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Hepatitis and co-infections

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Liver-related mortality has been increasing worldwide. We aimed to estimate the age-standardized mortality rates from viral hepatitis in Brazil.

    Authors: Hugo Perazzo, Antonio G Pacheco, Paula M Luz, Rodolfo Castro, Chris Hyde, Juliana Fittipaldi, Caroline Rigolon, Sandra W Cardoso, Beatriz Grinsztejn and Valdiléa G Veloso

    Citation: BMC Infectious Diseases 2017 17:527

    Content type: Research article

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  2. Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe. Nevertheless, HAV genotypes and stra...

    Authors: Roberto Bruni, Stefania Taffon, Michele Equestre, Eleonora Cella, Alessandra Lo Presti, Angela Costantino, Paola Chionne, Elisabetta Madonna, Elitsa Golkocheva-Markova, Diljana Bankova, Massimo Ciccozzi, Pavel Teoharov and Anna Rita Ciccaglione

    Citation: BMC Infectious Diseases 2017 17:497

    Content type: Research article

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  3. Hepatitis E is self-limiting, but can cause death in most at risk groups like pregnant women and those with preexisting acute liver disease. In developing countries it presents as epidemic, in 2014 Hepatitis E...

    Authors: Geofrey Amanya, Samuel Kizito, Immaculate Nabukenya, Joan Kalyango, Collins Atuheire, Hellen Nansumba, Stephen Akena Abwoye, Denis Nixon Opio, Edrisa Kibuuka and Charles Karamagi

    Citation: BMC Infectious Diseases 2017 17:451

    Content type: Research article

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  4. Treatment for chronic hepatitis B (CHB) is virtually absent in sub-Saharan Africa. Here we present early experiences from a pilot program for treatment of CHB in Ethiopia.

    Authors: Hanna Aberra, Hailemichael Desalegn, Nega Berhe, Girmay Medhin, Kathrine Stene-Johansen, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Infectious Diseases 2017 17:438

    Content type: Research article

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  5. The aims of this analysis were to investigate treatment completion and adherence among people with ongoing injecting drug use or receiving opioid substitution therapy (OST) in a study of response-guided therap...

    Authors: Evan B. Cunningham, Behzad Hajarizadeh, Olav Dalgard, Janaki Amin, Margaret Hellard, Graham R Foster, Philip Bruggmann, Brian Conway, Markus Backmund, Geert Robaeys, Tracy Swan, Philippa S. Marks, Sophie Quiene, Tanya L Applegate, Martin Weltman, David Shaw…

    Citation: BMC Infectious Diseases 2017 17:420

    Content type: Research article

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  6. Viral Hepatitis B is of a major public health concern globally, especially in developing countries. Expectant mothers’ knowledge of Mother-To-Child Transmission (MTCT) of the disease is significant in preventi...

    Authors: Frederick Dun-Dery, Martin Nyaaba Adokiya, Williams Walana, Ernestina Yirkyio and Juventus B. Ziem

    Citation: BMC Infectious Diseases 2017 17:416

    Content type: Research article

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  7. This Phase 3, open-label, rollover study (NCT01323244) investigated the efficacy and safety of simeprevir plus peginterferon α-2a (PegIFNα-2a) and ribavirin (RBV) in a well-characterized population of HCV geno...

    Authors: Edward J. Gane, Edwin DeJesus, Ewa Janczewska, Jacob George, Moises Diago, Mariliza Hendrique Da Silva, Henk Reesink, Igor Nikitin, Holger Hinrichsen, Stefan Bourgeois, Peter Ferenci, Umesh Shukla, Ronald Kalmeijer, Oliver Lenz, Bart Fevery, Chris Corbett…

    Citation: BMC Infectious Diseases 2017 17:389

    Content type: Research article

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  8. There is a need for validation of noninvasive alternatives to liver biopsy for the evaluation of fibrosis in children with chronic hepatitis C (CHC). The aim of this study was to evaluate the diagnostic perfor...

    Authors: Maria Pokorska-Śpiewak, Barbara Kowalik-Mikołajewska, Małgorzata Aniszewska, Magdalena Pluta and Magdalena Marczyńska

    Citation: BMC Infectious Diseases 2017 17:361

    Content type: Research article

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  9. In Japan, approximately 0.9% and 1% of the whole population are infected with HBV and HCV, respectively. Doctors from departments other than gastroenterology often order viral hepatitis tests before an invasiv...

