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Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Content type: Research article

    China is an endemic area for hepatitis E virus (HEV). The previous surveys of anti-HEV seroprevalence are cross-sectional. This study aimed to investigate the prevalence of infection among pregnant women and t...

    Authors: Guangyu Gu, Hongyu Huang, Le Zhang, Yongchun Bi, Yali Hu and Yi-Hua Zhou

    Citation: BMC Infectious Diseases 2015 15:560

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  2. Content type: Research article

    International guidelines and U.S. guidelines prior to 2012 only recommended testing for hepatitis C virus (HCV) infection among patients at risk, but adherence to guidelines is poor, and the majority of those ...

    Authors: William N. Southern, Brianna Norton, Meredith Steinman, Joseph DeLuca, Mari-Lynn Drainoni, Bryce D. Smith and Alain H. Litwin

    Citation: BMC Infectious Diseases 2015 15:553

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  3. Content type: Research article

    Geographic and sociodemographic characterization of hepatitis C virus (HCV) transmission amongst men who have sex with men (MSM) has been limited. Our aim was to characterize HCV prevalence, risk factors for H...

    Authors: Kara W. Chew, Martha L. Blum, Marjan Javanbakht, Laurel E. Clare, Lorelei D. Bornfleth, Robert Bolan, Debika Bhattacharya and Pamina M. Gorbach

    Citation: BMC Infectious Diseases 2015 15:538

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  4. Content type: Case report

    Hepatitis E virus (HEV) is the most recently discovered of the hepatotropic viruses, and is considered an emerging pathogen in developed countries with the possibility of fulminant hepatitis in immunocompromis...

    Authors: Detlev Schultze, Bernhard Mani, Günter Dollenmaier, Roland Sahli, Andrea Zbinden and Pierre Alexandre Krayenbühl

    Citation: BMC Infectious Diseases 2015 15:474

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  5. Content type: Research article

    Tissue factor (TF) is a protein that mediates the initiation of the coagulation cascade. TF expression is increased in patients with poorly-controlled HIV, and may be associated with increased immune activatio...

    Authors: Aimee C Hodowanec, Rebecca D Lee, Kirsten E Brady, Weihua Gao, Stacey Kincaid, Jill Plants, Mieoak Bahk, Nigel Mackman, Alan L Landay and Gregory D Huhn

    Citation: BMC Infectious Diseases 2015 15:190

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  6. Content type: Research article

    Hepatitis B (HB) infection is common in Mali. However, there is little information on molecular and biochemical characteristics of HB carriers.

    Authors: Fatou Traoré, Emmanuelle Gormally, Stéphanie Villar, Marlin D Friesen, John D Groopman, Guy Vernet, Souleymane Diallo, Pierre Hainaut and Moussa Y Maiga

    Citation: BMC Infectious Diseases 2015 15:180

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  7. Content type: Research article

    The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C p...

    Authors: Ching-Chih Hu, Chih-Lang Lin, Liang-Che Chang, Cheng-Hung Chien, Li-Wei Chen, Ching-Jung Liu and Rong-Nan Chien

    Citation: BMC Infectious Diseases 2015 15:156

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  8. Content type: Research article

    We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluc...

    Authors: Sarah Maylin, Jean-Marie Sire, Papa Saliou Mbaye, François Simon, Anna Sarr, Marie-Louise Evra, Fatou Fall, Jean Daveiga, Aboubakry Diallo, Jean-Marc Debonne, Loic Chartier and Muriel Vray

    Citation: BMC Infectious Diseases 2015 15:154

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  9. Content type: Research article

    Universal hepatitis B virus (HBV) vaccination of newborn babies was introduced in Italy in 1991 and was extended to 12-years-old children for the first 12 years of application so as to cover in a dozen years t...

    Authors: Nicola Coppola, Anna Rita Corvino, Stefania De Pascalis, Giuseppe Signoriello, Eliana Di Fiore, Albert Nienhaus, Evangelista Sagnelli and Monica Lamberti

    Citation: BMC Infectious Diseases 2015 15:149

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  10. Content type: Research article

    Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected ...

    Authors: Grace X Ma, Guo Yolanda Zhang, Shumenghui Zhai, Xiang Ma, Yin Tan, Steven E Shive and Min Qi Wang

    Citation: BMC Infectious Diseases 2015 15:120

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  11. Content type: Research article

    Hepatitis B infection is a major public health problem in Ethiopia. Health care workers are at increased risk of acquiring hepatitis B infection due to occupational exposure. There is effective and safe vaccin...

