Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Research article

    Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review

    Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...

    Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E. Thwaites, Ngoc Nghiem My, Stephen Baker and Thomas C. Darton

    BMC Infectious Diseases 2017 17:260

    Published on: 11 April 2017

  2. Research article

    Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

    In chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic s...

    Mariana Cavalheiro Magri, Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Celso Carmo Mazza and Fátima Mitiko Tengan

    BMC Infectious Diseases 2017 17:235

    Published on: 29 March 2017

  3. Research article

    Hepatitis C virus and HIV co-infection among pregnant women in Rwanda

    Hepatitis C virus (HCV) infection is a pandemic causing disease; more than 185 million people are infected worldwide. An HCV antibody (Ab) prevalence of 6.0% was estimated in Central African countries. The stu...

    Mwumvaneza Mutagoma, Helene Balisanga, Dieudonné Sebuhoro, Aimable Mbituyumuremyi, Eric Remera, Samuel S. Malamba, David J. Riedel and Sabin Nsanzimana

    BMC Infectious Diseases 2017 17:167

    Published on: 22 February 2017

  4. Research article

    The need for treatment scale-up to impact HCV transmission in people who inject drugs in Montréal, Canada: a modelling study

    HCV transmission remains high in people who inject drugs (PWID) in Montréal. New direct-acting antivirals (DAAs), highly effective and more tolerable than previous regimens, make a “Treatment as Prevention” (T...

    Anthony Cousien, Pascale Leclerc, Carole Morissette, Julie Bruneau, Élise Roy, Viet Chi Tran, Yazdan Yazdanpanah and Joseph Cox

    BMC Infectious Diseases 2017 17:162

    Published on: 21 February 2017

  5. Research article

    Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status

    The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an associ...

    Sayeh Ezzikouri, Hajar Chihab, Abdellah Elhabazi, Lahcen Wakrim and Soumaya Benjelloun

    BMC Infectious Diseases 2017 17:99

    Published on: 26 January 2017

  6. Research article

    Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

    Cocaine and crack use has been associated with HIV and HCV infections, but its consequences on HCV progression have not been well established. We analyzed the impact of cocaine/crack use on liver fibrosis prog...

    Valérie Martel-Laferrière, Roy Nitulescu, Joseph Cox, Curtis Cooper, Mark Tyndall, Danielle Rouleau, Sharon Walmsley, Leo Wong and Marina B. Klein

    BMC Infectious Diseases 2017 17:80

    Published on: 17 January 2017

  7. Research article

    Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line

    Toll like receptors (TLRs) play an important role in innate immunity and various studies suggest that TLRs play a crucial role in pathogenesis of hepatitis B virus (HBV) infection. The present study aims in lo...

    Dipanwita Das, Isha Sengupta, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivaram Prasad Singh, Sekhar Chakrabarti and Runu Chakravarty

    BMC Infectious Diseases 2017 17:76

    Published on: 14 January 2017

  8. Research article

    The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease

    There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatit...

    Jim Young, Nina Weis, Harald Hofer, William Irving, Ola Weiland, Emiliano Giostra, Juan Manuel Pascasio, Lluis Castells, Martin Prieto, Roelien Postema, Cinira Lefevre, David Evans, Heiner C. Bucher and Jose Luis Calleja

    BMC Infectious Diseases 2017 17:45

    Published on: 7 January 2017

  9. Research article

    Hepatitis B virus strains from Rwandan blood donors are genetically similar and form one clade within subgenotype A1

    Rwanda is a central African country with about 12 million inhabitants. The 1994 genocide against the Tutsi destroyed much of the infrastructure, including the health system. Although this has improved signific...

    Theogene Twagirumugabe, Gatare Swaibu, Timothy David Walker, Magnus Lindh, Jean Bosco Gahutu, Tomas Bergström and Heléne Norder

    BMC Infectious Diseases 2017 17:32

    Published on: 6 January 2017

  10. Research article

    Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

    The concentrations of hepatitis B virus (HBV) DNA and surface antigen (HBsAg) are two critical virological variables to be monitored in chronic hepatitis B. HBsAg is derived from the HBV genome. Thus, higher H...

    Chao-Wei Hsu, Kung-Hao Liang, Chih-Lang Lin, Tong-Hong Wang and Chau-Ting Yeh

    BMC Infectious Diseases 2017 17:9

    Published on: 5 January 2017

  11. Research article

    Hepatitis viruses in Ethiopia: a systematic review and meta-analysis

    The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic...