    Authors: Naoki Yoshioka, Akihiko Okumura, Yukie Yamamoto, Katsura Yamaguchi, Atsuro Kaga, Kentaro Yamada, Takuya Hirosaki, Daisuke Ishikawa, Shin Kunii, Kazumasa Watanabe, Setsuo Utsunomiya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto and Yoshiki Hirooka

    Citation: BMC Infectious Diseases 2017 17:330

    Content type: Research article

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  10. Hepatitis C virus (HCV) infections have increased during the past decade but little is known about geographic clustering patterns.

    Authors: Thomas J. Stopka, Michael A. Goulart, David J. Meyers, Marga Hutcheson, Kerri Barton, Shauna Onofrey, Daniel Church, Ashley Donahue and Kenneth K. H. Chui

    Citation: BMC Infectious Diseases 2017 17:294

    Content type: Research article

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  11. Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...

    Authors: Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E. Thwaites, Ngoc Nghiem My, Stephen Baker and Thomas C. Darton

    Citation: BMC Infectious Diseases 2017 17:260

    Content type: Research article

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  12. In chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic s...

    Authors: Mariana Cavalheiro Magri, Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Celso Carmo Mazza and Fátima Mitiko Tengan

    Citation: BMC Infectious Diseases 2017 17:235

    Content type: Research article

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  13. Hepatitis C virus (HCV) infection is a pandemic causing disease; more than 185 million people are infected worldwide. An HCV antibody (Ab) prevalence of 6.0% was estimated in Central African countries. The stu...

    Authors: Mwumvaneza Mutagoma, Helene Balisanga, Dieudonné Sebuhoro, Aimable Mbituyumuremyi, Eric Remera, Samuel S. Malamba, David J. Riedel and Sabin Nsanzimana

    Citation: BMC Infectious Diseases 2017 17:167

    Content type: Research article

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  14. HCV transmission remains high in people who inject drugs (PWID) in Montréal. New direct-acting antivirals (DAAs), highly effective and more tolerable than previous regimens, make a “Treatment as Prevention” (T...

    Authors: Anthony Cousien, Pascale Leclerc, Carole Morissette, Julie Bruneau, Élise Roy, Viet Chi Tran, Yazdan Yazdanpanah and Joseph Cox

    Citation: BMC Infectious Diseases 2017 17:162

    Content type: Research article

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  15. The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an associ...

    Authors: Sayeh Ezzikouri, Hajar Chihab, Abdellah Elhabazi, Lahcen Wakrim and Soumaya Benjelloun

    Citation: BMC Infectious Diseases 2017 17:99

    Content type: Research article

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  16. Cocaine and crack use has been associated with HIV and HCV infections, but its consequences on HCV progression have not been well established. We analyzed the impact of cocaine/crack use on liver fibrosis prog...

    Authors: Valérie Martel-Laferrière, Roy Nitulescu, Joseph Cox, Curtis Cooper, Mark Tyndall, Danielle Rouleau, Sharon Walmsley, Leo Wong and Marina B. Klein

    Citation: BMC Infectious Diseases 2017 17:80

    Content type: Research article

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  17. Toll like receptors (TLRs) play an important role in innate immunity and various studies suggest that TLRs play a crucial role in pathogenesis of hepatitis B virus (HBV) infection. The present study aims in lo...

    Authors: Dipanwita Das, Isha Sengupta, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivaram Prasad Singh, Sekhar Chakrabarti and Runu Chakravarty

    Citation: BMC Infectious Diseases 2017 17:76

    Content type: Research article

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  18. There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatit...

    Authors: Jim Young, Nina Weis, Harald Hofer, William Irving, Ola Weiland, Emiliano Giostra, Juan Manuel Pascasio, Lluis Castells, Martin Prieto, Roelien Postema, Cinira Lefevre, David Evans, Heiner C. Bucher and Jose Luis Calleja

    Citation: BMC Infectious Diseases 2017 17:45

    Content type: Research article

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  19. Rwanda is a central African country with about 12 million inhabitants. The 1994 genocide against the Tutsi destroyed much of the infrastructure, including the health system. Although this has improved signific...

    Authors: Theogene Twagirumugabe, Gatare Swaibu, Timothy David Walker, Magnus Lindh, Jean Bosco Gahutu, Tomas Bergström and Heléne Norder

    Citation: BMC Infectious Diseases 2017 17:32

    Content type: Research article

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  20. The concentrations of hepatitis B virus (HBV) DNA and surface antigen (HBsAg) are two critical virological variables to be monitored in chronic hepatitis B. HBsAg is derived from the HBV genome. Thus, higher H...