    Authors: Gedefaw Abeje and Muluken Azage

    Citation: BMC Infectious Diseases 2015 15:30

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  12. Content type: Research article

    The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases i...

    Authors: Hoang Van Tong, Le Huu Song, Nghiem Xuan Hoan, Bui Khac Cuong, Bui Tien Sy, Ho Anh Son, Do Quyet, Vu Quoc Binh, Peter G Kremsner, Claus Thomas Bock, Thirumalaisamy P Velavan and Nguyen Linh Toan

    Citation: BMC Infectious Diseases 2015 15:25

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  13. Content type: Research article

    The goal of chronic hepatitis C treatment is to remove the virus to avoid progression of HCV-related disease. Sustained virologic response (SVR) is the most widely used efficacy endpoint in clinical studies of...

    Authors: Jayne Smith-Palmer, Karin Cerri and William Valentine

    Citation: BMC Infectious Diseases 2015 15:19

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  14. Content type: Research article

    Variations at DEPDC5 gene have been recently reported as genetic markers associated with hepatocellular carcinoma (HCC) progression in chronic HCV-infected patients. This study was conducted to assess the asso...

    Authors: Mashael R Al-Anazi, Sabine Matou-Nasri, Ayman A Abdo, Faisal M Sanai, Mohammed Q Khan, Ali Albenmousa, Hamad I Al-Ashgar, Nisreen Z Khalaf, Mohammed N Al-Ahdal and Ahmed A Al-Qahtani

    Citation: BMC Infectious Diseases 2014 14:632

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  15. Content type: Research article

    Genes related to antigen presentation pathway, which are in the non-classical class-II region of human leukocyte antigen (HLA), play a vital role during the infection of hepatitis C virus (HCV).

    Authors: Peng Huang, Li Dong, Xiaomei Lu, Yuanyuan Zhang, Hongbo Chen, Jie Wang, Yun Zhang, Jing Su and Rongbin Yu

    Citation: BMC Infectious Diseases 2014 14:716

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  16. Content type: Research article

    Intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the original template for HBV replication. The persistence of cccDNA is responsible for the recurrence of HBV infection. The dete...

    Authors: Yanwei Zhong, Shuangye Hu, Chen Xu, Yulai Zhao, Dongping Xu, Yanqing Zhao, Jingmin Zhao, Zhibin Li, Xiuchang Zhang, Hongfei Zhang and Jin Li

    Citation: BMC Infectious Diseases 2014 14:608

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  17. Content type: Research article

    Collecting adequate information on key epidemiological indicators is a prerequisite to informing a public health response to reduce the impact of hepatitis C virus (HCV) infection in Malaysia. Our goal was to ...

    Authors: Scott A McDonald, Rosmawati Mohamed, Maznah Dahlui, Herlianna Naning and Adeeba Kamarulzaman

    Citation: BMC Infectious Diseases 2014 14:564

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  18. Content type: Research article

    The measurement of hepatitis C virus core antigen (HCV-coreAg) has been shown to be an indicator of active HCV infection. The aim of the present study was 1) to investigate the stability and effectiveness of H...

    Authors: Lu Long, Tao Shen, Jian Gao, Zhaojun Duan, Hua Liang and Fengmin Lu

    Citation: BMC Infectious Diseases 2014 14:577

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  19. Content type: Research article

    Current estimates suggest over 218,000 individuals in Australia are chronically infected with hepatitis B virus. The majority of these people are migrants and refugees born in hepatitis B endemic countries, wh...

    Authors: Tanya FM Dahl, Benjamin C Cowie, Beverley-Ann Biggs, Karin Leder, Jennifer H MacLachlan and Caroline Marshall

    Citation: BMC Infectious Diseases 2014 14:537

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  20. Content type: Research article

    A decline in hemoglobin (Hb) concentration during antiviral therapy in chronic hepatitis C (CHC) is a serious side effect. It may compel to dose reduction or even termination of antiviral treatment. The activa...

    Authors: Ahmad Amanzada, Armin D Goralczyk, Lars Reinhardt, Federico Moriconi, Silke Cameron and Sabine Mihm

    Citation: BMC Infectious Diseases 2014 14:503

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  21. Content type: Research article

    Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV. This study evaluated the impact of adding the oral HCV NS3/4...