    Yeshambel Belyhun, Melanie Maier, Andargachew Mulu, Ermias Diro and Uwe Gerd Liebert

    BMC Infectious Diseases 2016 16:761

    Published on: 19 December 2016

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:114

  12. Research article

    Hepatitis E virus seroepidemiology: a post-earthquake study among blood donors in Nepal

    As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of wate...

    Ashish C. Shrestha, Robert L. P. Flower, Clive R. Seed, Manita Rajkarnikar, Shrawan K. Shrestha, Uru Thapa, Veronica C. Hoad and Helen M. Faddy

    BMC Infectious Diseases 2016 16:707

    Published on: 25 November 2016

  13. Research article

    Seroprevalence of hepatitis C virus among people living with HIV/AIDS in Latin America and the Caribbean: a systematic review

    Studies have shown that the immunosuppression induced by the human immunodeficiency virus (HIV) accelerates the natural history of liver disease associated with hepatitis C virus (HCV), with 3- to 5-fold highe...

    Fatima Mitiko Tengan, Karim Yakub Ibrahim, Bianca Peixoto Dantas, Caroline Manchiero, Mariana Cavalheiro Magri and Wanderley Marques Bernardo

    BMC Infectious Diseases 2016 16:663

    Published on: 9 November 2016

  14. Research article

    Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

    In the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands,...

    S. Sadik, G. G. C. van Rijckevorsel, M. S. van Rooijen, G. J. B. Sonder and S. M. Bruisten

    BMC Infectious Diseases 2016 16:659

    Published on: 8 November 2016

  15. Research article

    A prominent role of Hepatitis D Virus in liver cancers documented in Central Africa

    Hepatocellular Carcinoma (HCC) is one of the commonest cancers in Central Africa, a region with the unusual peculiarity to be hyperendemic for infections with Hepatitis B, C and D viruses. However, data estima...

    Marie Atsama Amougou, Dominique Noah Noah, Paul Fewou Moundipa, Pascal Pineau and Richard Njouom

    BMC Infectious Diseases 2016 16:647

    Published on: 7 November 2016

  16. Research article

    A multidimensional education program at substance dependence treatment centers improves patient knowledge and hepatitis C care

    HCV treatment among people who inject drugs (PWID) is low. Education programs may be suitable strategies to improve patients’ knowledge about their condition and to overcome barriers to access treatment.

    Rui Tato Marinho, António Costa, Teodomiro Pires, Helena Raposo, Carlos Vasconcelos, Cristina Polónia, Joaquim Borges, Mariana Soares, Graça Vilar and Ana Maria Nogueira

    BMC Infectious Diseases 2016 16:565

    Published on: 12 October 2016

  17. Research article

    Is Hepatitis Delta infections important in Brazil?

    The Hepatitis Delta Virus (HDV) can increase the incidence of fulminant hepatitis. For this infection occurs, the host must also be infected with Hepatitis B Virus. Previous studies demonstrated the endemicity...

    Maira Ferreira Cicero, Nathalia Mantovani Pena, Luiz Claudio Santana, Rafael Arnold, Rafael Gonçalves Azevedo, Élcio de Souza Leal, Ricardo Sobhie Diaz and Shirley Vasconcelos Komninakis

    BMC Infectious Diseases 2016 16:525

    Published on: 29 September 2016

  18. Research article

    Association of vitamin D deficiency with hepatitis B virus - related liver diseases

    As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver ...

    Nghiem Xuan Hoan, Nguyen Khuyen, Mai Thanh Binh, Dao Phuong Giang, Hoang Van Tong, Phan Quoc Hoan, Ngo Tat Trung, Do Tuan Anh, Nguyen Linh Toan, Christian G. Meyer, Peter G. Kremsner, Thirumalaisamy P. Velavan and Le Huu Song

    BMC Infectious Diseases 2016 16:507

    Published on: 23 September 2016

  19. Research article

    Prevalence of hepatitis B surface antigen (HBsAg) in a blood donor population born prior to and after implementation of universal HBV vaccination in Shenzhen, China

    Neonatal hepatitis B vaccination program at birth has been implemented nationwide since 1992 in China. However, current HBV prevalence status in blood donors has not been entirely examined, which may impact HB...

    Zhen Wang, Jinfeng Zeng, Tingting Li, Xin Zheng, Xiaoxuan Xu, Xianlin Ye, Liang Lu, Weigang Zhu, Baocheng Yang, Jean-Pierre Allain and Chengyao Li

    BMC Infectious Diseases 2016 16:498

    Published on: 20 September 2016

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