    Authors: Chao-Wei Hsu, Kung-Hao Liang, Chih-Lang Lin, Tong-Hong Wang and Chau-Ting Yeh

    Citation: BMC Infectious Diseases 2017 17:9

    Content type: Research article

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  21. The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic...

    Authors: Yeshambel Belyhun, Melanie Maier, Andargachew Mulu, Ermias Diro and Uwe Gerd Liebert

    Citation: BMC Infectious Diseases 2016 16:761

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:114

  22. As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of wate...

    Authors: Ashish C. Shrestha, Robert L. P. Flower, Clive R. Seed, Manita Rajkarnikar, Shrawan K. Shrestha, Uru Thapa, Veronica C. Hoad and Helen M. Faddy

    Citation: BMC Infectious Diseases 2016 16:707

    Content type: Research article

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  23. Studies have shown that the immunosuppression induced by the human immunodeficiency virus (HIV) accelerates the natural history of liver disease associated with hepatitis C virus (HCV), with 3- to 5-fold highe...

    Authors: Fatima Mitiko Tengan, Karim Yakub Ibrahim, Bianca Peixoto Dantas, Caroline Manchiero, Mariana Cavalheiro Magri and Wanderley Marques Bernardo

    Citation: BMC Infectious Diseases 2016 16:663

    Content type: Research article

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  24. In the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands,...

    Authors: S. Sadik, G. G. C. van Rijckevorsel, M. S. van Rooijen, G. J. B. Sonder and S. M. Bruisten

    Citation: BMC Infectious Diseases 2016 16:659

    Content type: Research article

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  25. Hepatocellular Carcinoma (HCC) is one of the commonest cancers in Central Africa, a region with the unusual peculiarity to be hyperendemic for infections with Hepatitis B, C and D viruses. However, data estima...

    Authors: Marie Atsama Amougou, Dominique Noah Noah, Paul Fewou Moundipa, Pascal Pineau and Richard Njouom

    Citation: BMC Infectious Diseases 2016 16:647

    Content type: Research article

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  26. HCV treatment among people who inject drugs (PWID) is low. Education programs may be suitable strategies to improve patients’ knowledge about their condition and to overcome barriers to access treatment.

    Authors: Rui Tato Marinho, António Costa, Teodomiro Pires, Helena Raposo, Carlos Vasconcelos, Cristina Polónia, Joaquim Borges, Mariana Soares, Graça Vilar and Ana Maria Nogueira

    Citation: BMC Infectious Diseases 2016 16:565

    Content type: Research article

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  27. The Hepatitis Delta Virus (HDV) can increase the incidence of fulminant hepatitis. For this infection occurs, the host must also be infected with Hepatitis B Virus. Previous studies demonstrated the endemicity...

    Authors: Maira Ferreira Cicero, Nathalia Mantovani Pena, Luiz Claudio Santana, Rafael Arnold, Rafael Gonçalves Azevedo, Élcio de Souza Leal, Ricardo Sobhie Diaz and Shirley Vasconcelos Komninakis

    Citation: BMC Infectious Diseases 2016 16:525

    Content type: Research article

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  28. As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver ...

    Authors: Nghiem Xuan Hoan, Nguyen Khuyen, Mai Thanh Binh, Dao Phuong Giang, Hoang Van Tong, Phan Quoc Hoan, Ngo Tat Trung, Do Tuan Anh, Nguyen Linh Toan, Christian G. Meyer, Peter G. Kremsner, Thirumalaisamy P. Velavan and Le Huu Song

    Citation: BMC Infectious Diseases 2016 16:507

    Content type: Research article

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  29. Neonatal hepatitis B vaccination program at birth has been implemented nationwide since 1992 in China. However, current HBV prevalence status in blood donors has not been entirely examined, which may impact HB...

    Authors: Zhen Wang, Jinfeng Zeng, Tingting Li, Xin Zheng, Xiaoxuan Xu, Xianlin Ye, Liang Lu, Weigang Zhu, Baocheng Yang, Jean-Pierre Allain and Chengyao Li

    Citation: BMC Infectious Diseases 2016 16:498

    Content type: Research article

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  30. Hepatitis C virus (HCV) infection causes significant morbidity and mortality among people who inject drugs (PWID) and HIV+ men who have sex with men (MSM). Characterizing spontaneous viral clearance of HCV inf...