    Authors: Jane Scott, Kathleen Rosa, Min Fu, Karin Cerri, Monika Peeters, Maria Beumont, Stefan Zeuzem, Donna M Evon and Leen Gilles

    Citation: BMC Infectious Diseases 2014 14:465

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  22. Content type: Research article

    Hepatitis A virus (HAV) and hepatitis E virus (HEV) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. The endemicity of HAV infection has sh...

    Authors: Claudia Lamarca Vitral, Mônica da Silva-Nunes, Marcelo Alves Pinto, Jaqueline Mendes de Oliveira, Ana Maria Coimbra Gaspar, Rebeca Cristina Costa Pereira and Marcelo Urbano Ferreira

    Citation: BMC Infectious Diseases 2014 14:458

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  23. Content type: Research article

    Despite hepatitis B vaccination at birth and at 6, 10 and 14 weeks of age, hepatitis B virus (HBV) infection continues to be endemic in the Lao People’s Democratic Republic (PDR). We carried out a cross-sectio...

    Authors: Antony P Black, Phonethipsavanh Nouanthong, Naphavan Nanthavong, Chanthasone Souvannaso, Keooudomphone Vilivong, Prapan Jutavijittum, Bounthome Samountry, Nina Lütteke, Judith M Hübschen, Sylvie Goossens, Fabrice Quet, Yves Buisson and Claude P Muller

    Citation: BMC Infectious Diseases 2014 14:457

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  24. Content type: Research article

    The durability of off-treatment virologic responses has not been fully elucidated in chronic hepatitis B (CHB) patients who have previously achieved complete virologic suppression with nucleos(t)ide analog (NA...

    Authors: Hyung Rae Sohn, Bo Young Min, Joon Chang Song, Mun Hyuk Seong, Sang Soo Lee, Eun Sun Jang, Cheol Min Shin, Young Soo Park, Jin-Hyeok Hwang, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee and Jin-Wook Kim

    Citation: BMC Infectious Diseases 2014 14:439

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  25. Content type: Research article

    Transient elastography (TE) is widely used for non-invasive assessment of liver fibrosis in HIV-HCV co-infected patients. TE, however, cannot determine liver morphology. Acoustic radiation force impulse (ARFI)...

    Authors: Nora Frulio, Hervé Trillaud, Paul Perez, Julien Asselineau, Marianne Vandenhende, Mojgan Hessamfar, Fabrice Bonnet, Florent Maire, Jean Delaune, Victor De Ledinghen and Philippe Morlat

    Citation: BMC Infectious Diseases 2014 14:405

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  26. Content type: Research article

    Hypervariable region 1 (HVR1) contained within envelope protein 2 (E2) gene is the most variable part of HCV genome and its translation product is a major target for the host immune response. Variability withi...

    Authors: Kamila Caraballo Cortés, Osvaldo Zagordi, Karol Perlejewski, Tomasz Laskus, Krzysztof Maroszek, Iwona Bukowska-Ośko, Agnieszka Pawełczyk, Rafał Płoski, Hanna Berak, Andrzej Horban and Marek Radkowski

    Citation: BMC Infectious Diseases 2014 14:389

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  27. Content type: Research article

    The impact of pregnancy on the clinical course of acute hepatitis B (AHB) is still largely unclear, mainly because most studies have not included matched controls. This study was conducted to investigate the c...

    Authors: Yong-Tao Han, Chao Sun, Cai-Xia Liu, Shuang-Shuang Xie, Di Xiao, Li Liu, Jin-Hong Yu, Wen-Wen Li and Qiang Li

    Citation: BMC Infectious Diseases 2014 14:368

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  28. Content type: Research article

    Hepatitis E Virus (HEV) infection is a newly recognized serious threat to global public health and Africa is suspected to be among the most severely affected regions in the world. Understanding HEV epidemiolog...

    Authors: Jong-Hoon Kim, Kenrad E Nelson, Ursula Panzner, Yogita Kasture, Alain B Labrique and Thomas F Wierzba

    Citation: BMC Infectious Diseases 2014 14:308

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    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:187

  29. Content type: Research article

    Hepatitis B virus (HBV) infection is prevalent in Asian immigrants in the USA. California’s Inland Empire region has a population of approximately four million, including an estimated 19,000 first generation K...

