HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Research article

    Using risk-tracing snowball approach to increase HIV case detection among high-risk populations in Cambodia: an intervention study

    Early HIV diagnosis and initiation onto antiretroviral therapy may prevent ongoing spread of HIV. Risk Tracing Snowball Approach (RTSA) has been shown to be effective in detecting new HIV cases in other settin...

    Srean Chhim, John Macom, Chettana Pav, Nirada Nim, Phearun Yun, Sopheap Seng, Kolab Chhim, Sovannary Tuot and Siyan Yi

    BMC Infectious Diseases 2017 17:689

    Published on: 18 October 2017

  2. Research article

    Infection by and genotype characteristics of Enterocytozoon bieneusi in HIV/AIDS patients from Guangxi Zhuang autonomous region, China

    Enterocytozoon bieneusi has been increasingly reported to infect humans and various mammals. Microsporidia cause diarrhea in HIV-infected patients worldwide. PCR amplification and sequ...

    Hua Liu, Zhihua Jiang, Zhongying Yuan, Jianhai Yin, Zunfu Wang, Bingxue Yu, Dongsheng Zhou, Yujuan Shen and Jianping Cao

    BMC Infectious Diseases 2017 17:684

    Published on: 13 October 2017

  3. Research article

    Five-year trends in treatment changes in an adult cohort of HIV/AIDS patients in Ghana: a retrospective cohort study

    There is limited information on patterns of treatment change among new initiators of highly active antiretroviral therapy (HAART) in the regions most affected by HIV/AIDS. This makes it difficult to identify t...

    Daniel N. A. Ankrah, Margaret Lartey, Aukje K. Mantel-Teeuwisse and Hubert G. M. Leufkens

    BMC Infectious Diseases 2017 17:664

    Published on: 2 October 2017

  4. Research article

    A dual regimen of ritonavir/darunavir plus dolutegravir for rescue or simplification of rescue therapy: 48 weeks’ observational data

    Dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy.

    Amedeo F. Capetti, Maria Vittoria Cossu, Giancarlo Orofino, Gaetana Sterrantino, Giovanni Cenderello, Giuseppe V. De Socio, Anna Maria Cattelan, Alessandro Soria, Stefano Rusconi, Niccolò Riccardi, Gian Maria Baldin, Fosca P. Niero, Giorgio Barbarini and Giuliano Rizzardini

    BMC Infectious Diseases 2017 17:658

    Published on: 30 September 2017

  5. Research article

    A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa

    Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed. ART is also included in recent infection test...

    Helena Huerga, Fisseha Shiferie, Eduard Grebe, Ruggero Giuliani, Jihane Ben Farhat, Gilles Van-Cutsem and Karen Cohen

    BMC Infectious Diseases 2017 17:653

    Published on: 29 September 2017

  6. Research article

    Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1

    Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28...

    Hiroki Yagura, Dai Watanabe, Hiroyuki Kushida, Kosuke Tomishima, Hiroaki Togami, Atsushi Hirano, Masaaki Takahashi, Kazuyuki Hirota, Motoko Ikuma, Daisuke Kasai, Yasuharu Nishida, Munehiro Yoshino, Kunio Yamazaki, Tomoko Uehira and Takuma Shirasaka

    BMC Infectious Diseases 2017 17:622

    Published on: 16 September 2017

  7. Study protocol

    The Canadian HIV and aging cohort study - determinants of increased risk of cardio-vascular diseases in HIV-infected individuals: rationale and study protocol

    With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the in...

    Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Guy Baril, Sylvie Trottier, Benoit Trottier, Marianne Harris, Sharon Walmsley, Brian Conway, Alexander Wong, Jean-Pierre Routy, Colin Kovacs, Paul A. MacPherson, Kenneth Marc Monteith, Samer Mansour, George Thanassoulis, Michal Abrahamowicz…

    BMC Infectious Diseases 2017 17:611

    Published on: 11 September 2017

  8. Research article

    Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients

    Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we e...

    Tatiana Pereira da Silva, Carmem Beatriz Wagner Giacoia-Gripp, Carolina A. Schmaltz, Flavia Marinho Sant’Anna, Maria Helena Saad, Juliana Arruda de Matos, Julio Castro Alves de Lima e Silva, Valeria Cavalcanti Rolla and Mariza Gonçalves Morgado

    BMC Infectious Diseases 2017 17:606

    Published on: 6 September 2017

  9. Research article

    Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique

    We describe the accumulation of HIV-1 drug resistance and its effect on the activity of next-line components in patients with virological failure (HIV-1 RNA >1000 copies/mL) after 1 year (t1) of first-line ant...

    Andrea De Luca, Zita Jorge Sidumo, Giacomo Zanelli, Noorjehan Abdul Magid, Richard Luhanga, Davide Brambilla, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi, Leonardo Palombi and Susanna Ceffa

    BMC Infectious Diseases 2017 17:605

    Published on: 5 September 2017

  10. Research article

    Rates of switching to second-line antiretroviral therapy and impact of delayed switching on immunologic, virologic, and mortality outcomes among HIV-infected adults with virologic failure in Rakai, Uganda

    Switch from first to second-line ART is recommended by WHO for patients with virologic failure. Delays in switching may contribute to accumulated drug resistance, advanced immunosuppression, increased morbidit...

    Victor Ssempijja, Gertrude Nakigozi, Larry Chang, Ron Gray, Maria Wawer, Anthony Ndyanabo, Jingo Kasule, David Serwadda, Barbara Castelnuovo, Anja van’t Hoog and Steven James Reynolds

    BMC Infectious Diseases 2017 17:582

    Published on: 22 August 2017

  11. Research article

    Evaluation of HIV-DNA and inflammatory markers in HIV-infected individuals with different viral load patterns

    Persistent residual viremia (RV) and low grade inflammation and immune activation have been associated with non-AIDS defining events. The impact of persistent RV and HIV-DNA load on immune activation/inflammat...

    Francesca Falasca, Daniele Di Carlo, Corrado De Vito, Isabella Bon, Gabriella d’Ettorre, Alessandra Fantauzzi, Ivano Mezzaroma, Caterina Fimiani, Maria Carla Re, Vincenzo Vullo, Guido Antonelli and Ombretta Turriziani

    BMC Infectious Diseases 2017 17:581

    Published on: 22 August 2017

  12. Review

    Cardiovascular risk and dyslipidemia among persons living with HIV: a review

    Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or...

    Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D’Abbraccio, Gabriella d’Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo and Nicola Squillace

    BMC Infectious Diseases 2017 17:551

    Published on: 9 August 2017

  13. Research article

    Improving ART programme retention and viral suppression are key to maximising impact of treatment as prevention – a modelling study

    UNAIDS calls for fewer than 500,000 new HIV infections/year by 2020, with treatment-as-prevention being a key part of their strategy for achieving the target. A better understanding of the contribution to tran...

    Nicky McCreesh, Ioannis Andrianakis, Rebecca N. Nsubuga, Mark Strong, Ian Vernon, Trevelyan J. McKinley, Jeremy E. Oakley, Michael Goldstein, Richard Hayes and Richard G. White

    BMC Infectious Diseases 2017 17:557

    Published on: 9 August 2017

  14. Research article

    Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project

    Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.

    Stefan Schlabe, Martin Vogel, Christoph Boesecke, Carolynne Schwarze-Zander, Jürgen K. Rockstroh, Christian Körner, Klara Brixius and Jan-Christian Wasmuth

    BMC Infectious Diseases 2017 17:550

    Published on: 8 August 2017

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