    Authors: Daniel J. Smith, Ashly E. Jordan, Mayu Frank and Holly Hagan

    Citation: BMC Infectious Diseases 2016 16:471

    Content type: Research article

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  31. Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects ...

    Authors: Andrew Richard Armstrong, Susan Elizabeth Herrmann, Olivier Chassany, Christophe Lalanne, Mariliza Henrique Da Silva, Eliana Galano, Patrizia M. Carrieri, Vincent Estellon, Philippe Sogni and Martin Duracinsky

    Citation: BMC Infectious Diseases 2016 16:443

    Content type: Research article

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  32. Chronic hepatitis B virus(HBV) infection is a major cause of liver related morbidity and mortality. HBV infection remains largely underdiagnosed in Asian American population, and it is also poorly linked to cl...

    Authors: Chul S. Hyun, Sue Kim, Seung Y. Kang, Seo Jung and Seulgi Lee

    Citation: BMC Infectious Diseases 2016 16:415

    Content type: Research article

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  33. Multi-drug resistant tuberculosis (MDR-TB) is a major public health problem especially in developing countries. World Health Organization (WHO) recommends use of Xpert MTB/RIF assay to simultaneously detecting My...

    Authors: Irfan Ullah, Aamer Ali Shah, Anila Basit, Mazhar Ali, Afsar khan, Ubaid Ullah, Muhammad Ihtesham, Sumaira Mehreen, Anita Mughal and Arshad Javaid

    Citation: BMC Infectious Diseases 2016 16:413

    Content type: Research article

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  34. Currently, no system for appropriate intra-hospital collaboration regarding hepatitis virus positive individuals exists, even in medical institutions with hepatologists among their staff. The main objective of...

    Authors: Hideki Fujii, Seiko Yamaguchi, Osamu Kurai, Masato Miyano, Wataru Ueda, Hiroko Oba, Tetsuya Aoki, Masaru Enomoto, Norifumi Kawada and Kiyotaka Okawa

    Citation: BMC Infectious Diseases 2016 16:410

    Content type: Research article

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  35. Chronic hepatitis B virus (HBV) infection is complicated by cirrhosis and liver cancer. In Thailand, 6-7 % of adults are chronically infected with HBV. The risk of mother-to-child transmission (MTCT) of HBV ha...

    Authors: Gonzague Jourdain, Nicole Ngo-Giang-Huong, Tim R. Cressey, Lei Hua, Linda Harrison, Camlin Tierney, Nicolas Salvadori, Luc Decker, Patrinee Traisathit, Wasna Sirirungsi, Woottichai Khamduang, Chureeratana Bowonwatanuwong, Thanyawee Puthanakit, George K. Siberry, Diane Heather Watts, Trudy V. Murphy…

    Citation: BMC Infectious Diseases 2016 16:393

    Content type: Study protocol

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  36. To fully understand the burden of hepatitis C (HCV) infection in Ghana towards informing appropriate preventive measures, accurate prevalence estimates are needed. In this study, we estimate the prevalence of ...

    Authors: Akosua Adom Agyeman, Richard Ofori-Asenso, Andy Mprah and George Ashiagbor

    Citation: BMC Infectious Diseases 2016 16:391

    Content type: Research article

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  37. Hepatitis B virus is one of the most causative agents of human liver disease, including acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma. The disease is a great health problem worldwide, wit...

    Authors: Daniel Gebreegziabher, Gebrekidan Gebregzabher Asfeha and Hagos Amare Gebreyesus

    Citation: BMC Infectious Diseases 2016 16:383

    Content type: Research article

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  38. Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor. The etiology of ICC remains poorly understood. Recently, hepatitis B virus (HBV) infection has been implicated as a potential risk factor for IC...

    Authors: Caixia Wang, Haiyan Jing, Dan Sha, Weibo Wang, Jianpeng Chen, Yangang Cui and Junqing Han

    Citation: BMC Infectious Diseases 2016 16:295

    Content type: Case report

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  39. Hepatitis C (HCV) is a deleterious virus that can be cured with new, highly effective anti-viral treatments, yet more than 185 million individuals worldwide remain HCV positive (with the vast majority un-diagn...