    Authors: Natali Navarro, Nelson Lim, Jiah Kim, Elliot Joo, Kendrick Che, Bruce Allen Runyon and Michel Henry Mendler

    Citation: BMC Infectious Diseases 2014 14:269

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  30. Content type: Research article

    A good correlation between HCV core antigen (HCVAg) and different HCV-RNA assays has been described, but little data are available in HCV/HIV co-infection. We aimed to evaluate HCVAg in comparison with HCV-RNA...

    Authors: Anna Rosa Garbuglia, Alessia Monachetti, Claudio Galli, Rosella Sabatini, Monica Lucia Ferreri, Maria Rosaria Capobianchi and Patrizia Bagnarelli

    Citation: BMC Infectious Diseases 2014 14:222

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  31. Content type: Research article

    In HIV infected patients, the impact of ribavirin (RBV) pharmacology on sustained virologic response (SVR) to hepatitis C virus (HCV) treatment has not been fully investigated. The objective of this study was ...

    Authors: Giorgiana Hatu, François Bailly, Emmanuel Pourcelot, Pierre Pradat, Patrick Miailhes, Marianne Maynard, François Parant, Pierre Chiarello, Jean-Michel Livrozet, Fabien Zoulim and Marie-Claude Gagnieu

    Citation: BMC Infectious Diseases 2014 14:150

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  32. Content type: Research article

    Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) are the two most important agents of infectious diseases. Both HBV and HIV share common modes of transmission and have serious effects on both pre...

    Authors: Yohannes Zenebe, Wondemagegn Mulu, Mulat Yimer and Bayeh Abera

    Citation: BMC Infectious Diseases 2014 14:118

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  33. Content type: Case report

    Prior to initiating immunosuppressive therapy in the treatment of autoimmune inflammatory conditions, it is a requirement to screen for certain viral serology, including hepatitis B (HBV). A positive result ma...

    Authors: Simon Parker, Eliza Gil, Patricia Hewitt, Katherine Ward, Yasmin Reyal, Sasha Wilson and Jessica Manson

    Citation: BMC Infectious Diseases 2014 14:99

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  34. Content type: Research article

    Hepatitis B virus (HBV) and hepatitis D virus (HDV) represent important public health problems in the Western Amazon region with reported cases of fulminant hepatitis. This cross sectional study describes HBV ...

    Authors: Myuki Alfaia Esashika Crispim, Nelson Abrahim Fraiji, Sonia Cordeiro Campello, Nicolaus Albert Schriefer, Mariane Martins Araújo Stefani and Dagmar Kiesslich

    Citation: BMC Infectious Diseases 2014 14:94

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  35. Content type: Research article

    Hepatitis B virus (HBV) DNA levels are crucial for managing chronic hepatitis B (CHB). It was unclear whether Daan real-time polymerase chain reaction test (Daan test) or COBAS TaqMan HBV DNA Test (Cobas TaqMa...

    Authors: Shao-hang Cai, Fang-fang Lv, Yong-hong Zhang, Ye-gui Jiang and Jie Peng

    Citation: BMC Infectious Diseases 2014 14:85

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  36. Content type: Research article

    In China, caregivers of chronic viral hepatitis patients experience considerable burdens, stress and disruption of their own well-being and social activities. Measurement of the effect on caregivers is an unde...

    Authors: Hong Ren, Yan Yu, Jia-Yu Hu, Yang Shi, Yi-Han Lu and Wei Meng

    Citation: BMC Infectious Diseases 2014 14:82

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  37. Content type: Research article

    In an attempt to curtail the rising morbidity and mortality from undiagnosed HCV (hepatitis C virus) in the United States, screening guidelines have been expanded to high-risk individuals and persons born 1945...

    Authors: Brianna L Norton, Corrine I Voils, Sarah H Timberlake, Emily J Hecker, Neela D Goswami, Kim M Huffman, Anneka Landgraf, Susanna Naggie and Jason E Stout

    Citation: BMC Infectious Diseases 2014 14:74

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  38. Content type: Research article

    Hepatitis C virus (HCV) is mainly transmitted by parenteral route, being blood transfusion and intravenous drug use the most frequent risk factors. However, it has been suggested that there are other routes of...

