

    Delphine Sculier, Angèle Gayet-Ageron, Manuel Battegay, Matthias Cavassini, Jan Fehr, Cedric Hirzel, Patrick Schmid, Enos Bernasconi and Alexandra Calmy

    BMC Infectious Diseases 2017 17:476

    Published on: 6 July 2017

  9. Research article

    Transitioning from antenatal surveillance surveys to routine HIV testing: a turning point in the mother-to-child transmission prevention programme for HIV surveillance in Brazil

    In Brazil, due to the rapid increase in programmes for the prevention of mother-to-child transmission (PMTCT), routine programme data are widely available. The objective of this study was to assess the utility...

    Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso and Adele Schwartz Benzaken

    BMC Infectious Diseases 2017 17:469

    Published on: 5 July 2017

  10. Research article

    Prevalence of hepatitis B and delta according to HIV-type: a multi-country cross-sectional survey in West Africa

    In West Africa where HIV-1 and HIV-2 co-circulate, the co-infection with hepatitis B virus (HBV) and hepatitis Delta virus (HDV) is not well described. This study aimed at estimating the prevalence of HBV and ...

    Patrick A. Coffie, Boris K. Tchounga, Guillaume Bado, Mathieu Kabran, Daouda K. Minta, Gilles Wandeler, Geoffrey S. Gottlieb, François Dabis, Serge P. Eholie and Didier K. Ekouevi

    BMC Infectious Diseases 2017 17:466

    Published on: 4 July 2017

  11. Study protocol

    Efficacy of an enhanced linkage to HIV care intervention at improving linkage to HIV care and achieving viral suppression following home-based HIV testing in rural Uganda: study protocol for the Ekkubo/PATH cluster randomized controlled trial

    Though home-based human immunodeficiency virus (HIV) counseling and testing (HBHCT) is implemented in many sub-Saharan African countries as part of their HIV programs, linkage to HIV care remains a challenge. ...

    Susan M. Kiene, Seth C. Kalichman, Katelyn M. Sileo, Nicolas A. Menzies, Rose Naigino, Chii-Dean Lin, Moses H. Bateganya, Haruna Lule and Rhoda K. Wanyenze

    BMC Infectious Diseases 2017 17:460

    Published on: 3 July 2017

  12. Research article

    A cross-sectional study to evaluate second line virological failure and elevated bilirubin as a surrogate for adherence to atazanavir/ritonavir in two urban HIV clinics in Lilongwe, Malawi

    Malawi’s national antiretroviral therapy program provides atazanavir/ritonavir–based second line regimens which cause concentration-dependent rise in indirect bilirubin. We sought to determine if elevated bili...

    Dennis Miyoge Ongubo, Robertino Lim, Hannock Tweya, Christopher Chikhosi Stanley, Petros Tembo, Richard Broadhurst, Salem Gugsa, McNeil Ngongondo, Colin Speight, Tom Heller, Sam Phiri and Mina C. Hosseinipour

    BMC Infectious Diseases 2017 17:461

    Published on: 3 July 2017

  13. Research article

    Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection

    HIV infection is associated with increased risk of cardiovascular disease beyond that explained by traditional risk factors. Altered gut microbiota, microbial translocation, and immune activation have been pro...

    Judith M. Haissman, Anna K. Haugaard, Sisse R. Ostrowski, Rolf K. Berge, Johannes R. Hov, Marius Trøseid and Susanne D. Nielsen

    BMC Infectious Diseases 2017 17:445

    Published on: 23 June 2017

  14. Research article

    MSM HIV testing following an online testing intervention in China

    Scaling up HIV testing is the first step in the HIV treatment continuum which is important for controlling the HIV epidemic among men who have sex with men (MSM). Following an online HIV testing intervention a...

    Ngai Sze Wong, Weiming Tang, Larry Han, John Best, Ye Zhang, Shujie Huang, Heping Zheng, Bin Yang, Chongyi Wei, Stephen W. Pan and Joseph D. Tucker

    BMC Infectious Diseases 2017 17:437

    Published on: 19 June 2017

  15. Research article

    Antiretroviral therapy initiation within seven days of enrolment: outcomes and time to undetectable viral load among children at an urban HIV clinic in Uganda

    Viral suppression is a critical indicator of HIV treatment success. In the era of test-and-start, little is known about treatment outcomes and time to undetectable viral loads. This study compares treatment ou...

    Rogers Ssebunya, Rhoda K. Wanyenze, Heather Lukolyo, Milton Mutto, Grace Kisitu, Pauline Amuge, Albert Maganda and Adeodata Kekitiinwa

    BMC Infectious Diseases 2017 17:439

    Published on: 19 June 2017

  16. Research article

    Treatment decisions and mortality in HIV-positive presumptive smear-negative TB in the Xpert® MTB/RIF era: a cohort study

    The Xpert® MTB/RIF (XP) has a higher sensitivity than sputum smear microscopy (70% versus 35%) for TB diagnosis and has been endorsed by the WHO for TB high burden countries to increase case finding among HIV ...

    Sabine M. Hermans, Juliet A. Babirye, Olive Mbabazi, Francis Kakooza, Robert Colebunders, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, Rosalind Parkes-Ratanshi and Yukari C. Manabe

    BMC Infectious Diseases 2017 17:433

    Published on: 16 June 2017

  17. Research article

    Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men

    Early treatment of acute HIV-1 infection (AHI) is beneficial for patients and could reduce onward transmission. However, guidelines on whom to test for AHI with HIV-1 RNA testing are lacking.

    Maartje Dijkstra, Godelieve J. de Bree, Ineke G. Stolte, Udi Davidovich, Eduard J. Sanders, Maria Prins and Maarten F. Schim van der Loeff

    BMC Infectious Diseases 2017 17:425

    Published on: 14 June 2017

  18. Research article

    Observed versus predicted cardiovascular events and all-cause death in HIV infection: a longitudinal cohort study

    The aim of the study was to assess the applicability of an algorithm predicting 10-year cardiovascular disease (CVD) generated in the setting of the Framingham Heart Study to a real-life, contemporary Italian ...

    Giuseppe Vittorio De Socio, Giacomo Pucci, Franco Baldelli and Giuseppe Schillaci

    BMC Infectious Diseases 2017 17:414

    Published on: 12 June 2017

  19. Research article

    Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients

    Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use. Intracellul...

    S. E. Salvaggio, A. Giacomelli, F. S. Falvella, M. L. Oreni, P. Meraviglia, C. Atzori, E. G. I. Clementi, M. Galli and S. Rusconi

    BMC Infectious Diseases 2017 17:396

    Published on: 5 June 2017

  20. Case report

    Inguinal and anorectal Lymphogranuloma Venereum: a case series from a sexually transmitted disease center in Rome, Italy

    Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Aim of this report is to describe the...

    Alessandra Latini, Mauro Zaccarelli, Maria Grazia Paglia, Maria Gabriella Donà, Amalia Giglio, Domenico Moretto, Antonella Vulcano, Massimo Giuliani, Manuela Colafigli, Marina Ambrifi, Fulvia Pimpinelli and Antonio Cristaudo

    BMC Infectious Diseases 2017 17:386

    Published on: 2 June 2017

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