    Authors: Nallely Mora, William H. Adams, Stephanie Kliethermes, Lara Dugas, Neelam Balasubramanian, Jasmin Sandhu, Helen Nde, Christina Small, Joanne Jose, Steven Scaglione and Jennifer E. Layden

    Citation: BMC Infectious Diseases 2016 16:283

    Content type: Research article

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  40. Information on reporting completeness of passive surveillance systems can improve the quality of and public health response to surveillance data and better inform public health planning. As a result, we system...

    Authors: Rachel D. Savage, Laura C. Rosella, Kevin A. Brown, Kamran Khan and Natasha S. Crowcroft

    Citation: BMC Infectious Diseases 2016 16:281

    Content type: Research article

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  41. Hepatitis B virus (HBV) variants belong to different genotypes, A-J, whose worldwide distribution is linked with geography, probably because viral spread was associated with ancient human migrations. HBV genot...

    Authors: Marion Cornelissen, Fokla Zorgdrager, Sylvia M. Bruisten, Margreet Bakker, Ben Berkhout and Antoinette C. van der Kuyl

    Citation: BMC Infectious Diseases 2016 16:268

    Content type: Research article

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  42. Prisoners represent a vulnerable population for blood-borne and sexually transmitted infections which can potentially lead to liver fibrosis and ultimately cirrhosis. However, little is known about the prevale...

    Authors: Antoine Jaquet, Gilles Wandeler, Judicaël Tine, Claver A. Dagnra, Alain Attia, Akouda Patassi, Abdoulaye Ndiaye, Victor de Ledinghen, Didier K. Ekouevi, Moussa Seydi and François Dabis

    Citation: BMC Infectious Diseases 2016 16:249

    Content type: Research article

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  43. Human immunodeficiency virus (HIV) infection leads to more rapid progression of hepatitis C virus (HCV)-related liver fibrosis, which could be linked to differences in the severity of liver inflammation among ...

    Authors: François M. J. Lamoury, Behzad Hajarizadeh, Elizabeth Keoshkerian, Jordan J. Feld, Janaki Amin, Suzy Teutsch, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Tanya L. Applegate and Jason Grebely

    Citation: BMC Infectious Diseases 2016 16:241

    Content type: Research article

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  44. Hepatitis C virus (HCV) treatment uptake globally is low. A barrier to treatment is the necessity to attend specialists, usually in a tertiary hospital. We investigate the literature to assess the effect of pr...

    Authors: Amanda J. Wade, Vanessa Veronese, Margaret E. Hellard and Joseph S. Doyle

    Citation: BMC Infectious Diseases 2016 16:202

    Content type: Research article

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  45. Interleukin-33 (IL-33) and ST2 have been demonstrated to be associated with liver damage. However, their potential value in hepatitis B virus (HBV) infection remains unknown. This study was designed to investi...

    Authors: Shu-Ling Huan, Ji-Guang Zhao, Zhen-Li Wang, Shuai Gao and Kai Wang

    Citation: BMC Infectious Diseases 2016 16:200

    Content type: Research article

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  46. Cirrhosis and severe sepsis are factors associated with increased mortality in intensive care unit (ICU), but chronic hepatitis C (CHC) has been less studied in ICU. The aim of this study was to analyze the im...

    Authors: Alejandro Álvaro-Meca, María A. Jiménez-Sousa, Alexandre Boyer, José Medrano, Holger Reulen, Thomas Kneib and Salvador Resino

    Citation: BMC Infectious Diseases 2016 16:122

    Content type: Research article

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  47. Viral hepatitis is a major concern worldwide, with hepatitis A (HAV) and E (HEV) viruses showing sporadic outbreaks while hepatitis B (HBV) and C (HCV) viruses are associated with chronic hepatitis, cirrhosis ...

    Authors: Missiani Ochwoto, James H. Kimotho, Julius Oyugi, Fredrick Okoth, Henry Kioko, Simeon Mining, Nancy L. M. Budambula, Elizabeth Giles, Anton Andonov, Elijah Songok and Carla Osiowy

    Citation: BMC Infectious Diseases 2016 16:101

    Content type: Research article

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  48. Hepatitis E virus (HEV) is a major cause of hepatitis in developing countries and poses a threat to public health worldwide. Tree shrew (Tupaia belangeri chinensis) is a useful animal model in studies on hepatiti...

    Authors: Wenhai Yu, Chenchen Yang, Yanhong Bi, Feiyan Long, Yunlong Li, Jue Wang and Fen Huang

    Citation: BMC Infectious Diseases 2016 16:80

    Content type: Research article

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