    Authors: Francisca Sosa-Jurado, Verónica L Hernández-Galindo, Daniel Meléndez-Mena, Miguel A Mendoza-Torres, Fernando J Martínez-Arroniz, Verónica Vallejo-Ruiz, Julio Reyes-Leyva and Gerardo Santos-López

    Citation: BMC Infectious Diseases 2014 14:72

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  39. Content type: Research article

    IFN-α has been used to treat patients with chronic active hepatitis B (CAHB). Recent studies have implicated the IL-23/Th-17 pathway in the pathogenesis of CAHB. In this study, we investigated whether IFN-α co...

    Authors: Fang Cui, Jiangping Meng, Peng Luo and Pu Chen

    Citation: BMC Infectious Diseases 2014 14:55

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  40. Content type: Research article

    Hepatitis B virus (HBV) is divided into 8 definite (A-H) and 2 putative (I, J) genotypes that show a geographical distribution. HBV genotype G, however, is an aberrant genotype of unknown origin that demonstra...

    Authors: Antoinette C van der Kuyl, Fokla Zorgdrager, Boris Hogema, Margreet Bakker, Suzanne Jurriaans, Nicole KT Back, Ben Berkhout, Hans L Zaaijer and Marion Cornelissen

    Citation: BMC Infectious Diseases 2013 13:540

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  41. Content type: Research article

    Neither HBV DNA nor HBsAg positivity at birth is an accurate marker for HBV infection of infants. No data is available for continuous changes of HBV markers in newborns to HBsAg(+) mothers. This prospective, m...

    Authors: Tianyan Chen, Jing Wang, Yuling Feng, Zhi Yan, Tieying Zhang, Minghui Liu, Yun Bai, Hongxia Song, Hongli Liu, Yuan Yang, Jinfeng Liu, Yingli He, Yunru Chen, Shulin Zhang, Guihua Zhuang, Xiaofeng Liang…

    Citation: BMC Infectious Diseases 2013 13:524

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  42. Content type: Research article

    Hepatitis E virus (HEV) has been described as an emerging pathogen in Brazil and seems to be widely disseminated among swine herds. An autochthonous human case of acute hepatitis E was recently reported. To ob...

    Authors: Lilian G de Carvalho, Renato S Marchevsky, Debora RL dos Santos, Jaqueline M de Oliveira, Vanessa S de Paula, Leilane M Lopes, Wilhelmus HM Van der Poel, Jorge E González, Maria S Munné, Julio Moran, Ana Carolina R A Cajaraville, Marcelo Pelajo-Machado, Oswaldo G Cruz and Marcelo A Pinto

    Citation: BMC Infectious Diseases 2013 13:495

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  43. Content type: Research article

    Hepatitis B e Antigen (HBeAg)-negative chronic hepatitis B (CHB) patients have an active liver disease with a high risk of progression to decompensated cirrhosis and hepatocellular carcinoma. The management st...

    Authors: Dengming He, Shimin Guo, Wen Chen, Xianli Chen, Guohua Yan, Jie Wang, Maoshi Li, Peng Zhu, Hongfei Huang and Yuming Wang

    Citation: BMC Infectious Diseases 2013 13:458

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  44. Content type: Research article

    Sporadic hepatitis E has become an important public health concern in China. Accurate forecasting of the incidence of hepatitis E is needed to better plan future medical needs. Few mathematical models can be u...

    Authors: Hong Ren, Jian Li, Zheng-An Yuan, Jia-Yu Hu, Yan Yu and Yi-Han Lu

    Citation: BMC Infectious Diseases 2013 13:421

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  45. Content type: Research article

    In Australia, higher rates of chronic hepatitis B (HBsAg) have been reported among Aboriginal and Torres Strait Islander (Indigenous) compared with non-Indigenous people. In 2000, the Australian government imp...

    Authors: Simon Graham, Rebecca J Guy, Benjamin Cowie, Handan C Wand, Basil Donovan, Snehal P Akre and James S Ward

    Citation: BMC Infectious Diseases 2013 13:403

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  46. Content type: Case report

    Reactivation of hepatitis B virus (HBV), characterized by increased levels of serum HBV DNA, abnormal liver function and hepatic failure, is a frequent complication of immunosuppressive therapy and chemotherap...

    Authors: Wenjun Du, Zhaomin Zheng, Shaolei Han, Shumin Ma and Shijun Chen

    Citation: BMC Infectious Diseases 2013 13:394

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